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Protein

Allograft inflammatory factor 1-like

Gene

AIF1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi60 – 711PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • calcium ion binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Allograft inflammatory factor 1-like
Alternative name(s):
Ionized calcium-binding adapter molecule 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AIF1L
Synonyms:C9orf58, IBA2
ORF Names:UNQ672/PRO1306
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000126878.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28904 AIF1L

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BQI0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000126878

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164715250

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AIF1L

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000738702 – 150Allograft inflammatory factor 1-likeAdd BLAST149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei134PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BQI0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BQI0

PeptideAtlas

More...
PeptideAtlasi
Q9BQI0

PRoteomics IDEntifications database

More...
PRIDEi
Q9BQI0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78678
78679 [Q9BQI0-2]
78680 [Q9BQI0-3]
78681 [Q9BQI0-4]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9BQI0-2 [Q9BQI0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BQI0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BQI0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000126878 Expressed in 188 organ(s), highest expression level in renal medulla

CleanEx database of gene expression profiles

More...
CleanExi
HS_AIF1L

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BQI0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BQI0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020522
HPA056852

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (Potential). Monomer.Curated1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123676, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BQI0, 3 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1150
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9BQI0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BQI0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9BQI0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 82EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini83 – 117EF-hand 2; degeneratePROSITE-ProRule annotationAdd BLAST35

Keywords - Domaini

Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013846

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231928

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004002

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BQI0

KEGG Orthology (KO)

More...
KOi
K18617

Identification of Orthologs from Complete Genome Data

More...
OMAi
LMSVKRM

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0ZI9

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BQI0

TreeFam database of animal gene trees

More...
TreeFami
TF320736

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028453 Aif1-like
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10356:SF5 PTHR10356:SF5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BQI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGELSNRFQ GGKAFGLLKA RQERRLAEIN REFLCDQKYS DEENLPEKLT
60 70 80 90 100
AFKEKYMEFD LNNEGEIDLM SLKRMMEKLG VPKTHLEMKK MISEVTGGVS
110 120 130 140 150
DTISYRDFVN MMLGKRSAVL KLVMMFEGKA NESSPKPVGP PPERDIASLP
Length:150
Mass (Da):17,068
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74614436B9DEB5F6
GO
Isoform 2 (identifier: Q9BQI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-31: R → RYCAGREPQLQRISCSQHSCLLALLFQ

Show »
Length:176
Mass (Da):20,015
Checksum:i1F6AE2733802261E
GO
Isoform 3 (identifier: Q9BQI0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-67: Missing.

Show »
Length:142
Mass (Da):16,183
Checksum:iF3A22B50146CBE82
GO
Isoform 4 (identifier: Q9BQI0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-102: VSDT → SHDV
     103-150: Missing.

Note: No experimental confirmation available.
Show »
Length:102
Mass (Da):11,817
Checksum:i5B0A3F4AE73E042D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6PVM9A6PVM9_HUMAN
Allograft inflammatory factor 1-lik...
AIF1L
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JUP3Q5JUP3_HUMAN
Allograft inflammatory factor 1-lik...
AIF1L
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JUP1Q5JUP1_HUMAN
Allograft inflammatory factor 1-lik...
AIF1L
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C605H7C605_HUMAN
Allograft inflammatory factor 1-lik...
AIF1L
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33F → L in BAB14269 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01715031R → RYCAGREPQLQRISCSQHSC LLALLFQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_01715160 – 67Missing in isoform 3. 1 Publication8
Alternative sequenceiVSP_01715299 – 102VSDT → SHDV in isoform 4. 1 Publication4
Alternative sequenceiVSP_017153103 – 150Missing in isoform 4. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL136566 mRNA Translation: CAB66501.1
AY359067 mRNA Translation: AAQ89426.1
AK022845 mRNA Translation: BAB14269.1
AK091912 mRNA Translation: BAC03770.1
AK128526 mRNA Translation: BAC87480.1
AK314600 mRNA Translation: BAG37171.1
AL833896 mRNA Translation: CAD38752.1
AL157938 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87958.1
BC021253 mRNA Translation: AAH21253.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55348.1 [Q9BQI0-2]
CCDS55349.1 [Q9BQI0-4]
CCDS6939.1 [Q9BQI0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001172024.1, NM_001185095.1 [Q9BQI0-2]
NP_001172025.1, NM_001185096.1 [Q9BQI0-4]
NP_113614.1, NM_031426.3 [Q9BQI0-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.4944

