UniProtKB - Q9BQ70 (TCF25_HUMAN)
Protein
Transcription factor 25
Gene
TCF25
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development.1 Publication
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: UniProtKB
GO - Biological processi
- heart development Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9BQ70 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor 25Short name: TCF-25 Alternative name(s): Nuclear localized protein 1 |
Gene namesi | Name:TCF25 Synonyms:KIAA1049, NULP1 ORF Names:FKSG26 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000141002.18 |
HGNCi | HGNC:29181, TCF25 |
MIMi | 612326, gene |
neXtProti | NX_Q9BQ70 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 22980 |
OpenTargetsi | ENSG00000141002 |
PharmGKBi | PA145007492 |
Miscellaneous databases
Pharosi | Q9BQ70, Tbio |
Polymorphism and mutation databases
BioMutai | TCF25 |
DMDMi | 23396596 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087265 | 1 – 676 | Transcription factor 25Add BLAST | 676 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 602 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9BQ70 |
jPOSTi | Q9BQ70 |
MassIVEi | Q9BQ70 |
MaxQBi | Q9BQ70 |
PaxDbi | Q9BQ70 |
PeptideAtlasi | Q9BQ70 |
PRIDEi | Q9BQ70 |
ProteomicsDBi | 78638 |
PTM databases
iPTMneti | Q9BQ70 |
MetOSitei | Q9BQ70 |
PhosphoSitePlusi | Q9BQ70 |
Expressioni
Tissue specificityi
In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart.1 Publication
Gene expression databases
Bgeei | ENSG00000141002, Expressed in left lobe of thyroid gland and 242 other tissues |
ExpressionAtlasi | Q9BQ70, baseline and differential |
Genevisiblei | Q9BQ70, HS |
Organism-specific databases
HPAi | ENSG00000141002, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with XIAP.
By similarityBinary interactionsi
Hide detailsQ9BQ70
Protein-protein interaction databases
BioGRIDi | 116629, 48 interactors |
IntActi | Q9BQ70, 40 interactors |
MINTi | Q9BQ70 |
STRINGi | 9606.ENSP00000263346 |
Miscellaneous databases
RNActi | Q9BQ70, protein |
Family & Domainsi
Domaini
The C-terminal region mediates transcriptional repression.1 Publication
Sequence similaritiesi
Belongs to the TCF25 family.Curated
Phylogenomic databases
eggNOGi | KOG2422, Eukaryota |
GeneTreei | ENSGT00390000005563 |
HOGENOMi | CLU_008321_3_2_1 |
InParanoidi | Q9BQ70 |
OMAi | CRIQEDQ |
OrthoDBi | 1428505at2759 |
PhylomeDBi | Q9BQ70 |
TreeFami | TF106155 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR006994, TCF25/Rqc1 IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR22684, PTHR22684, 1 hit |
Pfami | View protein in Pfam PF04910, Tcf25, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
Q9BQ70-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRRALRRLR GEQRGQEPLG PGALHFDLRD DDDAEEEGPK RELGVRRPGG
60 70 80 90 100
AGKEGVRVNN RFELINIDDL EDDPVVNGER SGCALTDAVA PGNKGRGQRG
110 120 130 140 150
NTESKTDGDD TETVPSEQSH ASGKLRKKKK KQKNKKSSTG EASENGLEDI
160 170 180 190 200
DRILERIEDS TGLNRPGPAP LSSRKHVLYV EHRHLNPDTE LKRYFGARAI
210 220 230 240 250
LGEQRPRQRQ RVYPKCTWLT TPKSTWPRYS KPGLSMRLLE SKKGLSFFAF
260 270 280 290 300
EHSEEYQQAQ HKFLVAVESM EPNNIVVLLQ TSPYHVDSLL QLSDACRFQE
310 320 330 340 350
DQEMARDLVE RALYSMECAF HPLFSLTSGA CRLDYRRPEN RSFYLALYKQ
360 370 380 390 400
MSFLEKRGCP RTALEYCKLI LSLEPDEDPL CMLLLIDHLA LRARNYEYLI
410 420 430 440 450
RLFQEWEAHR NLSQLPNFAF SVPLAYFLLS QQTDLPECEQ SSARQKASLL
460 470 480 490 500
IQQALTMFPG VLLPLLESCS VRPDASVSSH RFFGPNAEIS QPPALSQLVN
510 520 530 540 550
LYLGRSHFLW KEPATMSWLE ENVHEVLQAV DAGDPAVEAC ENRRKVLYQR
560 570 580 590 600
APRNIHRHVI LSEIKEAVAA LPPDVTTQSV MGFDPLPPSD TIYSYVRPER
610 620 630 640 650
LSPISHGNTI ALFFRSLLPN YTMEGERPEE GVAGGLNRNQ GLNRLMLAVR
660 670
DMMANFHLND LEAPHEDDAE GEGEWD
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9H7D3 | Q9H7D3_HUMAN | NULP1, isoform CRA_c | TCF25 NULP1, hCG_16354 | 216 | Annotation score: | ||
