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Entry version 139 (13 Feb 2019)
Sequence version 1 (01 Jun 2001)
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Protein

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

Gene

DPH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peptidyl-diphthamide biosynthesis

This protein is involved in the pathway peptidyl-diphthamide biosynthesis, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway peptidyl-diphthamide biosynthesis and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • peptidyl-diphthamide biosynthetic process from peptidyl-histidine Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5358493 Synthesis of diphthamide-EEF2

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00559

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2Curated (EC:2.5.1.108By similarity)
Alternative name(s):
Diphthamide biosynthesis protein 2
Diphtheria toxin resistance protein 2Curated
S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DPH2
Synonyms:DPH2L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000132768.13

Human Gene Nomenclature Database

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HGNCi
HGNC:3004 DPH2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603456 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BQC3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1802

Open Targets

More...
OpenTargetsi
ENSG00000132768

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27462

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DPH2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74761201

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003078891 – 4892-(3-amino-3-carboxypropyl)histidine synthase subunit 2Add BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei7PhosphoserineCombined sources1
Modified residuei435PhosphothreonineCombined sources1
Modified residuei446PhosphoserineCombined sources1
Modified residuei456PhosphoserineCombined sources1
Modified residuei467PhosphothreonineCombined sources1
Modified residuei488PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BQC3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BQC3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9BQC3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BQC3

PeptideAtlas

More...
PeptideAtlasi
Q9BQC3

PRoteomics IDEntifications database

More...
PRIDEi
Q9BQC3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78655

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BQC3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BQC3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in skeletal muscle. Moderately expressed in heart, small intestine, liver, pancreas, testis and colon. Weakly expressed in brain, placenta, kidney, spleen, thymus, prostate, ovary and lymphocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132768 Expressed in 196 organ(s), highest expression level in left coronary artery

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BQC3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9BQC3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045796

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DPH1.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
IL17AQ165523EBI-10237931,EBI-10237926

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108136, 28 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BQC3, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000255108

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9BQC3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DPH1/DPH2 family. DPH2 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2648 Eukaryota
COG1736 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153694

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015311

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107823

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BQC3

KEGG Orthology (KO)

More...
KOi
K17866

Identification of Orthologs from Complete Genome Data

More...
OMAi
FGNACRS

Database of Orthologous Groups

More...
OrthoDBi
750182at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BQC3

TreeFam database of animal gene trees

More...
TreeFami
TF313832

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010014 DHP2_euk
IPR016435 DPH1/DPH2

The PANTHER Classification System

More...
PANTHERi
PTHR10762 PTHR10762, 1 hit
PTHR10762:SF2 PTHR10762:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01866 Diphthamide_syn, 1 hit

Structure-Function Linkage Database

More...
SFLDi
SFLDS00032 Radical_SAM_3-amino-3-carboxyp, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00322 diphth2_R, 1 hit
TIGR00272 DPH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BQC3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESMFSSPAE AALQRETGVP GLLTPLPDLD GVYELERVAG FVRDLGCERV
60 70 80 90 100
ALQFPDQLLG DAVAVAARLE ETTGSKMFIL GDTAYGSCCV DVLGAEQAGA
110 120 130 140 150
QALIHFGPAC LSPPARPLPV AFVLRQRSVA LELCVKAFEA QNPDPKAPVV
160 170 180 190 200
LLSEPACAHA LEALATLLRP RYLDLLVSSP AFPQPVGSLS PEPMPLERFG
210 220 230 240 250
RRFPLAPGRR LEEYGAFYVG GSKASPDPDL DPDLSRLLLG WAPGQPFSSC
260 270 280 290 300
CPDTGKTQDE GARAGRLRAR RRYLVERARD ARVVGLLAGT LGVAQHREAL
310 320 330 340 350
AHLRNLTQAA GKRSYVLALG RPTPAKLANF PEVDVFVLLA CPLGALAPQL
360 370 380 390 400
SGSFFQPILA PCELEAACNP AWPPPGLAPH LTHYADLLPG SPFHVALPPP
410 420 430 440 450
ESELWETPDV SLITGDLRPP PAWKSSNDHG SLALTPRPQL ELAESSPAAS
460 470 480
FLSSRSWQGL EPRLGQTPVT EAVSGRRGIA IAYEDEGSG
Length:489
Mass (Da):52,083
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2908FB7E816E3AEF
GO
Isoform 2 (identifier: Q9BQC3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-389: Missing.

Note: Gene prediction based on EST data.
Show »
Length:261
Mass (Da):27,529
Checksum:iCC4F41D6B2CE16BA
GO
Isoform 3 (identifier: Q9BQC3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MESMFSSPAEAALQRETGVPGLLTPL → MLWLWLHDWRRRQGQRCSFWVTQPTA
     27-161: Missing.

