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Entry version 146 (13 Feb 2019)
Sequence version 3 (08 Feb 2011)
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Protein

FYVE and coiled-coil domain-containing protein 1

Gene

FYCO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May mediate microtubule plus end-directed vesicle transport.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1173 – 1231FYVE-typePROSITE-ProRule annotationAdd BLAST59

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FYVE and coiled-coil domain-containing protein 1
Alternative name(s):
Zinc finger FYVE domain-containing protein 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FYCO1
Synonyms:ZFYVE7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000163820.14

Human Gene Nomenclature Database

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HGNCi
HGNC:14673 FYCO1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607182 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BQS8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Lysosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cataract 18 (CTRCT18)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. Pathogenic mutations in FYCO1 can affect intracellular transport of autophagocytic vesicles from the perinuclear area to the periphery, leading to an accumulation of large numbers of vesicles and hence loss of lens transparency (PubMed:21636066).1 Publication
Disease descriptionAn opacification of the crystalline lens of the eye becoming evident at birth or in infancy. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.
See also OMIM:610019
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0659741376L → P in CTRCT18. 1 PublicationCorresponds to variant dbSNP:rs387906965EnsemblClinVar.1

Keywords - Diseasei

Cataract, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
79443

MalaCards human disease database

More...
MalaCardsi
FYCO1
MIMi610019 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000163820

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
98991 Early-onset nuclear cataract
98994 Total early-onset cataract

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28453

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FYCO1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
322510128

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002458372 – 1478FYVE and coiled-coil domain-containing protein 1Add BLAST1477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei196PhosphoserineCombined sources1
Modified residuei342PhosphoserineCombined sources1
Modified residuei381PhosphothreonineBy similarity1
Modified residuei878PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BQS8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9BQS8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BQS8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BQS8

PeptideAtlas

More...
PeptideAtlasi
Q9BQS8

PRoteomics IDEntifications database

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PRIDEi
Q9BQS8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78718
78719 [Q9BQS8-2]
78720 [Q9BQS8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BQS8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BQS8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163820 Expressed in 227 organ(s), highest expression level in biceps brachii

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BQS8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BQS8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035526
HPA057966

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can form homodimers. Interacts (via C-terminus) with MAP1LC3B. Interacts with RAB7A; the interaction with RAB7A induces FYCO1 recruitment to late endosomal/lysosomal compartments. Interacts with MAP1LC3B (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122669, 53 interactors

Database of interacting proteins

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DIPi
DIP-60600N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q9BQS8

Protein interaction database and analysis system

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IntActi
Q9BQS8, 39 interactors

Molecular INTeraction database

More...
MINTi
Q9BQS8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000296137

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11478
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CX3X-ray2.30E/F/G/H1273-1298[»]
5D94X-ray1.53B1276-1288[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9BQS8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BQS8

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 169RUNPROSITE-ProRule annotationAdd BLAST134
Domaini1337 – 1466GOLDPROSITE-ProRule annotationAdd BLAST130

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili4 – 33Sequence analysisAdd BLAST30
Coiled coili225 – 280Sequence analysisAdd BLAST56
Coiled coili394 – 555Sequence analysisAdd BLAST162
Coiled coili596 – 1151Sequence analysisAdd BLAST556

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1173 – 1231FYVE-typePROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1729 Eukaryota
ENOG410XPJK LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154044

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168295

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG063805

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BQS8

KEGG Orthology (KO)

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KOi
K21954

Identification of Orthologs from Complete Genome Data

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OMAi
CNNYVLT

Database of Orthologous Groups

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OrthoDBi
962969at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BQS8

