HINFP

Functionⁱ

Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.7 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	15 – 39	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	129 – 153	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	169 – 193	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	199 – 221	C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	229 – 251	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	255 – 278	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	284 – 306	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	312 – 337	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	26
Zinc fingerⁱ	345 – 368	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- Ref.13
  "The histone gene cell cycle regulator HiNF-P is a unique zinc finger transcription factor with a novel conserved auxiliary DNA-binding motif."
  Medina R., Buck T., Zaidi S.K., Miele-Chamberland A., Lian J.B., Stein J.L., van Wijnen A.J., Stein G.S.
  Biochemistry 47:11415-11423(2008) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, SUBCELLULAR LOCATION, REGION, MUTAGENESIS OF TYR-381.
- "The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes."
  Aziz F., van Wijnen A.J., Vaughan P.S., Wu S., Shakoori A.R., Lian J.B., Soprano K.J., Stein J.L., Stein G.S.
  Mol. Biol. Rep. 25:1-12(1998) [PubMed] [Europe PMC] [Abstract]
DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from direct assayⁱ
- Ref.13
  "The histone gene cell cycle regulator HiNF-P is a unique zinc finger transcription factor with a novel conserved auxiliary DNA-binding motif."
  Medina R., Buck T., Zaidi S.K., Miele-Chamberland A., Lian J.B., Stein J.L., van Wijnen A.J., Stein G.S.
  Biochemistry 47:11415-11423(2008) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, SUBCELLULAR LOCATION, REGION, MUTAGENESIS OF TYR-381.
- "CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P."
  Mitra P., Ghule P.N., van der Deen M., Medina R., Xie R.L., Holmes W.F., Ye X., Nakayama K.I., Harper J.W., Stein J.L., Stein G.S., van Wijnen A.J.
  J Cell Physiol 219:438-448(2009) [PubMed] [Europe PMC] [Abstract]
DNA-binding transcription factor activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- "The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes."
  Aziz F., van Wijnen A.J., Vaughan P.S., Wu S., Shakoori A.R., Lian J.B., Soprano K.J., Stein J.L., Stein G.S.
  Mol. Biol. Rep. 25:1-12(1998) [PubMed] [Europe PMC] [Abstract]
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- Ref.6
  "Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2."
  Sekimata M., Takahashi A., Murakami-Sekimata A., Homma Y.
  J. Biol. Chem. 276:42632-42638(2001) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH MBD2.
histone binding
Source: UniProtKB
Inferred from physical interactionⁱ
- Ref.7
  "Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase."
  Mitra P., Xie R.-L., Medina R., Hovhannisyan H., Zaidi S.K., Wei Y., Harper J.W., Stein J.L., van Wijnen A.J., Stein G.S.
  Mol. Cell. Biol. 23:8110-8123(2003) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
- "The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes."
  Aziz F., van Wijnen A.J., Vaughan P.S., Wu S., Shakoori A.R., Lian J.B., Soprano K.J., Stein J.L., Stein G.S.
  Mol. Biol. Rep. 25:1-12(1998) [PubMed] [Europe PMC] [Abstract]
metal ion binding Source: UniProtKB-KW
RNA polymerase II cis-regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
RNA polymerase II transcription regulatory region sequence-specific DNA binding
Source: ARUK-UCL
Inferred from direct assayⁱ
- Ref.13
  "The histone gene cell cycle regulator HiNF-P is a unique zinc finger transcription factor with a novel conserved auxiliary DNA-binding motif."
  Medina R., Buck T., Zaidi S.K., Miele-Chamberland A., Lian J.B., Stein J.L., van Wijnen A.J., Stein G.S.
  Biochemistry 47:11415-11423(2008) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, SUBCELLULAR LOCATION, REGION, MUTAGENESIS OF TYR-381.
transcription regulatory region sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- Ref.8
  "Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF."
  Sekimata M., Homma Y.
  Nucleic Acids Res. 32:590-597(2004) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION.
- "Regulation of Rb gene expression by an MBD2-interacting zinc finger protein MIZF during myogenic differentiation."
  Sekimata M., Homma Y.
  Biochem Biophys Res Commun 325:653-659(2004) [PubMed] [Europe PMC] [Abstract]
- Ref.9
  "HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition."
  Miele A., Braastad C.D., Holmes W.F., Mitra P., Medina R., Xie R.-L., Zaidi S.K., Ye X., Wei Y., Harper J.W., van Wijnen A.J., Stein J.L., Stein G.S.
  Mol. Cell. Biol. 25:6140-6153(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, INTERACTION WITH NPAT, SUBCELLULAR LOCATION.
- Ref.11
  "The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes."
  Medina R., van der Deen M., Miele-Chamberland A., Xie R.-L., van Wijnen A.J., Stein J.L., Stein G.S.
  Cancer Res. 67:10334-10342(2007) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION.

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

PathwayCommonsⁱ	Q9BQA5
SignaLinkⁱ	Q9BQA5

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Histone H4 transcription factor Alternative name(s): Histone nuclear factor P Short name: HiNF-P MBD2-interacting zinc finger protein Methyl-CpG-binding protein 2-interacting zinc finger protein
Gene namesⁱ	Name:HINFP Synonyms:MIZF, ZNF743
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17850, HINFP
MIMⁱ	607099, gene
neXtProtⁱ	NX_Q9BQA5
VEuPathDBⁱ	HostDB:ENSG00000172273.12

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	381	Y → A: Abolishes DNA-Binding. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	25988
Open Targets More...OpenTargetsⁱ	ENSG00000172273
PharmGKBⁱ	PA164720597

Miscellaneous databases

Pharosⁱ	Q9BQA5, Tbio

Pharosⁱ

Q9BQA5, Tbio

Genetic variation databases

BioMutaⁱ	HINFP
DMDMⁱ	322510032

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047218	1 – 517	Histone H4 transcription factorAdd BLAST		517

Post-translational modificationⁱ

Ubiquitinated. Ubiquitination may lead to proteasome-mediated degradation.1 Publication

Keywords - PTMⁱ

Ubl conjugation

Proteomic databases

EPDⁱ	Q9BQA5
MassIVEⁱ	Q9BQA5
PaxDbⁱ	Q9BQA5
PeptideAtlas More...PeptideAtlasⁱ	Q9BQA5
PRIDEⁱ	Q9BQA5
ProteomicsDBⁱ	23003 78648 [Q9BQA5-1]

PTM databases

iPTMnetⁱ	Q9BQA5
PhosphoSitePlusⁱ	Q9BQA5

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Highly expressed in brain, heart, skeletal muscle, spleen, kidney, small intestine, placenta and liver.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000172273, Expressed in cerebellar hemisphere and 182 other tissues
ExpressionAtlasⁱ	Q9BQA5, baseline and differential
Genevisibleⁱ	Q9BQA5, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000172273, Low tissue specificity

HPAⁱ

ENSG00000172273, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Binds MBD2 and a histone deacetylase complex.

Interacts with NPAT.

2 Publications

Binary interactionsⁱ

Hide details

Q9BQA5

With	#Exp.	IntAct
MORN3 [Q6PF18]	3	EBI-749065,EBI-9675802
NDUFAB1 [O14561]	3	EBI-749065,EBI-1246261

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	117469, 38 interactors
IntActⁱ	Q9BQA5, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q9BQA5
STRINGⁱ	9606.ENSP00000318085

Miscellaneous databases

RNActⁱ	Q9BQA5, protein

RNActⁱ

Q9BQA5, protein

Structureⁱ

3D structure databases

SMRⁱ	Q9BQA5
ModBaseⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	373 – 517	Interaction with NPAT1 PublicationAdd BLAST		145
Regionⁱ	374 – 407	Required for activation of histone H4 transcription and contributes to DNA-bindingAdd BLAST		34

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	49 – 56	Poly-Glu		8
Compositional biasⁱ	440 – 444	Poly-Glu		5

