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UniProtKB - Q9BQS8 (FYCO1_HUMAN)

Entry version 163 (23 Feb 2022)
Sequence version 3 (08 Feb 2011)
Previous versions | rss
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Protein

FYVE and coiled-coil domain-containing protein 1

Gene

FYCO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May mediate microtubule plus end-directed vesicle transport.

1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1179Zinc 1PROSITE-ProRule annotation1
Metal bindingi1182Zinc 1PROSITE-ProRule annotation1
Metal bindingi1195Zinc 2PROSITE-ProRule annotation1
Metal bindingi1198Zinc 2PROSITE-ProRule annotation1
Metal bindingi1203Zinc 1PROSITE-ProRule annotation1
Metal bindingi1206Zinc 1PROSITE-ProRule annotation1
Metal bindingi1223Zinc 2PROSITE-ProRule annotation1
Metal bindingi1226Zinc 2PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1173 – 1231FYVE-typePROSITE-ProRule annotationAdd BLAST59

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BQS8

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9BQS8

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9BQS8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FYVE and coiled-coil domain-containing protein 1
Alternative name(s):
Zinc finger FYVE domain-containing protein 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FYCO1
Synonyms:ZFYVE7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14673, FYCO1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607182, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BQS8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163820

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Lysosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cataract 18 (CTRCT18)1 Publication
The disease is caused by variants affecting the gene represented in this entry. Pathogenic mutations in FYCO1 can affect intracellular transport of autophagocytic vesicles from the perinuclear area to the periphery, leading to an accumulation of large numbers of vesicles and hence loss of lens transparency (PubMed:21636066).2 Publications
Disease descriptionAn opacification of the crystalline lens of the eye becoming evident at birth or in infancy. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_084824270 – 1478Missing in CTRCT18; unknown pathological significance. 1 PublicationAdd BLAST1209
Natural variantiVAR_0659741376L → P in CTRCT18. 1 PublicationCorresponds to variant dbSNP:rs387906965EnsemblClinVar.1

Keywords - Diseasei

Cataract, Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		79443

MalaCards human disease database

More...MalaCardsi		FYCO1
MIMi610019, phenotype

Open Targets

More...OpenTargetsi		ENSG00000163820

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		98991, Early-onset nuclear cataract
98994, Total early-onset cataract

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28453

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BQS8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FYCO1

Domain mapping of disease mutations (DMDM)

More...DMDMi		322510128

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002458372 – 1478FYVE and coiled-coil domain-containing protein 1Add BLAST1477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei196PhosphoserineCombined sources1
Modified residuei342PhosphoserineCombined sources1
Modified residuei381PhosphothreonineBy similarity1
Modified residuei878PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BQS8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BQS8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BQS8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BQS8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BQS8

PeptideAtlas

More...PeptideAtlasi		Q9BQS8

PRoteomics IDEntifications database

More...PRIDEi		Q9BQS8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		7193
78718 [Q9BQS8-1]
78719 [Q9BQS8-2]
78720 [Q9BQS8-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9BQS8, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BQS8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BQS8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163820, Expressed in quadriceps femoris and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BQS8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BQS8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163820, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can form homodimers.

Interacts (via C-terminus) with MAP1LC3B.

Interacts with RAB7A; the interaction with RAB7A induces FYCO1 recruitment to late endosomal/lysosomal compartments.

Interacts with MAP1LC3B (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122669, 91 interactors

Database of interacting proteins

More...DIPi		DIP-60600N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q9BQS8

Protein interaction database and analysis system

More...IntActi		Q9BQS8, 58 interactors

Molecular INTeraction database

More...MINTi		Q9BQS8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000296137

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BQS8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11478
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BQS8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 169RUNPROSITE-ProRule annotationAdd BLAST134
Domaini1337 – 1466GOLDPROSITE-ProRule annotationAdd BLAST130

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni586 – 613DisorderedSequence analysisAdd BLAST28
Regioni1231 – 1277DisorderedSequence analysisAdd BLAST47
Regioni1294 – 1332DisorderedSequence analysisAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili4 – 33Sequence analysisAdd BLAST30
Coiled coili225 – 280Sequence analysisAdd BLAST56
Coiled coili394 – 555Sequence analysisAdd BLAST162
Coiled coili596 – 1151Sequence analysisAdd BLAST556

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1233 – 1268Polar residuesSequence analysisAdd BLAST36
Compositional biasi1294 – 1327Polar residuesSequence analysisAdd BLAST34

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1173 – 1231FYVE-typePROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1729, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154044

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004445_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BQS8

Identification of Orthologs from Complete Genome Data

More...OMAi		QTASYCD

Database of Orthologous Groups

More...OrthoDBi		962969at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BQS8

TreeFam database of animal gene trees

More...TreeFami		TF341788

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.58.900, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR042654, FYCO1
IPR009038, GOLD_dom
IPR036598, GOLD_dom_sf
IPR004012, Run_dom
IPR037213, Run_dom_sf
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...PANTHERi		PTHR23164:SF18, PTHR23164:SF18, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01363, FYVE, 1 hit
PF02759, RUN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00064, FYVE, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101576, SSF101576, 1 hit
SSF140741, SSF140741, 1 hit
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50866, GOLD, 1 hit
PS50826, RUN, 1 hit
PS50178, ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BQS8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASTNAESQL QRIIRDLQDA VTELSKEFQE AGEPITDDST SLHKFSYKLE 
        60         70         80         90        100
YLLQFDQKEK ATLLGNKKDY WDYFCACLAK VKGANDGIRF VKSISELRTS 
       110        120        130        140        150
LGKGRAFIRY SLVHQRLADT LQQCFMNTKV TSDWYYARSP FLQPKLSSDI 
       160        170        180        190        200
VGQLYELTEV QFDLASRGFD LDAAWPTFAR RTLTTGSSAY LWKPPSRSSS 
       210        220        230        240        250
MSSLVSSYLQ TQEMVSNFDL NSPLNNEALE GFDEMRLELD QLEVREKQLR 
       260        270        280        290        300
ERMQQLDREN QELRAAVSQQ GEQLQTERER GRTAAEDNVR LTCLVAELQK 
       310        320        330        340        350
QWEVTQATQN TVKELQTCLQ GLELGAAEKE EDYHTALRRL ESMLQPLAQE 
       360        370        380        390        400
LEATRDSLDK KNQHLASFPG WLAMAQQKAD TASDTKGRQE PIPSDAAQEM 
       410        420        430        440        450
QELGEKLQAL ERERTKVEEV NRQQSAQLEQ LVKELQLKED ARASLERLVK 
       460        470        480        490        500
EMAPLQEELS GKGQEADQLW RRLQELLAHT SSWEEELAEL RREKKQQQEE 
       510        520        530        540        550
KELLEQEVRS LTRQLQFLET QLAQVSQHVS DLEEQKKQLI QDKDHLSQQV 
       560        570        580        590        600
GMLERLAGPP GPELPVAGEK NEALVPVNSS LQEAWGKPEE EQRGLQEAQL 
       610        620        630        640        650
DDTKVQEGSQ EEELRQANRE LEKELQNVVG RNQLLEGKLQ ALQADYQALQ 
       660        670        680        690        700
QRESAIQGSL ASLEAEQASI RHLGDQMEAS LLAVRKAKEA MKAQMAEKEA 
       710        720        730        740        750
ILQSKEGECQ QLREEVEQCQ QLAEARHREL RALESQCQQQ TQLIEVLTAE 
       760        770        780        790        800
KGQQGVGPPT DNEARELAAQ LALSQAQLEV HQGEVQRLQA QVVDLQAKMR 
       810        820        830        840        850
AALDDQDKVQ SQLSMAEAVL REHKTLVQQL KEQNEALNRA HVQELLQCSE 
       860        870        880        890        900
REGALQEERA DEAQQREEEL RALQEELSQA KCSSEEAQLE HAELQEQLHR 
       910        920        930        940        950
ANTDTAELGI QVCALTVEKE RVEEALACAV QELQDAKEAA SREREGLERQ 
       960        970        980        990       1000
VAGLQQEKES LQEKLKAAKA AAGSLPGLQA QLAQAEQRAQ SLQEAAHQEL 
      1010       1020       1030       1040       1050
NTLKFQLSAE IMDYQSRLKN AGEECKSLRG QLEEQGRQLQ AAEEAVEKLK 
      1060       1070       1080       1090       1100
ATQADMGEKL SCTSNHLAEC QAAMLRKDKE GAALREDLER TQKELEKATT 
      1110       1120       1130       1140       1150
KIQEYYNKLC QEVTNRERND QKMLADLDDL NRTKKYLEER LIELLRDKDA 
      1160       1170       1180       1190       1200
LWQKSDALEF QQKLSAEERW LGDTEANHCL DCKREFSWMV RRHHCRICGR 
      1210       1220       1230       1240       1250
IFCYYCCNNY VLSKHGGKKE RCCRACFQKL SEGPGSPDSS GSGTSQGEPS 
      1260       1270       1280       1290       1300
PALSPASPGP QATGGQGANT DYRPPDDAVF DIITDEELCQ IQESGSSLPE 
      1310       1320       1330       1340       1350
TPTETDSLDP NAAEQDTTST SLTPEDTEDM PVGQDSEICL LKSGELMIKV 
      1360       1370       1380       1390       1400
PLTVDEIASF GEGSRELFVR SSTYSLIPIT VAEAGLTISW VFSSDPKSIS 
      1410       1420       1430       1440       1450
FSVVFQEAED TPLDQCKVLI PTTRCNSHKE NIQGQLKVRT PGIYMLIFDN 
      1460       1470 
TFSRFVSKKV FYHLTVDRPV IYDGSDFL
Length:1,478
Mass (Da):166,983
Last modified:February 8, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i11AB671A9F2B3D21
GO
Isoform 2 (identifier: Q9BQS8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-380: QQKAD → LHVGD
     381-1478: Missing.

Show »
Length:380
Mass (Da):43,482
Checksum:i141833AF14C25727
GO
Isoform 3 (identifier: Q9BQS8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-380: QQKAD → HLSE
     381-1478: Missing.

Show »
Length:379
Mass (Da):43,427
Checksum:i4B54D9D20257275F
GO
Isoform 4 (identifier: Q9BQS8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1315-1315: Q → QASVGASKGLGNLLCESSACR

Show »
Length:1,498
Mass (Da):168,888
Checksum:iBF5ABFEDF2712834
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BZ74H7BZ74_HUMAN
FYVE and coiled-coil domain-contain...
FYCO1
267Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2W6C9J2W6_HUMAN
FYVE and coiled-coil domain-contain...
FYCO1
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH07218 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14559 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB84991 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti155Y → C in CAD91151 (PubMed:17974005).Curated1
Sequence conflicti359D → G in CAD91151 (PubMed:17974005).Curated1
Sequence conflicti365L → S in BAB14559 (PubMed:14702039).Curated1
Sequence conflicti381T → S in CAC33883 (PubMed:11896456).Curated1
Sequence conflicti916T → I in CAD89924 (PubMed:17974005).Curated1
Sequence conflicti964K → E in CAD89924 (PubMed:17974005).Curated1
Sequence conflicti1382A → P in CAC33883 (PubMed:11896456).Curated1
Sequence conflicti1385G → A in CAC33883 (PubMed:11896456).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027006250R → Q4 PublicationsCorresponds to variant dbSNP:rs4683158EnsemblClinVar.1
Natural variantiVAR_084824270 – 1478Missing in CTRCT18; unknown pathological significance. 1 PublicationAdd BLAST1209
Natural variantiVAR_027007282R → H. Corresponds to variant dbSNP:rs9875356EnsemblClinVar.1
Natural variantiVAR_027008321G → A4 PublicationsCorresponds to variant dbSNP:rs3733100EnsemblClinVar.1
Natural variantiVAR_027009381T → M. Corresponds to variant dbSNP:rs3733101EnsemblClinVar.1
Natural variantiVAR_056882447R → C. Corresponds to variant dbSNP:rs33910087EnsemblClinVar.1
Natural variantiVAR_027010679A → V1 PublicationCorresponds to variant dbSNP:rs3796375EnsemblClinVar.1
Natural variantiVAR_056883994E → K. Corresponds to variant dbSNP:rs34801630EnsemblClinVar.1
Natural variantiVAR_0270111001N → D. Corresponds to variant dbSNP:rs13059238EnsemblClinVar.1
Natural variantiVAR_0659741376L → P in CTRCT18. 1 PublicationCorresponds to variant dbSNP:rs387906965EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_019795376 – 380QQKAD → LHVGD in isoform 2. 1 Publication5
Alternative sequenceiVSP_019796376 – 380QQKAD → HLSE in isoform 3. 1 Publication5
Alternative sequenceiVSP_019797381 – 1478Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST1098
Alternative sequenceiVSP_0544771315Q → QASVGASKGLGNLLCESSAC R in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ292348 mRNA Translation: CAC33883.1
AL833308 mRNA Translation: CAD89924.1
AL832358 mRNA Translation: CAD91151.1
AC099782 Genomic DNA No translation available.
BC007218 mRNA Translation: AAH07218.1 Different initiation.
BC101468 mRNA Translation: AAI01469.1
BC101470 mRNA Translation: AAI01471.1
BC143368 mRNA Translation: AAI43369.1
AK023397 mRNA Translation: BAB14559.1 Different initiation.
AK074165 mRNA Translation: BAB84991.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2734.1 [Q9BQS8-1]

NCBI Reference Sequences

More...RefSeqi		NP_078789.2, NM_024513.3 [Q9BQS8-1]
XP_006713396.1, XM_006713333.3 [Q9BQS8-1]
XP_006713397.1, XM_006713334.3 [Q9BQS8-1]
XP_011532413.1, XM_011534111.2 [Q9BQS8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000296137; ENSP00000296137; ENSG00000163820
ENST00000535325; ENSP00000441178; ENSG00000163820 [Q9BQS8-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79443

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79443

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000296137.7; ENSP00000296137.2; NM_024513.4; NP_078789.2

UCSC genome browser

More...UCSCi		uc003cpb.6, human [Q9BQS8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ292348 mRNA Translation: CAC33883.1
AL833308 mRNA Translation: CAD89924.1
AL832358 mRNA Translation: CAD91151.1
AC099782 Genomic DNA No translation available.
BC007218 mRNA Translation: AAH07218.1 Different initiation.
BC101468 mRNA Translation: AAI01469.1
BC101470 mRNA Translation: AAI01471.1
BC143368 mRNA Translation: AAI43369.1
AK023397 mRNA Translation: BAB14559.1 Different initiation.
AK074165 mRNA Translation: BAB84991.1 Frameshift.
CCDSiCCDS2734.1 [Q9BQS8-1]
RefSeqiNP_078789.2, NM_024513.3 [Q9BQS8-1]
XP_006713396.1, XM_006713333.3 [Q9BQS8-1]
XP_006713397.1, XM_006713334.3 [Q9BQS8-1]
XP_011532413.1, XM_011534111.2 [Q9BQS8-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CX3X-ray2.30E/F/G/H1273-1298[»]
5D94X-ray1.53B1276-1288[»]
7BQIX-ray1.30A1-178[»]
SMRiQ9BQS8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122669, 91 interactors
DIPiDIP-60600N
ELMiQ9BQS8
IntActiQ9BQS8, 58 interactors
MINTiQ9BQS8
STRINGi9606.ENSP00000296137

PTM databases

GlyGeniQ9BQS8, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9BQS8
PhosphoSitePlusiQ9BQS8

Genetic variation databases

BioMutaiFYCO1
DMDMi322510128

Proteomic databases

EPDiQ9BQS8
jPOSTiQ9BQS8
MassIVEiQ9BQS8
MaxQBiQ9BQS8
PaxDbiQ9BQS8
PeptideAtlasiQ9BQS8
PRIDEiQ9BQS8
ProteomicsDBi7193
78718 [Q9BQS8-1]
78719 [Q9BQS8-2]
78720 [Q9BQS8-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29634, 142 antibodies from 24 providers

The DNASU plasmid repository

More...DNASUi		79443

Genome annotation databases

EnsembliENST00000296137; ENSP00000296137; ENSG00000163820
ENST00000535325; ENSP00000441178; ENSG00000163820 [Q9BQS8-4]
GeneIDi79443
KEGGihsa:79443
MANE-SelectiENST00000296137.7; ENSP00000296137.2; NM_024513.4; NP_078789.2
UCSCiuc003cpb.6, human [Q9BQS8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79443
DisGeNETi79443

GeneCards: human genes, protein and diseases

More...GeneCardsi		FYCO1
HGNCiHGNC:14673, FYCO1
HPAiENSG00000163820, Tissue enhanced (skeletal)
MalaCardsiFYCO1
MIMi607182, gene
610019, phenotype
neXtProtiNX_Q9BQS8
OpenTargetsiENSG00000163820
Orphaneti98991, Early-onset nuclear cataract
98994, Total early-onset cataract
PharmGKBiPA28453
VEuPathDBiHostDB:ENSG00000163820

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1729, Eukaryota
GeneTreeiENSGT00940000154044
HOGENOMiCLU_004445_0_0_1
InParanoidiQ9BQS8
OMAiQTASYCD
OrthoDBi962969at2759
PhylomeDBiQ9BQS8
TreeFamiTF341788

Enzyme and pathway databases

PathwayCommonsiQ9BQS8
SignaLinkiQ9BQS8
SIGNORiQ9BQS8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79443, 1 hit in 1048 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FYCO1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79443
PharosiQ9BQS8, Tbio

Protein Ontology

More...PROi		PR:Q9BQS8
RNActiQ9BQS8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163820, Expressed in quadriceps femoris and 239 other tissues
ExpressionAtlasiQ9BQS8, baseline and differential
GenevisibleiQ9BQS8, HS

Family and domain databases

Gene3Di1.20.58.900, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR042654, FYCO1
IPR009038, GOLD_dom
IPR036598, GOLD_dom_sf
IPR004012, Run_dom
IPR037213, Run_dom_sf
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR23164:SF18, PTHR23164:SF18, 1 hit
PfamiView protein in Pfam
PF01363, FYVE, 1 hit
PF02759, RUN, 1 hit
SMARTiView protein in SMART
SM00064, FYVE, 1 hit
SUPFAMiSSF101576, SSF101576, 1 hit
SSF140741, SSF140741, 1 hit
SSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50866, GOLD, 1 hit
PS50826, RUN, 1 hit
PS50178, ZF_FYVE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFYCO1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BQS8
Secondary accession number(s): B7ZKT7
, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: February 8, 2011
Last modified: February 23, 2022
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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