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000247291; ENSP00000247291; ENSG00000126878 [Q9BQI0-1]
ENST00000372300; ENSP00000361374; ENSG00000126878 [Q9BQI0-4]
ENST00000372302; ENSP00000361376; ENSG00000126878 [Q9BQI0-3]
ENST00000372309; ENSP00000361383; ENSG00000126878 [Q9BQI0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
83543

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:83543

UCSC genome browser

More...
UCSCi
uc004cab.3 human [Q9BQI0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136566 mRNA Translation: CAB66501.1
AY359067 mRNA Translation: AAQ89426.1
AK022845 mRNA Translation: BAB14269.1
AK091912 mRNA Translation: BAC03770.1
AK128526 mRNA Translation: BAC87480.1
AK314600 mRNA Translation: BAG37171.1
AL833896 mRNA Translation: CAD38752.1
AL157938 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87958.1
BC021253 mRNA Translation: AAH21253.1
CCDSiCCDS55348.1 [Q9BQI0-2]
CCDS55349.1 [Q9BQI0-4]
CCDS6939.1 [Q9BQI0-1]
RefSeqiNP_001172024.1, NM_001185095.1 [Q9BQI0-2]
NP_001172025.1, NM_001185096.1 [Q9BQI0-4]
NP_113614.1, NM_031426.3 [Q9BQI0-1]
UniGeneiHs.4944

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JJZX-ray2.15B/C/D1-150[»]
2VTGX-ray2.45A1-150[»]
ProteinModelPortaliQ9BQI0
SMRiQ9BQI0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123676, 6 interactors
IntActiQ9BQI0, 3 interactors

PTM databases

iPTMnetiQ9BQI0
PhosphoSitePlusiQ9BQI0

Polymorphism and mutation databases

BioMutaiAIF1L

Proteomic databases

EPDiQ9BQI0
MaxQBiQ9BQI0
PeptideAtlasiQ9BQI0
PRIDEiQ9BQI0
ProteomicsDBi78678
78679 [Q9BQI0-2]
78680 [Q9BQI0-3]
78681 [Q9BQI0-4]
TopDownProteomicsiQ9BQI0-2 [Q9BQI0-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
83543
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247291; ENSP00000247291; ENSG00000126878 [Q9BQI0-1]
ENST00000372300; ENSP00000361374; ENSG00000126878 [Q9BQI0-4]
ENST00000372302; ENSP00000361376; ENSG00000126878 [Q9BQI0-3]
ENST00000372309; ENSP00000361383; ENSG00000126878 [Q9BQI0-2]
GeneIDi83543
KEGGihsa:83543
UCSCiuc004cab.3 human [Q9BQI0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
83543
EuPathDBiHostDB:ENSG00000126878.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AIF1L
HGNCiHGNC:28904 AIF1L
HPAiHPA020522
HPA056852
neXtProtiNX_Q9BQI0
OpenTargetsiENSG00000126878
PharmGKBiPA164715250

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

GeneTreeiENSGT00390000013846
HOGENOMiHOG000231928
HOVERGENiHBG004002
InParanoidiQ9BQI0
KOiK18617
OMAiLMSVKRM
OrthoDBiEOG091G0ZI9
PhylomeDBiQ9BQI0
TreeFamiTF320736

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AIF1L human
EvolutionaryTraceiQ9BQI0

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
C9orf58

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
83543

Protein Ontology

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PROi
PR:Q9BQI0

Gene expression databases

BgeeiENSG00000126878 Expressed in 188 organ(s), highest expression level in renal medulla
CleanExiHS_AIF1L
ExpressionAtlasiQ9BQI0 baseline and differential
GenevisibleiQ9BQI0 HS

Family and domain databases

InterProiView protein in InterPro
IPR028453 Aif1-like
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
PANTHERiPTHR10356:SF5 PTHR10356:SF5, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAIF1L_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BQI0
Secondary accession number(s): B2RBC4
, Q6ZR40, Q8NAX7, Q8WU47, Q9H9G0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2001
Last modified: December 5, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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