UniProtKB - Q9BQW3 (COE4_HUMAN)
Protein
Transcription factor COE4
Gene
EBF4
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional factor which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 152 – 171 | C5-typeSequence analysisAdd BLAST | 20 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9BQW3 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor COE4Alternative name(s): Early B-cell factor 4 Short name: EBF-4 Olf-1/EBF-like 4 Short name: O/E-4 Short name: OE-4 |
Gene namesi | Name:EBF4 Synonyms:COE4, KIAA1442 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29278, EBF4 |
MIMi | 609935, gene |
neXtProti | NX_Q9BQW3 |
VEuPathDBi | HostDB:ENSG00000088881.20 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000088881 |
PharmGKBi | PA162384262 |
Miscellaneous databases
Pharosi | Q9BQW3, Tbio |
Genetic variation databases
BioMutai | EBF4 |
DMDMi | 152031576 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000107835 | 1 – 602 | Transcription factor COE4Add BLAST | 602 |
Proteomic databases
jPOSTi | Q9BQW3 |
MassIVEi | Q9BQW3 |
PaxDbi | Q9BQW3 |
PeptideAtlasi | Q9BQW3 |
PRIDEi | Q9BQW3 |
ProteomicsDBi | 78725 [Q9BQW3-2] 78726 [Q9BQW3-1] |
TopDownProteomicsi | Q9BQW3-1 [Q9BQW3-1] |
PTM databases
iPTMneti | Q9BQW3 |
PhosphoSitePlusi | Q9BQW3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000088881, Expressed in prostate gland and 177 other tissues |
ExpressionAtlasi | Q9BQW3, baseline and differential |
Organism-specific databases
HPAi | ENSG00000088881, Low tissue specificity |
Interactioni
Subunit structurei
Forms either a homodimer or a heterodimer with a related family member.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 164 | Interaction with DNABy similarity | 1 | |
Sitei | 173 | Interaction with DNABy similarity | 1 |
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 121644, 3 interactors |
IntActi | Q9BQW3, 1 interactor |
STRINGi | 9606.ENSP00000370022 |
Miscellaneous databases
RNActi | Q9BQW3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 256 – 338 | IPT/TIGAdd BLAST | 83 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 64 – 67 | Interaction with DNABy similarity | 4 | |
Regioni | 198 – 205 | Interaction with DNABy similarity | 8 | |
Regioni | 237 – 240 | Interaction with DNABy similarity | 4 |
Sequence similaritiesi
Belongs to the COE family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 152 – 171 | C5-typeSequence analysisAdd BLAST | 20 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3836, Eukaryota |
GeneTreei | ENSGT00950000182859 |
InParanoidi | Q9BQW3 |
OrthoDBi | 817293at2759 |
PhylomeDBi | Q9BQW3 |
Family and domain databases
CDDi | cd11606, COE_DBD, 1 hit cd01175, IPT_COE, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.3180, 1 hit 4.10.280.10, 2 hits |
InterProi | View protein in InterPro IPR032200, COE_DBD IPR038173, COE_DBD_sf IPR032201, COE_HLH IPR038006, COE_IPT IPR036638, HLH_DNA-bd_sf IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR003523, Transcription_factor_COE IPR018350, Transcription_factor_COE_CS |
PANTHERi | PTHR10747, PTHR10747, 1 hit |
Pfami | View protein in Pfam PF16422, COE1_DBD, 1 hit PF16423, COE1_HLH, 1 hit PF01833, TIG, 1 hit |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS01345, COE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 2 (identifier: Q9BQW3-2) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFPAQDALPR SGLNLKEEPL LPAGLGSVRS WMQGAGILDA STAAQSGVGL
60 70 80 90 100
ARAHFEKQPP SNLRKSNFFH FVLAMYDRQG QPVEVERTAF IDFVEKDREP
110 120 130 140 150
GAEKTNNGIH YRLRLVYNNG LRTEQDLYVR LIDSMSKQAI IYEGQDKNPE
160 170 180 190 200
MCRVLLTHEI MCSRCCDRKS CGNRNETPSD PVIIDRFFLK FFLKCNQNCL
210 220 230 240 250
KNAGNPRDMR RFQVVVSTTV SVDGHVLAVS DNMFVHNNSK HGRRARRLDP
260 270 280 290 300
SEAATPCIKA ISPGEGWTTG GATVIVIGDN FFDGLQVVFG NVLVWSELIT
310 320 330 340 350
PHAIRVQTPP RHIPGVVEVT LSYKSKQFCK GCPGRFVYTA LNEPTIDYGF
360 370 380 390 400
QRLQKVIPRH PGDPERLPKE VLLKRAADLA EALYGVPGSN QELLLKRAAD
410 420 430 440 450
VAEALYSTPR APGPLAPLAP SHPHPAVVGI NAFSSPLAIA VGDATPGPEP
460 470 480 490 500
GYARSCSSAS PRGFAPSPGS QQSGYGGGLG AGLGGYGAPG VAGLGVPGSP
510 520 530 540 550
SFLNGSTATS PFAIMPSSPP LAAASSMSLP AAAPTTSVFS FSPVNMISAV
560 570 580 590 600