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	15 – 39	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	129 – 153	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	169 – 193	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	199 – 221	C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	229 – 251	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	255 – 278	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	284 – 306	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	312 – 337	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	26
Zinc fingerⁱ	345 – 368	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3608, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136508
HOGENOMⁱ	CLU_026599_0_0_1
InParanoidⁱ	Q9BQA5
OMAⁱ	HEDGFMR
Database of Orthologous Groups More...OrthoDBⁱ	1318335at2759
PhylomeDBⁱ	Q9BQA5
TreeFamⁱ	TF350923

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096, zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00355, ZnF_C2H2, 10 hits
SUPFAMⁱ	SSF57667, SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9BQA5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPPGKVPRK ENLWLQCEWG SCSFVCSTME KFFEHVTQHL QQHLHGSGEE 
        60         70         80         90        100
EEEEEEDDPL EEEFSCLWQE CGFCSLDSSA DLIRHVYFHC YHTKLKQWGL 
       110        120        130        140        150
QALQSQADLG PCILDFQSRN VIPDIPDHFL CLWEHCENSF DNPEWFYRHV 
       160        170        180        190        200
EAHSLCCEYE AVGKDNPVVL CGWKGCTCTF KDRSKLREHL RSHTQEKVVA 
       210        220        230        240        250
CPTCGGMFAN NTKFLDHIRR QTSLDQQHFQ CSHCSKRFAT ERLLRDHMRN 
       260        270        280        290        300
HVNHYKCPLC DMTCPLPSSL RNHMRFRHSE DRPFKCDCCD YSCKNLIDLQ 
       310        320        330        340        350
KHLDTHSEEP AYRCDFENCT FSARSLCSIK SHYRKVHEGD SEPRYKCHVC 
       360        370        380        390        400
DKCFTRGNNL TVHLRKKHQF KWPSGHPRFR YKEHEDGYMR LQLVRYESVE 
       410        420        430        440        450
LTQQLLRQPQ EGSGLGTSLN ESSLQGIILE TVPGEPGRKE EEEEGKGSEG 
       460        470        480        490        500
TALSASQDNP SSVIHVVNQT NAQGQQEIVY YVLSEAPGEP PPAPEPPSGG 
       510 
IMEKLQGIAE EPEIQMV

Length:517

Mass (Da):59,678

Last modified:February 8, 2011 - v2

Checksum:ⁱ2CE1910737B0B6EB

GO

Isoform 2 (identifier: Q9BQA5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
381-419: YKEHEDGYMR...QEGSGLGTSL → LGHFCIPLPG...CGCSWFATRV
420-517: Missing.

« Hide

        10         20         30         40         50
MPPPGKVPRK ENLWLQCEWG SCSFVCSTME KFFEHVTQHL QQHLHGSGEE 
        60         70         80         90        100
EEEEEEDDPL EEEFSCLWQE CGFCSLDSSA DLIRHVYFHC YHTKLKQWGL 
       110        120        130        140        150
QALQSQADLG PCILDFQSRN VIPDIPDHFL CLWEHCENSF DNPEWFYRHV 
       160        170        180        190        200
EAHSLCCEYE AVGKDNPVVL CGWKGCTCTF KDRSKLREHL RSHTQEKVVA 
       210        220        230        240        250
CPTCGGMFAN NTKFLDHIRR QTSLDQQHFQ CSHCSKRFAT ERLLRDHMRN 
       260        270        280        290        300
HVNHYKCPLC DMTCPLPSSL RNHMRFRHSE DRPFKCDCCD YSCKNLIDLQ 
       310        320        330        340        350
KHLDTHSEEP AYRCDFENCT FSARSLCSIK SHYRKVHEGD SEPRYKCHVC 
       360        370        380        390        400
DKCFTRGNNL TVHLRKKHQF KWPSGHPRFR LGHFCIPLPG FAALYAPTSP 
       410 
GTRNMKMAIC GCSWFATRV

Show »

Length:419

Mass (Da):48,993

Checksum:ⁱ31245BA4887EEC8C

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PL67	E9PL67_HUMAN	Histone H4 transcription factor Histone H4 transcription factor	HINFP	100	Annotation score:
E9PJA3	E9PJA3_HUMAN	Histone H4 transcription factor Histone H4 transcription factor	HINFP	54	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	62	E → G in BAG62976 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_026547	4	P → S1 PublicationCorresponds to variant dbSNP:rs17850972Ensembl.	1
Natural variantⁱVAR_026548	78	S → C1 PublicationCorresponds to variant dbSNP:rs17850974Ensembl.	1
Natural variantⁱVAR_038793	352	K → R. Corresponds to variant dbSNP:rs34118252Ensembl.	1
Natural variantⁱVAR_019424	493	A → V1 PublicationCorresponds to variant dbSNP:rs100803Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_044719	381 – 419	YKEHE…LGTSL → LGHFCIPLPGFAALYAPTSP GTRNMKMAICGCSWFATRV in isoform 2. 1 PublicationAdd BLAST		39
Alternative sequenceⁱVSP_044720	420 – 517	Missing in isoform 2. 1 PublicationAdd BLAST		98

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK056362 mRNA Translation: BAG51688.1 AK301452 mRNA Translation: BAG62976.1 AP002956 Genomic DNA No translation available. AP003391 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67461.1 BC001073 mRNA Translation: AAH01073.1 BC001945 mRNA Translation: AAH01945.1 BC012856 mRNA Translation: AAH12856.1 BC017234 mRNA Translation: AAH17234.1 AL080201 mRNA Translation: CAB45773.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS58188.1 [Q9BQA5-2] CCDS8414.1 [Q9BQA5-1]
PIRⁱ	T12509
NCBI Reference Sequences More...RefSeqⁱ	NP_001230188.1, NM_001243259.1 [Q9BQA5-2] NP_056332.2, NM_015517.4 [Q9BQA5-1] NP_945322.1, NM_198971.2 [Q9BQA5-1] XP_011541047.1, XM_011542745.2

Genome annotation databases

Ensemblⁱ	ENST00000350777; ENSP00000318085; ENSG00000172273 [Q9BQA5-1] ENST00000527410; ENSP00000436815; ENSG00000172273 [Q9BQA5-2]
GeneIDⁱ	25988
KEGGⁱ	hsa:25988
UCSC genome browser More...UCSCⁱ	uc001pvq.4, human [Q9BQA5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BQA5	MBD2-interacting zinc finger, isoform CRA_b		HUMAN		517	UniRef100_Q9BQA5
HINFP isoform 1		PANTR		517
Histone H4 transcription factor		GORGO		517
Histone H4 transcription factor		PANTR		517
Histone H4 transcription factor (Fragment)		HUMAN		100
+2
Q9BQA5-2	HINFP isoform 4		PANTR		419	UniRef100_A0A2J8N2A1

Protein	Similar proteins		Species	Score	Length	Source
Q9BQA5	MBD2-interacting zinc finger, isoform CRA_b		HUMAN		517	UniRef90_Q9BQA5
HINFP isoform 1		PANTR		517
Histone H4 transcription factor		GORGO		517
Uncharacterized protein (Fragment)		GULGU		633
histone H4 transcription factor isoform X1		PUMCO		541
+73
Q9BQA5-2	Histone H4 transcription factor		HORSE		414	UniRef90_A0A5F5Q192
HINFP isoform 4		PANTR		419
HINFP isoform 4		PONAB		419
+9

Protein	Similar proteins		Species	Score	Length	Source
Q9BQA5	Histone H4 transcription factor		BOVIN		516	UniRef50_Q9BQA5
MBD2-interacting zinc finger, isoform CRA_b		HUMAN		517
HINFP isoform 1		PANTR		517
Histone H4 transcription factor		GORGO		517
Uncharacterized protein (Fragment)		GULGU		633
+614
Q9BQA5-2	Histone H4 transcription factor		MOUSE		503	UniRef50_Q8K1K9
histone H4 transcription factor isoform X1		MUSCR		530
Histone H4 transcription factor		RAT		514
histone H4 transcription factor		PERMB		513
histone H4 transcription factor		MESAU		507
+60

