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Entry version 134 (16 Oct 2019)
Sequence version 2 (05 Sep 2006)
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Protein

SH3-containing GRB2-like protein 3-interacting protein 1

Gene

SGIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH3-containing GRB2-like protein 3-interacting protein 1
Alternative name(s):
Endophilin-3-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SGIP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25412 SGIP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611540 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BQI5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84251

Open Targets

More...
OpenTargetsi
ENSG00000118473

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134909202

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BQI5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SGIP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
114152158

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002483951 – 828SH3-containing GRB2-like protein 3-interacting protein 1Add BLAST828

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei78PhosphoserineBy similarity1
Modified residuei104PhosphoserineBy similarity1
Modified residuei105PhosphoserineBy similarity1
Modified residuei107PhosphoserineBy similarity1
Modified residuei149PhosphoserineBy similarity1
Modified residuei151PhosphoserineBy similarity1
Modified residuei156PhosphoserineBy similarity1
Modified residuei169PhosphoserineBy similarity1
Modified residuei180PhosphothreonineBy similarity1
Modified residuei182PhosphothreonineBy similarity1
Modified residuei236PhosphoserineBy similarity1
Modified residuei247PhosphothreonineBy similarity1
Modified residuei259PhosphothreonineBy similarity1
Modified residuei265PhosphoserineBy similarity1
Modified residuei287PhosphoserineBy similarity1
Modified residuei300PhosphoserineBy similarity1
Modified residuei316PhosphoserineBy similarity1
Modified residuei319PhosphoserineBy similarity1
Modified residuei324PhosphothreonineBy similarity1
Modified residuei328PhosphothreonineBy similarity1
Modified residuei372PhosphoserineBy similarity1
Modified residuei399PhosphoserineBy similarity1
Modified residuei410PhosphothreonineBy similarity1
Modified residuei486PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BQI5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BQI5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BQI5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BQI5

PeptideAtlas

More...
PeptideAtlasi
Q9BQI5

PRoteomics IDEntifications database

More...
PRIDEi
Q9BQI5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78685 [Q9BQI5-1]
78686 [Q9BQI5-2]
78687 [Q9BQI5-3]
78688 [Q9BQI5-4]
78689 [Q9BQI5-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BQI5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BQI5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9BQI5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000118473 Expressed in 137 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BQI5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BQI5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017963

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with proteins essential or regulating the formation of functional clathrin-coated pits (Probable).

Interacts with CANX (By similarity).

Interacts with AP2A1 (By similarity).

Interacts with EPS15 (PubMed:26822536).

Interacts with SH3GL3 (PubMed:15919751).

Interacts with AMPH (PubMed:20946875).

Interacts with ITSN1 (via SH3 domains) (PubMed:20946875).

Interacts with and REPS1 (PubMed:20946875).

By similarityCurated3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123979, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BQI5, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360076

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1828
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BQI5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini559 – 827MHDPROSITE-ProRule annotationAdd BLAST269

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni561 – 567Interaction with DPF motifs-containing proteinsCombined sources1 Publication7
Regioni593 – 595Interaction with DPF motifs-containing proteinsCombined sources1 Publication3
Regioni649 – 828Necessary and sufficient to mediate interaction with CANXBy similarityAdd BLAST180
Regioni667 – 670Interaction with DPF motifs-containing proteinsCombined sources1 Publication4
Regioni813 – 818Interaction with DPF motifs-containing proteinsCombined sources1 Publication6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi106 – 112Poly-GluSequence analysis7
Compositional biasi176 – 499Pro-richPROSITE-ProRule annotationAdd BLAST324

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IU8J Eukaryota
ENOG410XTCY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156301

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BQI5

KEGG Orthology (KO)

More...
KOi
K20065

Identification of Orthologs from Complete Genome Data

More...
OMAi
NYNRLEH

Database of Orthologous Groups

More...
OrthoDBi
638761at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BQI5

TreeFam database of animal gene trees

More...
TreeFami
TF328986

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09266 SGIP1_MHD, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR028565 MHD
IPR018808 Muniscin_C
IPR037984 SGIP1_MHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10291 muHD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49447 SSF49447, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51072 MHD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BQI5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMEGLKKRTR KAFGIRKKEK DTDSTGSPDR DGIQPSPHEP PYNSKAECAR
60 70 80 90 100
EGGKKVSKKS NGAPNGFYAE IDWERYNSPE LDEEGYSIRP EEPGSTKGKH
110 120 130 140 150
FYSSSESEEE EESHKKFNIK IKPLQSKDIL KNAATVDELK ASIGNIALSP
160 170 180 190 200
SPVRKSPRRS PGAIKRNLSS EEVARPRRST PTPELISKKP PDDTTALAPL
210 220 230 240 250
FGPPLESAFD EQKTEVLLDQ PEIWGSGQPI NPSMESPKLT RPFPTGTPPP
260 270 280 290 300
LPPKNVPATP PRTGSPLTIG PGNDQSATEV KIEKLPSIND LDSIFGPVLS
310 320 330 340 350
PKSVAVNAEE KWVHFSDTSP EHVTPELTPR EKVVSPPATP DNPADSPAPG
360 370 380 390 400
PLGPPGPTGP PGPPGPPRNV LSPLNLEEVQ KKVAEQTFIK DDYLETISSP
410 420 430 440 450
KDFGLGQRAT PPPPPPPTYR TVVSSPGPGS GPGPGTTSGA SSPARPATPL
460 470 480 490 500
VPCRSTTPPP PPPRPPSRPK LPPGKPGVGD VSRPFSPPIH SSSPPPIAPL
510 520 530 540 550
ARAESTSSIS STNSLSAATT PTVENEQPSL VWFDRGKFYL TFEGSSRGPS
560 570 580 590 600
PLTMGAQDTL PVAAAFTETV NAYFKGADPS KCIVKITGEM VLSFPAGITR
610 620 630 640 650
HFANNPSPAA LTFRVINFSR LEHVLPNPQL LCCDNTQNDA NTKEFWVNMP
660 670 680 690 700
NLMTHLKKVS EQKPQATYYN VDMLKYQVSA QGIQSTPLNL AVNWRCEPSS
710 720 730 740 750
TDLRIDYKYN TDAMTTAVAL NNVQFLVPID GGVTKLQAVL PPAVWNAEQQ
760 770 780 790 800
RILWKIPDIS QKSENGGVGS LLARFQLSEG PSKPSPLVVQ FTSEGSTLSG
810 820
CDIELVGAGY RFSLIKKRFA AGKYLADN
Length:828
Mass (Da):89,109
Last modified:September 5, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86D2B6AE3099CDEA
GO
Isoform 2 (identifier: Q9BQI5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-57: PSPHEPPYNSKAECAREGGKKVS → GKKKTQKTQLLLTSCFWLRALSLTLSQ

Show »
Length:832
Mass (Da):89,734
Checksum:i67A0B74D0A09918D
GO
Isoform 3 (identifier: Q9BQI5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-57: PSPHEPPYNSKAECAREGGKKVS → GKKKTQKTQLLLTSCFWLRALSLTLSQ
     437-437: T → TSDGKTEAQRYQVICPSLQAGGNELDSY

Note: No experimental confirmation available.
Show »
Length:859
Mass (Da):92,646
Checksum:i823A19AEAB727F86
GO
Isoform 4 (identifier: Q9BQI5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-57: Missing.
     154-161: Missing.
     272-438: Missing.

Show »
Length:629
Mass (Da):68,240
Checksum:iB42E8BBA6AF8B3A2
GO
Isoform 5 (identifier: Q9BQI5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-57: Missing.
     154-161: Missing.
     272-438: Missing.
     524-543: ENEQPSLVWFDRGKFYLTFE → VSEDDVFYDKLPSFERRCETPA

Show »
Length:631
Mass (Da):68,338
Checksum:iAA5403263C766B24
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6ZV33Q6ZV33_HUMAN
SH3-containing GRB2-like protein 3-...
SGIP1
333Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6R8P8F6R8P8_HUMAN
SH3-containing GRB2-like protein 3-...
SGIP1
260Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE06121 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti81L → V in CAH18344 (PubMed:17974005).Curated1
Sequence conflicti212Q → R in CAH18344 (PubMed:17974005).Curated1
Sequence conflicti498A → V in CAH18344 (PubMed:17974005).Curated1
Sequence conflicti772L → S in CAH18344 (PubMed:17974005).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variation in SGIP1 is associated with fat mass and SGIP1 may be a determinant of obesity-related traits.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027297112E → Q. Corresponds to variant dbSNP:rs17490057Ensembl.1
Natural variantiVAR_027298131K → R3 PublicationsCorresponds to variant dbSNP:rs7526812Ensembl.1
Natural variantiVAR_027299161P → Q1 PublicationCorresponds to variant dbSNP:rs17855645Ensembl.1
Natural variantiVAR_027300575K → E1 PublicationCorresponds to variant dbSNP:rs17854026Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02027334 – 57Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_02027435 – 57PSPHE…GKKVS → GKKKTQKTQLLLTSCFWLRA LSLTLSQ in isoform 2 and isoform 3. 2 PublicationsAdd BLAST23
Alternative sequenceiVSP_020275154 – 161Missing in isoform 4 and isoform 5. 1 Publication8
Alternative sequenceiVSP_020276272 – 438Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST167
Alternative sequenceiVSP_020277437T → TSDGKTEAQRYQVICPSLQA GGNELDSY in isoform 3. 1 Publication1
Alternative sequenceiVSP_020278524 – 543ENEQP…YLTFE → VSEDDVFYDKLPSFERRCET PA in isoform 5. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL136561 mRNA Translation: CAB66496.1
AB210039 mRNA Translation: BAE06121.1 Different initiation.
BX640813 mRNA Translation: CAE45891.1
CR749541 mRNA Translation: CAH18344.1
AL139147 Genomic DNA No translation available.
AL354978 Genomic DNA No translation available.
AL356913 Genomic DNA No translation available.
BC040516 mRNA Translation: AAH40516.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30744.1 [Q9BQI5-1]
CCDS76171.1 [Q9BQI5-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001295132.1, NM_001308203.1 [Q9BQI5-5]
NP_115667.2, NM_032291.3 [Q9BQI5-1]
XP_005271321.1, XM_005271264.3
XP_005271327.1, XM_005271270.4 [Q9BQI5-4]
XP_006711037.1, XM_006710974.2 [Q9BQI5-5]
XP_016858000.1, XM_017002511.1 [Q9BQI5-1]
XP_016858001.1, XM_017002512.1 [Q9BQI5-1]
XP_016858023.1, XM_017002534.1 [Q9BQI5-4]
XP_016858024.1, XM_017002535.1 [Q9BQI5-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000237247; ENSP00000237247; ENSG00000118473 [Q9BQI5-3]
ENST00000371037; ENSP00000360076; ENSG00000118473 [Q9BQI5-1]
ENST00000371039; ENSP00000360078; ENSG00000118473 [Q9BQI5-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84251