KQRSAFAPVL RPPSSPPQAC PRAHGEGLPD QSFEDSDKFH SPARGLQGLA
YS
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PEI2 | E9PEI2_HUMAN | Transcription factor COE4 | EBF4 | 598 | Annotation score: | ||
A0A0A0MSW2 | A0A0A0MSW2_HUMAN | Transcription factor COE4 | EBF4 | 540 | Annotation score: | ||
A0A6I8PR97 | A0A6I8PR97_HUMAN | Transcription factor COE4 | EBF4 | 98 | Annotation score: | ||
A0A6I8PRX3 | A0A6I8PRX3_HUMAN | Transcription factor COE4 | EBF4 | 138 | Annotation score: | ||
A0A6I8PL90 | A0A6I8PL90_HUMAN | Transcription factor COE4 | EBF4 | 53 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 425 | P → S in BAA92680 (PubMed:10718198).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_026469 | 1 – 5 | MFPAQ → MARARGQAPGSGGRRRPRRG GAGTGPRGESAGLLLLLLQV LPPGATAGPGRRGTRGAGGG GVCWPGAAPAFPRDARLLLL LPPLPPLSPPPPSSAPAASA SRM in isoform 1. 1 Publication | 5 | |
Alternative sequenceiVSP_026470 | 514 – 602 | IMPSS…GLAYS → KERLRPRAAPPKLPTPGLPQ SPRRGASRPVF in isoform 1. 1 PublicationAdd BLAST | 89 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL035460 Genomic DNA No translation available. AB037863 mRNA Translation: BAA92680.1 |
RefSeqi | NP_001103984.1, NM_001110514.1 |
Genome annotation databases
Ensembli | ENST00000609451; ENSP00000477023; ENSG00000088881 [Q9BQW3-2] |
GeneIDi | 57593 |
KEGGi | hsa:57593 |
UCSCi | uc061vby.1, human [Q9BQW3-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL035460 Genomic DNA No translation available. AB037863 mRNA Translation: BAA92680.1 |
RefSeqi | NP_001103984.1, NM_001110514.1 |
3D structure databases
SMRi | Q9BQW3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121644, 3 interactors |
IntActi | Q9BQW3, 1 interactor |
STRINGi | 9606.ENSP00000370022 |
PTM databases
iPTMneti | Q9BQW3 |
PhosphoSitePlusi | Q9BQW3 |
Genetic variation databases
BioMutai | EBF4 |
DMDMi | 152031576 |
Proteomic databases
jPOSTi | Q9BQW3 |
MassIVEi | Q9BQW3 |
PaxDbi | Q9BQW3 |
PeptideAtlasi | Q9BQW3 |
PRIDEi | Q9BQW3 |
ProteomicsDBi | 78725 [Q9BQW3-2] 78726 [Q9BQW3-1] |
TopDownProteomicsi | Q9BQW3-1 [Q9BQW3-1] |
Protocols and materials databases
Antibodypediai | 23277, 92 antibodies |
Genome annotation databases
Ensembli | ENST00000609451; ENSP00000477023; ENSG00000088881 [Q9BQW3-2] |
GeneIDi | 57593 |
KEGGi | hsa:57593 |
UCSCi | uc061vby.1, human [Q9BQW3-2] |
Organism-specific databases
CTDi | 57593 |
GeneCardsi | EBF4 |
HGNCi | HGNC:29278, EBF4 |
HPAi | ENSG00000088881, Low tissue specificity |
MIMi | 609935, gene |
neXtProti | NX_Q9BQW3 |
OpenTargetsi | ENSG00000088881 |
PharmGKBi | PA162384262 |
VEuPathDBi | HostDB:ENSG00000088881.20 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3836, Eukaryota |
GeneTreei | ENSGT00950000182859 |
InParanoidi | Q9BQW3 |
OrthoDBi | 817293at2759 |
PhylomeDBi | Q9BQW3 |
Enzyme and pathway databases
PathwayCommonsi | Q9BQW3 |
Miscellaneous databases
BioGRID-ORCSi | 57593, 10 hits in 1011 CRISPR screens |
ChiTaRSi | EBF4, human |
GenomeRNAii | 57593 |
Pharosi | Q9BQW3, Tbio |
PROi | PR:Q9BQW3 |
RNActi | Q9BQW3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000088881, Expressed in prostate gland and 177 other tissues |
ExpressionAtlasi | Q9BQW3, baseline and differential |
Family and domain databases
CDDi | cd11606, COE_DBD, 1 hit cd01175, IPT_COE, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.3180, 1 hit 4.10.280.10, 2 hits |
InterProi | View protein in InterPro IPR032200, COE_DBD IPR038173, COE_DBD_sf IPR032201, COE_HLH IPR038006, COE_IPT IPR036638, HLH_DNA-bd_sf IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR003523, Transcription_factor_COE IPR018350, Transcription_factor_COE_CS |
PANTHERi | PTHR10747, PTHR10747, 1 hit |
Pfami | View protein in Pfam PF16422, COE1_DBD, 1 hit PF16423, COE1_HLH, 1 hit PF01833, TIG, 1 hit |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS01345, COE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COE4_HUMAN | |
Accessioni | Q9BQW3Primary (citable) accession number: Q9BQW3 Secondary accession number(s): Q1MTP7 Q9P2A6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2002 |
Last sequence update: | July 10, 2007 | |
Last modified: | April 7, 2021 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families