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK056362 mRNA Translation: BAG51688.1 AK301452 mRNA Translation: BAG62976.1 AP002956 Genomic DNA No translation available. AP003391 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67461.1 BC001073 mRNA Translation: AAH01073.1 BC001945 mRNA Translation: AAH01945.1 BC012856 mRNA Translation: AAH12856.1 BC017234 mRNA Translation: AAH17234.1 AL080201 mRNA Translation: CAB45773.1
CCDSⁱ	CCDS58188.1 [Q9BQA5-2] CCDS8414.1 [Q9BQA5-1]
PIRⁱ	T12509
RefSeqⁱ	NP_001230188.1, NM_001243259.1 [Q9BQA5-2] NP_056332.2, NM_015517.4 [Q9BQA5-1] NP_945322.1, NM_198971.2 [Q9BQA5-1] XP_011541047.1, XM_011542745.2

3D structure databases

SMRⁱ	Q9BQA5
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	117469, 38 interactors
IntActⁱ	Q9BQA5, 7 interactors
MINTⁱ	Q9BQA5
STRINGⁱ	9606.ENSP00000318085

PTM databases

iPTMnetⁱ	Q9BQA5
PhosphoSitePlusⁱ	Q9BQA5

Genetic variation databases

BioMutaⁱ	HINFP
DMDMⁱ	322510032

Proteomic databases

EPDⁱ	Q9BQA5
MassIVEⁱ	Q9BQA5
PaxDbⁱ	Q9BQA5
PeptideAtlasⁱ	Q9BQA5
PRIDEⁱ	Q9BQA5
ProteomicsDBⁱ	23003 78648 [Q9BQA5-1]

Protocols and materials databases

Antibodypediaⁱ	32617, 189 antibodies
The DNASU plasmid repository More...DNASUⁱ	25988

Genome annotation databases

Ensemblⁱ	ENST00000350777; ENSP00000318085; ENSG00000172273 [Q9BQA5-1] ENST00000527410; ENSP00000436815; ENSG00000172273 [Q9BQA5-2]
GeneIDⁱ	25988
KEGGⁱ	hsa:25988
UCSCⁱ	uc001pvq.4, human [Q9BQA5-1]

Organism-specific databases

CTDⁱ	25988
DisGeNETⁱ	25988
GeneCardsⁱ	HINFP
HGNCⁱ	HGNC:17850, HINFP
HPAⁱ	ENSG00000172273, Low tissue specificity
MIMⁱ	607099, gene
neXtProtⁱ	NX_Q9BQA5
OpenTargetsⁱ	ENSG00000172273
PharmGKBⁱ	PA164720597
VEuPathDBⁱ	HostDB:ENSG00000172273.12
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3608, Eukaryota
GeneTreeⁱ	ENSGT00870000136508
HOGENOMⁱ	CLU_026599_0_0_1
InParanoidⁱ	Q9BQA5
OMAⁱ	HEDGFMR
OrthoDBⁱ	1318335at2759
PhylomeDBⁱ	Q9BQA5
TreeFamⁱ	TF350923

Enzyme and pathway databases

PathwayCommonsⁱ	Q9BQA5
SignaLinkⁱ	Q9BQA5

Miscellaneous databases

BioGRID-ORCSⁱ	25988, 783 hits in 1024 CRISPR screens
ChiTaRSⁱ	HINFP, human
GeneWikiⁱ	MIZF
GenomeRNAiⁱ	25988
Pharosⁱ	Q9BQA5, Tbio
Protein Ontology More...PROⁱ	PR:Q9BQA5
RNActⁱ	Q9BQA5, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000172273, Expressed in cerebellar hemisphere and 182 other tissues
ExpressionAtlasⁱ	Q9BQA5, baseline and differential
Genevisibleⁱ	Q9BQA5, HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096, zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00355, ZnF_C2H2, 10 hits
SUPFAMⁱ	SSF57667, SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HINFP_HUMAN
Accessionⁱ	Q9BQA5Primary (citable) accession number: Q9BQA5 Secondary accession number(s): B3KPH6 , B4DWB4, E9PQF4, Q96E65, Q9Y4M7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	February 8, 2011
	Last modified:	April 7, 2021
	This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9BQA5 (HINFP_HUMAN)

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Histone H4 transcription factor

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Q9BQA5

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Zinc finger

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

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Miscellaneousⁱ

Keywords - Technical termⁱ