UniProtKB - Q9BQ39 (DDX50_HUMAN)
Protein
ATP-dependent RNA helicase DDX50
Gene
DDX50
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.6.4.13
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 181 – 188 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB
- RNA helicase activity Source: GO_Central
Keywordsi
Molecular function | Helicase, Hydrolase, RNA-binding |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9BQ39 |
Names & Taxonomyi
Protein namesi | Recommended name: ATP-dependent RNA helicase DDX50 (EC:3.6.4.13)Alternative name(s): DEAD box protein 50 Gu-beta Nucleolar protein Gu2 |
Gene namesi | Name:DDX50 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17906, DDX50 |
MIMi | 610373, gene |
neXtProti | NX_Q9BQ39 |
VEuPathDBi | HostDB:ENSG00000107625.12 |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
Nucleus
- nucleolus Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- membrane Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 79009 |
OpenTargetsi | ENSG00000107625 |
PharmGKBi | PA134948525 |
Miscellaneous databases
Pharosi | Q9BQ39, Tbio |
Genetic variation databases
BioMutai | DDX50 |
DMDMi | 55976580 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000055054 | 1 – 737 | ATP-dependent RNA helicase DDX50Add BLAST | 737 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 41 | PhosphoserineCombined sources | 1 | |
Modified residuei | 82 | PhosphoserineCombined sources | 1 | |
Modified residuei | 86 | PhosphoserineCombined sources | 1 | |
Modified residuei | 121 | PhosphoserineBy similarity | 1 | |
Modified residuei | 122 | PhosphoserineBy similarity | 1 | |
Cross-linki | 125 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 247 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 518 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9BQ39 |
jPOSTi | Q9BQ39 |
MassIVEi | Q9BQ39 |
MaxQBi | Q9BQ39 |
PaxDbi | Q9BQ39 |
PeptideAtlasi | Q9BQ39 |
PRIDEi | Q9BQ39 |
ProteomicsDBi | 78619 |
2D gel databases
SWISS-2DPAGEi | Q9BQ39 |
PTM databases
iPTMneti | Q9BQ39 |
MetOSitei | Q9BQ39 |
PhosphoSitePlusi | Q9BQ39 |
SwissPalmi | Q9BQ39 |
Expressioni
Gene expression databases
Bgeei | ENSG00000107625, Expressed in calcaneal tendon and 123 other tissues |
ExpressionAtlasi | Q9BQ39, baseline and differential |
Genevisiblei | Q9BQ39, HS |
Organism-specific databases
HPAi | ENSG00000107625, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with C1QBP.
1 PublicationProtein-protein interaction databases
BioGRIDi | 122480, 99 interactors |
IntActi | Q9BQ39, 40 interactors |
MINTi | Q9BQ39 |
STRINGi | 9606.ENSP00000362687 |
Miscellaneous databases
RNActi | Q9BQ39, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q9BQ39 |
SMRi | Q9BQ39 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BQ39 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 168 – 347 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 180 | |
Domaini | 380 – 524 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 145 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 137 – 165 | Q motifAdd BLAST | 29 | |
Motifi | 290 – 293 | DEVD box | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 677 – 728 | Arg-richAdd BLAST | 52 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0331, Eukaryota |
GeneTreei | ENSGT00940000155901 |
HOGENOMi | CLU_003041_20_0_1 |
InParanoidi | Q9BQ39 |
OMAi | EHTMQRF |
OrthoDBi | 1139373at2759 |
PhylomeDBi | Q9BQ39 |
TreeFami | TF328622 |
Family and domain databases
InterProi | View protein in InterPro IPR011545, DEAD/DEAH_box_helicase_dom IPR012562, GUCT IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR035979, RBD_domain_sf IPR014014, RNA_helicase_DEAD_Q_motif |
Pfami | View protein in Pfam PF00270, DEAD, 1 hit PF08152, GUCT, 1 hit PF00271, Helicase_C, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51195, Q_MOTIF, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9BQ39-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGKLLWGDI MELEAPLEES ESQKKERQKS DRRKSRHHYD SDEKSETREN
60 70 80 90 100
GVTDDLDAPK AKKSKMKEKL NGDTEEGFNR LSDEFSKSHK SRRKDLPNGD
110 120 130 140 150
IDEYEKKSKR VSSLDTSTHK SSDNKLEETL TREQKEGAFS NFPISEETIK
160 170 180 190 200
LLKGRGVTYL FPIQVKTFGP VYEGKDLIAQ ARTGTGKTFS FAIPLIERLQ
210 220 230 240 250
RNQETIKKSR SPKVLVLAPT RELANQVAKD FKDITRKLSV ACFYGGTSYQ
260 270 280 290 300
SQINHIRNGI DILVGTPGRI KDHLQSGRLD LSKLRHVVLD EVDQMLDLGF
310 320 330 340 350
AEQVEDIIHE SYKTDSEDNP QTLLFSATCP QWVYKVAKKY MKSRYEQVDL
