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Protein

Mitochondrial genome maintenance exonuclease 1

Gene

MGME1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells.UniRule annotation2 Publications

Miscellaneous

This protein may be expected to contain an N-terminal transit peptide but none has been predicted.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2381 Publication1
Active sitei2511 Publication1
Active sitei2531 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • single-stranded DNA exodeoxyribonuclease activity Source: UniProtKB

GO - Biological processi

  • mitochondrial DNA repair Source: UniProtKB
  • mitochondrial DNA replication Source: UniProtKB
  • mitochondrial genome maintenance Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitochondrial genome maintenance exonuclease 1UniRule annotation (EC:3.1.-.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MGME1UniRule annotation
Synonyms:C20orf72, DDK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000125871.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16205 MGME1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615076 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BQP7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mitochondrial DNA depletion syndrome 11 (MTDPS11)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive mitochondrial disorder characterized by onset in childhood or adulthood of progressive external ophthalmoplegia, muscle weakness and atrophy, exercise intolerance, and respiratory insufficiency due to muscle weakness. More variable features include spinal deformity, emaciation, and cardiac abnormalities. Skeletal muscle biopsies show deletion and depletion of mitochondrial DNA (mtDNA) with variable defects in respiratory chain enzyme activities.
See also OMIM:615084
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069102233Y → C in MTDPS11; impaired exonuclease activity. 1 PublicationCorresponds to variant dbSNP:rs587776944Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi251D → A: Abolishes catalytic activity. 1 Publication1
Mutagenesisi253K → A: Abolishes catalytic activity. 2 Publications1
Mutagenesisi253K → A: Abolishes exonuclease activity. 2 Publications1

Keywords - Diseasei

Disease mutation, Primary mitochondrial disease, Progressive external ophthalmoplegia

Organism-specific databases

DisGeNET

More...
DisGeNETi
92667

MalaCards human disease database

More...
MalaCardsi
MGME1
MIMi615084 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000125871

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
352447 Progressive external ophthalmoplegia-myopathy-emaciation syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25783

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MGME1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
25452901

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000794391 – 344Mitochondrial genome maintenance exonuclease 1Add BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei343PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BQP7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BQP7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BQP7

PeptideAtlas

More...
PeptideAtlasi
Q9BQP7

PRoteomics IDEntifications database

More...
PRIDEi
Q9BQP7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78703

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BQP7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BQP7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000125871 Expressed in 194 organ(s), highest expression level in metanephros

CleanEx database of gene expression profiles

More...
CleanExi
HS_C20orf72

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BQP7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BQP7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040913

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124964, 21 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BQP7, 11 interactors

Molecular INTeraction database

More...
MINTi
Q9BQP7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000366939

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1344
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9BQP7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BQP7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MGME1 family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFA1 Eukaryota
ENOG410XWHK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003349

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231693

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051175

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BQP7

KEGG Orthology (KO)

More...
KOi
K19465

Identification of Orthologs from Complete Genome Data

More...
OMAi
WAKWLLR

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0CCD

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BQP7

TreeFam database of animal gene trees

More...
TreeFami
TF320375

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_03030 MGME1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026970 MGME1
IPR038726 PDDEXK_AddAB-type
IPR011335 Restrct_endonuc-II-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12705 PDDEXK_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52980 SSF52980, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9BQP7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKMKLFQTIC RQLRSSKFSV ESAALVAFST SSYSCGRKKK VNPYEEVDQE
60 70 80 90 100
KYSNLVQSVL SSRGVAQTPG SVEEDALLCG PVSKHKLPNQ GEDRRVPQNW
110 120 130 140 150
FPIFNPERSD KPNASDPSVP LKIPLQRNVI PSVTRVLQQT MTKQQVFLLE
160 170 180 190 200
RWKQRMILEL GEDGFKEYTS NVFLQGKRFH EALESILSPQ ETLKERDENL
210 220 230 240 250
LKSGYIESVQ HILKDVSGVR ALESAVQHET LNYIGLLDCV AEYQGKLCVI
260 270 280 290 300
DWKTSEKPKP FIQSTFDNPL QVVAYMGAMN HDTNYSFQVQ CGLIVVAYKD
310 320 330 340
GSPAHPHFMD AELCSQYWTK WLLRLEEYTE KKKNQNIQKP EYSE
Length:344
Mass (Da):39,421
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i923DEE90FCFED6C6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5QPE8Q5QPE8_HUMAN
Mitochondrial genome maintenance ex...
MGME1
264Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5QPE7Q5QPE7_HUMAN
Mitochondrial genome maintenance ex...
MGME1
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti308F → L in BAB55160 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03375815S → C. Corresponds to variant dbSNP:rs11551768EnsemblClinVar.1
Natural variantiVAR_069102233Y → C in MTDPS11; impaired exonuclease activity. 1 PublicationCorresponds to variant dbSNP:rs587776944Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK027503 mRNA Translation: BAB55160.1
AK315532 mRNA Translation: BAG37912.1
AL121585 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10260.1
CH471133 Genomic DNA Translation: EAX10261.1
BC016869 mRNA Translation: AAH16869.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13131.1

NCBI Reference Sequences

More...
RefSeqi
NP_001297267.1, NM_001310338.1
NP_001297268.1, NM_001310339.1
NP_443097.1, NM_052865.3
XP_016883616.1, XM_017028127.1
XP_016883617.1, XM_017028128.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.320823

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000377710; ENSP00000366939; ENSG00000125871

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
92667

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:92667

UCSC genome browser

More...
UCSCi
uc002wqh.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027503 mRNA Translation: BAB55160.1
AK315532 mRNA Translation: BAG37912.1
AL121585 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10260.1
CH471133 Genomic DNA Translation: EAX10261.1
BC016869 mRNA Translation: AAH16869.1
CCDSiCCDS13131.1
RefSeqiNP_001297267.1, NM_001310338.1
NP_001297268.1, NM_001310339.1
NP_443097.1, NM_052865.3
XP_016883616.1, XM_017028127.1
XP_016883617.1, XM_017028128.1
UniGeneiHs.320823

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ZYTX-ray2.70A/B/C/D21-344[»]
5ZYUX-ray1.75A/B91-344[»]
5ZYVX-ray2.72A91-344[»]
5ZYWX-ray2.20A91-344[»]
ProteinModelPortaliQ9BQP7
SMRiQ9BQP7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124964, 21 interactors
IntActiQ9BQP7, 11 interactors
MINTiQ9BQP7
STRINGi9606.ENSP00000366939

PTM databases

iPTMnetiQ9BQP7
PhosphoSitePlusiQ9BQP7

Polymorphism and mutation databases

BioMutaiMGME1
DMDMi25452901

Proteomic databases

EPDiQ9BQP7
MaxQBiQ9BQP7
PaxDbiQ9BQP7
PeptideAtlasiQ9BQP7
PRIDEiQ9BQP7
ProteomicsDBi78703

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
92667
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377710; ENSP00000366939; ENSG00000125871
GeneIDi92667
KEGGihsa:92667
UCSCiuc002wqh.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
92667
DisGeNETi92667
EuPathDBiHostDB:ENSG00000125871.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MGME1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0015662
HGNCiHGNC:16205 MGME1
HPAiHPA040913
MalaCardsiMGME1
MIMi615076 gene
615084 phenotype
neXtProtiNX_Q9BQP7
OpenTargetsiENSG00000125871
Orphaneti352447 Progressive external ophthalmoplegia-myopathy-emaciation syndrome
PharmGKBiPA25783

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFA1 Eukaryota
ENOG410XWHK LUCA
GeneTreeiENSGT00390000003349
HOGENOMiHOG000231693
HOVERGENiHBG051175
InParanoidiQ9BQP7
KOiK19465
OMAiWAKWLLR
OrthoDBiEOG091G0CCD
PhylomeDBiQ9BQP7
TreeFamiTF320375

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MGME1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
92667

Protein Ontology

More...
PROi
PR:Q9BQP7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000125871 Expressed in 194 organ(s), highest expression level in metanephros
CleanExiHS_C20orf72
ExpressionAtlasiQ9BQP7 baseline and differential
GenevisibleiQ9BQP7 HS

Family and domain databases

HAMAPiMF_03030 MGME1, 1 hit
InterProiView protein in InterPro
IPR026970 MGME1
IPR038726 PDDEXK_AddAB-type
IPR011335 Restrct_endonuc-II-like
PfamiView protein in Pfam
PF12705 PDDEXK_1, 1 hit
SUPFAMiSSF52980 SSF52980, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMGME1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BQP7
Secondary accession number(s): B2RDG5, D3DW29, Q96SW3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: June 1, 2001
Last modified: December 5, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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