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Protein

Neuralized-like protein 2

Gene

NEURL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Neuralized-like protein 2
Gene namesi
Name:NEURL2
Synonyms:C20orf163
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000124257.6
HGNCiHGNC:16156 NEURL2
MIMi608597 gene
neXtProtiNX_Q9BR09

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi140825
OpenTargetsiENSG00000124257
PharmGKBiPA25705

Polymorphism and mutation databases

DMDMi33301415

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001812571 – 285Neuralized-like protein 2Add BLAST285

Proteomic databases

PaxDbiQ9BR09
PRIDEiQ9BR09
ProteomicsDBi78735

Expressioni

Tissue specificityi

Expressed specifically in skeletal and cardiac muscles.1 Publication

Gene expression databases

BgeeiENSG00000124257 Expressed in 144 organ(s), highest expression level in adrenal gland
CleanExiHS_NEURL2
ExpressionAtlasiQ9BR09 baseline and differential
GenevisibleiQ9BR09 HS

Organism-specific databases

HPAiHPA043402
HPA059842

Interactioni

Subunit structurei

Probable component the ECS(NEURL2) E3 ubiquitin-protein ligase complex consisting of ELOB/Elongin B, ELOC/Elongin C, CUL5, RBX1 and NEURL2. Interacts with CTNNB1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000361596

Structurei

3D structure databases

ProteinModelPortaliQ9BR09
SMRiQ9BR09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 244NHRPROSITE-ProRule annotationAdd BLAST222
Domaini250 – 285SOCS boxPROSITE-ProRule annotationAdd BLAST36

Domaini

The SOCS domain mediates the interaction with ELOB and ELOC, while the NHR domain may be involved in ubiquitination substrate binding.By similarity

Phylogenomic databases

eggNOGiENOG410IMDX Eukaryota
ENOG4111F7Q LUCA
GeneTreeiENSGT00730000110931
HOGENOMiHOG000231005
HOVERGENiHBG052607
InParanoidiQ9BR09
KOiK16782
OMAiCIEQFRI
OrthoDBiEOG091G0IKU
PhylomeDBiQ9BR09
TreeFamiTF314368

Family and domain databases

InterProiView protein in InterPro
IPR037962 Neuralized
IPR006573 NHR_dom
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR12429 PTHR12429, 1 hit
PfamiView protein in Pfam
PF07177 Neuralized, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00588 NEUZ, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
PROSITEiView protein in PROSITE
PS51065 NHR, 1 hit
PS50225 SOCS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BR09-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAASEPVDS GALWGLERPE PPPTRFHRVH GANIRVDPSG TRATRVESFA
60 70 80 90 100
HGVCFSREPL APGQVFLVEI EEKELGWCGH LRLGLTALDP ASLAPVPEFS
110 120 130 140 150
LPDLVNLGHT WVFAITRHHN RVPREGRPEA EAAAPSRPPT LLVEPYLRIE
160 170 180 190 200
QFRIPRDRLV GRSRPGLYSH LLDQLYELNV LPPTARRSRL GVLFCPRPDG
210 220 230 240 250
TADMHIIING EDMGPSARGL PAAQPLYAVV DVFASTKSVR LVQLEYGLPS
260 270 280
LQTLCRLVIQ RSMVHRLAID GLHLPKELKD FCKYE
Length:285
Mass (Da):31,690
Last modified:June 1, 2001 - v1
Checksum:i6C79A17CC41BF180
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YGA6H0YGA6_HUMAN
Neuralized-like protein 2
NEURL2
90Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052033211E → K. Corresponds to variant dbSNP:rs35342327Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054821 mRNA Translation: BAB70810.1
AJ295985 mRNA Translation: CAC82498.1
AL008726 Genomic DNA No translation available.
BC074737 mRNA Translation: AAH74737.1
BC105935 mRNA Translation: AAI05936.1
BC107485 mRNA Translation: AAI07486.1
CCDSiCCDS13384.1
RefSeqiNP_001265464.1, NM_001278535.1
NP_542787.1, NM_080749.3
UniGeneiHs.517094
Hs.609336

Genome annotation databases

EnsembliENST00000372518; ENSP00000361596; ENSG00000124257
GeneIDi140825
KEGGihsa:140825
UCSCiuc002xqg.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054821 mRNA Translation: BAB70810.1
AJ295985 mRNA Translation: CAC82498.1
AL008726 Genomic DNA No translation available.
BC074737 mRNA Translation: AAH74737.1
BC105935 mRNA Translation: AAI05936.1
BC107485 mRNA Translation: AAI07486.1
CCDSiCCDS13384.1
RefSeqiNP_001265464.1, NM_001278535.1
NP_542787.1, NM_080749.3
UniGeneiHs.517094
Hs.609336

3D structure databases

ProteinModelPortaliQ9BR09
SMRiQ9BR09
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000361596

Polymorphism and mutation databases

DMDMi33301415

Proteomic databases

PaxDbiQ9BR09
PRIDEiQ9BR09
ProteomicsDBi78735

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372518; ENSP00000361596; ENSG00000124257
GeneIDi140825
KEGGihsa:140825
UCSCiuc002xqg.3 human

Organism-specific databases

CTDi140825
DisGeNETi140825
EuPathDBiHostDB:ENSG00000124257.6
GeneCardsiNEURL2
HGNCiHGNC:16156 NEURL2
HPAiHPA043402
HPA059842
MIMi608597 gene
neXtProtiNX_Q9BR09
OpenTargetsiENSG00000124257
PharmGKBiPA25705
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMDX Eukaryota
ENOG4111F7Q LUCA
GeneTreeiENSGT00730000110931
HOGENOMiHOG000231005
HOVERGENiHBG052607
InParanoidiQ9BR09
KOiK16782
OMAiCIEQFRI
OrthoDBiEOG091G0IKU
PhylomeDBiQ9BR09
TreeFamiTF314368

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-8951664 Neddylation

Miscellaneous databases

GeneWikiiNEURL2
GenomeRNAii140825
PROiPR:Q9BR09
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124257 Expressed in 144 organ(s), highest expression level in adrenal gland
CleanExiHS_NEURL2
ExpressionAtlasiQ9BR09 baseline and differential
GenevisibleiQ9BR09 HS

Family and domain databases

InterProiView protein in InterPro
IPR037962 Neuralized
IPR006573 NHR_dom
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR12429 PTHR12429, 1 hit
PfamiView protein in Pfam
PF07177 Neuralized, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00588 NEUZ, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
PROSITEiView protein in PROSITE
PS51065 NHR, 1 hit
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNEUL2_HUMAN
AccessioniPrimary (citable) accession number: Q9BR09
Secondary accession number(s): Q3KR34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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