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Entry version 151 (16 Oct 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Vitamin K epoxide reductase complex subunit 1

Gene

VKORC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.6 Publications

Miscellaneous

The location of two cysteine active-site residues within a proposed transmembrane is consistent both with the known hydrophobic environment of the thiol redox site of the enzyme and with the lipophilicity of vitamin K and warfarin (coumadin).

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by warfarin (coumadin).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS15548-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.1.4.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6806664 Metabolism of vitamin K

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
Q9BQB6 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vitamin K epoxide reductase complex subunit 1 (EC:1.17.4.44 Publications)
Alternative name(s):
Vitamin K1 2,3-epoxide reductase subunit 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VKORC1
Synonyms:VKOR
ORF Names:MSTP134, MSTP576, UNQ308/PRO351
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23663 VKORC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608547 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BQB6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8LumenalSequence analysis8
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 29HelicalCuratedAdd BLAST21
Topological domaini30 – 74CytoplasmicSequence analysisAdd BLAST45
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Transmembranei101 – 123HelicalCuratedAdd BLAST23
Topological domaini124 – 126LumenalCurated3
Transmembranei127 – 149HelicalCuratedAdd BLAST23
Topological domaini150 – 163CytoplasmicCuratedAdd BLAST14

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Combined deficiency of vitamin K-dependent clotting factors 2 (VKCFD2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionVKCFD leads to a bleeding tendency that is usually reversed by oral administration of vitamin K.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02182498R → W in VKCFD2; strongly reduced enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs72547528EnsemblClinVar.1
Coumarin resistance (CMRES)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by partial or complete resistance to warfarin or other 4-hydroxycoumarin derivatives. These drugs are used as anti-coagulants for the prevention of thromboembolic diseases in subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06578526A → T in CMRES. 1 PublicationCorresponds to variant dbSNP:rs770703948Ensembl.1
Natural variantiVAR_02182129V → L in CMRES. 2 PublicationsCorresponds to variant dbSNP:rs104894539EnsemblClinVar.1
Natural variantiVAR_06578636D → G in CMRES. 1 Publication1
Natural variantiVAR_06578736D → Y in CMRES. 1 PublicationCorresponds to variant dbSNP:rs61742245EnsemblClinVar.1
Natural variantiVAR_02182245V → A in CMRES. 1 PublicationCorresponds to variant dbSNP:rs104894540EnsemblClinVar.1
Natural variantiVAR_06578852S → W in CMRES. 1 Publication1
Natural variantiVAR_06578956S → F in CMRES. 1 Publication1
Natural variantiVAR_02182358R → G in CMRES. 1 PublicationCorresponds to variant dbSNP:rs104894541EnsemblClinVar.1
Natural variantiVAR_06579059W → C in CMRES. 1 Publication1
Natural variantiVAR_06579159W → L in CMRES. 1 Publication1
Natural variantiVAR_06579266V → G in CMRES. 1 Publication1
Natural variantiVAR_06579366V → M in CMRES. 1 PublicationCorresponds to variant dbSNP:rs72547529Ensembl.1
Natural variantiVAR_06579471G → A in CMRES. 1 Publication1
Natural variantiVAR_06579577N → S in CMRES. 1 Publication1
Natural variantiVAR_06579677N → Y in CMRES. 1 PublicationCorresponds to variant dbSNP:rs755767348Ensembl.1
Natural variantiVAR_065797123I → N in CMRES. 1 Publication1
Natural variantiVAR_021825128L → R in CMRES. 1 PublicationCorresponds to variant dbSNP:rs104894542EnsemblClinVar.1
Natural variantiVAR_065798139Y → H in CMRES. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi16C → A or S: Reduces enzyme activity by about 80%. 1 Publication1
Mutagenesisi35R → P: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi43C → A or S: Reduces enzyme activity. 2 Publications1
Mutagenesisi51C → A or S: Reduces enzyme activity. 2 Publications1
Mutagenesisi56S → P: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi57S → A: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi85C → A: Reduces enzyme activity by about 25%. 1 Publication1
Mutagenesisi85C → S: Reduces enzyme activity by about 75%. 1 Publication1
Mutagenesisi96C → A or S: Reduces enzyme activity by about 70%. 1 Publication1
Mutagenesisi98R → D or E: Reduces enzyme activity by about 80%. Decreases inhibition by warfarin. 1 Publication1
Mutagenesisi98R → K: No effect on enzyme activity. Decreases inhibition by warfarin. 1 Publication1
Mutagenesisi120L → Q: Decreases enzyme activity moderately. Decreases inhibition by warfarin. 1 Publication1
Mutagenesisi128L → Q or S: Decreases enzyme activity by about 80%. Decreases inhibition by warfarin. 1 Publication1
Mutagenesisi132C → S: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi135C → S: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi139Y → C, G or S: Decreases enzyme activity moderately. Strongly decreases inhibition by warfarin. 2 Publications1
Mutagenesisi139Y → F: No effect on enzyme activity. Strongly decreases inhibition by warfarin. 2 Publications1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
79001

