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Entry version 126 (12 Aug 2020)
Sequence version 1 (01 Jun 2001)
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Protein

Cytochrome b-245 chaperone 1

Gene

CYBC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer. Controls the phagocyte respiratory burst and is essential for innate immunity.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processImmunity, Innate immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9BQA9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome b-245 chaperone 1Curated
Alternative name(s):
Essential for reactive oxygen species proteinBy similarity
Short name:
ErosBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYBC1Imported
Synonyms:C17orf62Imported, EROSBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000178927.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28672, CYBC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618334, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BQA9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 42HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79415

MalaCards human disease database

More...
MalaCardsi
CYBC1

Open Targets

More...
OpenTargetsi
ENSG00000178927

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
379, Chronic granulomatous disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672245

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BQA9, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C17orf62

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74732825

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002814181 – 187Cytochrome b-245 chaperone 1Add BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei168PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BQA9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BQA9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BQA9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BQA9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BQA9

PeptideAtlas

More...
PeptideAtlasi
Q9BQA9

PRoteomics IDEntifications database

More...
PRIDEi
Q9BQA9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
15206
78649 [Q9BQA9-1]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9BQA9-1 [Q9BQA9-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BQA9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BQA9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in macrophages, neutrophils and monocytes.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In macrophages, expression is induced after treatment with IFNG or a combination of IFNG and Salmonella Tiphimurium.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000178927, Expressed in blood and 223 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BQA9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BQA9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000178927, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CYBB; CYBC1 may act as a chaperone stabilizing Cytochrome b-245 heterodimer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9BQA9
With#Exp.IntAct
ADIPOQ [Q15848]3EBI-2680384,EBI-10827839
AGTRAP - isoform 2 [Q6RW13-2]3EBI-2680384,EBI-11522760
AHNAK2 - isoform 3 [Q8IVF2-3]3EBI-2680384,EBI-12078468
AIG1 - isoform 2 [Q9NVV5-2]3EBI-2680384,EBI-11957045
APCDD1L [Q8NCL9]3EBI-2680384,EBI-12904424
APOA2 [P02652]3EBI-2680384,EBI-1171525
APOL2 [Q9BQE5]3EBI-2680384,EBI-4290634
AQP10 [Q96PS8]3EBI-2680384,EBI-12820279
AQP6 [Q13520]3EBI-2680384,EBI-13059134
AQP8 [O94778]3EBI-2680384,EBI-19124986
BET1 [O15155]3EBI-2680384,EBI-749204
C4orf3 - isoform 2 [Q8WVX3-2]3EBI-2680384,EBI-12003442
CCDC155 [Q8N6L0]6EBI-2680384,EBI-749265
CD53 [P19397]3EBI-2680384,EBI-6657396
CISD2 [Q8N5K1]3EBI-2680384,EBI-1045797
CLDN7 [O95471]3EBI-2680384,EBI-740744
CLN6 [Q9NWW5]3EBI-2680384,EBI-6165897
COQ9 [O75208]3EBI-2680384,EBI-724524
CPLX4 [Q7Z7G2]3EBI-2680384,EBI-18013275
CYBB [P04839]3EBI-2680384,EBI-6253630
ERGIC3 [Q9Y282]3EBI-2680384,EBI-781551
ETS1 [P14921]3EBI-2680384,EBI-913209
FAM209A [Q5JX71]3EBI-2680384,EBI-18304435
GJA8 [P48165]3EBI-2680384,EBI-17458373
GPR151 [Q8TDV0]3EBI-2680384,EBI-11955647
GPR152 [Q8TDT2]3EBI-2680384,EBI-13345167
HSD17B11 [Q8NBQ5]3EBI-2680384,EBI-1052304
HSD17B13 [Q7Z5P4]3EBI-2680384,EBI-18053395
INSIG2 [Q9Y5U4]3EBI-2680384,EBI-8503746
JAGN1 [Q8N5M9]3EBI-2680384,EBI-10266796
KIR2DL3 [P43628]3EBI-2680384,EBI-8632435
LAT - isoform 2 [O43561-2]3EBI-2680384,EBI-8070286
LXN [Q9BS40]3EBI-2680384,EBI-1044504
MFF - isoform 5 [Q9GZY8-5]3EBI-2680384,EBI-11956541
MFSD14B [Q5SR56]3EBI-2680384,EBI-373355
MGST3 [O14880]3EBI-2680384,EBI-724754
MTIF3 [Q9H2K0]3EBI-2680384,EBI-3923617
NINJ2 [Q9NZG7]3EBI-2680384,EBI-10317425
NOX3 [Q9HBY0]3EBI-2680384,EBI-13069010
NRAC [Q8N912]3EBI-2680384,EBI-12051377
NRM [Q8IXM6]3EBI-2680384,EBI-10262547
P2RX1 [P51575]5EBI-2680384,EBI-11599725
PDZK1IP1 [Q13113]3EBI-2680384,EBI-716063
PEX12 [O00623]3EBI-2680384,EBI-594836
PLIN3 [O60664]3EBI-2680384,EBI-725795
PLP1 - isoform DM-20 [P60201-2]3EBI-2680384,EBI-12188331
PLP2 [Q04941]3EBI-2680384,EBI-608347
SCD [O00767]3EBI-2680384,EBI-2684237
SHISA4 [Q96DD7]3EBI-2680384,EBI-18035902
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-2680384,EBI-17295964
SPN [P16150]3EBI-2680384,EBI-10049055
SSMEM1 [Q8WWF3]3EBI-2680384,EBI-17280858
STX2 - isoform 1 [P32856-2]3EBI-2680384,EBI-11956649
THBD [P07204]3EBI-2680384,EBI-941422
TM4SF19 [Q96DZ7]3EBI-2680384,EBI-6448756
TMEM128 - isoform 2 [Q5BJH2-2]3EBI-2680384,EBI-10694905
TMEM80 [Q96HE8]3EBI-2680384,EBI-11742770
TMPRSS2 - isoform 2 [O15393-2]3EBI-2680384,EBI-12345267
TMX2 [Q9Y320]3EBI-2680384,EBI-6447886
TRAM1L1 [Q8N609]3EBI-2680384,EBI-11996766
TSPAN12 [O95859]3EBI-2680384,EBI-2466403

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
122665, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BQA9, 66 interactors

Molecular INTeraction database

More...
MINTi
Q9BQA9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000388909

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BQA9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BQA9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CYBC1 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S06T, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000004691

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_100734_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BQA9

Identification of Orthologs from Complete Genome Data

More...
OMAi
IRSWSLC

Database of Orthologous Groups

More...
OrthoDBi
1293240at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BQA9

TreeFam database of animal gene trees

More...
TreeFami
TF332389

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027846, Cybc1

The PANTHER Classification System

More...
PANTHERi
PTHR31837, PTHR31837, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15169, DUF4564, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BQA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYLQVETRTS SRLHLKRAPG IRSWSLLVGI LSIGLAAAYY SGDSLGWKLF
60 70 80 90 100
YVTGCLFVAV QNLEDWEEAI FDKSTGKVVL KTFSLYKKLL TLFRAGHDQV
110 120 130 140 150
VVLLHDVRDV SVEEEKVRYF GKGYMVVLRL ATGFSHPLTQ SAVMGHRSDV
160 170 180
EAIAKLITSF LELHCLESPT ELSQSSDSEA GDPASQS
Length:187
Mass (Da):20,774
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i363321B2FC5D36A7
GO
Isoform 2 (identifier: Q9BQA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-42: Missing.