TreeFam database of animal gene trees

More...
TreeFami
TF341788

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
IPR004012 Run_dom
IPR037213 Run_dom_sf
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01363 FYVE, 1 hit
PF02759 RUN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00064 FYVE, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF101576 SSF101576, 1 hit
SSF140741 SSF140741, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50866 GOLD, 1 hit
PS50826 RUN, 1 hit
PS50178 ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BQS8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASTNAESQL QRIIRDLQDA VTELSKEFQE AGEPITDDST SLHKFSYKLE
60 70 80 90 100
YLLQFDQKEK ATLLGNKKDY WDYFCACLAK VKGANDGIRF VKSISELRTS
110 120 130 140 150
LGKGRAFIRY SLVHQRLADT LQQCFMNTKV TSDWYYARSP FLQPKLSSDI
160 170 180 190 200
VGQLYELTEV QFDLASRGFD LDAAWPTFAR RTLTTGSSAY LWKPPSRSSS
210 220 230 240 250
MSSLVSSYLQ TQEMVSNFDL NSPLNNEALE GFDEMRLELD QLEVREKQLR
260 270 280 290 300
ERMQQLDREN QELRAAVSQQ GEQLQTERER GRTAAEDNVR LTCLVAELQK
310 320 330 340 350
QWEVTQATQN TVKELQTCLQ GLELGAAEKE EDYHTALRRL ESMLQPLAQE
360 370 380 390 400
LEATRDSLDK KNQHLASFPG WLAMAQQKAD TASDTKGRQE PIPSDAAQEM
410 420 430 440 450
QELGEKLQAL ERERTKVEEV NRQQSAQLEQ LVKELQLKED ARASLERLVK
460 470 480 490 500
EMAPLQEELS GKGQEADQLW RRLQELLAHT SSWEEELAEL RREKKQQQEE
510 520 530 540 550
KELLEQEVRS LTRQLQFLET QLAQVSQHVS DLEEQKKQLI QDKDHLSQQV
560 570 580 590 600
GMLERLAGPP GPELPVAGEK NEALVPVNSS LQEAWGKPEE EQRGLQEAQL
610 620 630 640 650
DDTKVQEGSQ EEELRQANRE LEKELQNVVG RNQLLEGKLQ ALQADYQALQ
660 670 680 690 700
QRESAIQGSL ASLEAEQASI RHLGDQMEAS LLAVRKAKEA MKAQMAEKEA
710 720 730 740 750
ILQSKEGECQ QLREEVEQCQ QLAEARHREL RALESQCQQQ TQLIEVLTAE
760 770 780 790 800
KGQQGVGPPT DNEARELAAQ LALSQAQLEV HQGEVQRLQA QVVDLQAKMR
810 820 830 840 850
AALDDQDKVQ SQLSMAEAVL REHKTLVQQL KEQNEALNRA HVQELLQCSE
860 870 880 890 900
REGALQEERA DEAQQREEEL RALQEELSQA KCSSEEAQLE HAELQEQLHR
910 920 930 940 950
ANTDTAELGI QVCALTVEKE RVEEALACAV QELQDAKEAA SREREGLERQ
960 970 980 990 1000
VAGLQQEKES LQEKLKAAKA AAGSLPGLQA QLAQAEQRAQ SLQEAAHQEL
1010 1020 1030 1040 1050
NTLKFQLSAE IMDYQSRLKN AGEECKSLRG QLEEQGRQLQ AAEEAVEKLK
1060 1070 1080 1090 1100
ATQADMGEKL SCTSNHLAEC QAAMLRKDKE GAALREDLER TQKELEKATT
1110 1120 1130 1140 1150
KIQEYYNKLC QEVTNRERND QKMLADLDDL NRTKKYLEER LIELLRDKDA
1160 1170 1180 1190 1200
LWQKSDALEF QQKLSAEERW LGDTEANHCL DCKREFSWMV RRHHCRICGR
1210 1220 1230 1240 1250
IFCYYCCNNY VLSKHGGKKE RCCRACFQKL SEGPGSPDSS GSGTSQGEPS
1260 1270 1280 1290 1300
PALSPASPGP QATGGQGANT DYRPPDDAVF DIITDEELCQ IQESGSSLPE
1310 1320 1330 1340 1350
TPTETDSLDP NAAEQDTTST SLTPEDTEDM PVGQDSEICL LKSGELMIKV
1360 1370 1380 1390 1400
PLTVDEIASF GEGSRELFVR SSTYSLIPIT VAEAGLTISW VFSSDPKSIS
1410 1420 1430 1440 1450
FSVVFQEAED TPLDQCKVLI PTTRCNSHKE NIQGQLKVRT PGIYMLIFDN
1460 1470
TFSRFVSKKV FYHLTVDRPV IYDGSDFL
Length:1,478
Mass (Da):166,983
Last modified:February 8, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i11AB671A9F2B3D21
GO
Isoform 2 (identifier: Q9BQS8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-380: QQKAD → LHVGD
     381-1478: Missing.

