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Entry version 137 (12 Aug 2020)
Sequence version 3 (19 Jul 2005)
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Protein

Phosphatidate phosphatase LPIN3

Gene

LPIN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates fatty acid metabolism. Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by N-ethylmaleimide.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9BQK8

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1483191, Synthesis of PC
R-HSA-1483213, Synthesis of PE
R-HSA-4419969, Depolymerisation of the Nuclear Lamina
R-HSA-75109, Triglyceride biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidate phosphatase LPIN3 (EC:3.1.3.4)
Alternative name(s):
Lipin-3
Lipin-3-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LPIN3
Synonyms:LIPN3L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000132793.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14451, LPIN3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605520, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BQK8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64900

Open Targets

More...
OpenTargetsi
ENSG00000132793

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30438

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BQK8, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LPIN3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71153524

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002098831 – 851Phosphatidate phosphatase LPIN3Add BLAST851

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei159PhosphothreonineCombined sources1
Modified residuei161PhosphoserineCombined sources1
Modified residuei162PhosphoserineCombined sources1
Modified residuei224PhosphoserineBy similarity1
Modified residuei463PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BQK8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BQK8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BQK8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BQK8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BQK8

PeptideAtlas

More...
PeptideAtlasi
Q9BQK8

PRoteomics IDEntifications database

More...
PRIDEi
Q9BQK8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78695 [Q9BQK8-1]
78696 [Q9BQK8-2]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
LPIN3

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BQK8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BQK8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Significant expression in intestine and other regions of the gastrointestinal tract.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132793, Expressed in zone of skin and 113 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BQK8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BQK8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000132793, Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122340, 51 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BQK8, 15 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362354

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BQK8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BQK8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 108N-LIPAdd BLAST108
Regioni590 – 792C-LIPAdd BLAST203

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi141 – 148Nuclear localization signalSequence analysis8
Motifi644 – 648DXDXT motif5
Motifi655 – 659LXXIL motif5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the lipin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2116, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160046

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002546_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BQK8

KEGG Orthology (KO)

More...
KOi
K15728

Identification of Orthologs from Complete Genome Data

More...
OMAi
KPHIFKM

Database of Orthologous Groups

More...
OrthoDBi
866929at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BQK8

TreeFam database of animal gene trees

More...
TreeFami
TF314095

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036412, HAD-like_sf
IPR026058, LIPIN
IPR031703, Lipin_mid
IPR007651, Lipin_N
IPR013209, LNS2
IPR031315, LNS2/PITP

The PANTHER Classification System

More...
PANTHERi
PTHR12181, PTHR12181, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16876, Lipin_mid, 1 hit
PF04571, Lipin_N, 1 hit
PF08235, LNS2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00775, LNS2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784, SSF56784, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BQK8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNYVGQLAET VFGTVKELYR GLNPATLSGG IDVLVVKQVD GSFRCSPFHV
60 70 80 90 100
RFGKLGVLRS REKVVDIELN GEPVDLHMKL GDSGEAFFVQ ELESDDEHVP
110 120 130 140 150
PGLCTSPIPW GGLSGFPSDS QLGTASEPEG LVMAGTASTG RRKRRRRRKP
160 170 180 190 200
KQKEDAVATD SSPEELEAGA ESELSLPEKL RPEPPGVQLE EKSSLQPKDI
210 220 230 240 250
YPYSDGEWPP QASLSAGELT SPKSDSELEV RTPEPSPLRA ESHMQWAWGR
260 270 280 290 300
LPKVARAERP ESSVVLEGRA GATSPPRGGP STPSTSVAGG VDPLGLPIQQ
310 320 330 340 350
TEAGADLQPD TEDPTLVGPP LHTPETEESK TQSSGDMGLP PASKSWSWAT
360 370 380 390 400
LEVPVPTGQP ERVSRGKGSP KRSQHLGPSD IYLDDLPSLD SENAALYFPQ
410 420 430 440 450
SDSGLGARRW SEPSSQKSLR DPNPEHEPEP TLDTVDTIAL SLCGGLADSR
460 470 480 490 500
DISLEKFNQH SVSYQDLTKN PGLLDDPNLV VKINGKHYNW AVAAPMILSL
510 520 530 540 550
QAFQKNLPKS TMDKLEREKM PRKGGRWWFS WRRRDFLAEE RSAQKEKTAA
560 570 580 590 600
KEQQGEKTEV LSSDDDAPDS PVILEIPSLP PSTPPSTPTY KKSLRLSSDQ
610 620 630 640 650
IRRLNLQEGA NDVVFSVTTQ YQGTCRCKAT IYLWKWDDKV VISDIDGTIT
660 670 680 690 700
KSDALGHILP QLGKDWTHQG ITSLYHKIQL NGYKFLYCSA RAIGMADLTK
710 720 730 740 750
GYLQWVSEGG CSLPKGPILL SPSSLFSALH REVIEKKPEV FKVACLSDIQ
760 770 780 790 800
QLFLPHGQPF YAAFGNRPND VFAYRQVGLP ESRIFTVNPR GELIQELIKN
810 820 830 840 850
HKSTYERLGE VVELLFPPVA RGPSTDLANP EYSNFCYWRE PLPAVDLDTL