MalaCards human disease database

More...
MalaCardsi
VKORC1
MIMi122700 phenotype
607473 phenotype

Open Targets

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OpenTargetsi
ENSG00000167397

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
98434 Hereditary combined deficiency of vitamin K-dependent clotting factors
413684 Resistance to vitamin K antagonists
413674 Vitamin K antagonists toxicity or dose selection

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA133787052

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BQB6

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL1930

Drug and drug target database

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DrugBanki
DB01418 Acenocoumarol
DB00266 Dicoumarol
DB09332 Kappadione
DB00170 Menadione
DB00498 Phenindione
DB00946 Phenprocoumon
DB00682 Warfarin

DrugCentral

More...
DrugCentrali
Q9BQB6

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2645

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
VKORC1

Domain mapping of disease mutations (DMDM)

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DMDMi
62511226

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001916681 – 163Vitamin K epoxide reductase complex subunit 1Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi132 ↔ 135Redox-active

Keywords - PTMi

Disulfide bond, Quinone

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BQB6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9BQB6

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9BQB6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BQB6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BQB6

PeptideAtlas

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PeptideAtlasi
Q9BQB6

PRoteomics IDEntifications database

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PRIDEi
Q9BQB6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78652 [Q9BQB6-1]
78653 [Q9BQB6-2]
78654 [Q9BQB6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9BQB6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BQB6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9BQB6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at highest levels in fetal and adult liver, followed by fetal heart, kidney, and lung, adult heart, and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167397 Expressed in 226 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BQB6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BQB6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042720

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122472, 102 interactors

Protein interaction database and analysis system

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IntActi
Q9BQB6, 49 interactors

Molecular INTeraction database

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MINTi
Q9BQB6

STRING: functional protein association networks

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STRINGi
9606.ENSP00000378426

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q9BQB6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The number of transmembrane domains and the membrane topology are controversial; supporting evidence is available both for models with three transmembrane domains (PubMed:15716279 and PubMed:22923610) and four transmembrane domains (PubMed:20696932 and PubMed:20978134). According to PubMed:15716279 and PubMed:22923610 the N-terminus of the protein is in the endoplasmic reticulum lumen, while the C-terminus is in the cytosol, which is in favor of three transmembrane domains. According to PubMed:20696932, both N-terminus and C-terminus are in the cytosol, indicating the presence of four transmembrane domains. Besides, the 3D-structure of a bacterial ortholog shows four transmembrane domains. Moreover, proteins that reside in the endoplasmic reticulum lumen can catalyze the reduction of the active site cysteines, possibly via Cys-43 and Cys-51 (PubMed:20696932 and PubMed:20978134), but less efficiently than the synthetic compound dithiothreitol (in vitro). Location of Cys-43 and Cys-51 in the endoplasmic reticulum lumen would be in agreement with four transmembrane domains. Again, these data are controversial, and papers do not agree on the effects of mutating Cys-43 and Cys-51, probably because of differences in the assay systems.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VKOR family.Curated

Keywords - Domaini

Redox-active center, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J0HT Eukaryota
ENOG4111UX7 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157421

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230752

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BQB6

KEGG Orthology (KO)

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KOi
K05357

Identification of Orthologs from Complete Genome Data

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OMAi
LYLAWIL

Database of Orthologous Groups

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OrthoDBi
1153545at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BQB6

TreeFam database of animal gene trees

More...
TreeFami
TF328467

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12917 VKOR_euk, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1440.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012932 VKOR
IPR038354 VKOR_sf
IPR042406 VKORC1/VKORC1L1

The PANTHER Classification System

More...
PANTHERi
PTHR14519 PTHR14519, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07884 VKOR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00756 VKc, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BQB6-1) [UniParc]FASTAAdd to basket
Also known as: MST576

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSTWGSPGW VRLALCLTGL VLSLYALHVK AARARDRDYR ALCDVGTAIS
60 70 80 90 100
CSRVFSSRWG RGFGLVEHVL GQDSILNQSN SIFGCIFYTL QLLLGCLRTR
110 120 130 140 150
WASVLMLLSS LVSLAGSVYL AWILFFVLYD FCIVCITTYA INVSLMWLSF
160
RKVQEPQGKA KRH
Length:163
Mass (Da):18,235
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F00526A6C561D5A
GO
Isoform 2 (identifier: Q9BQB6-2) [UniParc]FASTAAdd to basket
Also known as: MST134

The sequence of this isoform differs from the canonical sequence as follows:
     95-163: GCLRTRWASV...QEPQGKAKRH → DGVSPCCPGW...PGLDPVLRAL

Show »
Length:156
Mass (Da):16,701
Checksum:iFBB87922208F471C
GO
Isoform 3 (identifier: Q9BQB6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-163: WGRGFGLVEH...QEPQGKAKRH → LPADTLGLCPDAAELPGVSRWFCLPGLDPVLRAL

Note: No experimental confirmation available.
Show »
Length:92
Mass (Da):9,875
Checksum:iCB4ADA0C5ED486BD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W9H0F8W9H0_HUMAN
Vitamin K epoxide reductase complex...
VKORC1
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1P9I3L1P9_HUMAN
Vitamin K epoxide reductase complex...
VKORC1
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MV79A8MV79_HUMAN
Vitamin K epoxide reductase complex...
VKORC1
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z3Q2F2Z3Q2_HUMAN
Vitamin K epoxide reductase complex...
VKORC1
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YF24H0YF24_HUMAN
Vitamin K epoxide reductase complex...
VKORC1
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ88821 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06578526A → T in CMRES. 1 PublicationCorresponds to variant dbSNP:rs770703948Ensembl.1
Natural variantiVAR_02182129V → L in CMRES. 2 PublicationsCorresponds to variant dbSNP:rs104894539EnsemblClinVar.1
Natural variantiVAR_06578636D → G in CMRES. 1 Publication1
Natural variantiVAR_06578736D → Y in CMRES. 1 PublicationCorresponds to variant dbSNP:rs61742245EnsemblClinVar.1
Natural variantiVAR_02182245V → A in CMRES. 1 PublicationCorresponds to variant dbSNP:rs104894540EnsemblClinVar.1
Natural variantiVAR_06578852S → W in CMRES. 1 Publication1
Natural variantiVAR_06578956S → F in CMRES. 1 Publication1
Natural variantiVAR_02182358R → G in CMRES. 1 PublicationCorresponds to variant dbSNP:rs104894541EnsemblClinVar.1
Natural variantiVAR_06579059W → C in CMRES. 1 Publication1
Natural variantiVAR_06579159W → L in CMRES. 1 Publication1
Natural variantiVAR_06579266V → G in CMRES. 1 Publication1
Natural variantiVAR_06579366V → M in CMRES. 1 PublicationCorresponds to variant dbSNP:rs72547529Ensembl.1
Natural variantiVAR_06579471G → A in CMRES. 1 Publication1
Natural variantiVAR_06579577N → S in CMRES. 1 Publication1
Natural variantiVAR_06579677N → Y in CMRES. 1 PublicationCorresponds to variant dbSNP:rs755767348Ensembl.1
Natural variantiVAR_02182498R → W in VKCFD2; strongly reduced enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs72547528EnsemblClinVar.1
Natural variantiVAR_065797123I → N in CMRES. 1 Publication1
Natural variantiVAR_021825128L → R in CMRES. 1 PublicationCorresponds to variant dbSNP:rs104894542EnsemblClinVar.1
Natural variantiVAR_065798139Y → H in CMRES. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04340759 – 163WGRGF…KAKRH → LPADTLGLCPDAAELPGVSR WFCLPGLDPVLRAL in isoform 3. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_01336395 – 163GCLRT…KAKRH → DGVSPCCPGWSQAICLPQPP KVLGGLQALPADTLGLCPDA AELPGVSRWFCLPGLDPVLR AL in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY423044 mRNA Translation: AAR82914.1
AY521634 mRNA Translation: AAS01052.1
AF176924 mRNA Translation: AAQ13668.1
AY466113 mRNA Translation: AAR28759.1
AY587020 Genomic DNA Translation: AAS83106.1
AK289790 mRNA Translation: BAF82479.1
AK312005 mRNA Translation: BAG34943.1
AC135050 Genomic DNA No translation available.
CH471192 Genomic DNA Translation: EAW52167.1
CH471192 Genomic DNA Translation: EAW52168.1
BC002911 mRNA Translation: AAH02911.1
AY358456 mRNA Translation: AAQ88821.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10703.1 [Q9BQB6-1]
CCDS10704.1 [Q9BQB6-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001298240.1, NM_001311311.1
NP_076869.1, NM_024006.5 [Q9BQB6-1]
NP_996560.1, NM_206824.2 [Q9BQB6-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000319788; ENSP00000326135; ENSG00000167397 [Q9BQB6-2]
ENST00000354895; ENSP00000346969; ENSG00000167397 [Q9BQB6-3]
ENST00000394975; ENSP00000378426; ENSG00000167397 [Q9BQB6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79001

