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Protein

Allograft inflammatory factor 1-like

Gene

AIF1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi60 – 711PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • calcium ion binding Source: InterPro

Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Allograft inflammatory factor 1-like
Alternative name(s):
Ionized calcium-binding adapter molecule 2
Gene namesi
Name:AIF1L
Synonyms:C9orf58, IBA2
ORF Names:UNQ672/PRO1306
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000126878.12
HGNCiHGNC:28904 AIF1L
neXtProtiNX_Q9BQI0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000126878
PharmGKBiPA164715250

Polymorphism and mutation databases

BioMutaiAIF1L

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000738702 – 150Allograft inflammatory factor 1-likeAdd BLAST149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei134PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BQI0
MaxQBiQ9BQI0
PeptideAtlasiQ9BQI0
PRIDEiQ9BQI0
ProteomicsDBi78678
78679 [Q9BQI0-2]
78680 [Q9BQI0-3]
78681 [Q9BQI0-4]
TopDownProteomicsiQ9BQI0-2 [Q9BQI0-2]

PTM databases

iPTMnetiQ9BQI0
PhosphoSitePlusiQ9BQI0

Expressioni

Gene expression databases

BgeeiENSG00000126878
CleanExiHS_AIF1L
ExpressionAtlasiQ9BQI0 baseline and differential
GenevisibleiQ9BQI0 HS

Organism-specific databases

HPAiHPA020522
HPA056852

Interactioni

Subunit structurei

Homodimer (Potential). Monomer.Curated1 Publication

GO - Molecular functioni

  • actin filament binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123676, 6 interactors
IntActiQ9BQI0, 4 interactors

Structurei

Secondary structure

1150
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi17 – 34Combined sources18
Helixi37 – 39Combined sources3
Helixi45 – 56Combined sources12
Beta strandi65 – 67Combined sources3
Helixi69 – 78Combined sources10
Helixi85 – 96Combined sources12
Beta strandi101 – 103Combined sources3
Helixi105 – 113Combined sources9
Beta strandi114 – 116Combined sources3
Helixi119 – 124Combined sources6

3D structure databases

ProteinModelPortaliQ9BQI0
SMRiQ9BQI0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BQI0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 82EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini83 – 117EF-hand 2; degeneratePROSITE-ProRule annotationAdd BLAST35

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00390000013846
HOGENOMiHOG000231928
HOVERGENiHBG004002
InParanoidiQ9BQI0
KOiK18617
OMAiLMSVKRM
OrthoDBiEOG091G0ZI9
PhylomeDBiQ9BQI0
TreeFamiTF320736

Family and domain databases

InterProiView protein in InterPro
IPR028453 Aif1-like
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
PANTHERiPTHR10356:SF5 PTHR10356:SF5, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BQI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGELSNRFQ GGKAFGLLKA RQERRLAEIN REFLCDQKYS DEENLPEKLT
60 70 80 90 100
AFKEKYMEFD LNNEGEIDLM SLKRMMEKLG VPKTHLEMKK MISEVTGGVS
110 120 130 140 150
DTISYRDFVN MMLGKRSAVL KLVMMFEGKA NESSPKPVGP PPERDIASLP
Length:150
Mass (Da):17,068
Last modified:June 1, 2001 - v1
Checksum:i74614436B9DEB5F6
GO
Isoform 2 (identifier: Q9BQI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-31: R → RYCAGREPQLQRISCSQHSCLLALLFQ

Show »
Length:176
Mass (Da):20,015
Checksum:i1F6AE2733802261E
GO
Isoform 3 (identifier: Q9BQI0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-67: Missing.

Show »
Length:142
Mass (Da):16,183
Checksum:iF3A22B50146CBE82
GO
Isoform 4 (identifier: Q9BQI0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-102: VSDT → SHDV
     103-150: Missing.

Note: No experimental confirmation available.
Show »
Length:102
Mass (Da):11,817
Checksum:i5B0A3F4AE73E042D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33F → L in BAB14269 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01715031R → RYCAGREPQLQRISCSQHSC LLALLFQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_01715160 – 67Missing in isoform 3. 1 Publication8
Alternative sequenceiVSP_01715299 – 102VSDT → SHDV in isoform 4. 1 Publication4
Alternative sequenceiVSP_017153103 – 150Missing in isoform 4. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136566 mRNA Translation: CAB66501.1
AY359067 mRNA Translation: AAQ89426.1
AK022845 mRNA Translation: BAB14269.1
AK091912 mRNA Translation: BAC03770.1
AK128526 mRNA Translation: BAC87480.1
AK314600 mRNA Translation: BAG37171.1
AL833896 mRNA Translation: CAD38752.1
AL157938 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87958.1
BC021253 mRNA Translation: AAH21253.1
CCDSiCCDS55348.1 [Q9BQI0-2]
CCDS55349.1 [Q9BQI0-4]
CCDS6939.1 [Q9BQI0-1]
RefSeqiNP_001172024.1, NM_001185095.1 [Q9BQI0-2]
NP_001172025.1, NM_001185096.1 [Q9BQI0-4]
NP_113614.1, NM_031426.3 [Q9BQI0-1]
UniGeneiHs.4944

Genome annotation databases

EnsembliENST00000247291; ENSP00000247291; ENSG00000126878 [Q9BQI0-1]
ENST00000372300; ENSP00000361374; ENSG00000126878 [Q9BQI0-4]
ENST00000372302; ENSP00000361376; ENSG00000126878 [Q9BQI0-3]
ENST00000372309; ENSP00000361383; ENSG00000126878 [Q9BQI0-2]
GeneIDi83543
KEGGihsa:83543
UCSCiuc004cab.3 human [Q9BQI0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAIF1L_HUMAN
AccessioniPrimary (citable) accession number: Q9BQI0
Secondary accession number(s): B2RBC4
, Q6ZR40, Q8NAX7, Q8WU47, Q9H9G0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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