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UniProtKB - Q9BQ83 (SLX1_HUMAN)

Entry version 149 (23 Feb 2022)
Sequence version 1 (01 Jun 2001)
Previous versions | rss
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Protein

Structure-specific endonuclease subunit SLX1

Gene

SLX1A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.

UniRule annotation3 Publications

Caution

Found in a segmental duplication on p arm of chromosome 16 giving rise to two identical copies of this gene sharing exons with SULT1A3 and SULT1A4.Curated

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

a divalent metal cation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri186 – 238SLX1-typeUniRule annotationAdd BLAST53

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA recombination, DNA repair
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BQ83

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5693568, Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-6783310, Fanconi Anemia Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9BQ83

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Structure-specific endonuclease subunit SLX1UniRule annotation (EC:3.1.-.-UniRule annotation)
Alternative name(s):
GIY-YIG domain-containing protein 1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLX1AUniRule annotation
Synonyms:GIYD1UniRule annotation, SLX1
AND
Name:SLX1BUniRule annotation
Synonyms:GIYD2, SLX1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20922, SLX1A
HGNC:28748, SLX1B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615822, gene
615823, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BQ83

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000132207
HostDB:ENSG00000181625

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi41R → A: Abolishes endonucleolytic activity. 1 Publication1
Mutagenesisi82E → A: Abolishes endonucleolytic activity. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		548593
79008

Open Targets

More...OpenTargetsi		ENSG00000132207

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671738

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BQ83, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLX1A

Domain mapping of disease mutations (DMDM)

More...DMDMi		74732820

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003321201 – 275Structure-specific endonuclease subunit SLX1Add BLAST275

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BQ83

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BQ83

PeptideAtlas

More...PeptideAtlasi		Q9BQ83

PRoteomics IDEntifications database

More...PRIDEi		Q9BQ83

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BQ83

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BQ83

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000132207, Expressed in testis and 111 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BQ83, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BQ83, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000132207, Low tissue specificity
ENSG00000181625, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer with SLX4.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122479, 45 interactors
139225, 26 interactors

Protein interaction database and analysis system

More...IntActi		Q9BQ83, 70 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000251303

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BQ83, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BQ83

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 95GIY-YIGUniRule annotationAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni148 – 179DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi148 – 164Pro residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLX1 family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri186 – 238SLX1-typeUniRule annotationAdd BLAST53

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3005, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000013368

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_030739_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BQ83

Identification of Orthologs from Complete Genome Data

More...OMAi		LQFEHAW

Database of Orthologous Groups

More...OrthoDBi		844266at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BQ83

TreeFam database of animal gene trees

More...TreeFami		TF352344

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit
3.40.1440.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_03100, Endonuc_su_Slx1, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000305, GIY-YIG_endonuc
IPR035901, GIY-YIG_endonuc_sf
IPR027520, Slx1
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01541, GIY-YIG, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF82771, SSF82771, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50164, GIY_YIG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BQ83-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPAGVAARP GRFFGVYLLY CLNPRYRGRV YVGFTVNTAR RVQQHNGGRK 
        60         70         80         90        100
KGGAWRTSGR GPWEMVLVVH GFPSSVAALR FEWAWQHPHA SRRLAHVGPR 
       110        120        130        140        150
LRGETAFAFH LRVLAHMLRA PPWARLPLTL RWVRPDLRQD LCLPPPPHVP 
       160        170        180        190        200
LAFGPPPPQA PAPRRRAGPF DDAEPEPDQG DPGACCSLCA QTIQDEEGPL 
       210        220        230        240        250
CCPHPGCLLR AHVICLAEEF LQEEPGQLLP LEGQCPCCEK SLLWGDLIWL 
       260        270 
CQMDTEKEVE DSELEEAHWT DLLET
Length:275
Mass (Da):30,771
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57DF055F2E59CF70
GO
Isoform 2 (identifier: Q9BQ83-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-194: Missing.

Show »
Length:161
Mass (Da):18,012
Checksum:i4182E39967F1FDE9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPC3H3BPC3_HUMAN
Structure-specific endonuclease sub...
SLX1A
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRR6H3BRR6_HUMAN
Structure-specific endonuclease sub...
SLX1B
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03333181 – 194Missing in isoform 2. 1 PublicationAdd BLAST114

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC106782 Genomic DNA No translation available.
AC133555 Genomic DNA No translation available.
BC000754 mRNA Translation: AAH00754.1
BC000803 mRNA Translation: AAH00803.1
BC015990 mRNA Translation: AAH15990.1
BC019306 mRNA Translation: AAH19306.1
BC069007 mRNA Translation: AAH69007.1
BC130545 mRNA Translation: AAI30546.1
BC130547 mRNA Translation: AAI30548.1
BC144462 mRNA Translation: AAI44463.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10648.1 [Q9BQ83-1]
CCDS10649.1 [Q9BQ83-2]
CCDS32431.1 [Q9BQ83-1]
CCDS32432.1 [Q9BQ83-2]

NCBI Reference Sequences

More...RefSeqi		NP_001014999.1, NM_001014999.2 [Q9BQ83-1]
NP_001015000.1, NM_001015000.2 [Q9BQ83-2]
NP_076949.1, NM_024044.3 [Q9BQ83-1]
NP_835145.1, NM_178044.2 [Q9BQ83-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000251303; ENSP00000251303; ENSG00000132207
ENST00000330181; ENSP00000328940; ENSG00000181625
ENST00000345535; ENSP00000333945; ENSG00000132207 [Q9BQ83-2]
ENST00000351581; ENSP00000335316; ENSG00000181625 [Q9BQ83-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		548593
79008

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:548593
hsa:79008

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000251303.11; ENSP00000251303.7; NM_001014999.3; NP_001014999.1
ENST00000330181.9; ENSP00000328940.5; NM_024044.4; NP_076949.1

UCSC genome browser

More...UCSCi		uc002dsx.4, human [Q9BQ83-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106782 Genomic DNA No translation available.
AC133555 Genomic DNA No translation available.
BC000754 mRNA Translation: AAH00754.1
BC000803 mRNA Translation: AAH00803.1
BC015990 mRNA Translation: AAH15990.1
BC019306 mRNA Translation: AAH19306.1
BC069007 mRNA Translation: AAH69007.1
BC130545 mRNA Translation: AAI30546.1
BC130547 mRNA Translation: AAI30548.1
BC144462 mRNA Translation: AAI44463.1
CCDSiCCDS10648.1 [Q9BQ83-1]
CCDS10649.1 [Q9BQ83-2]
CCDS32431.1 [Q9BQ83-1]
CCDS32432.1 [Q9BQ83-2]
RefSeqiNP_001014999.1, NM_001014999.2 [Q9BQ83-1]
NP_001015000.1, NM_001015000.2 [Q9BQ83-2]
NP_076949.1, NM_024044.3 [Q9BQ83-1]
NP_835145.1, NM_178044.2 [Q9BQ83-2]

3D structure databases

SMRiQ9BQ83
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122479, 45 interactors
139225, 26 interactors
IntActiQ9BQ83, 70 interactors
STRINGi9606.ENSP00000251303

PTM databases

iPTMnetiQ9BQ83
PhosphoSitePlusiQ9BQ83

Genetic variation databases

BioMutaiSLX1A
DMDMi74732820

Proteomic databases

MassIVEiQ9BQ83
PaxDbiQ9BQ83
PeptideAtlasiQ9BQ83
PRIDEiQ9BQ83

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26716, 58 antibodies from 16 providers
63854, 7 antibodies from 5 providers

The DNASU plasmid repository

More...DNASUi		79008

Genome annotation databases

EnsembliENST00000251303; ENSP00000251303; ENSG00000132207
ENST00000330181; ENSP00000328940; ENSG00000181625
ENST00000345535; ENSP00000333945; ENSG00000132207 [Q9BQ83-2]
ENST00000351581; ENSP00000335316; ENSG00000181625 [Q9BQ83-2]
GeneIDi548593
79008
KEGGihsa:548593
hsa:79008
MANE-SelectiENST00000251303.11; ENSP00000251303.7; NM_001014999.3; NP_001014999.1
ENST00000330181.9; ENSP00000328940.5; NM_024044.4; NP_076949.1
UCSCiuc002dsx.4, human [Q9BQ83-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		548593
79008
DisGeNETi548593
79008

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLX1A
SLX1B
HGNCiHGNC:20922, SLX1A
HGNC:28748, SLX1B
HPAiENSG00000132207, Low tissue specificity
ENSG00000181625, Low tissue specificity
MIMi615822, gene
615823, gene
neXtProtiNX_Q9BQ83
OpenTargetsiENSG00000132207
PharmGKBiPA142671738
VEuPathDBiHostDB:ENSG00000132207
HostDB:ENSG00000181625

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3005, Eukaryota
GeneTreeiENSGT00390000013368
HOGENOMiCLU_030739_0_0_1
InParanoidiQ9BQ83
OMAiLQFEHAW
OrthoDBi844266at2759
PhylomeDBiQ9BQ83
TreeFamiTF352344

Enzyme and pathway databases

PathwayCommonsiQ9BQ83
ReactomeiR-HSA-5693568, Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-6783310, Fanconi Anemia Pathway
SignaLinkiQ9BQ83

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		548593, 26 hits in 573 CRISPR screens
79008, 12 hits in 194 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLX1A, human
PharosiQ9BQ83, Tbio

Protein Ontology

More...PROi		PR:Q9BQ83
RNActiQ9BQ83, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000132207, Expressed in testis and 111 other tissues
ExpressionAtlasiQ9BQ83, baseline and differential
GenevisibleiQ9BQ83, HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
3.40.1440.10, 1 hit
HAMAPiMF_03100, Endonuc_su_Slx1, 1 hit
InterProiView protein in InterPro
IPR000305, GIY-YIG_endonuc
IPR035901, GIY-YIG_endonuc_sf
IPR027520, Slx1
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01541, GIY-YIG, 1 hit
SUPFAMiSSF82771, SSF82771, 1 hit
PROSITEiView protein in PROSITE
PS50164, GIY_YIG, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLX1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BQ83
Secondary accession number(s): B7ZME1, Q6NTG6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2001
Last modified: February 23, 2022
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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