Note: No experimental confirmation available.
Show »
Length:380
Mass (Da):43,482
Checksum:i141833AF14C25727
GO
Isoform 3 (identifier: Q9BQS8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-380: QQKAD → HLSE
     381-1478: Missing.

Note: No experimental confirmation available.
Show »
Length:379
Mass (Da):43,427
Checksum:i4B54D9D20257275F
GO
Isoform 4 (identifier: Q9BQS8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1315-1315: Q → QASVGASKGLGNLLCESSACR

Note: No experimental confirmation available.
Show »
Length:1,498
Mass (Da):168,888
Checksum:iBF5ABFEDF2712834
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J2W6C9J2W6_HUMAN
FYVE and coiled-coil domain-contain...
FYCO1
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ74H7BZ74_HUMAN
FYVE and coiled-coil domain-contain...
FYCO1
267Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH07218 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14559 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB84991 differs from that shown. Reason: Frameshift at position 1402.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti155Y → C in CAD91151 (PubMed:17974005).Curated1
Sequence conflicti359D → G in CAD91151 (PubMed:17974005).Curated1
Sequence conflicti365L → S in BAB14559 (PubMed:14702039).Curated1
Sequence conflicti381T → S in CAC33883 (PubMed:11896456).Curated1
Sequence conflicti916T → I in CAD89924 (PubMed:17974005).Curated1
Sequence conflicti964K → E in CAD89924 (PubMed:17974005).Curated1
Sequence conflicti1382A → P in CAC33883 (PubMed:11896456).Curated1
Sequence conflicti1385G → A in CAC33883 (PubMed:11896456).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027006250R → Q4 PublicationsCorresponds to variant dbSNP:rs4683158EnsemblClinVar.1
Natural variantiVAR_027007282R → H. Corresponds to variant dbSNP:rs9875356EnsemblClinVar.1
Natural variantiVAR_027008321G → A4 PublicationsCorresponds to variant dbSNP:rs3733100EnsemblClinVar.1
Natural variantiVAR_027009381T → M. Corresponds to variant dbSNP:rs3733101EnsemblClinVar.1
Natural variantiVAR_056882447R → C. Corresponds to variant dbSNP:rs33910087EnsemblClinVar.1
Natural variantiVAR_027010679A → V1 PublicationCorresponds to variant dbSNP:rs3796375EnsemblClinVar.1
Natural variantiVAR_056883994E → K. Corresponds to variant dbSNP:rs34801630EnsemblClinVar.1
Natural variantiVAR_0270111001N → D. Corresponds to variant dbSNP:rs13059238EnsemblClinVar.1
Natural variantiVAR_0659741376L → P in CTRCT18. 1 PublicationCorresponds to variant dbSNP:rs387906965EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_019795376 – 380QQKAD → LHVGD in isoform 2. 1 Publication5
Alternative sequenceiVSP_019796376 – 380QQKAD → HLSE in isoform 3. 1 Publication5
Alternative sequenceiVSP_019797381 – 1478Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST1098
Alternative sequenceiVSP_0544771315Q → QASVGASKGLGNLLCESSAC R in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ292348 mRNA Translation: CAC33883.1
AL833308 mRNA Translation: CAD89924.1
AL832358 mRNA Translation: CAD91151.1
AC099782 Genomic DNA No translation available.
BC007218 mRNA Translation: AAH07218.1 Different initiation.
BC101468 mRNA Translation: AAI01469.1
BC101470 mRNA Translation: AAI01471.1
BC143368 mRNA Translation: AAI43369.1
AK023397 mRNA Translation: BAB14559.1 Different initiation.
AK074165 mRNA Translation: BAB84991.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS2734.1 [Q9BQS8-1]

NCBI Reference Sequences

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RefSeqi
NP_078789.2, NM_024513.3 [Q9BQS8-1]
XP_006713396.1, XM_006713333.3 [Q9BQS8-1]
XP_006713397.1, XM_006713334.3 [Q9BQS8-1]
XP_011532413.1, XM_011534111.2 [Q9BQS8-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.200227
Hs.739775

