UniProtKB - Q9BQ61 (TRIR_HUMAN)
Protein
Telomerase RNA component interacting RNase
Gene
TRIR
Organism
Homo sapiens (Human)
Status
Functioni
Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to all four unpaired RNA nucleotides from 5' end or 3' end with higher efficiency for purine bases (PubMed:28322335).1 Publication
Activity regulationi
Zn2+ inhibits the RNase activity while Mg2+, Ca2+, Mn2+, K+, Na+, EDTA and EGTA show little effect on the exoribonuclease activity (PubMed:28322335).1 Publication
pH dependencei
Optimum pH is 6.5-12.1 Publication
Temperature dependencei
Optimum temperature is 37-75 degrees Celsius.1 Publication
GO - Molecular functioni
- 3'-5' exonuclease activity Source: UniProtKB
- 5'-3' exonuclease activity Source: UniProtKB
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- RNA phosphodiester bond hydrolysis, exonucleolytic Source: UniProtKB
- rRNA catabolic process Source: UniProtKB
Keywordsi
Molecular function | Exonuclease, Hydrolase, Nuclease, RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9BQ61 |
Names & Taxonomyi
Protein namesi | Recommended name: Telomerase RNA component interacting RNase1 PublicationImported (EC:3.1.13.-1 Publication)Alternative name(s): Exoribonuclease TRIRCurated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28424, TRIR |
neXtProti | NX_Q9BQ61 |
VEuPathDBi | HostDB:ENSG00000123144.10 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000123144 |
PharmGKBi | PA144596476 |
Miscellaneous databases
Pharosi | Q9BQ61, Tdark |
Genetic variation databases
BioMutai | TRIR |
DMDMi | 74732813 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280762 | 1 – 176 | Telomerase RNA component interacting RNaseAdd BLAST | 176 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 146 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9BQ61 |
jPOSTi | Q9BQ61 |
MassIVEi | Q9BQ61 |
MaxQBi | Q9BQ61 |
PaxDbi | Q9BQ61 |
PeptideAtlasi | Q9BQ61 |
PRIDEi | Q9BQ61 |
ProteomicsDBi | 78631 |
TopDownProteomicsi | Q9BQ61 |
PTM databases
iPTMneti | Q9BQ61 |
PhosphoSitePlusi | Q9BQ61 |
Expressioni
Gene expression databases
Bgeei | ENSG00000123144, Expressed in metanephros and 216 other tissues |
ExpressionAtlasi | Q9BQ61, baseline and differential |
Genevisiblei | Q9BQ61, HS |
Organism-specific databases
HPAi | ENSG00000123144, Low tissue specificity |
Interactioni
Subunit structurei
Part of the telomerase RNA 3' end complex which contains about 488 proteins (PubMed:28322335).
1 PublicationBinary interactionsi
Q9BQ61
With | #Exp. | IntAct |
---|---|---|
SNRPA [P09012] | 10 | EBI-744881,EBI-607085 |
Protein-protein interaction databases
BioGRIDi | 122473, 22 interactors |
CORUMi | Q9BQ61 |
IntActi | Q9BQ61, 15 interactors |
MINTi | Q9BQ61 |
STRINGi | 9606.ENSP00000242784 |
Miscellaneous databases
RNActi | Q9BQ61, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 20 – 25 | Poly-Gly | 6 |
Domaini
The C-terminus contains a key domain which is responsible for the RNA digestion activity (PubMed:28322335).1 Publication
Phylogenomic databases
eggNOGi | ENOG502S83W, Eukaryota |
GeneTreei | ENSGT00390000012267 |
HOGENOMi | CLU_126877_0_0_1 |
InParanoidi | Q9BQ61 |
OMAi | MFKKKME |
OrthoDBi | 1538520at2759 |
PhylomeDBi | Q9BQ61 |
TreeFami | TF323808 |
Family and domain databases
InterProi | View protein in InterPro IPR038838, TRIR |
PANTHERi | PTHR34753, PTHR34753, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9BQ61-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAARGRRAEP QGREAPGPAG GGGGGSRWAE SGSGTSPESG DEEVSGAGSS
60 70 80 90 100
PVSGGVNLFA NDGSFLELFK RKMEEEQRQR QEEPPPGPQR PDQSAAAAGP
110 120 130 140 150
GDPKRKGGPG STLSFVGKRR GGNKLALKTG IVAKKQKTED EVLTSKGDAW
160 170
AKYMAEVKKY KAHQCGDDDK TRPLVK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ELS0 | K7ELS0_HUMAN | Telomerase RNA component-interactin... | TRIR | 132 | Annotation score: | ||
K7EN60 | K7EN60_HUMAN | Telomerase RNA component-interactin... | TRIR | 150 | Annotation score: | ||
K7ERU7 | K7ERU7_HUMAN | Telomerase RNA component-interactin... | TRIR | 133 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC000216 mRNA Translation: AAH00216.1 BC004533 mRNA Translation: AAH04533.1 BC015347 mRNA Translation: AAH15347.1 |
CCDSi | CCDS12279.1 |
RefSeqi | NP_001316667.1, NM_001329738.1 NP_076943.1, NM_024038.3 |
Genome annotation databases
Ensembli | ENST00000242784; ENSP00000242784; ENSG00000123144 |
GeneIDi | 79002 |
KEGGi | hsa:79002 |
UCSCi | uc002muu.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC000216 mRNA Translation: AAH00216.1 BC004533 mRNA Translation: AAH04533.1 BC015347 mRNA Translation: AAH15347.1 |
CCDSi | CCDS12279.1 |
RefSeqi | NP_001316667.1, NM_001329738.1 NP_076943.1, NM_024038.3 |
3D structure databases
SMRi | Q9BQ61 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122473, 22 interactors |
CORUMi | Q9BQ61 |
IntActi | Q9BQ61, 15 interactors |
MINTi | Q9BQ61 |
STRINGi | 9606.ENSP00000242784 |
PTM databases
iPTMneti | Q9BQ61 |
PhosphoSitePlusi | Q9BQ61 |
Genetic variation databases
BioMutai | TRIR |
DMDMi | 74732813 |
Proteomic databases
EPDi | Q9BQ61 |
jPOSTi | Q9BQ61 |
MassIVEi | Q9BQ61 |
MaxQBi | Q9BQ61 |
PaxDbi | Q9BQ61 |
PeptideAtlasi | Q9BQ61 |
PRIDEi | Q9BQ61 |
ProteomicsDBi | 78631 |
TopDownProteomicsi | Q9BQ61 |
Protocols and materials databases
Antibodypediai | 26146, 31 antibodies |
DNASUi | 79002 |
Genome annotation databases
Ensembli | ENST00000242784; ENSP00000242784; ENSG00000123144 |
GeneIDi | 79002 |
KEGGi | hsa:79002 |
UCSCi | uc002muu.4, human |
Organism-specific databases
CTDi | 79002 |
GeneCardsi | TRIR |
HGNCi | HGNC:28424, TRIR |
HPAi | ENSG00000123144, Low tissue specificity |
neXtProti | NX_Q9BQ61 |
OpenTargetsi | ENSG00000123144 |
PharmGKBi | PA144596476 |
VEuPathDBi | HostDB:ENSG00000123144.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S83W, Eukaryota |
GeneTreei | ENSGT00390000012267 |
HOGENOMi | CLU_126877_0_0_1 |
InParanoidi | Q9BQ61 |
OMAi | MFKKKME |
OrthoDBi | 1538520at2759 |
PhylomeDBi | Q9BQ61 |
TreeFami | TF323808 |
Enzyme and pathway databases
PathwayCommonsi | Q9BQ61 |
Miscellaneous databases
BioGRID-ORCSi | 79002, 122 hits in 979 CRISPR screens |
ChiTaRSi | C19orf43, human |
GenomeRNAii | 79002 |
Pharosi | Q9BQ61, Tdark |
PROi | PR:Q9BQ61 |
RNActi | Q9BQ61, protein |
Gene expression databases
Bgeei | ENSG00000123144, Expressed in metanephros and 216 other tissues |
ExpressionAtlasi | Q9BQ61, baseline and differential |
Genevisiblei | Q9BQ61, HS |
Family and domain databases
InterProi | View protein in InterPro IPR038838, TRIR |
PANTHERi | PTHR34753, PTHR34753, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRIR_HUMAN | |
Accessioni | Q9BQ61Primary (citable) accession number: Q9BQ61 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM