UniProtKB - Q9BQA5 (HINFP_HUMAN)
Histone H4 transcription factor
HINFP
Functioni
Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.
7 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 15 – 39 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 129 – 153 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 169 – 193 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 199 – 221 | C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 229 – 251 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 255 – 278 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 284 – 306 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 312 – 337 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 345 – 368 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
- enzyme binding Source: UniProtKB
- histone binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: ARUK-UCL
- transcription cis-regulatory region binding Source: UniProtKB
GO - Biological processi
- anatomical structure development Source: GO_Central
- DNA damage checkpoint signaling Source: UniProtKB
- DNA repair Source: UniProtKB
- establishment of protein localization Source: UniProtKB
- G1/S transition of mitotic cell cycle Source: UniProtKB
- in utero embryonic development Source: UniProtKB
- myoblast differentiation Source: UniProtKB
- negative regulation of gene expression Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: ARUK-UCL
- regulation of gene expression Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription involved in G1/S transition of mitotic cell cycle Source: UniProtKB
- transcription, DNA-templated Source: Ensembl
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9BQA5 |
SignaLinki | Q9BQA5 |
Names & Taxonomyi
Protein namesi | Recommended name: Histone H4 transcription factorAlternative name(s): Histone nuclear factor P Short name: HiNF-P MBD2-interacting zinc finger protein Methyl-CpG-binding protein 2-interacting zinc finger protein |
Gene namesi | Name:HINFP Synonyms:MIZF, ZNF743 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17850, HINFP |
MIMi | 607099, gene |
neXtProti | NX_Q9BQA5 |
VEuPathDBi | HostDB:ENSG00000172273 |
Subcellular locationi
Nucleus
- Nucleus 4 Publications
Note: Associated with discrete nuclear foci.
Nucleus
- Cajal body Source: UniProtKB
- nucleoplasm Source: UniProtKB
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 381 | Y → A: Abolishes DNA-Binding. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 25988 |
OpenTargetsi | ENSG00000172273 |
PharmGKBi | PA164720597 |
Miscellaneous databases
Pharosi | Q9BQA5, Tbio |
Genetic variation databases
BioMutai | HINFP |
DMDMi | 322510032 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047218 | 1 – 517 | Histone H4 transcription factorAdd BLAST | 517 |
Post-translational modificationi
Keywords - PTMi
Ubl conjugationProteomic databases
EPDi | Q9BQA5 |
MassIVEi | Q9BQA5 |
PaxDbi | Q9BQA5 |
PeptideAtlasi | Q9BQA5 |
PRIDEi | Q9BQA5 |
ProteomicsDBi | 23003 78648 [Q9BQA5-1] |
PTM databases
iPTMneti | Q9BQA5 |
PhosphoSitePlusi | Q9BQA5 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000172273, Expressed in cerebellar hemisphere and 182 other tissues |
ExpressionAtlasi | Q9BQA5, baseline and differential |
Genevisiblei | Q9BQA5, HS |
Organism-specific databases
HPAi | ENSG00000172273, Low tissue specificity |
Interactioni
Subunit structurei
Binds MBD2 and a histone deacetylase complex.
Interacts with NPAT.