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000296137; ENSP00000296137; ENSG00000163820 [Q9BQS8-1]
ENST00000535325; ENSP00000441178; ENSG00000163820 [Q9BQS8-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79443

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79443

UCSC genome browser

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UCSCi
uc003cpb.6 human [Q9BQS8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ292348 mRNA Translation: CAC33883.1
AL833308 mRNA Translation: CAD89924.1
AL832358 mRNA Translation: CAD91151.1
AC099782 Genomic DNA No translation available.
BC007218 mRNA Translation: AAH07218.1 Different initiation.
BC101468 mRNA Translation: AAI01469.1
BC101470 mRNA Translation: AAI01471.1
BC143368 mRNA Translation: AAI43369.1
AK023397 mRNA Translation: BAB14559.1 Different initiation.
AK074165 mRNA Translation: BAB84991.1 Frameshift.
CCDSiCCDS2734.1 [Q9BQS8-1]
RefSeqiNP_078789.2, NM_024513.3 [Q9BQS8-1]
XP_006713396.1, XM_006713333.3 [Q9BQS8-1]
XP_006713397.1, XM_006713334.3 [Q9BQS8-1]
XP_011532413.1, XM_011534111.2 [Q9BQS8-1]
UniGeneiHs.200227
Hs.739775

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CX3X-ray2.30E/F/G/H1273-1298[»]
5D94X-ray1.53B1276-1288[»]
ProteinModelPortaliQ9BQS8
SMRiQ9BQS8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122669, 53 interactors
DIPiDIP-60600N
ELMiQ9BQS8
IntActiQ9BQS8, 39 interactors
MINTiQ9BQS8
STRINGi9606.ENSP00000296137

PTM databases

iPTMnetiQ9BQS8
PhosphoSitePlusiQ9BQS8

Polymorphism and mutation databases

BioMutaiFYCO1
DMDMi322510128

Proteomic databases

EPDiQ9BQS8
jPOSTiQ9BQS8
MaxQBiQ9BQS8
PaxDbiQ9BQS8
PeptideAtlasiQ9BQS8
PRIDEiQ9BQS8
ProteomicsDBi78718
78719 [Q9BQS8-2]
78720 [Q9BQS8-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296137; ENSP00000296137; ENSG00000163820 [Q9BQS8-1]
ENST00000535325; ENSP00000441178; ENSG00000163820 [Q9BQS8-4]
GeneIDi79443
KEGGihsa:79443
UCSCiuc003cpb.6 human [Q9BQS8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79443
DisGeNETi79443
EuPathDBiHostDB:ENSG00000163820.14

GeneCards: human genes, protein and diseases

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GeneCardsi
FYCO1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0003244
HGNCiHGNC:14673 FYCO1
HPAiHPA035526
HPA057966
MalaCardsiFYCO1
MIMi607182 gene
610019 phenotype
neXtProtiNX_Q9BQS8
OpenTargetsiENSG00000163820
Orphaneti98991 Early-onset nuclear cataract
98994 Total early-onset cataract
PharmGKBiPA28453

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1729 Eukaryota
ENOG410XPJK LUCA
GeneTreeiENSGT00940000154044
HOGENOMiHOG000168295
HOVERGENiHBG063805
InParanoidiQ9BQS8
KOiK21954
OMAiCNNYVLT
OrthoDBi962969at2759
PhylomeDBiQ9BQS8
TreeFamiTF341788

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FYCO1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79443

Protein Ontology

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PROi
PR:Q9BQS8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163820 Expressed in 227 organ(s), highest expression level in biceps brachii
ExpressionAtlasiQ9BQS8 baseline and differential
GenevisibleiQ9BQS8 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
IPR004012 Run_dom
IPR037213 Run_dom_sf
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF02759 RUN, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
SSF140741 SSF140741, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50866 GOLD, 1 hit
PS50826 RUN, 1 hit
PS50178 ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFYCO1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BQS8
Secondary accession number(s): B7ZKT7
, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: February 8, 2011
Last modified: February 13, 2019
This is version 146 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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