UniProtKB - Q9BQG1 (SYT3_HUMAN)
Protein
Synaptotagmin-3
Gene
SYT3
Organism
Homo sapiens (Human)
Status
Functioni
Ca2+ sensor involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain. Ca2+ induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).By similarity1 Publication
Cofactori
Ca2+PROSITE-ProRule annotationNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 330 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 330 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 336 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 388 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 388 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 389 | Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 390 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 390 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 390 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 393 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 396 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 396 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 462 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 468 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 522 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 524 | Calcium 4PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- calcium-dependent phospholipid binding Source: GO_Central
- calcium ion binding Source: GO_Central
- clathrin binding Source: GO_Central
- phosphatidylserine binding Source: GO_Central
- SNARE binding Source: GO_Central
- syntaxin binding Source: GO_Central
GO - Biological processi
- calcium-ion regulated exocytosis Source: GO_Central
- calcium ion-regulated exocytosis of neurotransmitter Source: GO_Central
- cell differentiation Source: UniProtKB-KW
- cellular response to calcium ion Source: GO_Central
- positive regulation of dendrite extension Source: UniProtKB
- regulation of calcium ion-dependent exocytosis Source: GO_Central
- regulation of dopamine secretion Source: GO_Central
- vesicle-mediated transport Source: GO_Central
Keywordsi
Biological process | Differentiation |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9BQG1 |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptotagmin-3Alternative name(s): Synaptotagmin III Short name: SytIII |
Gene namesi | Name:SYT3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11511, SYT3 |
MIMi | 600327, gene |
neXtProti | NX_Q9BQG1 |
VEuPathDBi | HostDB:ENSG00000213023.9 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass membrane protein Sequence analysis
Other locations
- secretory vesicle membrane Curated; Single-pass membrane protein Sequence analysis
Endosome
- endosome Source: LIFEdb
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- exocytic vesicle Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
- presynapse Source: GOC
- transport vesicle membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 54 | VesicularSequence analysisAdd BLAST | 54 | |
Transmembranei | 55 – 75 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 76 – 590 | CytoplasmicSequence analysisAdd BLAST | 515 |
Keywords - Cellular componenti
Cell membrane, Cytoplasmic vesicle, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 84258 |
OpenTargetsi | ENSG00000213023 |
PharmGKBi | PA36292 |
Miscellaneous databases
Pharosi | Q9BQG1, Tbio |
Genetic variation databases
BioMutai | SYT3 |
DMDMi | 18202733 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000183945 | 1 – 590 | Synaptotagmin-3Add BLAST | 590 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 284 | Omega-N-methylarginineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, MethylationProteomic databases
EPDi | Q9BQG1 |
MassIVEi | Q9BQG1 |
MaxQBi | Q9BQG1 |
PaxDbi | Q9BQG1 |
PeptideAtlasi | Q9BQG1 |
PRIDEi | Q9BQG1 |
ProteomicsDBi | 78676 |
PTM databases
iPTMneti | Q9BQG1 |
PhosphoSitePlusi | Q9BQG1 |
Expressioni
Tissue specificityi
Expressed in melanocytes (PubMed:23999003).1 Publication
Gene expression databases
Bgeei | ENSG00000213023, Expressed in brain and 87 other tissues |
ExpressionAtlasi | Q9BQG1, baseline and differential |
Genevisiblei | Q9BQG1, HS |
Organism-specific databases
HPAi | ENSG00000213023, Tissue enriched (brain) |
Interactioni
Subunit structurei
Homodimer; disulfide-linked via the cysteine motif. Can also form heterodimers with SYT6, SYT9 and SYT10.
By similarityBinary interactionsi
Hide detailsQ9BQG1
GO - Molecular functioni
- clathrin binding Source: GO_Central
- SNARE binding Source: GO_Central
- syntaxin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 123985, 13 interactors |
ELMi | Q9BQG1 |
IntActi | Q9BQG1, 15 interactors |
STRINGi | 9606.ENSP00000340914 |
Miscellaneous databases
RNActi | Q9BQG1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 299 – 420 | C2 1PROSITE-ProRule annotationAdd BLAST | 122 | |
Domaini | 431 – 565 | C2 2PROSITE-ProRule annotationAdd BLAST | 135 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 10 – 34 | Cysteine motifBy similarityAdd BLAST | 25 |
Domaini
The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.By similarity
The first C2 domain mediates Ca2+-dependent phospholipid binding.By similarity
Sequence similaritiesi
