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Protein

Programmed cell death 1 ligand 2

Gene

PDCD1LG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-389948 PD-1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death 1 ligand 2
Short name:
PD-1 ligand 2
Short name:
PD-L2
Short name:
PDCD1 ligand 2
Short name:
Programmed death ligand 2
Alternative name(s):
Butyrophilin B7-DC
Short name:
B7-DC
CD_antigen: CD273
Gene namesi
Name:PDCD1LG2
Synonyms:B7DC, CD273, PDCD1L2, PDL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000197646.7
HGNCiHGNC:18731 PDCD1LG2
MIMi605723 gene
neXtProtiNX_Q9BQ51

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 220ExtracellularSequence analysisAdd BLAST201
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Topological domaini242 – 273CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi80380
OpenTargetsiENSG00000197646
PharmGKBiPA134891547

Chemistry databases

ChEMBLiCHEMBL3713006

Polymorphism and mutation databases

BioMutaiPDCD1LG2
DMDMi73917618

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001455520 – 273Programmed cell death 1 ligand 2Add BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi42 ↔ 102PROSITE-ProRule annotation
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi143 ↔ 192PROSITE-ProRule annotation
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9BQ51
MaxQBiQ9BQ51
PaxDbiQ9BQ51
PeptideAtlasiQ9BQ51
PRIDEiQ9BQ51
ProteomicsDBi78624
78625 [Q9BQ51-2]
78626 [Q9BQ51-3]

PTM databases

iPTMnetiQ9BQ51
PhosphoSitePlusiQ9BQ51
SwissPalmiQ9BQ51

Expressioni

Tissue specificityi

Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.1 Publication

Inductioni

Up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL4/interleukin-4.2 Publications

Gene expression databases

BgeeiENSG00000197646 Expressed in 82 organ(s), highest expression level in placenta
CleanExiHS_PDCD1LG2
GenevisibleiQ9BQ51 HS

Organism-specific databases

HPAiHPA013411

Interactioni

Subunit structurei

Interacts with PDCD1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PDCD1Q1511614EBI-16427978,EBI-4314328

Protein-protein interaction databases

BioGridi123259, 12 interactors
IntActiQ9BQ51, 21 interactors
STRINGi9606.ENSP00000380855

Structurei

3D structure databases

ProteinModelPortaliQ9BQ51
SMRiQ9BQ51
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 118Ig-like V-typeAdd BLAST98
Domaini122 – 203Ig-like C2-typeAdd BLAST82

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVCK Eukaryota
ENOG4111V14 LUCA
GeneTreeiENSGT00930000150918
HOGENOMiHOG000059625
HOVERGENiHBG082112
InParanoidiQ9BQ51
KOiK06708
OMAiPANTSHT
OrthoDBiEOG091G0F5W
PhylomeDBiQ9BQ51
TreeFamiTF331083

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BQ51-1) [UniParc]FASTAAdd to basket
Also known as: PD-L2I, Type I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIFLLLMLSL ELQLHQIAAL FTVTVPKELY IIEHGSNVTL ECNFDTGSHV
60 70 80 90 100
NLGAITASLQ KVENDTSPHR ERATLLEEQL PLGKASFHIP QVQVRDEGQY
110 120 130 140 150
QCIIIYGVAW DYKYLTLKVK ASYRKINTHI LKVPETDEVE LTCQATGYPL
160 170 180 190 200
AEVSWPNVSV PANTSHSRTP EGLYQVTSVL RLKPPPGRNF SCVFWNTHVR
210 220 230 240 250
ELTLASIDLQ SQMEPRTHPT WLLHIFIPFC IIAFIFIATV IALRKQLCQK
260 270
LYSSKDTTKR PVTTTKREVN SAI
Length:273
Mass (Da):30,957
Last modified:May 10, 2005 - v2
Checksum:i8B7E963C9BA26ED9
GO
Isoform 2 (identifier: Q9BQ51-2) [UniParc]FASTAAdd to basket
Also known as: PD-L2II, Type II

The sequence of this isoform differs from the canonical sequence as follows:
     121-211: ASYRKINTHI...LTLASIDLQS → G

Show »
Length:183
Mass (Da):20,867
Checksum:iADFCD2E70205B137
GO
Isoform 3 (identifier: Q9BQ51-3) [UniParc]FASTAAdd to basket
Also known as: PD-L2III, Type III

The sequence of this isoform differs from the canonical sequence as follows:
     121-182: ASYRKINTHI...LYQVTSVLRL → DGTQDPSNLA...NKEGSEQCYL
     183-273: Missing.

