SOST

Functionⁱ

Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.1 Publication

GO - Molecular functionⁱ

heparin binding Source: UniProtKB-KW
transcription factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17696759

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to parathyroid hormone stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 17696759
negative regulation of BMP signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 14633986
negative regulation of canonical Wnt signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 15908424
negative regulation of ossification
Source: UniProtKB
Non-traceable author statementⁱ
- 11181578
- 17696759
negative regulation of protein complex assembly
Source: BHF-UCL
Inferred from direct assayⁱ
- 15908424
ossification Source: Ensembl
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17696759
response to mechanical stimulus
Source: UniProtKB
Inferred from expression patternⁱ
- 21723865
Wnt signaling pathway Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Heparin-binding
Biological process	Wnt signaling pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists
SIGNORⁱ	Q9BQB4

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sclerostin
Gene namesⁱ	Name:SOST ORF Names:UNQ2976/PRO7455/PRO7476
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000167941.2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13771 SOST
MIMⁱ	605740 gene
neXtProtⁱ	NX_Q9BQB4

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Sclerosteosis 1 (SOST1)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive sclerosing bone dysplasia characterized by a generalized hyperostosis and sclerosis leading to a markedly thickened skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_063982	167	C → R in SOST1; leads to retention of the mutant protein in the endoplasmic reticulum; leads to a complete loss of function of the protein. 1 Publication		1

Van Buchem disease (VBCH)1 Publication

The disease is caused by mutations affecting the gene represented in this entry. A 52 kb deletion downstream of SOST results in SOST transcription suppression causing van Buchem disease.

Disease descriptionVBCH is an autosomal recessive sclerosing bone dysplasia characterized by endosteal hyperostosis of the mandible, skull, ribs, clavicles, and diaphyses of the long bones. Affected patients present a symmetrically increased thickness of bones, most frequently found as an enlarged jawbone, but also an enlargement of the skull, ribs, diaphysis of long bones, as well as tubular bones of hands and feet. The clinical consequence of increased thickness of the skull include facial nerve palsy causing hearing loss, visual problems, neurological pain, and, very rarely, blindness as a consequence of optic atrophy. Serum alkaline phosphatase levels are elevated.

Craniodiaphyseal dysplasia autosomal dominant (CDD)1 Publication

The disease is caused by mutations affecting the gene represented in this entry. Heterozygous mutations located in the secretion signal of the SOST gene prevent sclerostin secretion and can be responsible for craniodiaphyseal dysplasia.

Disease descriptionA severe bone dysplasia characterized by massive generalized hyperostosis and sclerosis, especially involving the skull and facial bones. The sclerosis is so severe that the resulting facial distortion is referred to as 'leontiasis ossea' (leonine faces) and the bone deposition results in progressive stenosis of craniofacial foramina. Respiratory obstruction due to choanal stenosis compromises the clinical outcomes of affected patients.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	50964
GeneReviewsⁱ	SOST
MalaCards human disease database More...MalaCardsⁱ	SOST
MIMⁱ	122860 phenotype 239100 phenotype 269500 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000167941
Orphanetⁱ	1513 Craniodiaphyseal dysplasia 3416 Hyperostosis corticalis generalisata 3152 Sclerosteosis
PharmGKBⁱ	PA37809

Chemistry databases

ChEMBLⁱ	CHEMBL3580487

ChEMBLⁱ

CHEMBL3580487

Polymorphism and mutation databases

BioMutaⁱ	SOST
DMDMⁱ	20140220

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	1 PublicationAdd BLAST		23
ChainⁱPRO_0000033177	24 – 213	SclerostinAdd BLAST		190

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	53	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	80 ↔ 134	1 Publication
Disulfide bondⁱ	94 ↔ 148	1 Publication
Disulfide bondⁱ	105 ↔ 165	1 Publication
Disulfide bondⁱ	109 ↔ 167	1 Publication
Glycosylationⁱ	175	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q9BQB4
PeptideAtlas More...PeptideAtlasⁱ	Q9BQB4
PRIDEⁱ	Q9BQB4
ProteomicsDBⁱ	78650 78651 [Q9BQB4-2]

Expressionⁱ

Tissue specificityⁱ

Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000167941 Expressed in 46 organ(s), highest expression level in metanephros
CleanExⁱ	HS_SOST
Genevisibleⁱ	Q9BQB4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025660

HPAⁱ

CAB025660

Interactionⁱ

Subunit structureⁱ

Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
LRP4	O75096	4	EBI-5746563,EBI-310873
LRP5	O75197	2	EBI-5746563,EBI-2466421
LRP6	O75581	6	EBI-5746563,EBI-910915

GO - Molecular functionⁱ

transcription factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17696759

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119186, 25 interactors
Database of interacting proteins More...DIPⁱ	DIP-59407N
ELMⁱ	Q9BQB4
IntActⁱ	Q9BQB4, 101 interactors
STRINGⁱ	9606.ENSP00000301691

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	78 – 80	Combined sources	3
Beta strandⁱ	82 – 87	Combined sources	6
Beta strandⁱ	95 – 98	Combined sources	4
Beta strandⁱ	100 – 105	Combined sources	6
Beta strandⁱ	139 – 147	Combined sources	9
Beta strandⁱ	155 – 162	Combined sources	8

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00926
ProteinModelPortalⁱ	Q9BQB4
SMRⁱ	Q9BQB4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q9BQB4

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	82 – 172	CTCKAdd BLAST		91

Sequence similaritiesⁱ

Belongs to the sclerostin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IVV4 Eukaryota ENOG4111KFN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014900
HOGENOMⁱ	HOG000252934
HOVERGENⁱ	HBG003729
InParanoidⁱ	Q9BQB4
KEGG Orthology (KO) More...KOⁱ	K16834
OMAⁱ	DVSEYSC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G13DX
PhylomeDBⁱ	Q9BQB4
TreeFamⁱ	TF353019

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR006207 Cys_knot_C IPR029034 Cystine-knot_cytokine IPR008835 Sclerostin/SOSTDC1 IPR015665 SOST
PANTHERⁱ	PTHR14903 PTHR14903, 1 hit PTHR14903:SF4 PTHR14903:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05463 Sclerostin, 1 hit
SMARTⁱ	View protein in SMART SM00041 CT, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9BQB4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQLPLALCLV CLLVHTAFRV VEGQGWQAFK NDATEIIPEL GEYPEPPPEL 
        60         70         80         90        100
ENNKTMNRAE NGGRPPHHPF ETKDVSEYSC RELHFTRYVT DGPCRSAKPV 
       110        120        130        140        150
TELVCSGQCG PARLLPNAIG RGKWWRPSGP DFRCIPDRYR AQRVQLLCPG 
       160        170        180        190        200
GEAPRARKVR LVASCKCKRL TRFHNQSELK DFGTEAARPQ KGRKPRPRAR 
       210 
SAKANQAELE NAY

Length:213

Mass (Da):24,031

Last modified:June 1, 2001 - v1

Checksum:ⁱ30DBD55CE73D5BB2

GO

Isoform 2 (identifier: Q9BQB4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
64-73: RPPHHPFETK → WPGGRPPSRAPLST

« Hide

        10         20         30         40         50
MQLPLALCLV CLLVHTAFRV VEGQGWQAFK NDATEIIPEL GEYPEPPPEL 
        60         70         80         90        100
ENNKTMNRAE NGGWPGGRPP SRAPLSTDVS EYSCRELHFT RYVTDGPCRS 
       110        120        130        140        150
AKPVTELVCS GQCGPARLLP NAIGRGKWWR PSGPDFRCIP DRYRAQRVQL 
       160        170        180        190        200
LCPGGEAPRA RKVRLVASCK CKRLTRFHNQ SELKDFGTEA ARPQKGRKPR 
       210 
PRARSAKANQ AELENAY

Note: No experimental confirmation available.

Show »

Length:217

Mass (Da):24,264

Checksum:ⁱ652294D9DE5DB402

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_065766	21	V → L in CDD; affects protein secretion. 1 Publication	1
Natural variantⁱVAR_065767	21	V → M in CDD; de novo mutation; affects protein secretion. 1 PublicationCorresponds to variant dbSNP:rs387907169EnsemblClinVar.	1
Natural variantⁱVAR_063982	167	C → R in SOST1; leads to retention of the mutant protein in the endoplasmic reticulum; leads to a complete loss of function of the protein. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_010189	64 – 73	RPPHHPFETK → WPGGRPPSRAPLST in isoform 2. 1 Publication		10

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF331844 mRNA Translation: AAK16158.1 AF326736 Genomic DNA Translation: AAK13451.1 AF326739 mRNA Translation: AAK13454.1 AY358203 mRNA Translation: AAQ88570.1 AY358627 mRNA Translation: AAQ88990.1 AC055813 Genomic DNA No translation available. BC101086 mRNA Translation: AAI01087.1 BC101087 mRNA Translation: AAI01088.1 BC101088 mRNA Translation: AAI01089.1 BC101089 mRNA Translation: AAI01090.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11468.1 [Q9BQB4-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_079513.1, NM_025237.2 [Q9BQB4-1]
UniGeneⁱ	Hs.349204

Genome annotation databases

Ensemblⁱ	ENST00000301691; ENSP00000301691; ENSG00000167941 [Q9BQB4-1]
GeneIDⁱ	50964
KEGGⁱ	hsa:50964
UCSC genome browser More...UCSCⁱ	uc002iec.1 human [Q9BQB4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q9BQB4	Sclerostin		CHLAE		213	UniRef90_Q9BQB4
Sclerostin		RAT		213
Sclerostin		BOVIN		212
Sclerostin		PAPAN		258
Sclerostin		MACMU		213
+78

Protein	Similar proteins		Species	Score	Length	Source
Q9BQB4	Sclerostin		RAT		213	UniRef50_Q9BQB4
Sclerostin		CHLAE		213
Sclerostin		BOVIN		212
Sclerostin	)	MOUSE		211
Sclerostin		PAPAN		258
+116

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF331844 mRNA Translation: AAK16158.1 AF326736 Genomic DNA Translation: AAK13451.1 AF326739 mRNA Translation: AAK13454.1 AY358203 mRNA Translation: AAQ88570.1 AY358627 mRNA Translation: AAQ88990.1 AC055813 Genomic DNA No translation available. BC101086 mRNA Translation: AAI01087.1 BC101087 mRNA Translation: AAI01088.1 BC101088 mRNA Translation: AAI01089.1 BC101089 mRNA Translation: AAI01090.1
CCDSⁱ	CCDS11468.1 [Q9BQB4-1]
RefSeqⁱ	NP_079513.1, NM_025237.2 [Q9BQB4-1]
UniGeneⁱ	Hs.349204

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2K8P	NMR	-	A	25-213	[»]
	3SOV	X-ray	1.27	Z	115-121	[»]
DisProtⁱ	DP00926
ProteinModelPortalⁱ	Q9BQB4
SMRⁱ	Q9BQB4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119186, 25 interactors
DIPⁱ	DIP-59407N
ELMⁱ	Q9BQB4
IntActⁱ	Q9BQB4, 101 interactors
STRINGⁱ	9606.ENSP00000301691

Chemistry databases

ChEMBLⁱ	CHEMBL3580487

ChEMBLⁱ

CHEMBL3580487

Polymorphism and mutation databases

BioMutaⁱ	SOST
DMDMⁱ	20140220

Proteomic databases

PaxDbⁱ	Q9BQB4
PeptideAtlasⁱ	Q9BQB4
PRIDEⁱ	Q9BQB4
ProteomicsDBⁱ	78650 78651 [Q9BQB4-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000301691; ENSP00000301691; ENSG00000167941 [Q9BQB4-1]
GeneIDⁱ	50964
KEGGⁱ	hsa:50964
UCSCⁱ	uc002iec.1 human [Q9BQB4-1]

Organism-specific databases

CTDⁱ	50964
DisGeNETⁱ	50964
EuPathDBⁱ	HostDB:ENSG00000167941.2
GeneCardsⁱ	SOST
GeneReviewsⁱ	SOST
HGNCⁱ	HGNC:13771 SOST
HPAⁱ	CAB025660
MalaCardsⁱ	SOST
MIMⁱ	122860 phenotype 239100 phenotype 269500 phenotype 605740 gene
neXtProtⁱ	NX_Q9BQB4
OpenTargetsⁱ	ENSG00000167941
Orphanetⁱ	1513 Craniodiaphyseal dysplasia 3416 Hyperostosis corticalis generalisata 3152 Sclerosteosis
PharmGKBⁱ	PA37809
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IVV4 Eukaryota ENOG4111KFN LUCA
GeneTreeⁱ	ENSGT00390000014900
HOGENOMⁱ	HOG000252934
HOVERGENⁱ	HBG003729
InParanoidⁱ	Q9BQB4
KOⁱ	K16834
OMAⁱ	DVSEYSC
OrthoDBⁱ	EOG091G13DX
PhylomeDBⁱ	Q9BQB4
TreeFamⁱ	TF353019

Enzyme and pathway databases

Reactomeⁱ	R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists
SIGNORⁱ	Q9BQB4

Miscellaneous databases

EvolutionaryTraceⁱ	Q9BQB4
GeneWikiⁱ	Sclerostin SOST
GenomeRNAiⁱ	50964
Protein Ontology More...PROⁱ	PR:Q9BQB4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000167941 Expressed in 46 organ(s), highest expression level in metanephros
CleanExⁱ	HS_SOST
Genevisibleⁱ	Q9BQB4 HS

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR006207 Cys_knot_C IPR029034 Cystine-knot_cytokine IPR008835 Sclerostin/SOSTDC1 IPR015665 SOST
PANTHERⁱ	PTHR14903 PTHR14903, 1 hit PTHR14903:SF4 PTHR14903:SF4, 1 hit
Pfamⁱ	View protein in Pfam PF05463 Sclerostin, 1 hit
SMARTⁱ	View protein in SMART SM00041 CT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SOST_HUMAN
Accessionⁱ	Q9BQB4Primary (citable) accession number: Q9BQB4 Secondary accession number(s): Q495N9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
	Last sequence update:	June 1, 2001
	Last modified:	September 12, 2018
	This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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Annotation systems

Supporting data

UniProtKB - Q9BQB4 (SOST_HUMAN)

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Sclerostin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Golgi apparatus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