H3BMJ8 | H3BMJ8_HUMAN | Transcription factor 25 | TCF25 | 210 | Annotation score: | ||
H3BTU3 | H3BTU3_HUMAN | Transcription factor 25 | TCF25 | 265 | Annotation score: | ||
H3BSP8 | H3BSP8_HUMAN | Transcription factor 25 | TCF25 | 233 | Annotation score: | ||
H3BQ53 | H3BQ53_HUMAN | Transcription factor 25 | TCF25 | 570 | Annotation score: | ||
Q9H384 | Q9H384_HUMAN | PRO2620 | TCF25 | 473 | Annotation score: | ||
H3BS87 | H3BS87_HUMAN | Transcription factor 25 | TCF25 | 146 | Annotation score: | ||
H3BR53 | H3BR53_HUMAN | Transcription factor 25 | TCF25 | 76 | Annotation score: | ||
H3BRP4 | H3BRP4_HUMAN | Transcription factor 25 | TCF25 | 209 | Annotation score: | ||
H3BSS3 | H3BSS3_HUMAN | Transcription factor 25 | TCF25 | 286 | Annotation score: | ||
There is more potential isoformShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ321703 mRNA Translation: ABC55265.1 AF322111 mRNA Translation: AAG50276.1 BC000959 mRNA Translation: AAH00959.1 BC009349 mRNA Translation: AAH09349.1 BC011884 mRNA Translation: AAH11884.1 AB028972 mRNA Translation: BAA83001.1 |
CCDSi | CCDS10987.1 |
RefSeqi | NP_055787.1, NM_014972.2 |
Genome annotation databases
Ensembli | ENST00000263346; ENSP00000263346; ENSG00000141002 ENST00000640279; ENSP00000491638; ENSG00000141002 |
GeneIDi | 22980 |
KEGGi | hsa:22980 |
UCSCi | uc002fpb.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ321703 mRNA Translation: ABC55265.1 AF322111 mRNA Translation: AAG50276.1 BC000959 mRNA Translation: AAH00959.1 BC009349 mRNA Translation: AAH09349.1 BC011884 mRNA Translation: AAH11884.1 AB028972 mRNA Translation: BAA83001.1 |
CCDSi | CCDS10987.1 |
RefSeqi | NP_055787.1, NM_014972.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116629, 48 interactors |
IntActi | Q9BQ70, 40 interactors |
MINTi | Q9BQ70 |
STRINGi | 9606.ENSP00000263346 |
PTM databases
iPTMneti | Q9BQ70 |
MetOSitei | Q9BQ70 |
PhosphoSitePlusi | Q9BQ70 |
Polymorphism and mutation databases
BioMutai | TCF25 |
DMDMi | 23396596 |
Proteomic databases
EPDi | Q9BQ70 |
jPOSTi | Q9BQ70 |
MassIVEi | Q9BQ70 |
MaxQBi | Q9BQ70 |
PaxDbi | Q9BQ70 |
PeptideAtlasi | Q9BQ70 |
PRIDEi | Q9BQ70 |
ProteomicsDBi | 78638 |
Protocols and materials databases
Antibodypediai | 30955, 187 antibodies |
DNASUi | 22980 |
Genome annotation databases
Ensembli | ENST00000263346; ENSP00000263346; ENSG00000141002 ENST00000640279; ENSP00000491638; ENSG00000141002 |
GeneIDi | 22980 |
KEGGi | hsa:22980 |
UCSCi | uc002fpb.3, human |
Organism-specific databases
CTDi | 22980 |
DisGeNETi | 22980 |
EuPathDBi | HostDB:ENSG00000141002.18 |
GeneCardsi | TCF25 |
HGNCi | HGNC:29181, TCF25 |
HPAi | ENSG00000141002, Low tissue specificity |
MIMi | 612326, gene |
neXtProti | NX_Q9BQ70 |
OpenTargetsi | ENSG00000141002 |
PharmGKBi | PA145007492 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2422, Eukaryota |
GeneTreei | ENSGT00390000005563 |
HOGENOMi | CLU_008321_3_2_1 |
InParanoidi | Q9BQ70 |
OMAi | CRIQEDQ |
OrthoDBi | 1428505at2759 |
PhylomeDBi | Q9BQ70 |
TreeFami | TF106155 |
Enzyme and pathway databases
PathwayCommonsi | Q9BQ70 |
Miscellaneous databases
BioGRID-ORCSi | 22980, 9 hits in 845 CRISPR screens |
ChiTaRSi | TCF25, human |
GenomeRNAii | 22980 |
Pharosi | Q9BQ70, Tbio |
PROi | PR:Q9BQ70 |
RNActi | Q9BQ70, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000141002, Expressed in left lobe of thyroid gland and 242 other tissues |
ExpressionAtlasi | Q9BQ70, baseline and differential |
Genevisiblei | Q9BQ70, HS |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR006994, TCF25/Rqc1 IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR22684, PTHR22684, 1 hit |
Pfami | View protein in Pfam PF04910, Tcf25, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TCF25_HUMAN | |
Accessioni | Q9BQ70Primary (citable) accession number: Q9BQ70 Secondary accession number(s): Q2MK75, Q9UPV3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM