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Entry version 128 (13 Feb 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Keratin-associated protein 4-12

Gene

KRTAP4-12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 4-12
Alternative name(s):
Keratin-associated protein 4.12
Ultrahigh sulfur keratin-associated protein 4.12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP4-12
Synonyms:KAP4.12, KRTAP4.12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000213416.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16776 KRTAP4-12

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BQ66

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000213416

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38416

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRTAP4-12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38258229

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001851781 – 201Keratin-associated protein 4-12Add BLAST201

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BQ66

PeptideAtlas

More...
PeptideAtlasi
Q9BQ66

PRoteomics IDEntifications database

More...
PRIDEi
Q9BQ66

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78635

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the hair follicles.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000213416 Expressed in 20 organ(s), highest expression level in upper arm skin

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BQ66 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9NWL93EBI-739863,EBI-10315054
ADAMTSL4Q6UY14-33EBI-739863,EBI-10173507
ALPPP051873EBI-739863,EBI-1211484
AXIN1A0A0S2Z4M13EBI-739863,EBI-16429430
AXIN1O151693EBI-739863,EBI-710484
CATSPER1Q8NEC510EBI-739863,EBI-744545
CRCT1Q9UGL95EBI-739863,EBI-713677
CREB5Q02930-37EBI-739863,EBI-10192698
GLRX3O760036EBI-739863,EBI-374781
GNEQ9Y2233EBI-739863,EBI-4291090
GPATCH2LQ9NWQ43EBI-739863,EBI-5666657
HOXA1P496396EBI-739863,EBI-740785
Hoxa1P090224EBI-739863,EBI-3957603From Mus musculus.
IFI30P132843EBI-739863,EBI-2868897
KRTAP10-5P603703EBI-739863,EBI-10172150
KRTAP10-8P604105EBI-739863,EBI-10171774
KRTAP10-9P604115EBI-739863,EBI-10172052
KRTAP26-1Q6PEX33EBI-739863,EBI-3957672
KRTAP5-6Q6L8G95EBI-739863,EBI-10250562
KRTAP5-9P263717EBI-739863,EBI-3958099
KRTAP9-2Q9BYQ45EBI-739863,EBI-1044640
LCE1AQ5T7P24EBI-739863,EBI-11962058
LCE1BQ5T7P35EBI-739863,EBI-10245913
LCE1DQ5T7524EBI-739863,EBI-11741311
LCE1FQ5T7544EBI-739863,EBI-11958008
LCE2BO146334EBI-739863,EBI-11478468
LCE2CQ5TA814EBI-739863,EBI-11973993
LCE2DQ5TA825EBI-739863,EBI-10246750
LCE3AQ5TA764EBI-739863,EBI-9394625
LCE3CQ5T5A84EBI-739863,EBI-10245291
LCE3DQ9BYE34EBI-739863,EBI-6658837
LCE3EQ5T5B05EBI-739863,EBI-10245456
LCE4AQ5TA787EBI-739863,EBI-10246358
LCE5AQ5TCM94EBI-739863,EBI-11955689
MAPKBP1O603365EBI-739863,EBI-947402
NOTCH2NLAQ7Z3S93EBI-739863,EBI-945833
NUFIP2Q7Z4179EBI-739863,EBI-1210753
OTX1P322426EBI-739863,EBI-740446
PCSK5Q928243EBI-739863,EBI-751290
POU4F2Q128374EBI-739863,EBI-17236143
PRKAB2O437413EBI-739863,EBI-1053424
RYDENQ9NUL53EBI-739863,EBI-10313866
RYDENQ9NUL5-44EBI-739863,EBI-11955083
SMCPP499019EBI-739863,EBI-750494
SPRY2O435974EBI-739863,EBI-742487
TBC1D23Q9NUY83EBI-739863,EBI-2853126
TXNDC5Q86UY05EBI-739863,EBI-2825190
ZNF20P170243EBI-739863,EBI-717634
ZNF415Q09FC83EBI-739863,EBI-10226171
ZNF581Q9P0T44EBI-739863,EBI-745520
ZSCAN26Q166703EBI-739863,EBI-3920053

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123756, 113 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BQ66, 148 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377582

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9BQ66

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati5 – 915
Repeati20 – 2425
Repeati25 – 2935
Repeati30 – 3445
Repeati35 – 3955
Repeati40 – 4465
Repeati45 – 4975
Repeati50 – 5485
Repeati55 – 5995
Repeati60 – 64105
Repeati65 – 69115
Repeati70 – 74125
Repeati75 – 79135
Repeati80 – 84145
Repeati85 – 89155
Repeati90 – 94165
Repeati95 – 99175
Repeati100 – 104185
Repeati105 – 109195
Repeati110 – 114205
Repeati115 – 119215
Repeati120 – 124225
Repeati125 – 129235
Repeati130 – 134245
Repeati135 – 139255
Repeati140 – 144265
Repeati145 – 149275
Repeati155 – 159285
Repeati160 – 164295
Repeati165 – 169305

