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Protein

ATP-dependent RNA helicase DDX50

Gene

DDX50

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi181 – 188ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DDX50 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 50
Gu-beta
Nucleolar protein Gu2
Gene namesi
Name:DDX50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000107625.12
HGNCiHGNC:17906 DDX50
MIMi610373 gene
neXtProtiNX_Q9BQ39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000107625
PharmGKBiPA134948525

Polymorphism and mutation databases

BioMutaiDDX50
DMDMi55976580

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550541 – 737ATP-dependent RNA helicase DDX50Add BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineCombined sources1
Modified residuei82PhosphoserineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei121PhosphoserineBy similarity1
Modified residuei122PhosphoserineBy similarity1
Cross-linki125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei247PhosphothreonineBy similarity1
Modified residuei518PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9BQ39
MaxQBiQ9BQ39
PaxDbiQ9BQ39
PeptideAtlasiQ9BQ39
PRIDEiQ9BQ39
ProteomicsDBi78619

2D gel databases

SWISS-2DPAGEiQ9BQ39

PTM databases

iPTMnetiQ9BQ39
PhosphoSitePlusiQ9BQ39
SwissPalmiQ9BQ39

Expressioni

Gene expression databases

BgeeiENSG00000107625
CleanExiHS_DDX50
ExpressionAtlasiQ9BQ39 baseline and differential
GenevisibleiQ9BQ39 HS

Organism-specific databases

HPAiHPA037388
HPA037389
HPA058196

Interactioni

Subunit structurei

Interacts with C1QBP.1 Publication

Protein-protein interaction databases

BioGridi122480, 61 interactors
IntActiQ9BQ39, 22 interactors
MINTiQ9BQ39
STRINGi9606.ENSP00000362687

Structurei

Secondary structure

1737
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi587 – 593Combined sources7
Helixi602 – 611Combined sources10
Helixi614 – 617Combined sources4
Beta strandi621 – 625Combined sources5
Beta strandi629 – 637Combined sources9
Helixi638 – 647Combined sources10
Beta strandi650 – 652Combined sources3
Beta strandi654 – 656Combined sources3

3D structure databases

ProteinModelPortaliQ9BQ39
SMRiQ9BQ39
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BQ39

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 347Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST180
Domaini380 – 524Helicase C-terminalPROSITE-ProRule annotationAdd BLAST145

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi137 – 165Q motifAdd BLAST29
Motifi290 – 293DEVD box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi677 – 728Arg-richAdd BLAST52

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0331 Eukaryota
COG0513 LUCA
GeneTreeiENSGT00920000149066
HOGENOMiHOG000268805
HOVERGENiHBG051331
InParanoidiQ9BQ39
KOiK13183
OMAiSGGHKRN
OrthoDBiEOG091G04F8
PhylomeDBiQ9BQ39
TreeFamiTF328622

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR012562 GUCT
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR035979 RBD_domain_sf
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF08152 GUCT, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BQ39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGKLLWGDI MELEAPLEES ESQKKERQKS DRRKSRHHYD SDEKSETREN
60 70 80 90 100
GVTDDLDAPK AKKSKMKEKL NGDTEEGFNR LSDEFSKSHK SRRKDLPNGD
110 120 130 140 150
IDEYEKKSKR VSSLDTSTHK SSDNKLEETL TREQKEGAFS NFPISEETIK
160 170 180 190 200
LLKGRGVTYL FPIQVKTFGP VYEGKDLIAQ ARTGTGKTFS FAIPLIERLQ
210 220 230 240 250
RNQETIKKSR SPKVLVLAPT RELANQVAKD FKDITRKLSV ACFYGGTSYQ
260 270 280 290 300
SQINHIRNGI DILVGTPGRI KDHLQSGRLD LSKLRHVVLD EVDQMLDLGF
310 320 330 340 350
AEQVEDIIHE SYKTDSEDNP QTLLFSATCP QWVYKVAKKY MKSRYEQVDL
360 370 380 390 400
VGKMTQKAAT TVEHLAIQCH WSQRPAVIGD VLQVYSGSEG RAIIFCETKK
410 420 430 440 450
NVTEMAMNPH IKQNAQCLHG DIAQSQREIT LKGFREGSFK VLVATNVAAR
460 470 480 490 500
GLDIPEVDLV IQSSPPQDVE SYIHRSGRTG RAGRTGICIC FYQPRERGQL
510 520 530 540 550
RYVEQKAGIT FKRVGVPSTM DLVKSKSMDA IRSLASVSYA AVDFFRPSAQ
560 570 580 590 600
RLIEEKGAVD ALAAALAHIS GASSFEPRSL ITSDKGFVTM TLESLEEIQD
610 620 630 640 650
VSCAWKELNR KLSSNAVSQI TRMCLLKGNM GVCFDVPTTE SERLQAEWHD
660 670 680 690 700
SDWILSVPAK LPEIEEYYDG NTSSNSRQRS GWSSGRSGRS GRSGGRSGGR
710 720 730
SGRQSRQGSR SGSRQDGRRR SGNRNRSRSG GHKRSFD
Length:737
Mass (Da):82,565
Last modified:June 1, 2001 - v1
Checksum:i9B7EF72EEC7C504E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti680S → I in AAH18637 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334103 mRNA Translation: AAK29402.1
AL359844 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54304.1
BC000210 mRNA Translation: AAH00210.1
BC000272 mRNA Translation: AAH00272.1
BC018637 mRNA Translation: AAH18637.2
CCDSiCCDS7283.1
RefSeqiNP_076950.1, NM_024045.1
XP_016872115.1, XM_017016626.1
UniGeneiHs.522984

Genome annotation databases

EnsembliENST00000373585; ENSP00000362687; ENSG00000107625
GeneIDi79009
KEGGihsa:79009
UCSCiuc001jou.3 human

Similar proteinsi

Entry informationi

Entry nameiDDX50_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ39
Secondary accession number(s): Q5VX37, Q8WV76, Q9BWI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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