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Protein

Kelch domain-containing protein 3

Gene

KLHDC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in meiotic recombination process.

GO - Molecular functioni

  • chromatin binding Source: UniProtKB

GO - Biological processi

  • IRE1-mediated unfolded protein response Source: Reactome
  • reciprocal meiotic recombination Source: UniProtKB

Keywordsi

Biological processMeiosis

Enzyme and pathway databases

ReactomeiR-HSA-381038 XBP1(S) activates chaperone genes

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 3
Alternative name(s):
Protein Peas
Testis intracellular mediator protein
Gene namesi
Name:KLHDC3
Synonyms:PEAS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124702.17
HGNCiHGNC:20704 KLHDC3
MIMi611248 gene
neXtProtiNX_Q9BQ90

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124702
PharmGKBiPA134892782

Polymorphism and mutation databases

BioMutaiKLHDC3
DMDMi74752233

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002289951 – 382Kelch domain-containing protein 3Add BLAST382

Proteomic databases

EPDiQ9BQ90
MaxQBiQ9BQ90
PaxDbiQ9BQ90
PeptideAtlasiQ9BQ90
PRIDEiQ9BQ90
ProteomicsDBi78644

PTM databases

iPTMnetiQ9BQ90
PhosphoSitePlusiQ9BQ90

Expressioni

Gene expression databases

BgeeiENSG00000124702 Expressed in 235 organ(s), highest expression level in right frontal lobe
CleanExiHS_KLHDC3
ExpressionAtlasiQ9BQ90 baseline and differential
GenevisibleiQ9BQ90 HS

Organism-specific databases

HPAiHPA030131
HPA030132
HPA030133
HPA030134

Interactioni

Protein-protein interaction databases

BioGridi125478, 55 interactors
IntActiQ9BQ90, 3 interactors
STRINGi9606.ENSP00000313995

Structurei

3D structure databases

ProteinModelPortaliQ9BQ90
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati25 – 77Kelch 1Add BLAST53
Repeati88 – 138Kelch 2Add BLAST51
Repeati139 – 189Kelch 3Add BLAST51
Repeati191 – 249Kelch 4Add BLAST59
Repeati251 – 301Kelch 5Add BLAST51

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379 Eukaryota
ENOG410Y5WM LUCA
GeneTreeiENSGT00760000119086
HOGENOMiHOG000276538
HOVERGENiHBG071311
InParanoidiQ9BQ90
PhylomeDBiQ9BQ90
TreeFamiTF354289

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR015915 Kelch-typ_b-propeller
IPR011498 Kelch_2
PfamiView protein in Pfam
PF07646 Kelch_2, 2 hits
SUPFAMiSSF117281 SSF117281, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9BQ90-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRWTVHLEG GPRRVNHAAV AVGHRVYSFG GYCSGEDYET LRQIDVHIFN
60 70 80 90 100
AVSLRWTKLP PVKSAIRGQA PVVPYMRYGH STVLIDDTVL LWGGRNDTEG
110 120 130 140 150
ACNVLYAFDV NTHKWFTPRV SGTVPGARDG HSACVLGKIM YIFGGYEQQA
160 170 180 190 200
DCFSNDIHKL DTSTMTWTLI CTKGSPARWR DFHSATMLGS HMYVFGGRAD
210 220 230 240 250
RFGPFHSNNE IYCNRIRVFD TRTEAWLDCP PTPVLPEGRR SHSAFGYNGE
260 270 280 290 300
LYIFGGYNAR LNRHFHDLWK FNPVSFTWKK IEPKGKGPCP RRRQCCCIVG
310 320 330 340 350
DKIVLFGGTS PSPEEGLGDE FDLIDHSDLH ILDFSPSLKT LCKLAVIQYN
360 370 380
LDQSCLPHDI RWELNAMTTN SNISRPIVSS HG
Length:382
Mass (Da):43,088
Last modified:June 1, 2001 - v1
Checksum:i49A3AB24BE7FFAFC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ERR0E7ERR0_HUMAN
Kelch domain-containing protein 3
KLHDC3
389Annotation score:
F8W6A4F8W6A4_HUMAN
Kelch domain-containing protein 3
KLHDC3
248Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055925 mRNA Translation: BAB63257.1
AK290384 mRNA Translation: BAF83073.1
AL136304 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04136.1
BC000295 mRNA Translation: AAH00295.1
BC001789 mRNA Translation: AAH01789.1
BC001793 mRNA Translation: AAH01793.1
BC007296 mRNA Translation: AAH07296.1
BC021546 mRNA Translation: AAH21546.1
CCDSiCCDS4880.1
RefSeqiNP_476502.1, NM_057161.3
UniGeneiHs.412468

Genome annotation databases

EnsembliENST00000326974; ENSP00000313995; ENSG00000124702
GeneIDi116138
KEGGihsa:116138
UCSCiuc003otl.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055925 mRNA Translation: BAB63257.1
AK290384 mRNA Translation: BAF83073.1
AL136304 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04136.1
BC000295 mRNA Translation: AAH00295.1
BC001789 mRNA Translation: AAH01789.1
BC001793 mRNA Translation: AAH01793.1
BC007296 mRNA Translation: AAH07296.1
BC021546 mRNA Translation: AAH21546.1
CCDSiCCDS4880.1
RefSeqiNP_476502.1, NM_057161.3
UniGeneiHs.412468

3D structure databases

ProteinModelPortaliQ9BQ90
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125478, 55 interactors
IntActiQ9BQ90, 3 interactors
STRINGi9606.ENSP00000313995

PTM databases

iPTMnetiQ9BQ90
PhosphoSitePlusiQ9BQ90

Polymorphism and mutation databases

BioMutaiKLHDC3
DMDMi74752233

Proteomic databases

EPDiQ9BQ90
MaxQBiQ9BQ90
PaxDbiQ9BQ90
PeptideAtlasiQ9BQ90
PRIDEiQ9BQ90
ProteomicsDBi78644

Protocols and materials databases

DNASUi116138
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326974; ENSP00000313995; ENSG00000124702
GeneIDi116138
KEGGihsa:116138
UCSCiuc003otl.4 human

Organism-specific databases

CTDi116138
EuPathDBiHostDB:ENSG00000124702.17
GeneCardsiKLHDC3
HGNCiHGNC:20704 KLHDC3
HPAiHPA030131
HPA030132
HPA030133
HPA030134
MIMi611248 gene
neXtProtiNX_Q9BQ90
OpenTargetsiENSG00000124702
PharmGKBiPA134892782
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0379 Eukaryota
ENOG410Y5WM LUCA
GeneTreeiENSGT00760000119086
HOGENOMiHOG000276538
HOVERGENiHBG071311
InParanoidiQ9BQ90
PhylomeDBiQ9BQ90
TreeFamiTF354289

Enzyme and pathway databases

ReactomeiR-HSA-381038 XBP1(S) activates chaperone genes

Miscellaneous databases

ChiTaRSiKLHDC3 human
GeneWikiiKLHDC3
GenomeRNAii116138
PROiPR:Q9BQ90
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124702 Expressed in 235 organ(s), highest expression level in right frontal lobe
CleanExiHS_KLHDC3
ExpressionAtlasiQ9BQ90 baseline and differential
GenevisibleiQ9BQ90 HS

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR015915 Kelch-typ_b-propeller
IPR011498 Kelch_2
PfamiView protein in Pfam
PF07646 Kelch_2, 2 hits
SUPFAMiSSF117281 SSF117281, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKLDC3_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ90
Secondary accession number(s): A8K2W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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