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Protein

Heat shock protein beta-9

Gene

HSPB9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Keywordsi

Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-9
Short name:
HspB9
Alternative name(s):
Cancer/testis antigen 51
Short name:
CT51
Gene namesi
Name:HSPB9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000260325.1
HGNCiHGNC:30589 HSPB9
MIMi608344 gene
neXtProtiNX_Q9BQS6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi94086
OpenTargetsiENSG00000260325
PharmGKBiPA134875756

Polymorphism and mutation databases

BioMutaiHSPB9
DMDMi46576635

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259501 – 159Heat shock protein beta-9Add BLAST159

Proteomic databases

PaxDbiQ9BQS6
PRIDEiQ9BQS6
ProteomicsDBi78715

PTM databases

PhosphoSitePlusiQ9BQS6

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSG00000260325 Expressed in 78 organ(s), highest expression level in quadriceps femoris
CleanExiHS_HSPB9
GenevisibleiQ9BQS6 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DYNLT1P631725EBI-1176448,EBI-1176455

Protein-protein interaction databases

BioGridi125108, 10 interactors
IntActiQ9BQS6, 3 interactors
STRINGi9606.ENSP00000347178

Structurei

3D structure databases

ProteinModelPortaliQ9BQS6
SMRiQ9BQS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 147sHSPPROSITE-ProRule annotationAdd BLAST112

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00510000049735
HOGENOMiHOG000230993
HOVERGENiHBG052041
InParanoidiQ9BQS6
KOiK09547
OMAiAMTCCLT
OrthoDBiEOG091G0WOM
PhylomeDBiQ9BQS6
TreeFamiTF338684

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BQS6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRVGNTFSN ESRVASRCPS VGLAERNRVA TMPVRLLRDS PAAQEDNDHA
60 70 80 90 100
RDGFQMKLDA HGFAPEELVV QVDGQWLMVT GQQQLDVRDP ERVSYRMSQK
110 120 130 140 150
VHRKMLPSNL SPTAMTCCLT PSGQLWVRGQ CVALALPEAQ TGPSPRLGSL

GSKASNLTR
Length:159
Mass (Da):17,486
Last modified:June 1, 2001 - v1
Checksum:iF28E40D0512C4997
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0220542Q → P. Corresponds to variant dbSNP:rs1122326Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302068 Genomic DNA Translation: CAC35727.1
AK093488 mRNA Translation: BAG52728.1
CH471152 Genomic DNA Translation: EAW60804.1
BC093991 mRNA Translation: AAH93991.1
BC093993 mRNA Translation: AAH93993.1
CCDSiCCDS11418.1
RefSeqiNP_149971.1, NM_033194.2
UniGeneiHs.620611

Genome annotation databases

EnsembliENST00000565659; ENSP00000458018; ENSG00000260325
GeneIDi94086
KEGGihsa:94086
UCSCiuc002hyy.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302068 Genomic DNA Translation: CAC35727.1
AK093488 mRNA Translation: BAG52728.1
CH471152 Genomic DNA Translation: EAW60804.1
BC093991 mRNA Translation: AAH93991.1
BC093993 mRNA Translation: AAH93993.1
CCDSiCCDS11418.1
RefSeqiNP_149971.1, NM_033194.2
UniGeneiHs.620611

3D structure databases

ProteinModelPortaliQ9BQS6
SMRiQ9BQS6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125108, 10 interactors
IntActiQ9BQS6, 3 interactors
STRINGi9606.ENSP00000347178

PTM databases

PhosphoSitePlusiQ9BQS6

Polymorphism and mutation databases

BioMutaiHSPB9
DMDMi46576635

Proteomic databases

PaxDbiQ9BQS6
PRIDEiQ9BQS6
ProteomicsDBi78715

Protocols and materials databases

DNASUi94086
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000565659; ENSP00000458018; ENSG00000260325
GeneIDi94086
KEGGihsa:94086
UCSCiuc002hyy.3 human

Organism-specific databases

CTDi94086
DisGeNETi94086
EuPathDBiHostDB:ENSG00000260325.1
GeneCardsiHSPB9
HGNCiHGNC:30589 HSPB9
MIMi608344 gene
neXtProtiNX_Q9BQS6
OpenTargetsiENSG00000260325
PharmGKBiPA134875756
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00510000049735
HOGENOMiHOG000230993
HOVERGENiHBG052041
InParanoidiQ9BQS6
KOiK09547
OMAiAMTCCLT
OrthoDBiEOG091G0WOM
PhylomeDBiQ9BQS6
TreeFamiTF338684

Miscellaneous databases

GenomeRNAii94086
PROiPR:Q9BQS6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000260325 Expressed in 78 organ(s), highest expression level in quadriceps femoris
CleanExiHS_HSPB9
GenevisibleiQ9BQS6 HS

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSPB9_HUMAN
AccessioniPrimary (citable) accession number: Q9BQS6
Secondary accession number(s): B3KSG6, Q52LB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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