Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 169 (18 Sep 2019)
Sequence version 2 (19 Jul 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Myb-binding protein 1A

Gene

MYBBP1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor
Biological processBiological rhythms, Ribosome biogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5250924 B-WICH complex positively regulates rRNA expression

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9BQG0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myb-binding protein 1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYBBP1A
Synonyms:P160
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7546 MYBBP1A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604885 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BQG0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10514

Open Targets

More...
OpenTargetsi
ENSG00000132382

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31346

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MYBBP1A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71153825

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000962551 – 1328Myb-binding protein 1AAdd BLAST1328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11PhosphoserineCombined sources1
Modified residuei71N6-acetyllysineCombined sources1
Modified residuei158N6-acetyllysineCombined sources1
Modified residuei775PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1159PhosphoserineCombined sources1
Modified residuei1163PhosphoserineCombined sources1
Modified residuei1186PhosphoserineCombined sources1
Modified residuei1190PhosphothreonineCombined sources1
Modified residuei1196PhosphothreonineCombined sources1
Modified residuei1207PhosphoserineCombined sources1
Modified residuei1232PhosphoserineCombined sources1
Modified residuei1239PhosphothreonineCombined sources1
Modified residuei1241PhosphoserineCombined sources1
Modified residuei1244PhosphothreonineBy similarity1
Modified residuei1248PhosphoserineCombined sources1
Modified residuei1267PhosphoserineCombined sources1
Modified residuei1269PhosphothreonineCombined sources1
Modified residuei1290PhosphoserineCombined sources1
Modified residuei1303PhosphoserineCombined sources1
Modified residuei1307CitrullineBy similarity1
Modified residuei1308PhosphoserineCombined sources1
Modified residuei1310PhosphoserineCombined sources1
Modified residuei1314PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-980

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BQG0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BQG0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BQG0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BQG0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BQG0

PeptideAtlas

More...
PeptideAtlasi
Q9BQG0

PRoteomics IDEntifications database

More...
PRIDEi
Q9BQG0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78674 [Q9BQG0-1]
78675 [Q9BQG0-2]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
Q9BQG0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BQG0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BQG0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9BQG0

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q9BQG0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132382 Expressed in 179 organ(s), highest expression level in left coronary artery

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BQG0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BQG0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005466

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to and represses JUN and MYB via the leucine zipper regions present in these proteins. Also binds to and represses PPARGC1A: this interaction is abrogated when PPARGC1A is phosphorylated by MAPK1/ERK. Binds to and stimulates transcription by AHR. Binds to KPNA2.

Interacts with CLOCK and CRY1 (By similarity).

Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115770, 163 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1099 B-WICH chromatin remodelling complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9BQG0

Protein interaction database and analysis system

More...
IntActi
Q9BQG0, 81 interactors

Molecular INTeraction database

More...
MINTi
Q9BQG0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000370968

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 582Interaction with MYBBy similarityAdd BLAST582
Regioni1151 – 1328Required for nuclear and nucleolar localizationBy similarityAdd BLAST178

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi240 – 258Nuclear export signal 1By similarityAdd BLAST19
Motifi263 – 281Nuclear export signal 2By similarityAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi720 – 784Glu-richAdd BLAST65

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MYBBP1A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1926 Eukaryota
ENOG410YFVF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017457

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113488

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BQG0

KEGG Orthology (KO)

More...
KOi
K02331

Identification of Orthologs from Complete Genome Data

More...
OMAi
RKWIIHR

Database of Orthologous Groups

More...
OrthoDBi
86051at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BQG0

TreeFam database of animal gene trees

More...
TreeFami
TF317401

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR007015 DNA_pol_V/MYBBP1A

The PANTHER Classification System

More...
PANTHERi
PTHR13213 PTHR13213, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04931 DNA_pol_phi, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BQG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESRDPAQPM SPGEATQSGA RPADRYGLLK HSREFLDFFW DIAKPEQETR
60 70 80 90 100
LAATEKLLEY LRGRPKGSEM KYALKRLITG LGVGRETARP CYSLALAQLL
110 120 130 140 150
QSFEDLPLCS ILQQIQEKYD LHQVKKAMLR PALFANLFGV LALFQSGRLV
160 170 180 190 200
KDQEALMKSV KLLQALAQYQ NHLQEQPRKA LVDILSEVSK ATLQEILPEV
210 220 230 240 250
LKADLNIILS SPEQLELFLL AQQKVPSKLK KLVGSVNLFS DENVPRLVNV
260 270 280 290 300
LKMAASSVKK DRKLPAIALD LLRLALKEDK FPRFWKEVVE QGLLKMQFWP
310 320 330 340 350
ASYLCFRLLG AALPLLTKEQ LHLVMQGDVI RHYGEHVCTA KLPKQFKFAP
360 370 380 390 400
EMDDYVGTFL EGCQDDPERQ LAVLVAFSSV TNQGLPVTPT FWRVVRFLSP
410 420 430 440 450
PALQGYVAWL RAMFLQPDLD SLVDFSTNNQ KKAQDSSLHM PERAVFRLRK
460 470 480 490 500
WIIFRLVSIV DSLHLEMEEA LTEQVARFCL FHSFFVTKKP TSQIPETKHP
510 520 530 540 550
FSFPLENQAR EAVSSAFFSL LQTLSTQFKQ APGQTQGGQP WTYHLVQFAD
560 570 580 590 600
LLLNHSHNVT TVTPFTAQQR QAWDRMLQTL KELEAHSAEA RAAAFQHLLL
610 620 630 640 650
LVGIHLLKSP AESCDLLGDI QTCIRKSLGE KPRRSRTKTI DPQEPPWVEV
660 670 680 690 700
LVEILLALLA QPSHLMRQVA RSVFGHICSH LTPRALQLIL DVLNPETSED
710 720 730 740 750
ENDRVVVTDD SDERRLKGAE DKSEEGEDNR SSESEEESEG EESEEEERDG
760 770 780 790 800
DVDQGFREQL MTVLQAGKAL GGEDSENEEE LGDEAMMALD QSLASLFAEQ
810 820 830 840 850
KLRIQARRDE KNKLQKEKAL RRDFQIRVLD LVEVLVTKQP ENALVLELLE
860 870 880 890 900
PLLSIIRRSL RSSSSKQEQD LLHKTARIFT HHLCRARRYC HDLGERAGAL
910 920 930 940 950
HAQVERLVQQ AGRQPDSPTA LYHFNASLYL LRVLKGNTAE GCVHETQEKQ
960 970 980 990 1000
KAGTDPSHMP TGPQAASCLD LNLVTRVYST ALSSFLTKRN SPLTVPMFLS
1010 1020 1030 1040 1050
LFSRHPVLCQ SLLPILVQHI TGPVRPRHQA CLLLQKTLSM REVRSCFEDP
1060 1070 1080 1090 1100
EWKQLMGQVL AKVTENLRVL GEAQTKAQHQ QALSSLELLN VLFRTCKHEK
1110 1120 1130 1140 1150
LTLDLTVLLG VLQGQQQSLQ QGAHSTGSSR LHDLYWQAMK TLGVQRPKLE
1160 1170 1180 1190 1200
KKDAKEIPSA TQSPISKKRK KKGFLPETKK RKKRKSEDGT PAEDGTPAAT
1210 1220 1230 1240 1250
GGSQPPSMGR KKRNRTKAKV PAQANGTPTT KSPAPGAPTR SPSTPAKSPK
1260 1270 1280 1290 1300
LQKKNQKPSQ VNGAPGSPTE PAGQKQHQKA LPKKGVLGKS PLSALARKKA
1310 1320
RLSLVIRSPS LLQSGAKKKA QVRKAGKP
Length:1,328
Mass (Da):148,855
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B053465D5B3511F
GO
Isoform 2 (identifier: Q9BQG0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1322-1328: VRKAGKP → TLRFTISSSKK

Note: May be due to competing donor and acceptor splice sites.
Show »
Length:1,332
Mass (Da):149,367
Checksum:iCF90678D49D64DB1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L1L3I3L1L3_HUMAN
Myb-binding protein 1A
MYBBP1A
1,252Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2H8I3L2H8_HUMAN
Myb-binding protein 1A
MYBBP1A
204Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L311I3L311_HUMAN
Myb-binding protein 1A
MYBBP1A
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB66530 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti307R → H in AAF33021 (PubMed:10644447).Curated1
Sequence conflicti570R → H in AAF33021 (PubMed:10644447).Curated1
Sequence conflicti601L → F in AAF33021 (PubMed:10644447).Curated1
Sequence conflicti1028H → R in AAH50546 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0230648Q → E. Corresponds to variant dbSNP:rs3809849Ensembl.1
Natural variantiVAR_051156680H → Y. Corresponds to variant dbSNP:rs899440Ensembl.1
Natural variantiVAR_051157958H → P. Corresponds to variant dbSNP:rs879797Ensembl.1
Natural variantiVAR_0511581208M → L. Corresponds to variant dbSNP:rs9905742Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0147861322 – 1328VRKAGKP → TLRFTISSSKK in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF147709 mRNA Translation: AAF33021.1
BC000641 mRNA Translation: AAH00641.2
BC050546 mRNA Translation: AAH50546.1
AL136595 mRNA Translation: CAB66530.1 Different initiation.
AL133098 mRNA Translation: CAB61409.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11046.1 [Q9BQG0-1]
CCDS42238.1 [Q9BQG0-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T42680

NCBI Reference Sequences

More...
RefSeqi
NP_001099008.1, NM_001105538.1 [Q9BQG0-2]
NP_055335.2, NM_014520.3 [Q9BQG0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000254718; ENSP00000254718; ENSG00000132382 [Q9BQG0-1]
ENST00000381556; ENSP00000370968; ENSG00000132382 [Q9BQG0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10514

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10514

UCSC genome browser

More...
UCSCi
uc002fxz.5 human [Q9BQG0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF147709 mRNA Translation: AAF33021.1
BC000641 mRNA Translation: AAH00641.2
BC050546 mRNA Translation: AAH50546.1
AL136595 mRNA Translation: CAB66530.1 Different initiation.
AL133098 mRNA Translation: CAB61409.1
CCDSiCCDS11046.1 [Q9BQG0-1]
CCDS42238.1 [Q9BQG0-2]
PIRiT42680
RefSeqiNP_001099008.1, NM_001105538.1 [Q9BQG0-2]
NP_055335.2, NM_014520.3 [Q9BQG0-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi115770, 163 interactors
ComplexPortaliCPX-1099 B-WICH chromatin remodelling complex
CORUMiQ9BQG0
IntActiQ9BQG0, 81 interactors
MINTiQ9BQG0
STRINGi9606.ENSP00000370968

PTM databases

iPTMnetiQ9BQG0
PhosphoSitePlusiQ9BQG0
SwissPalmiQ9BQG0

Polymorphism and mutation databases

BioMutaiMYBBP1A
DMDMi71153825

2D gel databases

SWISS-2DPAGEiQ9BQG0

Proteomic databases

CPTACiCPTAC-980
EPDiQ9BQG0
jPOSTiQ9BQG0
MassIVEiQ9BQG0
MaxQBiQ9BQG0
PaxDbiQ9BQG0
PeptideAtlasiQ9BQG0
PRIDEiQ9BQG0
ProteomicsDBi78674 [Q9BQG0-1]
78675 [Q9BQG0-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10514
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254718; ENSP00000254718; ENSG00000132382 [Q9BQG0-1]
ENST00000381556; ENSP00000370968; ENSG00000132382 [Q9BQG0-2]
GeneIDi10514
KEGGihsa:10514
UCSCiuc002fxz.5 human [Q9BQG0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10514
DisGeNETi10514

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MYBBP1A
HGNCiHGNC:7546 MYBBP1A
HPAiHPA005466
MIMi604885 gene
neXtProtiNX_Q9BQG0
OpenTargetsiENSG00000132382
PharmGKBiPA31346

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1926 Eukaryota
ENOG410YFVF LUCA
GeneTreeiENSGT00390000017457
HOGENOMiHOG000113488
InParanoidiQ9BQG0
KOiK02331
OMAiRKWIIHR
OrthoDBi86051at2759
PhylomeDBiQ9BQG0
TreeFamiTF317401

Enzyme and pathway databases

ReactomeiR-HSA-5250924 B-WICH complex positively regulates rRNA expression
SIGNORiQ9BQG0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MYBBP1A human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MYBBP1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10514

Pharos

More...
Pharosi
Q9BQG0
PMAP-CutDBiQ9BQG0

Protein Ontology

More...
PROi
PR:Q9BQG0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132382 Expressed in 179 organ(s), highest expression level in left coronary artery
ExpressionAtlasiQ9BQG0 baseline and differential
GenevisibleiQ9BQG0 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR007015 DNA_pol_V/MYBBP1A
PANTHERiPTHR13213 PTHR13213, 1 hit
PfamiView protein in Pfam
PF04931 DNA_pol_phi, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMBB1A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BQG0
Secondary accession number(s): Q86VM3
, Q9BW49, Q9P0V5, Q9UF99
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: September 18, 2019
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again