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84251

UCSC genome browser

More...
UCSCi
uc001dcr.4 human [Q9BQI5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136561 mRNA Translation: CAB66496.1
AB210039 mRNA Translation: BAE06121.1 Different initiation.
BX640813 mRNA Translation: CAE45891.1
CR749541 mRNA Translation: CAH18344.1
AL139147 Genomic DNA No translation available.
AL354978 Genomic DNA No translation available.
AL356913 Genomic DNA No translation available.
BC040516 mRNA Translation: AAH40516.1
CCDSiCCDS30744.1 [Q9BQI5-1]
CCDS76171.1 [Q9BQI5-5]
RefSeqiNP_001295132.1, NM_001308203.1 [Q9BQI5-5]
NP_115667.2, NM_032291.3 [Q9BQI5-1]
XP_005271321.1, XM_005271264.3
XP_005271327.1, XM_005271270.4 [Q9BQI5-4]
XP_006711037.1, XM_006710974.2 [Q9BQI5-5]
XP_016858000.1, XM_017002511.1 [Q9BQI5-1]
XP_016858001.1, XM_017002512.1 [Q9BQI5-1]
XP_016858023.1, XM_017002534.1 [Q9BQI5-4]
XP_016858024.1, XM_017002535.1 [Q9BQI5-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AWRX-ray2.50A552-828[»]
5AWSX-ray2.00A/B552-828[»]
5AWTX-ray2.70A552-828[»]
5AWUX-ray2.70A552-828[»]
6A9YX-ray2.70A558-828[»]
SMRiQ9BQI5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi123979, 8 interactors
IntActiQ9BQI5, 3 interactors
STRINGi9606.ENSP00000360076

PTM databases

iPTMnetiQ9BQI5
PhosphoSitePlusiQ9BQI5
SwissPalmiQ9BQI5

Polymorphism and mutation databases

BioMutaiSGIP1
DMDMi114152158

Proteomic databases

EPDiQ9BQI5
jPOSTiQ9BQI5
MassIVEiQ9BQI5
PaxDbiQ9BQI5
PeptideAtlasiQ9BQI5
PRIDEiQ9BQI5
ProteomicsDBi78685 [Q9BQI5-1]
78686 [Q9BQI5-2]
78687 [Q9BQI5-3]
78688 [Q9BQI5-4]
78689 [Q9BQI5-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
84251

Genome annotation databases

EnsembliENST00000237247; ENSP00000237247; ENSG00000118473 [Q9BQI5-3]
ENST00000371037; ENSP00000360076; ENSG00000118473 [Q9BQI5-1]
ENST00000371039; ENSP00000360078; ENSG00000118473 [Q9BQI5-5]
GeneIDi84251
KEGGihsa:84251
UCSCiuc001dcr.4 human [Q9BQI5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84251
DisGeNETi84251

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SGIP1
HGNCiHGNC:25412 SGIP1
HPAiHPA017963
MIMi611540 gene
neXtProtiNX_Q9BQI5
OpenTargetsiENSG00000118473
PharmGKBiPA134909202

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IU8J Eukaryota
ENOG410XTCY LUCA
GeneTreeiENSGT00940000156301
InParanoidiQ9BQI5
KOiK20065
OMAiNYNRLEH
OrthoDBi638761at2759
PhylomeDBiQ9BQI5
TreeFamiTF328986

Enzyme and pathway databases

ReactomeiR-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SGIP1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SGIP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84251
PharosiQ9BQI5

Protein Ontology

More...
PROi
PR:Q9BQI5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000118473 Expressed in 137 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ9BQI5 baseline and differential
GenevisibleiQ9BQI5 HS

Family and domain databases

CDDicd09266 SGIP1_MHD, 1 hit
InterProiView protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR028565 MHD
IPR018808 Muniscin_C
IPR037984 SGIP1_MHD
PfamiView protein in Pfam
PF10291 muHD, 1 hit
SUPFAMiSSF49447 SSF49447, 1 hit
PROSITEiView protein in PROSITE
PS51072 MHD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSGIP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BQI5
Secondary accession number(s): A6NL81
, A6NLD1, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: October 16, 2019
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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