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Entry version 172 (16 Oct 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Methylosome protein 50

Gene

WDR77

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-191859 snRNP Assembly
R-HSA-3214858 RMTs methylate histone arginines

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9BQA1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methylosome protein 50
Short name:
MEP-50
Alternative name(s):
Androgen receptor cofactor p44
WD repeat-containing protein 77
p44/Mep50
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR77
Synonyms:MEP50, WD45
ORF Names:HKMT1069, Nbla10071
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29652 WDR77

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611734 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BQA1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79084

Open Targets

More...
OpenTargetsi
ENSG00000116455

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670581

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BQA1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3137261

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDR77

Domain mapping of disease mutations (DMDM)

More...
DMDMi
32171507

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000510741 – 342Methylosome protein 50Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei5PhosphothreonineCombined sources1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BQA1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BQA1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BQA1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BQA1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BQA1

PeptideAtlas

More...
PeptideAtlasi
Q9BQA1

PRoteomics IDEntifications database

More...
PRIDEi
Q9BQA1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
4753
78647 [Q9BQA1-1]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00012202

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BQA1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BQA1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9BQA1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart, skeletal muscle, spleen, testis, uterus, prostate and thymus. In testis, expressed in germ cells and Leydig cells, but not in peritubular myocytes, nor in Sertoli cells. Expressed in prostate cancers, in seminomas and in Leydig cell tumors.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in Leydig cells during fetal testicular development, especially during the second semester. Germ cells expression is detected as early as 10 weeks of gestation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116455 Expressed in 218 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BQA1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BQA1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA026437
HPA026448
HPA027271

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the methylosome complex composed of PRMT5, WDR77 and CLNS1A (PubMed:21081503, PubMed:18984161).

Found in a complex composed of PRMT5, WDR77 and RIOK1 (PubMed:21081503). RIOK1 and CLNS1A bound directly to PRMT5 at the same binding site, in a mutually exclusive manner, which allows the recruitment of distinct methylation substrates, such as nucleolin/NCL and Sm proteins, respectively (PubMed:21081503).

Found in a complex with the component of the methylosome, PRMT5, CLNS1A, WDR77, PRMT1 and ERH (PubMed:25284789). Directly interacts with PRMT5, as well as with several Sm proteins, including SNRPB and SNRPD2 and, more weakly, SNRPD3 and SNRPE (PubMed:11756452).

Forms a compact hetero-octamer with PRMT5, decorating the outer surface of a PRMT5 tetramer.

Interacts with SUZ12 and histone H2A/HIST2H2AC, but not with histones H2B, H3 nor H4 (PubMed:16712789).

Interacts with CTDP1 and LSM11 (PubMed:12560496, PubMed:16087681).

Interacts with APEX1, AR and NKX3-1 (PubMed:19188445, PubMed:12972618).

Interacts with CHTOP (PubMed:25284789).

10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122532, 288 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-696 Methylosome

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9BQA1

Database of interacting proteins

More...
DIPi
DIP-38172N

Protein interaction database and analysis system

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IntActi
Q9BQA1, 79 interactors

Molecular INTeraction database

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MINTi
Q9BQA1

STRING: functional protein association networks

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STRINGi
9606.ENSP00000235090

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9BQA1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1342
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BQA1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati22 – 75WD 1PROSITE-ProRule annotation1 PublicationAdd BLAST54
Repeati78 – 116WD 2PROSITE-ProRule annotation1 PublicationAdd BLAST39
Repeati123 – 162WD 3PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati165 – 205WD 4PROSITE-ProRule annotation1 PublicationAdd BLAST41
Repeati209 – 250WD 5PROSITE-ProRule annotation1 PublicationAdd BLAST42
Repeati253 – 293WD 6PROSITE-ProRule annotation1 PublicationAdd BLAST41
Repeati295 – 330WD 7PROSITE-ProRule annotation1 PublicationAdd BLAST36

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IP8S Eukaryota
ENOG4111F0R LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010711

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000035094

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BQA1

KEGG Orthology (KO)

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KOi
K13221

Identification of Orthologs from Complete Genome Data

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OMAi
HQVIHHV

Database of Orthologous Groups

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OrthoDBi
774546at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9BQA1

TreeFam database of animal gene trees

More...
TreeFami
TF325967

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00320 WD40, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BQA1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRKETPPPLV PPAAREWNLP PNAPACMERQ LEAARYRSDG ALLLGASSLS
60 70 80 90 100
GRCWAGSLWL FKDPCAAPNE GFCSAGVQTE AGVADLTWVG ERGILVASDS
110 120 130 140 150
GAVELWELDE NETLIVSKFC KYEHDDIVST VSVLSSGTQA VSGSKDICIK
160 170 180 190 200
VWDLAQQVVL SSYRAHAAQV TCVAASPHKD SVFLSCSEDN RILLWDTRCP
210 220 230 240 250
KPASQIGCSA PGYLPTSLAW HPQQSEVFVF GDENGTVSLV DTKSTSCVLS
260 270 280 290 300
SAVHSQCVTG LVFSPHSVPF LASLSEDCSL AVLDSSLSEL FRSQAHRDFV
310 320 330 340
RDATWSPLNH SLLTTVGWDH QVVHHVVPTE PLPAPGPASV TE
Length:342
Mass (Da):36,724
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D355AEC68491ECB
GO
Isoform 2 (identifier: Q9BQA1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-164: Missing.

Note: No experimental confirmation available.
Show »
Length:278
Mass (Da):29,651
Checksum:i1A8FE679CD05CB24
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y711H0Y711_HUMAN
Methylosome protein 50
WDR77
291Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti244S → N in BAD96909 (PubMed:12972618).Curated1
Sequence conflicti313 – 342LTTVG…ASVTE → DLQVLLSRLDLRQKASPP in AAH09411 (PubMed:15489334).CuratedAdd BLAST30

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04290348S → I. Corresponds to variant dbSNP:rs7416672Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056166101 – 164Missing in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF478464 mRNA Translation: AAL79917.1
AK022860 mRNA Translation: BAG51128.1
AK298179 mRNA Translation: BAG60450.1
AK223189 mRNA Translation: BAD96909.1
AY225316 mRNA Translation: AAP79114.1
AB073603 mRNA Translation: BAD38641.1
AL390195 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56493.1
BC001679 mRNA Translation: AAH01679.1
BC006477 mRNA Translation: AAH06477.1
BC009411 mRNA Translation: AAH09411.1
BC011778 mRNA Translation: AAH11778.1
BC016946 mRNA Translation: AAH16946.1
AB074171 mRNA Translation: BAE45736.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS835.1 [Q9BQA1-1]

NCBI Reference Sequences

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RefSeqi
NP_001303991.1, NM_001317062.1
NP_001303992.1, NM_001317063.1
NP_001303993.1, NM_001317064.1 [Q9BQA1-2]
NP_077007.1, NM_024102.3 [Q9BQA1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000235090; ENSP00000235090; ENSG00000116455 [Q9BQA1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79084

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79084

UCSC genome browser

More...
UCSCi
uc001ebb.4 human [Q9BQA1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF478464 mRNA Translation: AAL79917.1
AK022860 mRNA Translation: BAG51128.1
AK298179 mRNA Translation: BAG60450.1
AK223189 mRNA Translation: BAD96909.1
AY225316 mRNA Translation: AAP79114.1
AB073603 mRNA Translation: BAD38641.1
AL390195 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56493.1
BC001679 mRNA Translation: AAH01679.1
BC006477 mRNA Translation: AAH06477.1
BC009411 mRNA Translation: AAH09411.1
BC011778 mRNA Translation: AAH11778.1
BC016946 mRNA Translation: AAH16946.1
AB074171 mRNA Translation: BAE45736.1
CCDSiCCDS835.1 [Q9BQA1-1]
RefSeqiNP_001303991.1, NM_001317062.1
NP_001303992.1, NM_001317063.1
NP_001303993.1, NM_001317064.1 [Q9BQA1-2]
NP_077007.1, NM_024102.3 [Q9BQA1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GQBX-ray2.06B2-342[»]
4X60X-ray2.35B2-342[»]
4X61X-ray2.85B2-342[»]
4X63X-ray3.05B2-342[»]
5C9ZX-ray2.36B2-342[»]
5EMJX-ray2.27B2-342[»]
5EMKX-ray2.52B2-342[»]
5EMLX-ray2.39B2-342[»]
5EMMX-ray2.37B2-342[»]
5FA5X-ray2.34B2-342[»]
6CKCX-ray2.80B2-342[»]
6K1SX-ray2.60B2-342[»]
SMRiQ9BQA1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi122532, 288 interactors
ComplexPortaliCPX-696 Methylosome
CORUMiQ9BQA1
DIPiDIP-38172N
IntActiQ9BQA1, 79 interactors
MINTiQ9BQA1
STRINGi9606.ENSP00000235090

Chemistry databases

BindingDBiQ9BQA1
ChEMBLiCHEMBL3137261

PTM databases

iPTMnetiQ9BQA1
PhosphoSitePlusiQ9BQA1
SwissPalmiQ9BQA1

Polymorphism and mutation databases

BioMutaiWDR77
DMDMi32171507

2D gel databases

REPRODUCTION-2DPAGEiIPI00012202

Proteomic databases

EPDiQ9BQA1
jPOSTiQ9BQA1
MassIVEiQ9BQA1
MaxQBiQ9BQA1
PaxDbiQ9BQA1
PeptideAtlasiQ9BQA1
PRIDEiQ9BQA1
ProteomicsDBi4753
78647 [Q9BQA1-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
79084

Genome annotation databases

EnsembliENST00000235090; ENSP00000235090; ENSG00000116455 [Q9BQA1-1]
GeneIDi79084
KEGGihsa:79084
UCSCiuc001ebb.4 human [Q9BQA1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79084
DisGeNETi79084

GeneCards: human genes, protein and diseases

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GeneCardsi
WDR77
HGNCiHGNC:29652 WDR77
HPAiHPA026437
HPA026448
HPA027271
MIMi611734 gene
neXtProtiNX_Q9BQA1
OpenTargetsiENSG00000116455
PharmGKBiPA142670581

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IP8S Eukaryota
ENOG4111F0R LUCA
GeneTreeiENSGT00390000010711
HOGENOMiHOG000035094
InParanoidiQ9BQA1
KOiK13221
OMAiHQVIHHV
OrthoDBi774546at2759
PhylomeDBiQ9BQA1
TreeFamiTF325967

Enzyme and pathway databases

ReactomeiR-HSA-191859 snRNP Assembly
R-HSA-3214858 RMTs methylate histone arginines
SignaLinkiQ9BQA1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
WDR77 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
WD_repeat-containing_protein_77

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79084
PharosiQ9BQA1

Protein Ontology

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PROi
PR:Q9BQA1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000116455 Expressed in 218 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ9BQA1 baseline and differential
GenevisibleiQ9BQA1 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEP50_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BQA1
Secondary accession number(s): B3KMW6
, B4DP38, Q3LID2, Q53FU2, Q6JZZ5, Q96GK4, Q9BWY3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 1, 2001
Last modified: October 16, 2019
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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