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Protein

Myb-binding protein 1A

Gene

MYBBP1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309).By similarity1 Publication

GO - Molecular functioni

  • E-box binding Source: Ensembl
  • RNA binding Source: UniProtKB
  • sequence-specific DNA binding Source: GO_Central
  • transcription corepressor activity Source: UniProtKB
  • transcription factor binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionActivator, Repressor
Biological processBiological rhythms, Ribosome biogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5250924 B-WICH complex positively regulates rRNA expression
SIGNORiQ9BQG0

Names & Taxonomyi

Protein namesi
Recommended name:
Myb-binding protein 1A
Gene namesi
Name:MYBBP1A
Synonyms:P160
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000132382.14
HGNCiHGNC:7546 MYBBP1A
MIMi604885 gene
neXtProtiNX_Q9BQG0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10514
OpenTargetsiENSG00000132382
PharmGKBiPA31346

Polymorphism and mutation databases

BioMutaiMYBBP1A
DMDMi71153825

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000962551 – 1328Myb-binding protein 1AAdd BLAST1328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineCombined sources1
Modified residuei71N6-acetyllysineCombined sources1
Modified residuei158N6-acetyllysineCombined sources1
Modified residuei775PhosphoserineCombined sources1
Cross-linki1148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1159PhosphoserineCombined sources1
Modified residuei1163PhosphoserineCombined sources1
Modified residuei1186PhosphoserineCombined sources1
Modified residuei1190PhosphothreonineCombined sources1
Modified residuei1196PhosphothreonineCombined sources1
Modified residuei1207PhosphoserineCombined sources1
Modified residuei1232PhosphoserineCombined sources1
Modified residuei1239PhosphothreonineCombined sources1
Modified residuei1241PhosphoserineCombined sources1
Modified residuei1244PhosphothreonineBy similarity1
Modified residuei1248PhosphoserineCombined sources1
Modified residuei1267PhosphoserineCombined sources1
Modified residuei1269PhosphothreonineCombined sources1
Modified residuei1290PhosphoserineCombined sources1
Modified residuei1303PhosphoserineCombined sources1
Modified residuei1307CitrullineBy similarity1
Modified residuei1308PhosphoserineCombined sources1
Modified residuei1310PhosphoserineCombined sources1
Modified residuei1314PhosphoserineCombined sources1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9BQG0
MaxQBiQ9BQG0
PaxDbiQ9BQG0
PeptideAtlasiQ9BQG0
PRIDEiQ9BQG0
ProteomicsDBi78674
78675 [Q9BQG0-2]

2D gel databases

SWISS-2DPAGEiQ9BQG0

PTM databases

iPTMnetiQ9BQG0
PhosphoSitePlusiQ9BQG0
SwissPalmiQ9BQG0

Miscellaneous databases

PMAP-CutDBiQ9BQG0

Expressioni

Gene expression databases

BgeeiENSG00000132382 Expressed in 179 organ(s), highest expression level in left coronary artery
CleanExiHS_MYBBP1A
ExpressionAtlasiQ9BQG0 baseline and differential
GenevisibleiQ9BQG0 HS

Organism-specific databases

HPAiHPA005466

Interactioni

Subunit structurei

Binds to and represses JUN and MYB via the leucine zipper regions present in these proteins. Also binds to and represses PPARGC1A: this interaction is abrogated when PPARGC1A is phosphorylated by MAPK1/ERK. Binds to and stimulates transcription by AHR. Binds to KPNA2. Interacts with CLOCK and CRY1 (By similarity). Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115770, 135 interactors
ComplexPortaliCPX-1099 B-WICH chromatin remodelling complex
CORUMiQ9BQG0
IntActiQ9BQG0, 51 interactors
MINTiQ9BQG0
STRINGi9606.ENSP00000370968

Structurei

3D structure databases

ProteinModelPortaliQ9BQG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 582Interaction with MYBBy similarityAdd BLAST582
Regioni1151 – 1328Required for nuclear and nucleolar localizationBy similarityAdd BLAST178

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi240 – 258Nuclear export signal 1By similarityAdd BLAST19
Motifi263 – 281Nuclear export signal 2By similarityAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi720 – 784Glu-richAdd BLAST65

Sequence similaritiesi

Belongs to the MYBBP1A family.Curated

Phylogenomic databases

eggNOGiKOG1926 Eukaryota
ENOG410YFVF LUCA
GeneTreeiENSGT00390000017457
HOGENOMiHOG000113488
HOVERGENiHBG081961
InParanoidiQ9BQG0
KOiK02331
OMAiRKWIIHR
OrthoDBiEOG091G00YE
PhylomeDBiQ9BQG0
TreeFamiTF317401

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR007015 DNA_pol_V/MYBBP1A
PANTHERiPTHR13213 PTHR13213, 1 hit
PfamiView protein in Pfam
PF04931 DNA_pol_phi, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BQG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESRDPAQPM SPGEATQSGA RPADRYGLLK HSREFLDFFW DIAKPEQETR
60 70 80 90 100
LAATEKLLEY LRGRPKGSEM KYALKRLITG LGVGRETARP CYSLALAQLL
110 120 130 140 150
QSFEDLPLCS ILQQIQEKYD LHQVKKAMLR PALFANLFGV LALFQSGRLV
160 170 180 190 200
KDQEALMKSV KLLQALAQYQ NHLQEQPRKA LVDILSEVSK ATLQEILPEV
210 220 230 240 250
LKADLNIILS SPEQLELFLL AQQKVPSKLK KLVGSVNLFS DENVPRLVNV
260 270 280 290 300
LKMAASSVKK DRKLPAIALD LLRLALKEDK FPRFWKEVVE QGLLKMQFWP
310 320 330 340 350
ASYLCFRLLG AALPLLTKEQ LHLVMQGDVI RHYGEHVCTA KLPKQFKFAP
360 370 380 390 400
EMDDYVGTFL EGCQDDPERQ LAVLVAFSSV TNQGLPVTPT FWRVVRFLSP
410 420 430 440 450
PALQGYVAWL RAMFLQPDLD SLVDFSTNNQ KKAQDSSLHM PERAVFRLRK
460 470 480 490 500
WIIFRLVSIV DSLHLEMEEA LTEQVARFCL FHSFFVTKKP TSQIPETKHP
510 520 530 540 550
FSFPLENQAR EAVSSAFFSL LQTLSTQFKQ APGQTQGGQP WTYHLVQFAD
560 570 580 590 600
LLLNHSHNVT TVTPFTAQQR QAWDRMLQTL KELEAHSAEA RAAAFQHLLL
610 620 630 640 650
LVGIHLLKSP AESCDLLGDI QTCIRKSLGE KPRRSRTKTI DPQEPPWVEV
660 670 680 690 700
LVEILLALLA QPSHLMRQVA RSVFGHICSH LTPRALQLIL DVLNPETSED
710 720 730 740 750
ENDRVVVTDD SDERRLKGAE DKSEEGEDNR SSESEEESEG EESEEEERDG
760 770 780 790 800
DVDQGFREQL MTVLQAGKAL GGEDSENEEE LGDEAMMALD QSLASLFAEQ
810 820 830 840 850
KLRIQARRDE KNKLQKEKAL RRDFQIRVLD LVEVLVTKQP ENALVLELLE
860 870 880 890 900
PLLSIIRRSL RSSSSKQEQD LLHKTARIFT HHLCRARRYC HDLGERAGAL
910 920 930 940 950
HAQVERLVQQ AGRQPDSPTA LYHFNASLYL LRVLKGNTAE GCVHETQEKQ
960 970 980 990 1000
KAGTDPSHMP TGPQAASCLD LNLVTRVYST ALSSFLTKRN SPLTVPMFLS
1010 1020 1030 1040 1050
LFSRHPVLCQ SLLPILVQHI TGPVRPRHQA CLLLQKTLSM REVRSCFEDP
1060 1070 1080 1090 1100
EWKQLMGQVL AKVTENLRVL GEAQTKAQHQ QALSSLELLN VLFRTCKHEK
1110 1120 1130 1140 1150
LTLDLTVLLG VLQGQQQSLQ QGAHSTGSSR LHDLYWQAMK TLGVQRPKLE
1160 1170 1180 1190 1200
KKDAKEIPSA TQSPISKKRK KKGFLPETKK RKKRKSEDGT PAEDGTPAAT
1210 1220 1230 1240 1250
GGSQPPSMGR KKRNRTKAKV PAQANGTPTT KSPAPGAPTR SPSTPAKSPK
1260 1270 1280 1290 1300
LQKKNQKPSQ VNGAPGSPTE PAGQKQHQKA LPKKGVLGKS PLSALARKKA
1310 1320
RLSLVIRSPS LLQSGAKKKA QVRKAGKP
Length:1,328
Mass (Da):148,855
Last modified:July 19, 2005 - v2
Checksum:i0B053465D5B3511F
GO
Isoform 2 (identifier: Q9BQG0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1322-1328: VRKAGKP → TLRFTISSSKK

Note: May be due to competing donor and acceptor splice sites.
Show »
Length:1,332
Mass (Da):149,367
Checksum:iCF90678D49D64DB1
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L1L3I3L1L3_HUMAN
Myb-binding protein 1A
MYBBP1A
1,252Annotation score:
I3L2H8I3L2H8_HUMAN
Myb-binding protein 1A
MYBBP1A
204Annotation score:
I3L311I3L311_HUMAN
Myb-binding protein 1A
MYBBP1A
69Annotation score:

