SLC25A21

Functionⁱ

Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.

GO - Molecular functionⁱ

alpha-ketoglutarate transmembrane transporter activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

lysine catabolic process Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-71064 Lysine catabolism

Reactomeⁱ

R-HSA-71064 Lysine catabolism

Protein family/group databases

TCDBⁱ	2.A.29.2.4 the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.2.4 the mitochondrial carrier (mc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mitochondrial 2-oxodicarboxylate carrier Alternative name(s): Solute carrier family 25 member 21
Gene namesⁱ	Name:SLC25A21 Synonyms:ODC
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000183032.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14411 SLC25A21
MIMⁱ	607571 gene
neXtProtⁱ	NX_Q9BQT8

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	17 – 37	Helical; Name=1Sequence analysisAdd BLAST	21
Transmembraneⁱ	70 – 89	Helical; Name=2Sequence analysisAdd BLAST	20
Transmembraneⁱ	113 – 133	Helical; Name=3Sequence analysisAdd BLAST	21
Transmembraneⁱ	167 – 187	Helical; Name=4Sequence analysisAdd BLAST	21
Transmembraneⁱ	205 – 225	Helical; Name=5Sequence analysisAdd BLAST	21
Transmembraneⁱ	277 – 297	Helical; Name=6Sequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	89874
Open Targets More...OpenTargetsⁱ	ENSG00000183032
PharmGKBⁱ	PA37880

Polymorphism and mutation databases

BioMutaⁱ	SLC25A21

BioMutaⁱ

SLC25A21

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000090644	1 – 299	Mitochondrial 2-oxodicarboxylate carrierAdd BLAST		299

Proteomic databases

EPDⁱ	Q9BQT8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BQT8
PaxDbⁱ	Q9BQT8
PeptideAtlas More...PeptideAtlasⁱ	Q9BQT8
PRIDEⁱ	Q9BQT8
ProteomicsDBⁱ	78721

PTM databases

iPTMnetⁱ	Q9BQT8
PhosphoSitePlusⁱ	Q9BQT8

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000183032 Expressed in 102 organ(s), highest expression level in liver
CleanExⁱ	HS_SLC25A21
Genevisibleⁱ	Q9BQT8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA000662

HPAⁱ

HPA000662

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	124629, 5 interactors
IntActⁱ	Q9BQT8, 2 interactors
STRINGⁱ	9606.ENSP00000329452

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BQT8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	11 – 100	Solcar 1Add BLAST	90
Repeatⁱ	107 – 196	Solcar 2Add BLAST	90
Repeatⁱ	205 – 294	Solcar 3Add BLAST	90

Sequence similaritiesⁱ

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0754 Eukaryota ENOG410XRZG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111119
HOGENOMⁱ	HOG000168307
HOVERGENⁱ	HBG105598
InParanoidⁱ	Q9BQT8
KEGG Orthology (KO) More...KOⁱ	K15110
OMAⁱ	KYNWTYP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DEF
PhylomeDBⁱ	Q9BQT8
TreeFamⁱ	TF314035

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR002067 Mit_carrier IPR040062 Mitochondrial_carrier_protein IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
PANTHERⁱ	PTHR24089 PTHR24089, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
PRINTSⁱ	PR00926 MITOCARRIER
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9BQT8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAKPEVSLV REASRQIVAG GSAGLVEICL MHPLDVVKTR FQIQRCATDP 
        60         70         80         90        100
NSYKSLVDSF RMIFQMEGLF GFYKGILPPI LAETPKRAVK FFTFEQYKKL 
       110        120        130        140        150
LGYVSLSPAL TFAIAGLGSG LTEAIVVNPF EVVKVGLQAN RNTFAEQPST 
       160        170        180        190        200
VGYARQIIKK EGWGLQGLNK GLTATLGRHG VFNMVYFGFY YNVKNMIPVN 
       210        220        230        240        250
KDPILEFWRK FGIGLLSGTI ASVINIPFDV AKSRIQGPQP VPGEIKYRTC 
       260        270        280        290 
FKTMATVYQE EGILALYKGL LPKIMRLGPG GAVMLLVYEY TYSWLQENW

Length:299

Mass (Da):33,303

Last modified:June 1, 2001 - v1

Checksum:ⁱ69A259400328AE19

GO

Isoform 2 (identifier: Q9BQT8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
299-299: Missing.

« Hide

        10         20         30         40         50
MSAKPEVSLV REASRQIVAG GSAGLVEICL MHPLDVVKTR FQIQRCATDP 
        60         70         80         90        100
NSYKSLVDSF RMIFQMEGLF GFYKGILPPI LAETPKRAVK FFTFEQYKKL 
       110        120        130        140        150
LGYVSLSPAL TFAIAGLGSG LTEAIVVNPF EVVKVGLQAN RNTFAEQPST 
       160        170        180        190        200
VGYARQIIKK EGWGLQGLNK GLTATLGRHG VFNMVYFGFY YNVKNMIPVN 
       210        220        230        240        250
KDPILEFWRK FGIGLLSGTI ASVINIPFDV AKSRIQGPQP VPGEIKYRTC 
       260        270        280        290 
FKTMATVYQE EGILALYKGL LPKIMRLGPG GAVMLLVYEY TYSWLQEN

Show »

Length:298

Mass (Da):33,117

Checksum:ⁱ0259400328AE1911

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050131	299	W → C. Corresponds to variant dbSNP:rs17104991Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046690	299	Missing in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ278148 mRNA Translation: CAC27562.1 AK289575 mRNA Translation: BAF82264.1 AL079303 Genomic DNA No translation available. AL079304 Genomic DNA No translation available. AL121775 Genomic DNA No translation available. AL162464 Genomic DNA No translation available. BC101521 mRNA Translation: AAI01522.1 BC113365 mRNA Translation: AAI13366.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS55913.1 [Q9BQT8-2] CCDS9663.1 [Q9BQT8-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001164641.1, NM_001171170.1 [Q9BQT8-2] NP_085134.1, NM_030631.3 [Q9BQT8-1]
UniGeneⁱ	Hs.730857

