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Protein

Mitochondrial 2-oxodicarboxylate carrier

Gene

SLC25A21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-71064 Lysine catabolism

Protein family/group databases

TCDBi2.A.29.2.4 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxodicarboxylate carrier
Alternative name(s):
Solute carrier family 25 member 21
Gene namesi
Name:SLC25A21
Synonyms:ODC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000183032.10
HGNCiHGNC:14411 SLC25A21
MIMi607571 gene
neXtProtiNX_Q9BQT8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei70 – 89Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei167 – 187Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei205 – 225Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei277 – 297Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi89874
OpenTargetsiENSG00000183032
PharmGKBiPA37880

Polymorphism and mutation databases

BioMutaiSLC25A21

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906441 – 299Mitochondrial 2-oxodicarboxylate carrierAdd BLAST299

Proteomic databases

EPDiQ9BQT8
MaxQBiQ9BQT8
PaxDbiQ9BQT8
PeptideAtlasiQ9BQT8
PRIDEiQ9BQT8
ProteomicsDBi78721

PTM databases

iPTMnetiQ9BQT8
PhosphoSitePlusiQ9BQT8

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000183032 Expressed in 102 organ(s), highest expression level in liver
CleanExiHS_SLC25A21
GenevisibleiQ9BQT8 HS

Organism-specific databases

HPAiHPA000662

Interactioni

Protein-protein interaction databases

BioGridi124629, 5 interactors
IntActiQ9BQT8, 2 interactors
STRINGi9606.ENSP00000329452

Structurei

3D structure databases

ProteinModelPortaliQ9BQT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 100Solcar 1Add BLAST90
Repeati107 – 196Solcar 2Add BLAST90
Repeati205 – 294Solcar 3Add BLAST90

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0754 Eukaryota
ENOG410XRZG LUCA
GeneTreeiENSGT00730000111119
HOGENOMiHOG000168307
HOVERGENiHBG105598
InParanoidiQ9BQT8
KOiK15110
OMAiKYNWTYP
OrthoDBiEOG091G0DEF
PhylomeDBiQ9BQT8
TreeFamiTF314035

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PANTHERiPTHR24089 PTHR24089, 1 hit
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BQT8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAKPEVSLV REASRQIVAG GSAGLVEICL MHPLDVVKTR FQIQRCATDP
60 70 80 90 100
NSYKSLVDSF RMIFQMEGLF GFYKGILPPI LAETPKRAVK FFTFEQYKKL
110 120 130 140 150
LGYVSLSPAL TFAIAGLGSG LTEAIVVNPF EVVKVGLQAN RNTFAEQPST
160 170 180 190 200
VGYARQIIKK EGWGLQGLNK GLTATLGRHG VFNMVYFGFY YNVKNMIPVN
210 220 230 240 250
KDPILEFWRK FGIGLLSGTI ASVINIPFDV AKSRIQGPQP VPGEIKYRTC
260 270 280 290
FKTMATVYQE EGILALYKGL LPKIMRLGPG GAVMLLVYEY TYSWLQENW
Length:299
Mass (Da):33,303
Last modified:June 1, 2001 - v1
Checksum:i69A259400328AE19
GO
Isoform 2 (identifier: Q9BQT8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-299: Missing.

Show »
Length:298
Mass (Da):33,117
Checksum:i0259400328AE1911
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050131299W → C. Corresponds to variant dbSNP:rs17104991Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046690299Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278148 mRNA Translation: CAC27562.1
AK289575 mRNA Translation: BAF82264.1
AL079303 Genomic DNA No translation available.
AL079304 Genomic DNA No translation available.
AL121775 Genomic DNA No translation available.
AL162464 Genomic DNA No translation available.
BC101521 mRNA Translation: AAI01522.1
BC113365 mRNA Translation: AAI13366.1
CCDSiCCDS55913.1 [Q9BQT8-2]
CCDS9663.1 [Q9BQT8-1]
RefSeqiNP_001164641.1, NM_001171170.1 [Q9BQT8-2]
NP_085134.1, NM_030631.3 [Q9BQT8-1]
UniGeneiHs.730857

Genome annotation databases

EnsembliENST00000331299; ENSP00000329452; ENSG00000183032 [Q9BQT8-1]
ENST00000555449; ENSP00000451873; ENSG00000183032 [Q9BQT8-2]
GeneIDi89874
KEGGihsa:89874
UCSCiuc001wtz.3 human [Q9BQT8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278148 mRNA Translation: CAC27562.1
AK289575 mRNA Translation: BAF82264.1
AL079303 Genomic DNA No translation available.
AL079304 Genomic DNA No translation available.
AL121775 Genomic DNA No translation available.
AL162464 Genomic DNA No translation available.
BC101521 mRNA Translation: AAI01522.1
BC113365 mRNA Translation: AAI13366.1
CCDSiCCDS55913.1 [Q9BQT8-2]
CCDS9663.1 [Q9BQT8-1]
RefSeqiNP_001164641.1, NM_001171170.1 [Q9BQT8-2]
NP_085134.1, NM_030631.3 [Q9BQT8-1]
UniGeneiHs.730857

3D structure databases

ProteinModelPortaliQ9BQT8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124629, 5 interactors
IntActiQ9BQT8, 2 interactors
STRINGi9606.ENSP00000329452

Protein family/group databases

TCDBi2.A.29.2.4 the mitochondrial carrier (mc) family

PTM databases

iPTMnetiQ9BQT8
PhosphoSitePlusiQ9BQT8

Polymorphism and mutation databases

BioMutaiSLC25A21

Proteomic databases

EPDiQ9BQT8
MaxQBiQ9BQT8
PaxDbiQ9BQT8
PeptideAtlasiQ9BQT8
PRIDEiQ9BQT8
ProteomicsDBi78721

Protocols and materials databases

DNASUi89874
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331299; ENSP00000329452; ENSG00000183032 [Q9BQT8-1]
ENST00000555449; ENSP00000451873; ENSG00000183032 [Q9BQT8-2]
GeneIDi89874
KEGGihsa:89874
UCSCiuc001wtz.3 human [Q9BQT8-1]

Organism-specific databases

CTDi89874
DisGeNETi89874
EuPathDBiHostDB:ENSG00000183032.10
GeneCardsiSLC25A21
H-InvDBiHIX0037719
HGNCiHGNC:14411 SLC25A21
HPAiHPA000662
MIMi607571 gene
neXtProtiNX_Q9BQT8
OpenTargetsiENSG00000183032
PharmGKBiPA37880
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0754 Eukaryota
ENOG410XRZG LUCA
GeneTreeiENSGT00730000111119
HOGENOMiHOG000168307
HOVERGENiHBG105598
InParanoidiQ9BQT8
KOiK15110
OMAiKYNWTYP
OrthoDBiEOG091G0DEF
PhylomeDBiQ9BQT8
TreeFamiTF314035

Enzyme and pathway databases

ReactomeiR-HSA-71064 Lysine catabolism

Miscellaneous databases

ChiTaRSiSLC25A21 human
GeneWikiiSLC25A21
GenomeRNAii89874
PROiPR:Q9BQT8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183032 Expressed in 102 organ(s), highest expression level in liver
CleanExiHS_SLC25A21
GenevisibleiQ9BQT8 HS

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PANTHERiPTHR24089 PTHR24089, 1 hit
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiODC_HUMAN
AccessioniPrimary (citable) accession number: Q9BQT8
Secondary accession number(s): A8K0L0, G3V4L5, Q3MJ99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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