Show »
Length:173
Mass (Da):19,436
Checksum:iA6E18600EE5C4C59
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KS78J3KS78_HUMAN
Essential for reactive oxygen speci...
CYBC1 C17orf62, hCG_30383
80Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSJ5J3KSJ5_HUMAN
Essential for reactive oxygen speci...
CYBC1
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKS6J3QKS6_HUMAN
Essential for reactive oxygen speci...
CYBC1
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLB7J3QLB7_HUMAN
Essential for reactive oxygen speci...
CYBC1
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRG5J3QRG5_HUMAN
Essential for reactive oxygen speci...
CYBC1
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRZ2J3QRZ2_HUMAN
Essential for reactive oxygen speci...
CYBC1
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSB6J3KSB6_HUMAN
Essential for reactive oxygen speci...
CYBC1
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y2X1H0Y2X1_HUMAN
Essential for reactive oxygen speci...
CYBC1 C17orf62, hCG_30383
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQQ4J3QQQ4_HUMAN
Essential for reactive oxygen speci...
CYBC1
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTI1J3KTI1_HUMAN
Essential for reactive oxygen speci...
CYBC1 C17orf62, hCG_30383
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB70818 differs from that shown. Wrong choice of frame.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04633529 – 42Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK054876 mRNA Translation: BAB70818.1 Sequence problems.
AC132938 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89786.1
BC004171 mRNA Translation: AAH04171.1
BC003595 mRNA Translation: AAH03595.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32776.1 [Q9BQA9-1]
CCDS45817.1 [Q9BQA9-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001028218.1, NM_001033046.3 [Q9BQA9-1]
NP_001093877.1, NM_001100407.2 [Q9BQA9-1]
NP_001093878.1, NM_001100408.2 [Q9BQA9-2]
NP_001180582.1, NM_001193653.1 [Q9BQA9-1]
NP_001180583.1, NM_001193654.1 [Q9BQA9-1]
NP_001180584.1, NM_001193655.1 [Q9BQA9-1]
NP_001180586.1, NM_001193657.1 [Q9BQA9-1]
XP_006722356.1, XM_006722293.2 [Q9BQA9-2]
XP_016880563.1, XM_017025074.1 [Q9BQA9-1]
XP_016880564.1, XM_017025075.1
XP_016880565.1, XM_017025076.1 [Q9BQA9-1]
XP_016880566.1, XM_017025077.1 [Q9BQA9-1]
XP_016880567.1, XM_017025078.1 [Q9BQA9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000306645; ENSP00000307765; ENSG00000178927 [Q9BQA9-1]
ENST00000434650; ENSP00000401626; ENSG00000178927 [Q9BQA9-2]
ENST00000437807; ENSP00000388909; ENSG00000178927 [Q9BQA9-1]
ENST00000577436; ENSP00000464633; ENSG00000178927 [Q9BQA9-2]
ENST00000577732; ENSP00000463228; ENSG00000178927 [Q9BQA9-1]
ENST00000578919; ENSP00000464080; ENSG00000178927 [Q9BQA9-1]
ENST00000585064; ENSP00000463846; ENSG00000178927 [Q9BQA9-1]
ENST00000585080; ENSP00000462529; ENSG00000178927 [Q9BQA9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79415

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79415

UCSC genome browser

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UCSCi
uc002kfa.5, human [Q9BQA9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054876 mRNA Translation: BAB70818.1 Sequence problems.
AC132938 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89786.1
BC004171 mRNA Translation: AAH04171.1
BC003595 mRNA Translation: AAH03595.1
CCDSiCCDS32776.1 [Q9BQA9-1]
CCDS45817.1 [Q9BQA9-2]
RefSeqiNP_001028218.1, NM_001033046.3 [Q9BQA9-1]
NP_001093877.1, NM_001100407.2 [Q9BQA9-1]
NP_001093878.1, NM_001100408.2 [Q9BQA9-2]
NP_001180582.1, NM_001193653.1 [Q9BQA9-1]
NP_001180583.1, NM_001193654.1 [Q9BQA9-1]
NP_001180584.1, NM_001193655.1 [Q9BQA9-1]
NP_001180586.1, NM_001193657.1 [Q9BQA9-1]
XP_006722356.1, XM_006722293.2 [Q9BQA9-2]
XP_016880563.1, XM_017025074.1 [Q9BQA9-1]
XP_016880564.1, XM_017025075.1
XP_016880565.1, XM_017025076.1 [Q9BQA9-1]
XP_016880566.1, XM_017025077.1 [Q9BQA9-1]
XP_016880567.1, XM_017025078.1 [Q9BQA9-2]

3D structure databases

SMRiQ9BQA9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122665, 10 interactors
IntActiQ9BQA9, 66 interactors
MINTiQ9BQA9
STRINGi9606.ENSP00000388909

PTM databases

iPTMnetiQ9BQA9
PhosphoSitePlusiQ9BQA9

Polymorphism and mutation databases

BioMutaiC17orf62
DMDMi74732825

Proteomic databases

EPDiQ9BQA9
jPOSTiQ9BQA9
MassIVEiQ9BQA9
MaxQBiQ9BQA9
PaxDbiQ9BQA9
PeptideAtlasiQ9BQA9
PRIDEiQ9BQA9
ProteomicsDBi15206
78649 [Q9BQA9-1]
TopDownProteomicsiQ9BQA9-1 [Q9BQA9-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
53358, 120 antibodies

The DNASU plasmid repository

More...
DNASUi
79415

Genome annotation databases

EnsembliENST00000306645; ENSP00000307765; ENSG00000178927 [Q9BQA9-1]
ENST00000434650; ENSP00000401626; ENSG00000178927 [Q9BQA9-2]
ENST00000437807; ENSP00000388909; ENSG00000178927 [Q9BQA9-1]
ENST00000577436; ENSP00000464633; ENSG00000178927 [Q9BQA9-2]
ENST00000577732; ENSP00000463228; ENSG00000178927 [Q9BQA9-1]
ENST00000578919; ENSP00000464080; ENSG00000178927 [Q9BQA9-1]
ENST00000585064; ENSP00000463846; ENSG00000178927 [Q9BQA9-1]
ENST00000585080; ENSP00000462529; ENSG00000178927 [Q9BQA9-1]
GeneIDi79415
KEGGihsa:79415
UCSCiuc002kfa.5, human [Q9BQA9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79415
DisGeNETi79415
EuPathDBiHostDB:ENSG00000178927.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CYBC1
HGNCiHGNC:28672, CYBC1
HPAiENSG00000178927, Low tissue specificity
MalaCardsiCYBC1
MIMi618334, gene
neXtProtiNX_Q9BQA9
OpenTargetsiENSG00000178927
Orphaneti379, Chronic granulomatous disease
PharmGKBiPA142672245

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S06T, Eukaryota
GeneTreeiENSGT00390000004691
HOGENOMiCLU_100734_0_0_1
InParanoidiQ9BQA9
OMAiIRSWSLC
OrthoDBi1293240at2759
PhylomeDBiQ9BQA9
TreeFamiTF332389

Enzyme and pathway databases

PathwayCommonsiQ9BQA9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
79415, 7 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C17orf62, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79415
PharosiQ9BQA9, Tdark

Protein Ontology

More...
PROi
PR:Q9BQA9
RNActiQ9BQA9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000178927, Expressed in blood and 223 other tissues
ExpressionAtlasiQ9BQA9, baseline and differential
GenevisibleiQ9BQA9, HS

Family and domain databases

InterProiView protein in InterPro
IPR027846, Cybc1
PANTHERiPTHR31837, PTHR31837, 1 hit
PfamiView protein in Pfam
PF15169, DUF4564, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCYBC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BQA9
Secondary accession number(s): E1B6X3, Q96NR1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2001
Last modified: August 12, 2020
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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