Sequence cautioni

The sequence CAB66530 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti307R → H in AAF33021 (PubMed:10644447).Curated1
Sequence conflicti570R → H in AAF33021 (PubMed:10644447).Curated1
Sequence conflicti601L → F in AAF33021 (PubMed:10644447).Curated1
Sequence conflicti1028H → R in AAH50546 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0230648Q → E. Corresponds to variant dbSNP:rs3809849Ensembl.1
Natural variantiVAR_051156680H → Y. Corresponds to variant dbSNP:rs899440Ensembl.1
Natural variantiVAR_051157958H → P. Corresponds to variant dbSNP:rs879797Ensembl.1
Natural variantiVAR_0511581208M → L. Corresponds to variant dbSNP:rs9905742Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0147861322 – 1328VRKAGKP → TLRFTISSSKK in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF147709 mRNA Translation: AAF33021.1
BC000641 mRNA Translation: AAH00641.2
BC050546 mRNA Translation: AAH50546.1
AL136595 mRNA Translation: CAB66530.1 Different initiation.
AL133098 mRNA Translation: CAB61409.1
CCDSiCCDS11046.1 [Q9BQG0-1]
CCDS42238.1 [Q9BQG0-2]
PIRiT42680
RefSeqiNP_001099008.1, NM_001105538.1 [Q9BQG0-2]
NP_055335.2, NM_014520.3 [Q9BQG0-1]
UniGeneiHs.22824
Hs.701718

Genome annotation databases

EnsembliENST00000254718; ENSP00000254718; ENSG00000132382 [Q9BQG0-1]
ENST00000381556; ENSP00000370968; ENSG00000132382 [Q9BQG0-2]
GeneIDi10514
KEGGihsa:10514
UCSCiuc002fxz.5 human [Q9BQG0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF147709 mRNA Translation: AAF33021.1
BC000641 mRNA Translation: AAH00641.2
BC050546 mRNA Translation: AAH50546.1
AL136595 mRNA Translation: CAB66530.1 Different initiation.
AL133098 mRNA Translation: CAB61409.1
CCDSiCCDS11046.1 [Q9BQG0-1]
CCDS42238.1 [Q9BQG0-2]
PIRiT42680
RefSeqiNP_001099008.1, NM_001105538.1 [Q9BQG0-2]
NP_055335.2, NM_014520.3 [Q9BQG0-1]
UniGeneiHs.22824
Hs.701718

3D structure databases

ProteinModelPortaliQ9BQG0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115770, 135 interactors
ComplexPortaliCPX-1099 B-WICH chromatin remodelling complex
CORUMiQ9BQG0
IntActiQ9BQG0, 51 interactors
MINTiQ9BQG0
STRINGi9606.ENSP00000370968

PTM databases

iPTMnetiQ9BQG0
PhosphoSitePlusiQ9BQG0
SwissPalmiQ9BQG0

Polymorphism and mutation databases

BioMutaiMYBBP1A
DMDMi71153825

2D gel databases

SWISS-2DPAGEiQ9BQG0

Proteomic databases

EPDiQ9BQG0
MaxQBiQ9BQG0
PaxDbiQ9BQG0
PeptideAtlasiQ9BQG0
PRIDEiQ9BQG0
ProteomicsDBi78674
78675 [Q9BQG0-2]

Protocols and materials databases

DNASUi10514
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254718; ENSP00000254718; ENSG00000132382 [Q9BQG0-1]
ENST00000381556; ENSP00000370968; ENSG00000132382 [Q9BQG0-2]
GeneIDi10514
KEGGihsa:10514
UCSCiuc002fxz.5 human [Q9BQG0-1]

Organism-specific databases

CTDi10514
DisGeNETi10514
EuPathDBiHostDB:ENSG00000132382.14
GeneCardsiMYBBP1A
H-InvDBiHIX0013445
HGNCiHGNC:7546 MYBBP1A
HPAiHPA005466
MIMi604885 gene
neXtProtiNX_Q9BQG0
OpenTargetsiENSG00000132382
PharmGKBiPA31346
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1926 Eukaryota
ENOG410YFVF LUCA
GeneTreeiENSGT00390000017457
HOGENOMiHOG000113488
HOVERGENiHBG081961
InParanoidiQ9BQG0
KOiK02331
OMAiRKWIIHR
OrthoDBiEOG091G00YE
PhylomeDBiQ9BQG0
TreeFamiTF317401

Enzyme and pathway databases

ReactomeiR-HSA-5250924 B-WICH complex positively regulates rRNA expression
SIGNORiQ9BQG0

Miscellaneous databases

ChiTaRSiMYBBP1A human
GeneWikiiMYBBP1A
GenomeRNAii10514
PMAP-CutDBiQ9BQG0
PROiPR:Q9BQG0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132382 Expressed in 179 organ(s), highest expression level in left coronary artery
CleanExiHS_MYBBP1A
ExpressionAtlasiQ9BQG0 baseline and differential
GenevisibleiQ9BQG0 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR007015 DNA_pol_V/MYBBP1A
PANTHERiPTHR13213 PTHR13213, 1 hit
PfamiView protein in Pfam
PF04931 DNA_pol_phi, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMBB1A_HUMAN
AccessioniPrimary (citable) accession number: Q9BQG0
Secondary accession number(s): Q86VM3
, Q9BW49, Q9P0V5, Q9UF99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 7, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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