360 370 380 390 400
VGKMTQKAAT TVEHLAIQCH WSQRPAVIGD VLQVYSGSEG RAIIFCETKK
410 420 430 440 450
NVTEMAMNPH IKQNAQCLHG DIAQSQREIT LKGFREGSFK VLVATNVAAR
460 470 480 490 500
GLDIPEVDLV IQSSPPQDVE SYIHRSGRTG RAGRTGICIC FYQPRERGQL
510 520 530 540 550
RYVEQKAGIT FKRVGVPSTM DLVKSKSMDA IRSLASVSYA AVDFFRPSAQ
560 570 580 590 600
RLIEEKGAVD ALAAALAHIS GASSFEPRSL ITSDKGFVTM TLESLEEIQD
610 620 630 640 650
VSCAWKELNR KLSSNAVSQI TRMCLLKGNM GVCFDVPTTE SERLQAEWHD
660 670 680 690 700
SDWILSVPAK LPEIEEYYDG NTSSNSRQRS GWSSGRSGRS GRSGGRSGGR
710 720 730
SGRQSRQGSR SGSRQDGRRR SGNRNRSRSG GHKRSFD
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WVC1 | A0A087WVC1_HUMAN | RNA helicase | DDX50 | 730 | Annotation score: | ||
S4R3V4 | S4R3V4_HUMAN | ATP-dependent RNA helicase DDX50 | DDX50 | 39 | Annotation score: | ||
S4R3G6 | S4R3G6_HUMAN | ATP-dependent RNA helicase DDX50 | DDX50 | 51 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 680 | S → I in AAH18637 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF334103 mRNA Translation: AAK29402.1 AL359844 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54304.1 BC000210 mRNA Translation: AAH00210.1 BC000272 mRNA Translation: AAH00272.1 BC018637 mRNA Translation: AAH18637.2 |
CCDSi | CCDS7283.1 |
RefSeqi | NP_076950.1, NM_024045.1 XP_016872115.1, XM_017016626.1 |
Genome annotation databases
Ensembli | ENST00000373585; ENSP00000362687; ENSG00000107625 |
GeneIDi | 79009 |
KEGGi | hsa:79009 |
UCSCi | uc001jou.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF334103 mRNA Translation: AAK29402.1 AL359844 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54304.1 BC000210 mRNA Translation: AAH00210.1 BC000272 mRNA Translation: AAH00272.1 BC018637 mRNA Translation: AAH18637.2 |
CCDSi | CCDS7283.1 |
RefSeqi | NP_076950.1, NM_024045.1 XP_016872115.1, XM_017016626.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2E29 | NMR | - | A | 575-659 | [»] | |
BMRBi | Q9BQ39 | |||||
SMRi | Q9BQ39 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122480, 99 interactors |
IntActi | Q9BQ39, 40 interactors |
MINTi | Q9BQ39 |
STRINGi | 9606.ENSP00000362687 |
PTM databases
iPTMneti | Q9BQ39 |
MetOSitei | Q9BQ39 |
PhosphoSitePlusi | Q9BQ39 |
SwissPalmi | Q9BQ39 |
Genetic variation databases
BioMutai | DDX50 |
DMDMi | 55976580 |
2D gel databases
SWISS-2DPAGEi | Q9BQ39 |
Proteomic databases
EPDi | Q9BQ39 |
jPOSTi | Q9BQ39 |
MassIVEi | Q9BQ39 |
MaxQBi | Q9BQ39 |
PaxDbi | Q9BQ39 |
PeptideAtlasi | Q9BQ39 |
PRIDEi | Q9BQ39 |
ProteomicsDBi | 78619 |
Protocols and materials databases
Antibodypediai | 14671, 164 antibodies |
DNASUi | 79009 |
Genome annotation databases
Ensembli | ENST00000373585; ENSP00000362687; ENSG00000107625 |
GeneIDi | 79009 |
KEGGi | hsa:79009 |
UCSCi | uc001jou.3, human |
Organism-specific databases
CTDi | 79009 |
DisGeNETi | 79009 |
GeneCardsi | DDX50 |
HGNCi | HGNC:17906, DDX50 |
HPAi | ENSG00000107625, Low tissue specificity |
MIMi | 610373, gene |
neXtProti | NX_Q9BQ39 |
OpenTargetsi | ENSG00000107625 |
PharmGKBi | PA134948525 |
VEuPathDBi | HostDB:ENSG00000107625.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0331, Eukaryota |
GeneTreei | ENSGT00940000155901 |
HOGENOMi | CLU_003041_20_0_1 |
InParanoidi | Q9BQ39 |
OMAi | EHTMQRF |
OrthoDBi | 1139373at2759 |
PhylomeDBi | Q9BQ39 |
TreeFami | TF328622 |
Enzyme and pathway databases
PathwayCommonsi | Q9BQ39 |
Miscellaneous databases
BioGRID-ORCSi | 79009, 26 hits in 876 CRISPR screens |
ChiTaRSi | DDX50, human |
EvolutionaryTracei | Q9BQ39 |
GeneWikii | DDX50 |
GenomeRNAii | 79009 |
Pharosi | Q9BQ39, Tbio |
PROi | PR:Q9BQ39 |
RNActi | Q9BQ39, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000107625, Expressed in calcaneal tendon and 123 other tissues |
ExpressionAtlasi | Q9BQ39, baseline and differential |
Genevisiblei | Q9BQ39, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011545, DEAD/DEAH_box_helicase_dom IPR012562, GUCT IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR035979, RBD_domain_sf IPR014014, RNA_helicase_DEAD_Q_motif |
Pfami | View protein in Pfam PF00270, DEAD, 1 hit PF08152, GUCT, 1 hit PF00271, Helicase_C, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51195, Q_MOTIF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DDX50_HUMAN | |
Accessioni | Q9BQ39Primary (citable) accession number: Q9BQ39 Secondary accession number(s): Q5VX37, Q8WV76, Q9BWI8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families