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni5 – 16931 X 5 AA repeats of C-C-[GRQVIL]-[SPTR]-[VSTQPC]Add BLAST165

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 4 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JD6Q Eukaryota
ENOG410ZG1J LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159486

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234030

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BQ66

Identification of Orthologs from Complete Genome Data

More...
OMAi
RRRCWCC

TreeFam database of animal gene trees

More...
TreeFami
TF351356

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002494 KAP

The PANTHER Classification System

More...
PANTHERi
PTHR23262 PTHR23262, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13885 Keratin_B2_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9BQ66-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNSCCGSVC SDQGCGLENC CRPSCCQTTC CRTTCCRPSC CVSSCCRPQC
60 70 80 90 100
CQSVCCQPTC CRPSCCQTTC CRTTCCRPSC CVSSCCRPQC CQSVCCQPTC
110 120 130 140 150
CRPSCCQTTC CRTTCCRPSC CVSSCCRPQC CQSVCCQPTC CRPSCCISSS
160 170 180 190 200
CCPSCCESSC CRPCCCLRPV CGRVSCHTTC YRPTCVISTC PRPLCCASSC

C
Length:201
Mass (Da):21,407
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7548ED69BF432804
GO

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Numerous size polymorphism are present in KRTAP4 gene family, which are mainly due to variations in the sequence encoding cysteine-rich repeat segments (PubMed:15955084).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_064563105 – 144Missing in allele KAP4.12-v1. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ406943 mRNA Translation: CAC27582.1
AC100808 Genomic DNA No translation available.
BC004180 mRNA Translation: AAH04180.1
BC004212 mRNA Translation: AAH04212.1
BC101159 mRNA Translation: AAI01160.1
BC101160 mRNA Translation: AAI01161.1
BC101162 mRNA Translation: AAI01163.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32649.1

NCBI Reference Sequences

More...
RefSeqi
NP_114060.1, NM_031854.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.572443

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000394014; ENSP00000377582; ENSG00000213416
ENST00000571271; ENSP00000458979; ENSG00000263236

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
83755

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:83755

UCSC genome browser

More...
UCSCi
uc002hwa.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ406943 mRNA Translation: CAC27582.1
AC100808 Genomic DNA No translation available.
BC004180 mRNA Translation: AAH04180.1
BC004212 mRNA Translation: AAH04212.1
BC101159 mRNA Translation: AAI01160.1
BC101160 mRNA Translation: AAI01161.1
BC101162 mRNA Translation: AAI01163.1
CCDSiCCDS32649.1
RefSeqiNP_114060.1, NM_031854.2
UniGeneiHs.572443

3D structure databases

ProteinModelPortaliQ9BQ66
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123756, 113 interactors
IntActiQ9BQ66, 148 interactors
STRINGi9606.ENSP00000377582

Polymorphism and mutation databases

BioMutaiKRTAP4-12
DMDMi38258229

Proteomic databases

PaxDbiQ9BQ66
PeptideAtlasiQ9BQ66
PRIDEiQ9BQ66
ProteomicsDBi78635

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
83755
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394014; ENSP00000377582; ENSG00000213416
ENST00000571271; ENSP00000458979; ENSG00000263236
GeneIDi83755
KEGGihsa:83755
UCSCiuc002hwa.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
83755
EuPathDBiHostDB:ENSG00000213416.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRTAP4-12
HGNCiHGNC:16776 KRTAP4-12
neXtProtiNX_Q9BQ66
OpenTargetsiENSG00000213416
PharmGKBiPA38416

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JD6Q Eukaryota
ENOG410ZG1J LUCA
GeneTreeiENSGT00940000159486
HOGENOMiHOG000234030
InParanoidiQ9BQ66
OMAiRRRCWCC
TreeFamiTF351356

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
83755

Protein Ontology

More...
PROi
PR:Q9BQ66

Gene expression databases

BgeeiENSG00000213416 Expressed in 20 organ(s), highest expression level in upper arm skin
GenevisibleiQ9BQ66 HS

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 3 hits
PfamiView protein in Pfam
PF13885 Keratin_B2_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKR412_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BQ66
Secondary accession number(s): A3KMC5, Q495I0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2001
Last modified: February 13, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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