2 PublicationsBinary interactionsi
GO - Molecular functioni
- enzyme binding Source: UniProtKB
- histone binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 117469, 40 interactors |
IntActi | Q9BQA5, 7 interactors |
MINTi | Q9BQA5 |
STRINGi | 9606.ENSP00000318085 |
Miscellaneous databases
RNActi | Q9BQA5, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q9BQA5 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 373 – 517 | Interaction with NPAT1 PublicationAdd BLAST | 145 | |
Regioni | 374 – 407 | Required for activation of histone H4 transcription and contributes to DNA-bindingAdd BLAST | 34 | |
Regioni | 431 – 460 | DisorderedSequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 434 – 448 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 15 – 39 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 129 – 153 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 169 – 193 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 199 – 221 | C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 229 – 251 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 255 – 278 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 284 – 306 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 312 – 337 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 345 – 368 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG3608, Eukaryota |
GeneTreei | ENSGT00870000136508 |
HOGENOMi | CLU_026599_0_0_1 |
InParanoidi | Q9BQA5 |
OMAi | GERNCLW |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9BQA5 |
TreeFami | TF350923 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPPPGKVPRK ENLWLQCEWG SCSFVCSTME KFFEHVTQHL QQHLHGSGEE
60 70 80 90 100
EEEEEEDDPL EEEFSCLWQE CGFCSLDSSA DLIRHVYFHC YHTKLKQWGL
110 120 130 140 150
QALQSQADLG PCILDFQSRN VIPDIPDHFL CLWEHCENSF DNPEWFYRHV
160 170 180 190 200
EAHSLCCEYE AVGKDNPVVL CGWKGCTCTF KDRSKLREHL RSHTQEKVVA
210 220 230 240 250
CPTCGGMFAN NTKFLDHIRR QTSLDQQHFQ CSHCSKRFAT ERLLRDHMRN
260 270 280 290 300
HVNHYKCPLC DMTCPLPSSL RNHMRFRHSE DRPFKCDCCD YSCKNLIDLQ
310 320 330 340 350
KHLDTHSEEP AYRCDFENCT FSARSLCSIK SHYRKVHEGD SEPRYKCHVC
360 370 380 390 400
DKCFTRGNNL TVHLRKKHQF KWPSGHPRFR YKEHEDGYMR LQLVRYESVE
410 420 430 440 450
LTQQLLRQPQ EGSGLGTSLN ESSLQGIILE TVPGEPGRKE EEEEGKGSEG
460 470 480 490 500
TALSASQDNP SSVIHVVNQT NAQGQQEIVY YVLSEAPGEP PPAPEPPSGG
510
IMEKLQGIAE EPEIQMV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PL67 | E9PL67_HUMAN | Histone H4 transcription factor | HINFP | 100 | Annotation score: | ||
E9PJA3 | E9PJA3_HUMAN | Histone H4 transcription factor | HINFP | 54 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 62 | E → G in BAG62976 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026547 | 4 | P → S1 PublicationCorresponds to variant dbSNP:rs17850972Ensembl. | 1 | |
Natural variantiVAR_026548 | 78 | S → C1 PublicationCorresponds to variant dbSNP:rs17850974Ensembl. | 1 | |
Natural variantiVAR_038793 | 352 | K → R. Corresponds to variant dbSNP:rs34118252Ensembl. | 1 | |
Natural variantiVAR_019424 | 493 | A → V1 PublicationCorresponds to variant dbSNP:rs100803Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044719 | 381 – 419 | YKEHE…LGTSL → LGHFCIPLPGFAALYAPTSP GTRNMKMAICGCSWFATRV in isoform 2. 1 PublicationAdd BLAST | 39 | |
Alternative sequenceiVSP_044720 | 420 – 517 | Missing in isoform 2. 1 PublicationAdd BLAST | 98 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056362 mRNA Translation: BAG51688.1 AK301452 mRNA Translation: BAG62976.1 AP002956 Genomic DNA No translation available. AP003391 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67461.1 BC001073 mRNA Translation: AAH01073.1 BC001945 mRNA Translation: AAH01945.1 BC012856 mRNA Translation: AAH12856.1 BC017234 mRNA Translation: AAH17234.1 AL080201 mRNA Translation: CAB45773.1 |