Show »
Length:182
Mass (Da):20,745
Checksum:i357E9952F65BCADC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04984258S → T. Corresponds to variant dbSNP:rs12339171Ensembl.1
Natural variantiVAR_022449229F → S4 PublicationsCorresponds to variant dbSNP:rs7854303Ensembl.1
Natural variantiVAR_049843241I → T. Corresponds to variant dbSNP:rs7854413Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013740121 – 211ASYRK…IDLQS → G in isoform 2. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_013738121 – 182ASYRK…SVLRL → DGTQDPSNLAASHFHPLLHH CFHFHSHSDSPKKTTLSKAV FFKRHNKKTCHHNKEGSEQC YL in isoform 3. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_013739183 – 273Missing in isoform 3. 1 PublicationAdd BLAST91

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329193 mRNA Translation: AAK31105.1
AF344424 mRNA Translation: AAK15370.1
AY254343 mRNA Translation: AAP13471.1
AY271901 mRNA Translation: AAP49000.1
AY271902 mRNA Translation: AAP49001.1
AL162253 Genomic DNA No translation available.
BC074766 mRNA Translation: AAH74766.1
BC113678 mRNA Translation: AAI13679.1
BC113680 mRNA Translation: AAI13681.1
CCDSiCCDS6465.1 [Q9BQ51-1]
RefSeqiNP_079515.2, NM_025239.3 [Q9BQ51-1]
UniGeneiHs.532279
Hs.617872

Genome annotation databases

EnsembliENST00000397747; ENSP00000380855; ENSG00000197646 [Q9BQ51-1]
GeneIDi80380
KEGGihsa:80380
UCSCiuc003zjg.5 human [Q9BQ51-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329193 mRNA Translation: AAK31105.1
AF344424 mRNA Translation: AAK15370.1
AY254343 mRNA Translation: AAP13471.1
AY271901 mRNA Translation: AAP49000.1
AY271902 mRNA Translation: AAP49001.1
AL162253 Genomic DNA No translation available.
BC074766 mRNA Translation: AAH74766.1
BC113678 mRNA Translation: AAI13679.1
BC113680 mRNA Translation: AAI13681.1
CCDSiCCDS6465.1 [Q9BQ51-1]
RefSeqiNP_079515.2, NM_025239.3 [Q9BQ51-1]
UniGeneiHs.532279
Hs.617872

3D structure databases

ProteinModelPortaliQ9BQ51
SMRiQ9BQ51
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123259, 12 interactors
IntActiQ9BQ51, 21 interactors
STRINGi9606.ENSP00000380855

Chemistry databases

ChEMBLiCHEMBL3713006

PTM databases

iPTMnetiQ9BQ51
PhosphoSitePlusiQ9BQ51
SwissPalmiQ9BQ51

Polymorphism and mutation databases

BioMutaiPDCD1LG2
DMDMi73917618

Proteomic databases

EPDiQ9BQ51
MaxQBiQ9BQ51
PaxDbiQ9BQ51
PeptideAtlasiQ9BQ51
PRIDEiQ9BQ51
ProteomicsDBi78624
78625 [Q9BQ51-2]
78626 [Q9BQ51-3]

Protocols and materials databases

DNASUi80380
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397747; ENSP00000380855; ENSG00000197646 [Q9BQ51-1]
GeneIDi80380
KEGGihsa:80380
UCSCiuc003zjg.5 human [Q9BQ51-1]

Organism-specific databases

CTDi80380
DisGeNETi80380
EuPathDBiHostDB:ENSG00000197646.7
GeneCardsiPDCD1LG2
H-InvDBiHIX0007901
HGNCiHGNC:18731 PDCD1LG2
HPAiHPA013411
MIMi605723 gene
neXtProtiNX_Q9BQ51
OpenTargetsiENSG00000197646
PharmGKBiPA134891547
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVCK Eukaryota
ENOG4111V14 LUCA
GeneTreeiENSGT00930000150918
HOGENOMiHOG000059625
HOVERGENiHBG082112
InParanoidiQ9BQ51
KOiK06708
OMAiPANTSHT
OrthoDBiEOG091G0F5W
PhylomeDBiQ9BQ51
TreeFamiTF331083

Enzyme and pathway databases

ReactomeiR-HSA-389948 PD-1 signaling

Miscellaneous databases

ChiTaRSiPDCD1LG2 human
GeneWikiiPDCD1LG2
GenomeRNAii80380
PROiPR:Q9BQ51
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197646 Expressed in 82 organ(s), highest expression level in placenta
CleanExiHS_PDCD1LG2
GenevisibleiQ9BQ51 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPD1L2_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ51
Secondary accession number(s): Q14CN8
, Q5T7Z6, Q6JXL8, Q6JXL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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