D
Length:851
Mass (Da):93,614
Last modified:July 19, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBBDFDA0A53722625
GO
Isoform 2 (identifier: Q9BQK8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-186: G → GS

Show »
Length:852
Mass (Da):93,701
Checksum:iE4BF4891F1A1550A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y5E1H0Y5E1_HUMAN
Phosphatidate phosphatase LPIN3
LPIN3
269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053489679Q → H. Corresponds to variant dbSNP:rs12625565Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036885186G → GS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL132654 Genomic DNA No translation available.
AL031667 Genomic DNA No translation available.
BC140806 mRNA Translation: AAI40807.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33469.2 [Q9BQK8-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001288789.1, NM_001301860.1 [Q9BQK8-2]
XP_016883509.1, XM_017028020.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373257; ENSP00000362354; ENSG00000132793 [Q9BQK8-1]
ENST00000632009; ENSP00000487971; ENSG00000132793 [Q9BQK8-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64900

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64900

UCSC genome browser

More...
UCSCi
uc002xjx.3, human [Q9BQK8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132654 Genomic DNA No translation available.
AL031667 Genomic DNA No translation available.
BC140806 mRNA Translation: AAI40807.1
CCDSiCCDS33469.2 [Q9BQK8-2]
RefSeqiNP_001288789.1, NM_001301860.1 [Q9BQK8-2]
XP_016883509.1, XM_017028020.1

3D structure databases

SMRiQ9BQK8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122340, 51 interactors
IntActiQ9BQK8, 15 interactors
STRINGi9606.ENSP00000362354

PTM databases

DEPODiLPIN3
iPTMnetiQ9BQK8
PhosphoSitePlusiQ9BQK8

Polymorphism and mutation databases

BioMutaiLPIN3
DMDMi71153524

Proteomic databases

EPDiQ9BQK8
jPOSTiQ9BQK8
MassIVEiQ9BQK8
MaxQBiQ9BQK8
PaxDbiQ9BQK8
PeptideAtlasiQ9BQK8
PRIDEiQ9BQK8
ProteomicsDBi78695 [Q9BQK8-1]
78696 [Q9BQK8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
27036, 149 antibodies

Genome annotation databases

EnsembliENST00000373257; ENSP00000362354; ENSG00000132793 [Q9BQK8-1]
ENST00000632009; ENSP00000487971; ENSG00000132793 [Q9BQK8-2]
GeneIDi64900
KEGGihsa:64900
UCSCiuc002xjx.3, human [Q9BQK8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64900
DisGeNETi64900
EuPathDBiHostDB:ENSG00000132793.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LPIN3
HGNCiHGNC:14451, LPIN3
HPAiENSG00000132793, Tissue enhanced (intestine)
MIMi605520, gene
neXtProtiNX_Q9BQK8
OpenTargetsiENSG00000132793
PharmGKBiPA30438

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2116, Eukaryota
GeneTreeiENSGT00940000160046
HOGENOMiCLU_002546_0_1_1
InParanoidiQ9BQK8
KOiK15728
OMAiKPHIFKM
OrthoDBi866929at2759
PhylomeDBiQ9BQK8
TreeFamiTF314095

Enzyme and pathway databases

PathwayCommonsiQ9BQK8
ReactomeiR-HSA-1483191, Synthesis of PC
R-HSA-1483213, Synthesis of PE
R-HSA-4419969, Depolymerisation of the Nuclear Lamina
R-HSA-75109, Triglyceride biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
64900, 4 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LPIN3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64900
PharosiQ9BQK8, Tbio

Protein Ontology

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PROi
PR:Q9BQK8
RNActiQ9BQK8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000132793, Expressed in zone of skin and 113 other tissues
ExpressionAtlasiQ9BQK8, baseline and differential
GenevisibleiQ9BQK8, HS

Family and domain databases

InterProiView protein in InterPro
IPR036412, HAD-like_sf
IPR026058, LIPIN
IPR031703, Lipin_mid
IPR007651, Lipin_N
IPR013209, LNS2
IPR031315, LNS2/PITP
PANTHERiPTHR12181, PTHR12181, 1 hit
PfamiView protein in Pfam
PF16876, Lipin_mid, 1 hit
PF04571, Lipin_N, 1 hit
PF08235, LNS2, 1 hit
SMARTiView protein in SMART
SM00775, LNS2, 1 hit
SUPFAMiSSF56784, SSF56784, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLPIN3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BQK8
Secondary accession number(s): B2RTT5
, Q5TDB9, Q9NPY8, Q9UJE5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: July 19, 2005
Last modified: August 12, 2020
This is version 137 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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