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Protein

39S ribosomal protein L34, mitochondrial

Gene

MRPL34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L34, mitochondrial
Short name:
L34mt
Short name:
MRP-L34
Alternative name(s):
Mitochondrial large ribosomal subunit protein bL34m1 Publication
Gene namesi
Name:MRPL34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130312.6
HGNCiHGNC:14488 MRPL34
MIMi611840 gene
neXtProtiNX_Q9BQ48

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130312
PharmGKBiPA30965

Polymorphism and mutation databases

BioMutaiMRPL34
DMDMi20139691

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46MitochondrionBy similarityAdd BLAST46
ChainiPRO_000003052047 – 9239S ribosomal protein L34, mitochondrialAdd BLAST46

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei71PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BQ48
MaxQBiQ9BQ48
PaxDbiQ9BQ48
PeptideAtlasiQ9BQ48
PRIDEiQ9BQ48
ProteomicsDBi78620
TopDownProteomicsiQ9BQ48

PTM databases

iPTMnetiQ9BQ48
PhosphoSitePlusiQ9BQ48

Expressioni

Gene expression databases

BgeeiENSG00000130312 Expressed in 209 organ(s), highest expression level in quadriceps femoris
CleanExiHS_MRPL34
ExpressionAtlasiQ9BQ48 baseline and differential
GenevisibleiQ9BQ48 HS

Organism-specific databases

HPAiHPA049276

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.3 Publications

Protein-protein interaction databases

BioGridi122367, 36 interactors
CORUMiQ9BQ48
IntActiQ9BQ48, 4 interactors
STRINGi9606.ENSP00000252602

Structurei

Secondary structure

192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BQ48
SMRiQ9BQ48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4612 Eukaryota
COG0230 LUCA
GeneTreeiENSGT00390000012240
HOGENOMiHOG000111573
HOVERGENiHBG018253
InParanoidiQ9BQ48
KOiK02914
PhylomeDBiQ9BQ48
TreeFamiTF324478

Family and domain databases

InterProiView protein in InterPro
IPR000271 Ribosomal_L34
PANTHERiPTHR14503 PTHR14503, 1 hit
PfamiView protein in Pfam
PF00468 Ribosomal_L34, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003101 Ribosomal_L34, 1 hit
TIGRFAMsiTIGR01030 rpmH_bact, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9BQ48-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVLAGSLLG PTSRSAALLG GRWLQPRAWL GFPDAWGLPT PQQARGKARG
60 70 80 90
NEYQPSNIKR KNKHGWVRRL STPAGVQVIL RRMLKGRKSL SH
Length:92
Mass (Da):10,165
Last modified:June 1, 2001 - v1
Checksum:i923C87BAFA01054C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R226M0R226_HUMAN
39S ribosomal protein L34, mitochon...
MRPL34
184Annotation score:
M0R093M0R093_HUMAN
39S ribosomal protein L34, mitochon...
MRPL34
36Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049652 mRNA Translation: BAB40857.1
BC000071 mRNA Translation: AAH00071.1
BC021801 mRNA Translation: AAH21801.1
CCDSiCCDS12356.1
RefSeqiNP_076426.1, NM_023937.3
XP_011526491.1, XM_011528189.2
UniGeneiHs.515242

Genome annotation databases

EnsembliENST00000252602; ENSP00000252602; ENSG00000130312
ENST00000594999; ENSP00000471820; ENSG00000130312
ENST00000600434; ENSP00000469581; ENSG00000130312
GeneIDi64981
KEGGihsa:64981
UCSCiuc002ngc.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049652 mRNA Translation: BAB40857.1
BC000071 mRNA Translation: AAH00071.1
BC021801 mRNA Translation: AAH21801.1
CCDSiCCDS12356.1
RefSeqiNP_076426.1, NM_023937.3
XP_011526491.1, XM_011528189.2
UniGeneiHs.515242

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4021-92[»]
3J9Melectron microscopy3.5021-92[»]
5OOLelectron microscopy3.0621-92[»]
5OOMelectron microscopy3.0321-92[»]
ProteinModelPortaliQ9BQ48
SMRiQ9BQ48
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122367, 36 interactors
CORUMiQ9BQ48
IntActiQ9BQ48, 4 interactors
STRINGi9606.ENSP00000252602

PTM databases

iPTMnetiQ9BQ48
PhosphoSitePlusiQ9BQ48

Polymorphism and mutation databases

BioMutaiMRPL34
DMDMi20139691

Proteomic databases

EPDiQ9BQ48
MaxQBiQ9BQ48
PaxDbiQ9BQ48
PeptideAtlasiQ9BQ48
PRIDEiQ9BQ48
ProteomicsDBi78620
TopDownProteomicsiQ9BQ48

Protocols and materials databases

DNASUi64981
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252602; ENSP00000252602; ENSG00000130312
ENST00000594999; ENSP00000471820; ENSG00000130312
ENST00000600434; ENSP00000469581; ENSG00000130312
GeneIDi64981
KEGGihsa:64981
UCSCiuc002ngc.1 human

Organism-specific databases

CTDi64981
EuPathDBiHostDB:ENSG00000130312.6
GeneCardsiMRPL34
HGNCiHGNC:14488 MRPL34
HPAiHPA049276
MIMi611840 gene
neXtProtiNX_Q9BQ48
OpenTargetsiENSG00000130312
PharmGKBiPA30965
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4612 Eukaryota
COG0230 LUCA
GeneTreeiENSGT00390000012240
HOGENOMiHOG000111573
HOVERGENiHBG018253
InParanoidiQ9BQ48
KOiK02914
PhylomeDBiQ9BQ48
TreeFamiTF324478

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL34 human
GenomeRNAii64981
PROiPR:Q9BQ48
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130312 Expressed in 209 organ(s), highest expression level in quadriceps femoris
CleanExiHS_MRPL34
ExpressionAtlasiQ9BQ48 baseline and differential
GenevisibleiQ9BQ48 HS

Family and domain databases

InterProiView protein in InterPro
IPR000271 Ribosomal_L34
PANTHERiPTHR14503 PTHR14503, 1 hit
PfamiView protein in Pfam
PF00468 Ribosomal_L34, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003101 Ribosomal_L34, 1 hit
TIGRFAMsiTIGR01030 rpmH_bact, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM34_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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