Belongs to the synaptotagmin family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1028, Eukaryota |
GeneTreei | ENSGT00940000161770 |
HOGENOMi | CLU_023008_8_3_1 |
InParanoidi | Q9BQG1 |
OMAi | GTPCGRI |
OrthoDBi | 925064at2759 |
PhylomeDBi | Q9BQG1 |
TreeFami | TF315600 |
Family and domain databases
Gene3Di | 2.60.40.150, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR001565, Synaptotagmin IPR028682, SYT3 |
PANTHERi | PTHR10024:SF176, PTHR10024:SF176, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 2 hits |
PRINTSi | PR00360, C2DOMAIN PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9BQG1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGDYEDDLC RRALILVSDL CARVRDADTN DRCQEFNDRI RGYPRGPDAD
60 70 80 90 100
ISVSLLSVIV TFCGIVLLGV SLFVSWKLCW VPWRDKGGSA VGGGPLRKDL
110 120 130 140 150
GPGVGLAGLV GGGGHHLAAG LGGHPLLGGP HHHAHAAHHP PFAELLEPGS
160 170 180 190 200
LGGSDTPEPS YLDMDSYPEA AAAAVAAGVK PSQTSPELPS EGGAGSGLLL
210 220 230 240 250
LPPSGGGLPS AQSHQQVTSL APTTRYPALP RPLTQQTLTS QPDPSSEERP
260 270 280 290 300
PALPLPLPGG EEKAKLIGQI KPELYQGTGP GGRRSGGGPG SGEAGTGAPC
310 320 330 340 350
GRISFALRYL YGSDQLVVRI LQALDLPAKD SNGFSDPYVK IYLLPDRKKK
360 370 380 390 400
FQTKVHRKTL NPVFNETFQF SVPLAELAQR KLHFSVYDFD RFSRHDLIGQ
410 420 430 440 450
VVLDNLLELA EQPPDRPLWR DIVEGGSEKA DLGELNFSLC YLPTAGRLTV
460 470 480 490 500
TIIKASNLKA MDLTGFSDPY VKASLISEGR RLKKRKTSIK KNTLNPTYNE
510 520 530 540 550
ALVFDVAPES VENVGLSIAV VDYDCIGHNE VIGVCRVGPD AADPHGREHW
560 570 580 590
AEMLANPRKP VEHWHQLVEE KTVTSFTKGS KGLSEKENSE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QY70 | M0QY70_HUMAN | Synaptotagmin-3 | SYT3 | 96 | Annotation score: | ||
M0QYH4 | M0QYH4_HUMAN | Synaptotagmin-3 | SYT3 | 79 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 82 | P → H in AAH31067 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 324 | L → M in AAH28379 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036389 | 474 | S → F in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136594 mRNA Translation: CAB66529.1 BC028379 mRNA Translation: AAH28379.1 BC031067 mRNA Translation: AAH31067.1 |
CCDSi | CCDS12798.1 |
RefSeqi | NP_001153800.1, NM_001160328.1 NP_001153801.1, NM_001160329.1 NP_115674.1, NM_032298.2 XP_011525692.1, XM_011527390.2 XP_011525693.1, XM_011527391.2 |
Genome annotation databases
Ensembli | ENST00000338916; ENSP00000340914; ENSG00000213023 ENST00000593901; ENSP00000468982; ENSG00000213023 ENST00000600079; ENSP00000469398; ENSG00000213023 |
GeneIDi | 84258 |
KEGGi | hsa:84258 |
UCSCi | uc002pst.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136594 mRNA Translation: CAB66529.1 BC028379 mRNA Translation: AAH28379.1 BC031067 mRNA Translation: AAH31067.1 |
CCDSi | CCDS12798.1 |
RefSeqi | NP_001153800.1, NM_001160328.1 NP_001153801.1, NM_001160329.1 NP_115674.1, NM_032298.2 XP_011525692.1, XM_011527390.2 XP_011525693.1, XM_011527391.2 |
3D structure databases
SMRi | Q9BQG1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123985, 13 interactors |
ELMi | Q9BQG1 |
IntActi | Q9BQG1, 15 interactors |
STRINGi | 9606.ENSP00000340914 |
PTM databases
iPTMneti | Q9BQG1 |
PhosphoSitePlusi | Q9BQG1 |
Genetic variation databases
BioMutai | SYT3 |
DMDMi | 18202733 |
Proteomic databases
EPDi | Q9BQG1 |
MassIVEi | Q9BQG1 |
MaxQBi | Q9BQG1 |
PaxDbi | Q9BQG1 |
PeptideAtlasi | Q9BQG1 |
PRIDEi | Q9BQG1 |
ProteomicsDBi | 78676 |
Protocols and materials databases
ABCDi | Q9BQG1, 1 sequenced antibody |
Antibodypediai | 32348, 201 antibodies |
DNASUi | 84258 |
Genome annotation databases
Ensembli | ENST00000338916; ENSP00000340914; ENSG00000213023 ENST00000593901; ENSP00000468982; ENSG00000213023 ENST00000600079; ENSP00000469398; ENSG00000213023 |
GeneIDi | 84258 |
KEGGi | hsa:84258 |
UCSCi | uc002pst.3, human |
Organism-specific databases
CTDi | 84258 |
DisGeNETi | 84258 |
GeneCardsi | SYT3 |
HGNCi | HGNC:11511, SYT3 |
HPAi | ENSG00000213023, Tissue enriched (brain) |
MIMi | 600327, gene |
neXtProti | NX_Q9BQG1 |
OpenTargetsi | ENSG00000213023 |
PharmGKBi | PA36292 |
VEuPathDBi | HostDB:ENSG00000213023.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1028, Eukaryota |
GeneTreei | ENSGT00940000161770 |
HOGENOMi | CLU_023008_8_3_1 |
InParanoidi | Q9BQG1 |
OMAi | GTPCGRI |
OrthoDBi | 925064at2759 |
PhylomeDBi | Q9BQG1 |
TreeFami | TF315600 |
Enzyme and pathway databases
PathwayCommonsi | Q9BQG1 |
Miscellaneous databases
BioGRID-ORCSi | 84258, 7 hits in 874 CRISPR screens |
GeneWikii | SYT3 |
GenomeRNAii | 84258 |
Pharosi | Q9BQG1, Tbio |
PROi | PR:Q9BQG1 |
RNActi | Q9BQG1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000213023, Expressed in brain and 87 other tissues |
ExpressionAtlasi | Q9BQG1, baseline and differential |
Genevisiblei | Q9BQG1, HS |
Family and domain databases
Gene3Di | 2.60.40.150, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR001565, Synaptotagmin IPR028682, SYT3 |
PANTHERi | PTHR10024:SF176, PTHR10024:SF176, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 2 hits |
PRINTSi | PR00360, C2DOMAIN PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYT3_HUMAN | |
Accessioni | Q9BQG1Primary (citable) accession number: Q9BQG1 Secondary accession number(s): Q8N5Z1, Q8N640 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families