CCDSi | CCDS58188.1 [Q9BQA5-2] CCDS8414.1 [Q9BQA5-1] |
PIRi | T12509 |
RefSeqi | NP_001230188.1, NM_001243259.1 [Q9BQA5-2] NP_056332.2, NM_015517.4 [Q9BQA5-1] NP_945322.1, NM_198971.2 [Q9BQA5-1] XP_011541047.1, XM_011542745.2 |
Genome annotation databases
Ensembli | ENST00000350777.7; ENSP00000318085.3; ENSG00000172273.13 ENST00000527410.3; ENSP00000436815.1; ENSG00000172273.13 [Q9BQA5-2] |
GeneIDi | 25988 |
KEGGi | hsa:25988 |
MANE-Selecti | ENST00000350777.7; ENSP00000318085.3; NM_198971.3; NP_945322.1 |
UCSCi | uc001pvq.4, human [Q9BQA5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056362 mRNA Translation: BAG51688.1 AK301452 mRNA Translation: BAG62976.1 AP002956 Genomic DNA No translation available. AP003391 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67461.1 BC001073 mRNA Translation: AAH01073.1 BC001945 mRNA Translation: AAH01945.1 BC012856 mRNA Translation: AAH12856.1 BC017234 mRNA Translation: AAH17234.1 AL080201 mRNA Translation: CAB45773.1 |
CCDSi | CCDS58188.1 [Q9BQA5-2] CCDS8414.1 [Q9BQA5-1] |
PIRi | T12509 |
RefSeqi | NP_001230188.1, NM_001243259.1 [Q9BQA5-2] NP_056332.2, NM_015517.4 [Q9BQA5-1] NP_945322.1, NM_198971.2 [Q9BQA5-1] XP_011541047.1, XM_011542745.2 |
3D structure databases
AlphaFoldDBi | Q9BQA5 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 117469, 40 interactors |
IntActi | Q9BQA5, 7 interactors |
MINTi | Q9BQA5 |
STRINGi | 9606.ENSP00000318085 |
PTM databases
iPTMneti | Q9BQA5 |
PhosphoSitePlusi | Q9BQA5 |
Genetic variation databases
BioMutai | HINFP |
DMDMi | 322510032 |
Proteomic databases
EPDi | Q9BQA5 |
MassIVEi | Q9BQA5 |
PaxDbi | Q9BQA5 |
PeptideAtlasi | Q9BQA5 |
PRIDEi | Q9BQA5 |
ProteomicsDBi | 23003 78648 [Q9BQA5-1] |
Protocols and materials databases
Antibodypediai | 32617, 195 antibodies from 25 providers |
DNASUi | 25988 |
Genome annotation databases
Ensembli | ENST00000350777.7; ENSP00000318085.3; ENSG00000172273.13 ENST00000527410.3; ENSP00000436815.1; ENSG00000172273.13 [Q9BQA5-2] |
GeneIDi | 25988 |
KEGGi | hsa:25988 |
MANE-Selecti | ENST00000350777.7; ENSP00000318085.3; NM_198971.3; NP_945322.1 |
UCSCi | uc001pvq.4, human [Q9BQA5-1] |
Organism-specific databases
CTDi | 25988 |
DisGeNETi | 25988 |
GeneCardsi | HINFP |
HGNCi | HGNC:17850, HINFP |
HPAi | ENSG00000172273, Low tissue specificity |
MIMi | 607099, gene |
neXtProti | NX_Q9BQA5 |
OpenTargetsi | ENSG00000172273 |
PharmGKBi | PA164720597 |
VEuPathDBi | HostDB:ENSG00000172273 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3608, Eukaryota |
GeneTreei | ENSGT00870000136508 |
HOGENOMi | CLU_026599_0_0_1 |
InParanoidi | Q9BQA5 |
OMAi | GERNCLW |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9BQA5 |
TreeFami | TF350923 |
Enzyme and pathway databases
PathwayCommonsi | Q9BQA5 |
SignaLinki | Q9BQA5 |
Miscellaneous databases
BioGRID-ORCSi | 25988, 789 hits in 1109 CRISPR screens |
ChiTaRSi | HINFP, human |
GeneWikii | MIZF |
GenomeRNAii | 25988 |
Pharosi | Q9BQA5, Tbio |
PROi | PR:Q9BQA5 |
RNActi | Q9BQA5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172273, Expressed in cerebellar hemisphere and 182 other tissues |
ExpressionAtlasi | Q9BQA5, baseline and differential |
Genevisiblei | Q9BQA5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | HINFP_HUMAN | |
Accessioni | Q9BQA5Primary (citable) accession number: Q9BQA5 Secondary accession number(s): B3KPH6 Q9Y4M7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | February 8, 2011 | |
Last modified: | May 25, 2022 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot