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Protein

Apolipoprotein L2

Gene

APOL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

GO - Molecular functioni

  • high-density lipoprotein particle binding Source: UniProtKB
  • lipid binding Source: UniProtKB
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

  • acute-phase response Source: UniProtKB
  • cholesterol metabolic process Source: UniProtKB
  • lipid metabolic process Source: UniProtKB
  • lipid transport Source: UniProtKB
  • lipoprotein metabolic process Source: InterPro
  • maternal process involved in female pregnancy Source: UniProtKB
  • multicellular organism development Source: UniProtKB

Keywordsi

Biological processLipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein L2
Alternative name(s):
Apolipoprotein L-II
Short name:
ApoL-II
Gene namesi
Name:APOL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000128335.13
HGNCiHGNC:619 APOL2
MIMi607252 gene
neXtProtiNX_Q9BQE5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi23780
MalaCardsiAPOL2
PharmGKBiPA24905

Polymorphism and mutation databases

BioMutaiAPOL2
DMDMi17433285

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001376011 – 337Apolipoprotein L2Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei250PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BQE5
MaxQBiQ9BQE5
PaxDbiQ9BQE5
PeptideAtlasiQ9BQE5
PRIDEiQ9BQE5
ProteomicsDBi78663

PTM databases

iPTMnetiQ9BQE5
PhosphoSitePlusiQ9BQE5

Expressioni

Tissue specificityi

Widely expressed; the highest levels are found in lung, thymus, pancreas, placenta, adult brain and prostate; also detected in spleen, liver, kidney, colon, small intestine, uterus, spinal cord, adrenal gland, salivary gland, trachea, mammary gland, skeletal muscle, testis and fetal brain and liver.

Gene expression databases

BgeeiENSG00000128335
ExpressionAtlasiQ9BQE5 baseline and differential
GenevisibleiQ9BQE5 HS

Interactioni

GO - Molecular functioni

  • signaling receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi117279, 38 interactors
IntActiQ9BQE5, 46 interactors
STRINGi9606.ENSP00000249066

Structurei

3D structure databases

ProteinModelPortaliQ9BQE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi157 – 162Poly-Ala6

Sequence similaritiesi

Belongs to the apolipoprotein L family.Curated

Phylogenomic databases

eggNOGiENOG410IWES Eukaryota
ENOG410Y0AF LUCA
HOVERGENiHBG074468
InParanoidiQ9BQE5
KOiK14480
PhylomeDBiQ9BQE5
TreeFamiTF334681

Family and domain databases

InterProiView protein in InterPro
IPR008405 ApoL
PANTHERiPTHR14096 PTHR14096, 1 hit
PfamiView protein in Pfam
PF05461 ApoL, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BQE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPESSIFIE DYLKYFQDQV SRENLLQLLT DDEAWNGFVA AAELPRDEAD
60 70 80 90 100
ELRKALNKLA SHMVMKDKNR HDKDQQHRQW FLKEFPRLKR ELEDHIRKLR
110 120 130 140 150
ALAEEVEQVH RGTTIANVVS NSVGTTSGIL TLLGLGLAPF TEGISFVLLD
160 170 180 190 200
TGMGLGAAAA VAGITCSVVE LVNKLRARAQ ARNLDQSGTN VAKVMKEFVG
210 220 230 240 250
GNTPNVLTLV DNWYQVTQGI GRNIRAIRRA RANPQLGAYA PPPHIIGRIS
260 270 280 290 300
AEGGEQVERV VEGPAQAMSR GTMIVGAATG GILLLLDVVS LAYESKHLLE
310 320 330
GAKSESAEEL KKRAQELEGK LNFLTKIHEM LQPGQDQ
Length:337
Mass (Da):37,092
Last modified:June 1, 2001 - v1
Checksum:i0A54640FCC029400
GO

Sequence cautioni

The sequence BAD92227 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186Q → R in BAD92227 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024366182R → C. Corresponds to variant dbSNP:rs7285167Ensembl.1
Natural variantiVAR_012978245I → V1 PublicationCorresponds to variant dbSNP:rs132760Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305225 mRNA Translation: AAK20211.1
AF324223 mRNA Translation: AAK11592.1
AF324224 mRNA Translation: AAK11593.1
AF324230, AF324228, AF324229 Genomic DNA Translation: AAK11598.1
AF305429 mRNA Translation: AAL09359.1
AK056938 mRNA Translation: BAB71315.1
AB208990 mRNA Translation: BAD92227.1 Different initiation.
AL031426 Genomic DNA No translation available.
Z82215 Genomic DNA No translation available.
Z95114 Genomic DNA No translation available.
BC004395 mRNA Translation: AAH04395.1
CCDSiCCDS43014.1
RefSeqiNP_112092.2, NM_030882.3
NP_663612.2, NM_145637.2
XP_011528376.1, XM_011530074.1
XP_011528377.1, XM_011530075.1
XP_011528378.1, XM_011530076.2
XP_011528379.1, XM_011530077.2
XP_011528380.1, XM_011530078.1
UniGeneiHs.474740

Genome annotation databases

EnsembliENST00000249066; ENSP00000249066; ENSG00000128335
ENST00000358502; ENSP00000351292; ENSG00000128335
GeneIDi23780
KEGGihsa:23780
UCSCiuc003aoz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAPOL2_HUMAN
AccessioniPrimary (citable) accession number: Q9BQE5
Secondary accession number(s): B0QYK7
, O95915, Q59GW9, Q5TH96, Q969T6, Q9BT28, Q9UGT1, Q9UH10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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