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UniProtKB - Q9BQG1 (SYT3_HUMAN)

Entry version 171 (10 Feb 2021)
Sequence version 1 (01 Jun 2001)
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Protein

Synaptotagmin-3

Gene

SYT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ca2+ sensor involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain. Ca2+ induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).By similarity1 Publication

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotationNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi330Calcium 1PROSITE-ProRule annotation1
Metal bindingi330Calcium 2PROSITE-ProRule annotation1
Metal bindingi336Calcium 1PROSITE-ProRule annotation1
Metal bindingi388Calcium 1PROSITE-ProRule annotation1
Metal bindingi388Calcium 2PROSITE-ProRule annotation1
Metal bindingi389Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi390Calcium 1PROSITE-ProRule annotation1
Metal bindingi390Calcium 2PROSITE-ProRule annotation1
Metal bindingi390Calcium 3PROSITE-ProRule annotation1
Metal bindingi393Calcium 3PROSITE-ProRule annotation1
Metal bindingi396Calcium 2PROSITE-ProRule annotation1
Metal bindingi396Calcium 3PROSITE-ProRule annotation1
Metal bindingi462Calcium 4PROSITE-ProRule annotation1
Metal bindingi468Calcium 4PROSITE-ProRule annotation1
Metal bindingi522Calcium 4PROSITE-ProRule annotation1
Metal bindingi524Calcium 4PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation
LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BQG1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptotagmin-3
Alternative name(s):
Synaptotagmin III
Short name:
SytIII
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYT3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11511, SYT3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600327, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BQG1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000213023.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 54VesicularSequence analysisAdd BLAST54
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 590CytoplasmicSequence analysisAdd BLAST515

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		84258

Open Targets

More...OpenTargetsi		ENSG00000213023

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36292

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BQG1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SYT3

Domain mapping of disease mutations (DMDM)

More...DMDMi		18202733

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001839451 – 590Synaptotagmin-3Add BLAST590

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei284Omega-N-methylarginineBy similarity1

Keywords - PTMi

Disulfide bond, Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BQG1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BQG1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BQG1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BQG1

PeptideAtlas

More...PeptideAtlasi		Q9BQG1

PRoteomics IDEntifications database

More...PRIDEi		Q9BQG1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78676

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BQG1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BQG1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in melanocytes (PubMed:23999003).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000213023, Expressed in brain and 87 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BQG1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BQG1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000213023, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked via the cysteine motif. Can also form heterodimers with SYT6, SYT9 and SYT10.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123985, 13 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q9BQG1

Protein interaction database and analysis system

More...IntActi		Q9BQG1, 15 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000340914

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BQG1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BQG1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini299 – 420C2 1PROSITE-ProRule annotationAdd BLAST122
Domaini431 – 565C2 2PROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni10 – 34Cysteine motifBy similarityAdd BLAST25

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.By similarity
The first C2 domain mediates Ca2+-dependent phospholipid binding.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1028, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161770

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023008_8_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BQG1

Identification of Orthologs from Complete Genome Data

More...OMAi		GTPCGRI

Database of Orthologous Groups

More...OrthoDBi		925064at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BQG1

TreeFam database of animal gene trees

More...TreeFami		TF315600

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR001565, Synaptotagmin
IPR028682, SYT3

The PANTHER Classification System

More...PANTHERi		PTHR10024:SF176, PTHR10024:SF176, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00360, C2DOMAIN
PR00399, SYNAPTOTAGMN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9BQG1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGDYEDDLC RRALILVSDL CARVRDADTN DRCQEFNDRI RGYPRGPDAD 
        60         70         80         90        100
ISVSLLSVIV TFCGIVLLGV SLFVSWKLCW VPWRDKGGSA VGGGPLRKDL 
       110        120        130        140        150
GPGVGLAGLV GGGGHHLAAG LGGHPLLGGP HHHAHAAHHP PFAELLEPGS 
       160        170        180        190        200
LGGSDTPEPS YLDMDSYPEA AAAAVAAGVK PSQTSPELPS EGGAGSGLLL 
       210        220        230        240        250
LPPSGGGLPS AQSHQQVTSL APTTRYPALP RPLTQQTLTS QPDPSSEERP 
       260        270        280        290        300
PALPLPLPGG EEKAKLIGQI KPELYQGTGP GGRRSGGGPG SGEAGTGAPC 
       310        320        330        340        350
GRISFALRYL YGSDQLVVRI LQALDLPAKD SNGFSDPYVK IYLLPDRKKK 
       360        370        380        390        400
FQTKVHRKTL NPVFNETFQF SVPLAELAQR KLHFSVYDFD RFSRHDLIGQ 
       410        420        430        440        450
VVLDNLLELA EQPPDRPLWR DIVEGGSEKA DLGELNFSLC YLPTAGRLTV 
       460        470        480        490        500
TIIKASNLKA MDLTGFSDPY VKASLISEGR RLKKRKTSIK KNTLNPTYNE 
       510        520        530        540        550
ALVFDVAPES VENVGLSIAV VDYDCIGHNE VIGVCRVGPD AADPHGREHW 
       560        570        580        590
AEMLANPRKP VEHWHQLVEE KTVTSFTKGS KGLSEKENSE
Length:590
Mass (Da):63,304
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E6B9F2CF44E7935
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QY70M0QY70_HUMAN
Synaptotagmin-3
SYT3
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYH4M0QYH4_HUMAN
Synaptotagmin-3
SYT3
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti82P → H in AAH31067 (PubMed:15489334).Curated1
Sequence conflicti324L → M in AAH28379 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036389474S → F in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL136594 mRNA Translation: CAB66529.1
BC028379 mRNA Translation: AAH28379.1
BC031067 mRNA Translation: AAH31067.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12798.1

NCBI Reference Sequences

More...RefSeqi		NP_001153800.1, NM_001160328.1
NP_001153801.1, NM_001160329.1
NP_115674.1, NM_032298.2
XP_011525692.1, XM_011527390.2
XP_011525693.1, XM_011527391.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000338916; ENSP00000340914; ENSG00000213023
ENST00000593901; ENSP00000468982; ENSG00000213023
ENST00000600079; ENSP00000469398; ENSG00000213023

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84258

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84258

UCSC genome browser

More...UCSCi		uc002pst.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136594 mRNA Translation: CAB66529.1
BC028379 mRNA Translation: AAH28379.1
BC031067 mRNA Translation: AAH31067.1
CCDSiCCDS12798.1
RefSeqiNP_001153800.1, NM_001160328.1
NP_001153801.1, NM_001160329.1
NP_115674.1, NM_032298.2
XP_011525692.1, XM_011527390.2
XP_011525693.1, XM_011527391.2

3D structure databases

SMRiQ9BQG1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123985, 13 interactors
ELMiQ9BQG1
IntActiQ9BQG1, 15 interactors
STRINGi9606.ENSP00000340914

PTM databases

iPTMnetiQ9BQG1
PhosphoSitePlusiQ9BQG1

Genetic variation databases

BioMutaiSYT3
DMDMi18202733

Proteomic databases

EPDiQ9BQG1
MassIVEiQ9BQG1
MaxQBiQ9BQG1
PaxDbiQ9BQG1
PeptideAtlasiQ9BQG1
PRIDEiQ9BQG1
ProteomicsDBi78676

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9BQG1, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32348, 201 antibodies

The DNASU plasmid repository

More...DNASUi		84258

Genome annotation databases

EnsembliENST00000338916; ENSP00000340914; ENSG00000213023
ENST00000593901; ENSP00000468982; ENSG00000213023
ENST00000600079; ENSP00000469398; ENSG00000213023
GeneIDi84258
KEGGihsa:84258
UCSCiuc002pst.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84258
DisGeNETi84258

GeneCards: human genes, protein and diseases

More...GeneCardsi		SYT3
HGNCiHGNC:11511, SYT3
HPAiENSG00000213023, Tissue enriched (brain)
MIMi600327, gene
neXtProtiNX_Q9BQG1
OpenTargetsiENSG00000213023
PharmGKBiPA36292
VEuPathDBiHostDB:ENSG00000213023.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1028, Eukaryota
GeneTreeiENSGT00940000161770
HOGENOMiCLU_023008_8_3_1
InParanoidiQ9BQG1
OMAiGTPCGRI
OrthoDBi925064at2759
PhylomeDBiQ9BQG1
TreeFamiTF315600

Enzyme and pathway databases

PathwayCommonsiQ9BQG1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		84258, 7 hits in 874 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SYT3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84258
PharosiQ9BQG1, Tbio

Protein Ontology

More...PROi		PR:Q9BQG1
RNActiQ9BQG1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000213023, Expressed in brain and 87 other tissues
ExpressionAtlasiQ9BQG1, baseline and differential
GenevisibleiQ9BQG1, HS

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR001565, Synaptotagmin
IPR028682, SYT3
PANTHERiPTHR10024:SF176, PTHR10024:SF176, 1 hit
PfamiView protein in Pfam
PF00168, C2, 2 hits
PRINTSiPR00360, C2DOMAIN
PR00399, SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239, C2, 2 hits
PROSITEiView protein in PROSITE
PS50004, C2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYT3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BQG1
Secondary accession number(s): Q8N5Z1, Q8N640
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 1, 2001
Last modified: February 10, 2021
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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