UniProtKB - Q9BQY4 (RHXF2_HUMAN)
Protein
Rhox homeobox family member 2
Gene
RHOXF2
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis.1 Publication
Caution
RHOF2 and RHOF2B are arranged in a head-to-head orientation and share high sequence similarity (>99%). They cannot easily be distinguished and are usually analyzed as a single gene.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 134 – 193 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- positive regulation of gene expression Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9BQY4 |
Names & Taxonomyi
Protein namesi | Recommended name: Rhox homeobox family member 2Alternative name(s): Paired-like homeobox protein PEPP-2 Testis homeobox gene 1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30011, RHOXF2 |
MIMi | 300447, gene |
neXtProti | NX_Q9BQY4 |
VEuPathDBi | HostDB:ENSG00000131721.5 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 84528 |
OpenTargetsi | ENSG00000131721 |
PharmGKBi | PA162401288 |
Miscellaneous databases
Pharosi | Q9BQY4, Tbio |
Genetic variation databases
BioMutai | RHOXF2 |
DMDMi | 37537987 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049246 | 1 – 288 | Rhox homeobox family member 2Add BLAST | 288 |
Proteomic databases
EPDi | Q9BQY4 |
MassIVEi | Q9BQY4 |
MaxQBi | Q9BQY4 |
PaxDbi | Q9BQY4 |
PeptideAtlasi | Q9BQY4 |
PRIDEi | Q9BQY4 |
ProteomicsDBi | 78727 |
PTM databases
iPTMneti | Q9BQY4 |
PhosphoSitePlusi | Q9BQY4 |
Expressioni
Tissue specificityi
Testis. Not detected in epididymis nor placenta. In testis, mainly expressed in germ cells, but also detected in somatic cells such as Sertoli cells, Leydig cells and peritubular cells (PubMed:28171660).2 Publications
Developmental stagei
Predominantly expressed in early stage germ cells, type-B spermatogonia and early spermatocytes.1 Publication
Gene expression databases
Bgeei | ENSG00000131721, Expressed in testis and 34 other tissues |
Genevisiblei | Q9BQY4, HS |
Organism-specific databases
HPAi | ENSG00000131721, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Q9BQY4
Protein-protein interaction databases
BioGRIDi | 124119, 107 interactors |
IntActi | Q9BQY4, 86 interactors |
STRINGi | 9606.ENSP00000360441 |
Miscellaneous databases
RNActi | Q9BQY4, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 186 – 195 | Nuclear localization signalBy similarity | 10 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 245 – 286 | Pro-richAdd BLAST | 42 |
Sequence similaritiesi
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000164624 |
HOGENOMi | CLU_044595_1_0_1 |
InParanoidi | Q9BQY4 |
OMAi | LCFSMSP |
OrthoDBi | 1514681at2759 |
PhylomeDBi | Q9BQY4 |
TreeFami | TF339348 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9BQY4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPPDQCSQY MTSLLSPAVD DEKELQDMNA MVLSLTEEVK EEEEDAQPEP
60 70 80 90 100
EQGTAAGEKL KSAGAQGGEE KDGGGEEKDG GGAGVPGHLW EGDLEGTSGS
110 120 130 140 150
DGNVEDSDQS EKEPGQQYSR PQGAVGGLEP GNAQQPNVHA FTPLQLQELE
160 170 180 190 200
RIFQREQFPS EFLRRRLARS MNVTELAVQI WFENRRAKWR RHQRALMARN
210 220 230 240 250
MLPFMAVGQP VMVTAAEAIT APLFISGMRD DYFWDHSHSS SLCFPMPPFP
260 270 280
PPSLPLPLML LPPMPPAGQA EFGPFPFVIV PSFTFPNV
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_078297 | 68 | G → R Found in infertile men; unknown pathological significance; decreased induction of target genes expression. 1 PublicationCorresponds to variant dbSNP:rs148604152Ensembl. | 1 | |
Natural variantiVAR_078298 | 176 | L → F Found in infertile men; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199871532Ensembl. | 1 | |
Natural variantiVAR_078299 | 227 | G → R Found in infertile men; unknown pathological significance; decreased induction of target genes expression. 1 PublicationCorresponds to variant dbSNP:rs1210761967Ensembl. | 1 | |
Natural variantiVAR_078300 | 235 | D → G Found in infertile men; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs6646602Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF317219 mRNA Translation: AAL02160.1 AL590526 mRNA Translation: CAC36519.1 AK058125 mRNA Translation: BAB71675.1 BC021719 mRNA Translation: AAH21719.1 |
CCDSi | CCDS14594.1 |
RefSeqi | NP_115887.1, NM_032498.2 |
Genome annotation databases
Ensembli | ENST00000371388; ENSP00000360441; ENSG00000131721 |
GeneIDi | 84528 |
KEGGi | hsa:84528 |
UCSCi | uc004esl.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF317219 mRNA Translation: AAL02160.1 AL590526 mRNA Translation: CAC36519.1 AK058125 mRNA Translation: BAB71675.1 BC021719 mRNA Translation: AAH21719.1 |
CCDSi | CCDS14594.1 |
RefSeqi | NP_115887.1, NM_032498.2 |
3D structure databases
SMRi | Q9BQY4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124119, 107 interactors |
IntActi | Q9BQY4, 86 interactors |
STRINGi | 9606.ENSP00000360441 |
PTM databases
iPTMneti | Q9BQY4 |
PhosphoSitePlusi | Q9BQY4 |
Genetic variation databases
BioMutai | RHOXF2 |
DMDMi | 37537987 |
Proteomic databases
EPDi | Q9BQY4 |
MassIVEi | Q9BQY4 |
MaxQBi | Q9BQY4 |
PaxDbi | Q9BQY4 |
PeptideAtlasi | Q9BQY4 |
PRIDEi | Q9BQY4 |
ProteomicsDBi | 78727 |
Protocols and materials databases
Antibodypediai | 520, 160 antibodies |
DNASUi | 84528 |
Genome annotation databases
Ensembli | ENST00000371388; ENSP00000360441; ENSG00000131721 |
GeneIDi | 84528 |
KEGGi | hsa:84528 |
UCSCi | uc004esl.4, human |
Organism-specific databases
CTDi | 84528 |
DisGeNETi | 84528 |
GeneCardsi | RHOXF2 |
HGNCi | HGNC:30011, RHOXF2 |
HPAi | ENSG00000131721, Tissue enriched (testis) |
MIMi | 300447, gene |
neXtProti | NX_Q9BQY4 |
OpenTargetsi | ENSG00000131721 |
PharmGKBi | PA162401288 |
VEuPathDBi | HostDB:ENSG00000131721.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000164624 |
HOGENOMi | CLU_044595_1_0_1 |
InParanoidi | Q9BQY4 |
OMAi | LCFSMSP |
OrthoDBi | 1514681at2759 |
PhylomeDBi | Q9BQY4 |
TreeFami | TF339348 |
Enzyme and pathway databases
PathwayCommonsi | Q9BQY4 |
Miscellaneous databases
BioGRID-ORCSi | 84528, 8 hits in 528 CRISPR screens |
GenomeRNAii | 84528 |
Pharosi | Q9BQY4, Tbio |
PROi | PR:Q9BQY4 |
RNActi | Q9BQY4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000131721, Expressed in testis and 34 other tissues |
Genevisiblei | Q9BQY4, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RHXF2_HUMAN | |
Accessioni | Q9BQY4Primary (citable) accession number: Q9BQY4 Secondary accession number(s): Q9BR00 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2003 |
Last sequence update: | June 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families