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):38,510
Checksum:iBD0FBC0456CAC76F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCR5H0YCR5_HUMAN
2-(3-amino-3-carboxypropyl)histidin...
DPH2
262Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMH7E9PMH7_HUMAN
2-(3-amino-3-carboxypropyl)histidin...
DPH2
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLL2E9PLL2_HUMAN
2-(3-amino-3-carboxypropyl)histidin...
DPH2
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPU3E9PPU3_HUMAN
2-(3-amino-3-carboxypropyl)histidin...
DPH2
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YED1H0YED1_HUMAN
2-(3-amino-3-carboxypropyl)histidin...
DPH2
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJH6E9PJH6_HUMAN
2-(3-amino-3-carboxypropyl)histidin...
DPH2
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIY4E9PIY4_HUMAN
2-(3-amino-3-carboxypropyl)histidin...
DPH2
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti125 – 153RQRSV…VVLLS → SSTFCGLGTLCQDLWGPKPR PQSACGAAG in AAC18086 (PubMed:9782084).CuratedAdd BLAST29
Sequence conflicti266R → G in AAC18086 (PubMed:9782084).Curated1
Sequence conflicti435T → N in AAC18086 (PubMed:9782084).Curated1
Sequence conflicti449A → V in AAC18086 (PubMed:9782084).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0560521 – 26MESMF…LLTPL → MLWLWLHDWRRRQGQRCSFW VTQPTA in isoform 3. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_05605327 – 161Missing in isoform 3. 1 PublicationAdd BLAST135
Alternative sequenceiVSP_047151162 – 389Missing in isoform 2. CuratedAdd BLAST228

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF053003 mRNA Translation: AAC18086.1
AK297933 mRNA Translation: BAG60250.1
AK315506 mRNA Translation: BAG37890.1
BT007431 mRNA Translation: AAP36099.1
AL357079 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07070.1
BC001389 mRNA Translation: AAH01389.1
BC003181 mRNA Translation: AAH03181.1
BC016956 mRNA Translation: AAH16956.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41314.1 [Q9BQC3-2]
CCDS504.1 [Q9BQC3-1]

NCBI Reference Sequences

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RefSeqi
NP_001034678.1, NM_001039589.1 [Q9BQC3-2]
NP_001306095.1, NM_001319166.1
NP_001306098.1, NM_001319169.1 [Q9BQC3-3]
NP_001375.2, NM_001384.4 [Q9BQC3-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.632398

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000255108; ENSP00000255108; ENSG00000132768 [Q9BQC3-1]
ENST00000396758; ENSP00000379981; ENSG00000132768 [Q9BQC3-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1802

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1802

UCSC genome browser

More...
UCSCi
uc001ckz.4 human [Q9BQC3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053003 mRNA Translation: AAC18086.1
AK297933 mRNA Translation: BAG60250.1
AK315506 mRNA Translation: BAG37890.1
BT007431 mRNA Translation: AAP36099.1
AL357079 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07070.1
BC001389 mRNA Translation: AAH01389.1
BC003181 mRNA Translation: AAH03181.1
BC016956 mRNA Translation: AAH16956.1
CCDSiCCDS41314.1 [Q9BQC3-2]
CCDS504.1 [Q9BQC3-1]
RefSeqiNP_001034678.1, NM_001039589.1 [Q9BQC3-2]
NP_001306095.1, NM_001319166.1
NP_001306098.1, NM_001319169.1 [Q9BQC3-3]
NP_001375.2, NM_001384.4 [Q9BQC3-1]
UniGeneiHs.632398

3D structure databases

ProteinModelPortaliQ9BQC3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108136, 28 interactors
IntActiQ9BQC3, 9 interactors
STRINGi9606.ENSP00000255108

PTM databases

iPTMnetiQ9BQC3
PhosphoSitePlusiQ9BQC3

Polymorphism and mutation databases

BioMutaiDPH2
DMDMi74761201

Proteomic databases

EPDiQ9BQC3
jPOSTiQ9BQC3
MaxQBiQ9BQC3
PaxDbiQ9BQC3
PeptideAtlasiQ9BQC3
PRIDEiQ9BQC3
ProteomicsDBi78655

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1802
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255108; ENSP00000255108; ENSG00000132768 [Q9BQC3-1]
ENST00000396758; ENSP00000379981; ENSG00000132768 [Q9BQC3-2]
GeneIDi1802
KEGGihsa:1802
UCSCiuc001ckz.4 human [Q9BQC3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1802
DisGeNETi1802
EuPathDBiHostDB:ENSG00000132768.13

GeneCards: human genes, protein and diseases

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GeneCardsi
DPH2
HGNCiHGNC:3004 DPH2
HPAiHPA045796
MIMi603456 gene
neXtProtiNX_Q9BQC3
OpenTargetsiENSG00000132768
PharmGKBiPA27462

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2648 Eukaryota
COG1736 LUCA
GeneTreeiENSGT00940000153694
HOGENOMiHOG000015311
HOVERGENiHBG107823
InParanoidiQ9BQC3
KOiK17866
OMAiFGNACRS
OrthoDBi750182at2759
PhylomeDBiQ9BQC3
TreeFamiTF313832

Enzyme and pathway databases

UniPathwayi
UPA00559

ReactomeiR-HSA-5358493 Synthesis of diphthamide-EEF2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DPH2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1802

Protein Ontology

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PROi
PR:Q9BQC3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132768 Expressed in 196 organ(s), highest expression level in left coronary artery
ExpressionAtlasiQ9BQC3 baseline and differential
GenevisibleiQ9BQC3 HS

Family and domain databases

InterProiView protein in InterPro
IPR010014 DHP2_euk
IPR016435 DPH1/DPH2
PANTHERiPTHR10762 PTHR10762, 1 hit
PTHR10762:SF2 PTHR10762:SF2, 1 hit
PfamiView protein in Pfam
PF01866 Diphthamide_syn, 1 hit
SFLDiSFLDS00032 Radical_SAM_3-amino-3-carboxyp, 1 hit
TIGRFAMsiTIGR00322 diphth2_R, 1 hit
TIGR00272 DPH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPH2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BQC3
Secondary accession number(s): A8MVC9
, B2RDE3, B4DNI8, O60623
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2001
Last modified: February 13, 2019
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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