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79001

UCSC genome browser

More...
UCSCi
uc002eas.4 human [Q9BQB6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY423044 mRNA Translation: AAR82914.1
AY521634 mRNA Translation: AAS01052.1
AF176924 mRNA Translation: AAQ13668.1
AY466113 mRNA Translation: AAR28759.1
AY587020 Genomic DNA Translation: AAS83106.1
AK289790 mRNA Translation: BAF82479.1
AK312005 mRNA Translation: BAG34943.1
AC135050 Genomic DNA No translation available.
CH471192 Genomic DNA Translation: EAW52167.1
CH471192 Genomic DNA Translation: EAW52168.1
BC002911 mRNA Translation: AAH02911.1
AY358456 mRNA Translation: AAQ88821.1 Different initiation.
CCDSiCCDS10703.1 [Q9BQB6-1]
CCDS10704.1 [Q9BQB6-3]
RefSeqiNP_001298240.1, NM_001311311.1
NP_076869.1, NM_024006.5 [Q9BQB6-1]
NP_996560.1, NM_206824.2 [Q9BQB6-3]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi122472, 102 interactors
IntActiQ9BQB6, 49 interactors
MINTiQ9BQB6
STRINGi9606.ENSP00000378426

Chemistry databases

BindingDBiQ9BQB6
ChEMBLiCHEMBL1930
DrugBankiDB01418 Acenocoumarol
DB00266 Dicoumarol
DB09332 Kappadione
DB00170 Menadione
DB00498 Phenindione
DB00946 Phenprocoumon
DB00682 Warfarin
DrugCentraliQ9BQB6
GuidetoPHARMACOLOGYi2645

Protein family/group databases

MoonDBiQ9BQB6 Predicted

PTM databases

iPTMnetiQ9BQB6
PhosphoSitePlusiQ9BQB6
SwissPalmiQ9BQB6

Polymorphism and mutation databases

BioMutaiVKORC1
DMDMi62511226

Proteomic databases

EPDiQ9BQB6
jPOSTiQ9BQB6
MassIVEiQ9BQB6
MaxQBiQ9BQB6
PaxDbiQ9BQB6
PeptideAtlasiQ9BQB6
PRIDEiQ9BQB6
ProteomicsDBi78652 [Q9BQB6-1]
78653 [Q9BQB6-2]
78654 [Q9BQB6-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79001

Genome annotation databases

EnsembliENST00000319788; ENSP00000326135; ENSG00000167397 [Q9BQB6-2]
ENST00000354895; ENSP00000346969; ENSG00000167397 [Q9BQB6-3]
ENST00000394975; ENSP00000378426; ENSG00000167397 [Q9BQB6-1]
GeneIDi79001
KEGGihsa:79001
UCSCiuc002eas.4 human [Q9BQB6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79001
DisGeNETi79001

GeneCards: human genes, protein and diseases

More...
GeneCardsi
VKORC1
HGNCiHGNC:23663 VKORC1
HPAiHPA042720
MalaCardsiVKORC1
MIMi122700 phenotype
607473 phenotype
608547 gene
neXtProtiNX_Q9BQB6
OpenTargetsiENSG00000167397
Orphaneti98434 Hereditary combined deficiency of vitamin K-dependent clotting factors
413684 Resistance to vitamin K antagonists
413674 Vitamin K antagonists toxicity or dose selection
PharmGKBiPA133787052

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J0HT Eukaryota
ENOG4111UX7 LUCA
GeneTreeiENSGT00940000157421
HOGENOMiHOG000230752
InParanoidiQ9BQB6
KOiK05357
OMAiLYLAWIL
OrthoDBi1153545at2759
PhylomeDBiQ9BQB6
TreeFamiTF328467

Enzyme and pathway databases

BioCyciMetaCyc:HS15548-MONOMER
BRENDAi1.1.4.1 2681
ReactomeiR-HSA-6806664 Metabolism of vitamin K

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
VKORC1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
VKORC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79001
PharosiQ9BQB6

Protein Ontology

More...
PROi
PR:Q9BQB6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000167397 Expressed in 226 organ(s), highest expression level in liver
ExpressionAtlasiQ9BQB6 baseline and differential
GenevisibleiQ9BQB6 HS

Family and domain databases

CDDicd12917 VKOR_euk, 1 hit
Gene3Di1.20.1440.130, 1 hit
InterProiView protein in InterPro
IPR012932 VKOR
IPR038354 VKOR_sf
IPR042406 VKORC1/VKORC1L1
PANTHERiPTHR14519 PTHR14519, 1 hit
PfamiView protein in Pfam
PF07884 VKOR, 1 hit
SMARTiView protein in SMART
SM00756 VKc, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVKOR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BQB6
Secondary accession number(s): A6NIQ6
, B2R4Z6, Q6UX90, Q7Z2R4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: October 16, 2019
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
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