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Protein

Ribosomal protein 63, mitochondrial

Gene

MRPL57

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein 63, mitochondrial
Short name:
hMRP63
Alternative name(s):
Mitochondrial large ribosomal subunit protein mL631 Publication
Mitochondrial ribosomal protein 63
Mitochondrial ribosomal protein L57
Gene namesi
Name:MRPL57
Synonyms:MRP63
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000173141.4
HGNCiHGNC:14514 MRPL57
MIMi611997 gene
neXtProtiNX_Q9BQC6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173141
PharmGKBiPA30937

Polymorphism and mutation databases

BioMutaiMRP63

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002535411 – 102Ribosomal protein 63, mitochondrialAdd BLAST102

Proteomic databases

EPDiQ9BQC6
MaxQBiQ9BQC6
PaxDbiQ9BQC6
PeptideAtlasiQ9BQC6
PRIDEiQ9BQC6
ProteomicsDBi78656
TopDownProteomicsiQ9BQC6

PTM databases

iPTMnetiQ9BQC6
PhosphoSitePlusiQ9BQC6

Expressioni

Gene expression databases

BgeeiENSG00000173141
CleanExiHS_MRP63
ExpressionAtlasiQ9BQC6 baseline and differential
GenevisibleiQ9BQC6 HS

Organism-specific databases

HPAiHPA039779
HPA059370

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.2 Publications

Protein-protein interaction databases

BioGridi122459, 33 interactors
IntActiQ9BQC6, 3 interactors
MINTiQ9BQC6
STRINGi9606.ENSP00000310726

Structurei

Secondary structure

1102
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 15Combined sources3
Beta strandi18 – 21Combined sources4
Helixi29 – 48Combined sources20
Turni56 – 58Combined sources3
Turni60 – 63Combined sources4
Helixi64 – 78Combined sources15
Helixi88 – 93Combined sources6
Helixi94 – 98Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40o1-102[»]
3J9Melectron microscopy3.50o1-102[»]
5OOLelectron microscopy3.06o1-102[»]
5OOMelectron microscopy3.03o1-102[»]
ProteinModelPortaliQ9BQC6
SMRiQ9BQC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J0KS Eukaryota
ENOG410XX1I LUCA
GeneTreeiENSGT00390000008171
HOGENOMiHOG000230903
HOVERGENiHBG079987
InParanoidiQ9BQC6
OMAiAENEYWL
OrthoDBiEOG091G13M7
PhylomeDBiQ9BQC6
TreeFamiTF324466

Family and domain databases

InterProiView protein in InterPro
IPR016576 Ribosomal_MRP63_mit
PANTHERiPTHR14520 PTHR14520, 1 hit
PfamiView protein in Pfam
PF14978 MRP-63, 1 hit
PIRSFiPIRSF011124 MRP63, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BQC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLTALLWRG RIPGRQWIGK HRRPRFVSLR AKQNMIRRLE IEAENHYWLS
60 70 80 90 100
MPYMTREQER GHAAVRRREA FEAIKAAATS KFPPHRFIAD QLDHLNVTKK

WS
Length:102
Mass (Da):12,266
Last modified:June 1, 2001 - v1
Checksum:i2456F3E663C6F683
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049957 mRNA Translation: BAB41010.1
AL158032 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08296.1
BC023616 mRNA Translation: AAH23616.1
BC068492 mRNA Translation: AAH68492.1
CCDSiCCDS9296.1
RefSeqiNP_076931.1, NM_024026.4
XP_016876229.1, XM_017020740.1
UniGeneiHs.458367

Genome annotation databases

EnsembliENST00000309594; ENSP00000310726; ENSG00000173141
GeneIDi78988
KEGGihsa:78988
UCSCiuc001unw.4 human

Similar proteinsi

Entry informationi

Entry nameiRT63_HUMAN
AccessioniPrimary (citable) accession number: Q9BQC6
Secondary accession number(s): A2A332
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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