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Protein

Nuclear receptor-interacting protein 2

Gene

NRIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Down-regulates transcriptional activation by nuclear receptors such as NR1F2.By similarity

GO - Molecular functioni

Keywordsi

Biological processTranscription, Transcription regulation

Protein family/group databases

MEROPSiA28.002

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor-interacting protein 2
Gene namesi
Name:NRIP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000053702.14
HGNCiHGNC:23078 NRIP2
neXtProtiNX_Q9BQI9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000053702
PharmGKBiPA134978127

Polymorphism and mutation databases

BioMutaiNRIP2
DMDMi251757451

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710561 – 281Nuclear receptor-interacting protein 2Add BLAST281

Proteomic databases

PaxDbiQ9BQI9
PeptideAtlasiQ9BQI9
PRIDEiQ9BQI9
ProteomicsDBi78692

PTM databases

iPTMnetiQ9BQI9
PhosphoSitePlusiQ9BQI9

Expressioni

Gene expression databases

BgeeiENSG00000053702 Expressed in 171 organ(s), highest expression level in olfactory bulb
CleanExiHS_NRIP2
ExpressionAtlasiQ9BQI9 baseline and differential
GenevisibleiQ9BQI9 HS

Organism-specific databases

HPAiHPA039197
HPA039860

Interactioni

Subunit structurei

Interacts with NR1F2, RARA and THRB in a ligand-dependent manner.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi123737, 4 interactors
IntActiQ9BQI9, 6 interactors
MINTiQ9BQI9
STRINGi9606.ENSP00000337501

Structurei

3D structure databases

ProteinModelPortaliQ9BQI9
SMRiQ9BQI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi244 – 248LXXLL motif5

Phylogenomic databases

eggNOGiKOG0012 Eukaryota
ENOG410XPA0 LUCA
GeneTreeiENSGT00510000046989
HOGENOMiHOG000236257
HOVERGENiHBG103468
InParanoidiQ9BQI9
KOiK13215
OMAiLKCCIDL
OrthoDBiEOG091G0L7S
PhylomeDBiQ9BQI9
TreeFamiTF333421

Family and domain databases

CDDicd05480 NRIP_C, 1 hit
Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR033821 NRIP_C
IPR019103 Peptidase_aspartic_DDI1-type
IPR021109 Peptidase_aspartic_dom_sf
PfamiView protein in Pfam
PF09668 Asp_protease, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BQI9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLFIFPLSLP WRPSCWKESC STGQRQAGRS REDSVTPPPS SPWPTPPAGA
60 70 80 90 100
MSTKQEARRD EGEARTRGQE AQLRDRAHLS QQRRLKQATQ FLHKDSADLL
110 120 130 140 150
PLDSLKRLGT SKDLQPRSVI QRRLVEGNPN WLQGEPPRMQ DLIHGQESRR
160 170 180 190 200
KTSRTEIPAL LVNCKCQDQL LRVAVDTGTQ YNRISAGCLS RLGLEKRVLK
210 220 230 240 250
ASAGDLAPGP PTQVEQLELQ LGQETVVCSA QVVDAESPEF CLGLQTLLSL
260 270 280
KCCIDLEHGV LRLKAPFSEL PFLPLYQEPG Q
Length:281
Mass (Da):31,331
Last modified:July 7, 2009 - v3
Checksum:iF92A490B1E7AF7D3
GO
Isoform 2 (identifier: Q9BQI9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-91: Missing.

Note: No experimental confirmation available.
Show »
Length:270
Mass (Da):29,945
Checksum:i387B639548D99925
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H2G5F5H2G5_HUMAN
Nuclear receptor-interacting protei...
NRIP2
175Annotation score:
F5H065F5H065_HUMAN
Nuclear receptor-interacting protei...
NRIP2
138Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29R → K in BAG62573 (PubMed:14702039).Curated1
Sequence conflicti243G → S in BAG62573 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05393081 – 91Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136557 mRNA Translation: CAB66492.1
AK098063 mRNA Translation: BAG53573.1
AK300944 mRNA Translation: BAG62573.1
AC005841 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88888.1
BC036063 mRNA Translation: AAH36063.1
BC131562 mRNA Translation: AAI31563.1
CCDSiCCDS8514.1 [Q9BQI9-1]
RefSeqiNP_113662.1, NM_031474.2 [Q9BQI9-1]
XP_005253854.1, XM_005253797.3 [Q9BQI9-1]
UniGeneiHs.530816

Genome annotation databases

EnsembliENST00000337508; ENSP00000337501; ENSG00000053702 [Q9BQI9-1]
GeneIDi83714
KEGGihsa:83714
UCSCiuc001qlc.4 human [Q9BQI9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136557 mRNA Translation: CAB66492.1
AK098063 mRNA Translation: BAG53573.1
AK300944 mRNA Translation: BAG62573.1
AC005841 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88888.1
BC036063 mRNA Translation: AAH36063.1
BC131562 mRNA Translation: AAI31563.1
CCDSiCCDS8514.1 [Q9BQI9-1]
RefSeqiNP_113662.1, NM_031474.2 [Q9BQI9-1]
XP_005253854.1, XM_005253797.3 [Q9BQI9-1]
UniGeneiHs.530816

3D structure databases

ProteinModelPortaliQ9BQI9
SMRiQ9BQI9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123737, 4 interactors
IntActiQ9BQI9, 6 interactors
MINTiQ9BQI9
STRINGi9606.ENSP00000337501

Protein family/group databases

MEROPSiA28.002

PTM databases

iPTMnetiQ9BQI9
PhosphoSitePlusiQ9BQI9

Polymorphism and mutation databases

BioMutaiNRIP2
DMDMi251757451

Proteomic databases

PaxDbiQ9BQI9
PeptideAtlasiQ9BQI9
PRIDEiQ9BQI9
ProteomicsDBi78692

Protocols and materials databases

DNASUi83714
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337508; ENSP00000337501; ENSG00000053702 [Q9BQI9-1]
GeneIDi83714
KEGGihsa:83714
UCSCiuc001qlc.4 human [Q9BQI9-1]

Organism-specific databases

CTDi83714
EuPathDBiHostDB:ENSG00000053702.14
GeneCardsiNRIP2
HGNCiHGNC:23078 NRIP2
HPAiHPA039197
HPA039860
neXtProtiNX_Q9BQI9
OpenTargetsiENSG00000053702
PharmGKBiPA134978127
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0012 Eukaryota
ENOG410XPA0 LUCA
GeneTreeiENSGT00510000046989
HOGENOMiHOG000236257
HOVERGENiHBG103468
InParanoidiQ9BQI9
KOiK13215
OMAiLKCCIDL
OrthoDBiEOG091G0L7S
PhylomeDBiQ9BQI9
TreeFamiTF333421

Miscellaneous databases

GeneWikiiNRIP2
GenomeRNAii83714
PROiPR:Q9BQI9

Gene expression databases

BgeeiENSG00000053702 Expressed in 171 organ(s), highest expression level in olfactory bulb
CleanExiHS_NRIP2
ExpressionAtlasiQ9BQI9 baseline and differential
GenevisibleiQ9BQI9 HS

Family and domain databases

CDDicd05480 NRIP_C, 1 hit
Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR033821 NRIP_C
IPR019103 Peptidase_aspartic_DDI1-type
IPR021109 Peptidase_aspartic_dom_sf
PfamiView protein in Pfam
PF09668 Asp_protease, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNRIP2_HUMAN
AccessioniPrimary (citable) accession number: Q9BQI9
Secondary accession number(s): A2RRE3, B4DV61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 7, 2009
Last modified: November 7, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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