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Protein

Transmembrane protein 47

Gene

TMEM47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B. During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 47
Alternative name(s):
Brain cell membrane protein 1
Transmembrane 4 superfamily member 10
Gene namesi
Name:TMEM47
Synonyms:BCMP1, TM4SF10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147027.3
HGNCiHGNC:18515 TMEM47
MIMi300698 gene
neXtProtiNX_Q9BQJ4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83604
OpenTargetsiENSG00000147027
PharmGKBiPA134971248

Polymorphism and mutation databases

BioMutaiTMEM47
DMDMi51316912

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000725732 – 181Transmembrane protein 47Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BQJ4
PaxDbiQ9BQJ4
PeptideAtlasiQ9BQJ4
PRIDEiQ9BQJ4
ProteomicsDBi78693

PTM databases

iPTMnetiQ9BQJ4
PhosphoSitePlusiQ9BQJ4
SwissPalmiQ9BQJ4

Expressioni

Tissue specificityi

Expressed in adult brain, fetal brain, cerebellum, heart, lung, prostate and thyroid.1 Publication

Gene expression databases

BgeeiENSG00000147027 Expressed in 238 organ(s), highest expression level in choroid plexus epithelium
CleanExiHS_TMEM47
ExpressionAtlasiQ9BQJ4 baseline and differential
GenevisibleiQ9BQJ4 HS

Organism-specific databases

HPAiHPA046658

Interactioni

Subunit structurei

Interacts with CTNNB1, CTNNA1, PRKCI, PARD6B, FYB1.By similarity

Protein-protein interaction databases

BioGridi123695, 6 interactors
IntActiQ9BQJ4, 4 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9BQJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM47 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4671 Eukaryota
ENOG4111P5K LUCA
GeneTreeiENSGT00530000063484
HOGENOMiHOG000124678
HOVERGENiHBG080233
InParanoidiQ9BQJ4
OMAiWTRDIGY
OrthoDBiEOG091G0S9P
PhylomeDBiQ9BQJ4
TreeFamiTF312855

Family and domain databases

InterProiView protein in InterPro
IPR015664 P53_induced
PANTHERiPTHR14399 PTHR14399, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BQJ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASAGSGMEE VRVSVLTPLK LVGLVCIFLA LCLDLGAVLS PAWVTADHQY
60 70 80 90 100
YLSLWESCRK PASLDIWHCE STLSSDWQIA TLALLLGGAA IILIAFLVGL
110 120 130 140 150
ISICVGSRRR FYRPVAVMLF AAVVLQVCSL VLYPIKFIET VSLKIYHEFN
160 170 180
WGYGLAWGAT IFSFGGAILY CLNPKNYEDY Y
Length:181
Mass (Da):19,998
Last modified:June 1, 2001 - v1
Checksum:iA73A03FD0C3B3FBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136550 mRNA Translation: CAB66485.1
AL596285 Genomic DNA No translation available.
BC039242 mRNA Translation: AAH39242.1
CCDSiCCDS14235.1
RefSeqiNP_113630.1, NM_031442.3
UniGeneiHs.8769

Genome annotation databases

EnsembliENST00000275954; ENSP00000275954; ENSG00000147027
GeneIDi83604
KEGGihsa:83604
UCSCiuc004ddh.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136550 mRNA Translation: CAB66485.1
AL596285 Genomic DNA No translation available.
BC039242 mRNA Translation: AAH39242.1
CCDSiCCDS14235.1
RefSeqiNP_113630.1, NM_031442.3
UniGeneiHs.8769

3D structure databases

ProteinModelPortaliQ9BQJ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123695, 6 interactors
IntActiQ9BQJ4, 4 interactors

PTM databases

iPTMnetiQ9BQJ4
PhosphoSitePlusiQ9BQJ4
SwissPalmiQ9BQJ4

Polymorphism and mutation databases

BioMutaiTMEM47
DMDMi51316912

Proteomic databases

EPDiQ9BQJ4
PaxDbiQ9BQJ4
PeptideAtlasiQ9BQJ4
PRIDEiQ9BQJ4
ProteomicsDBi78693

Protocols and materials databases

DNASUi83604
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275954; ENSP00000275954; ENSG00000147027
GeneIDi83604
KEGGihsa:83604
UCSCiuc004ddh.3 human

Organism-specific databases

CTDi83604
DisGeNETi83604
EuPathDBiHostDB:ENSG00000147027.3
GeneCardsiTMEM47
HGNCiHGNC:18515 TMEM47
HPAiHPA046658
MIMi300698 gene
neXtProtiNX_Q9BQJ4
OpenTargetsiENSG00000147027
PharmGKBiPA134971248
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4671 Eukaryota
ENOG4111P5K LUCA
GeneTreeiENSGT00530000063484
HOGENOMiHOG000124678
HOVERGENiHBG080233
InParanoidiQ9BQJ4
OMAiWTRDIGY
OrthoDBiEOG091G0S9P
PhylomeDBiQ9BQJ4
TreeFamiTF312855

Miscellaneous databases

GeneWikiiTMEM47
GenomeRNAii83604
PROiPR:Q9BQJ4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147027 Expressed in 238 organ(s), highest expression level in choroid plexus epithelium
CleanExiHS_TMEM47
ExpressionAtlasiQ9BQJ4 baseline and differential
GenevisibleiQ9BQJ4 HS

Family and domain databases

InterProiView protein in InterPro
IPR015664 P53_induced
PANTHERiPTHR14399 PTHR14399, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMM47_HUMAN
AccessioniPrimary (citable) accession number: Q9BQJ4
Secondary accession number(s): Q5JR44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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