Genome annotation databases

Ensemblⁱ	ENST00000331299; ENSP00000329452; ENSG00000183032 [Q9BQT8-1] ENST00000555449; ENSP00000451873; ENSG00000183032 [Q9BQT8-2]
GeneIDⁱ	89874
KEGGⁱ	hsa:89874
UCSC genome browser More...UCSCⁱ	uc001wtz.3 human [Q9BQT8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BQT8	Mitochondrial 2-oxodicarboxylate carrier		PONAB		299	UniRef90_Q9BQT8
Isoform 2 of Mitochondrial 2-oxodicarboxylate carrier		HUMAN		298
Solute carrier family 25 member 21		SAIBB		299
Uncharacterized protein		Cebus capucinus imitator		299
Uncharacterized protein		AOTNA		299
+62

Protein	Similar proteins		Species	Score	Length	Source
Q9BQT8	Mitochondrial 2-oxodicarboxylate carrier		PONAB		299	UniRef50_Q9BQT8
Mitochondrial 2-oxodicarboxylate carrier		BOVIN		299
Isoform 2 of Mitochondrial 2-oxodicarboxylate carrier		HUMAN		298
Uncharacterized protein		RHIBE		299
Uncharacterized protein		RHIRO		299
+269

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ278148 mRNA Translation: CAC27562.1 AK289575 mRNA Translation: BAF82264.1 AL079303 Genomic DNA No translation available. AL079304 Genomic DNA No translation available. AL121775 Genomic DNA No translation available. AL162464 Genomic DNA No translation available. BC101521 mRNA Translation: AAI01522.1 BC113365 mRNA Translation: AAI13366.1
CCDSⁱ	CCDS55913.1 [Q9BQT8-2] CCDS9663.1 [Q9BQT8-1]
RefSeqⁱ	NP_001164641.1, NM_001171170.1 [Q9BQT8-2] NP_085134.1, NM_030631.3 [Q9BQT8-1]
UniGeneⁱ	Hs.730857

3D structure databases

ProteinModelPortalⁱ	Q9BQT8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124629, 5 interactors
IntActⁱ	Q9BQT8, 2 interactors
STRINGⁱ	9606.ENSP00000329452

Protein family/group databases

TCDBⁱ	2.A.29.2.4 the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.2.4 the mitochondrial carrier (mc) family

PTM databases

iPTMnetⁱ	Q9BQT8
PhosphoSitePlusⁱ	Q9BQT8

Polymorphism and mutation databases

BioMutaⁱ	SLC25A21

BioMutaⁱ

SLC25A21

Proteomic databases

EPDⁱ	Q9BQT8
MaxQBⁱ	Q9BQT8
PaxDbⁱ	Q9BQT8
PeptideAtlasⁱ	Q9BQT8
PRIDEⁱ	Q9BQT8
ProteomicsDBⁱ	78721

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	89874
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000331299; ENSP00000329452; ENSG00000183032 [Q9BQT8-1] ENST00000555449; ENSP00000451873; ENSG00000183032 [Q9BQT8-2]
GeneIDⁱ	89874
KEGGⁱ	hsa:89874
UCSCⁱ	uc001wtz.3 human [Q9BQT8-1]

Organism-specific databases

CTDⁱ	89874
DisGeNETⁱ	89874
EuPathDBⁱ	HostDB:ENSG00000183032.10
GeneCardsⁱ	SLC25A21
H-InvDBⁱ	HIX0037719
HGNCⁱ	HGNC:14411 SLC25A21
HPAⁱ	HPA000662
MIMⁱ	607571 gene
neXtProtⁱ	NX_Q9BQT8
OpenTargetsⁱ	ENSG00000183032
PharmGKBⁱ	PA37880
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0754 Eukaryota ENOG410XRZG LUCA
GeneTreeⁱ	ENSGT00730000111119
HOGENOMⁱ	HOG000168307
HOVERGENⁱ	HBG105598
InParanoidⁱ	Q9BQT8
KOⁱ	K15110
OMAⁱ	KYNWTYP
OrthoDBⁱ	EOG091G0DEF
PhylomeDBⁱ	Q9BQT8
TreeFamⁱ	TF314035

Enzyme and pathway databases

Reactomeⁱ	R-HSA-71064 Lysine catabolism

Reactomeⁱ

R-HSA-71064 Lysine catabolism

Miscellaneous databases

ChiTaRSⁱ	SLC25A21 human
GeneWikiⁱ	SLC25A21
GenomeRNAiⁱ	89874
Protein Ontology More...PROⁱ	PR:Q9BQT8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000183032 Expressed in 102 organ(s), highest expression level in liver
CleanExⁱ	HS_SLC25A21
Genevisibleⁱ	Q9BQT8 HS

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR002067 Mit_carrier IPR040062 Mitochondrial_carrier_protein IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
PANTHERⁱ	PTHR24089 PTHR24089, 1 hit
Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
PRINTSⁱ	PR00926 MITOCARRIER
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ODC_HUMAN
Accessionⁱ	Q9BQT8Primary (citable) accession number: Q9BQT8 Secondary accession number(s): A8K0L0, G3V4L5, Q3MJ99
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

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UniProtKB - Q9BQT8 (ODC_HUMAN)

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Mitochondrial 2-oxodicarboxylate carrier

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