UniProtKB - Q9BQ31 (KCNS3_HUMAN)
Protein
Potassium voltage-gated channel subfamily S member 3
Gene
KCNS3
Organism
Homo sapiens (Human)
Status
Functioni
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:10484328). Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity).By similarity1 Publication
GO - Molecular functioni
- delayed rectifier potassium channel activity Source: ProtInc
- potassium channel regulator activity Source: ProtInc
- voltage-gated potassium channel activity Source: GO_Central
GO - Biological processi
- potassium ion transmembrane transport Source: GO_Central
- potassium ion transport Source: ProtInc
- protein homooligomerization Source: InterPro
- regulation of insulin secretion Source: Reactome
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Enzyme and pathway databases
PathwayCommonsi | Q9BQ31 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
Protein family/group databases
TCDBi | 1.A.1.2.15, the voltage-gated ion channel (vic) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium voltage-gated channel subfamily S member 3Alternative name(s): Delayed-rectifier K(+) channel alpha subunit 3 Voltage-gated potassium channel subunit Kv9.3 |
Gene namesi | Name:KCNS3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6302, KCNS3 |
MIMi | 603888, gene |
neXtProti | NX_Q9BQ31 |
VEuPathDBi | HostDB:ENSG00000170745.11 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Curated
Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 (PubMed:10484328).1 Publication
Cytosol
- cytosol Source: HPA
Golgi apparatus
- Golgi apparatus Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
- voltage-gated potassium channel complex Source: GO_Central
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 182 | CytoplasmicBy similarityAdd BLAST | 182 | |
Transmembranei | 183 – 204 | Helical; Name=Segment S1By similarityAdd BLAST | 22 | |
Topological domaini | 205 – 220 | ExtracellularBy similarityAdd BLAST | 16 | |
Transmembranei | 221 – 243 | Helical; Name=Segment S2By similarityAdd BLAST | 23 | |
Topological domaini | 244 – 254 | CytoplasmicBy similarityAdd BLAST | 11 | |
Transmembranei | 255 – 275 | Helical; Name=Segment S3By similarityAdd BLAST | 21 | |
Topological domaini | 276 – 285 | ExtracellularBy similarity | 10 | |
Transmembranei | 286 – 306 | Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST | 21 | |
Topological domaini | 307 – 321 | CytoplasmicBy similarityAdd BLAST | 15 | |
Transmembranei | 322 – 343 | Helical; Name=Segment S5By similarityAdd BLAST | 22 | |
Topological domaini | 344 – 357 | ExtracellularBy similarityAdd BLAST | 14 | |
Intramembranei | 358 – 369 | Helical; Name=Pore helixBy similarityAdd BLAST | 12 | |
Intramembranei | 370 – 377 | By similarity | 8 | |
Topological domaini | 378 – 384 | ExtracellularBy similarity | 7 | |
Transmembranei | 385 – 413 | Helical; Name=Segment S6By similarityAdd BLAST | 29 | |
Topological domaini | 414 – 491 | CytoplasmicBy similarityAdd BLAST | 78 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 3790 |
OpenTargetsi | ENSG00000170745 |
PharmGKBi | PA30080 |
Miscellaneous databases
Pharosi | Q9BQ31, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2362996 |
DrugBanki | DB00228, Enflurane DB01110, Miconazole DB01069, Promethazine |
DrugCentrali | Q9BQ31 |
Genetic variation databases
BioMutai | KCNS3 |
DMDMi | 311033434 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054087 | 1 – 491 | Potassium voltage-gated channel subfamily S member 3Add BLAST | 491 |
Proteomic databases
MassIVEi | Q9BQ31 |
PaxDbi | Q9BQ31 |
PeptideAtlasi | Q9BQ31 |
PRIDEi | Q9BQ31 |
ProteomicsDBi | 78618 |
Expressioni
Tissue specificityi
Detected in whole normal term placental and placental chorionic plate arteries and veins. Detected in syncytiotrophoblast and in blood vessel endothelium within intermediate villi and chorionic plate (at protein level) (PubMed:22943705). Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung (PubMed:10484328).2 Publications
Gene expression databases
Bgeei | ENSG00000170745, Expressed in skeletal muscle tissue and 207 other tissues |
ExpressionAtlasi | Q9BQ31, baseline and differential |
Genevisiblei | Q9BQ31, HS |
Organism-specific databases
HPAi | ENSG00000170745, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Protein-protein interaction databases
BioGRIDi | 109991, 36 interactors |
IntActi | Q9BQ31, 33 interactors |
STRINGi | 9606.ENSP00000385968 |
Miscellaneous databases
RNActi | Q9BQ31, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 370 – 375 | Selectivity filterBy similarity | 6 |
Domaini
The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity
Sequence similaritiesi
Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3713, Eukaryota |
GeneTreei | ENSGT00940000155979 |
HOGENOMi | CLU_011722_4_1_1 |
InParanoidi | Q9BQ31 |
OMAi | YIWLRLE |
OrthoDBi | 818306at2759 |
PhylomeDBi | Q9BQ31 |
TreeFami | TF313103 |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003971, K_chnl_volt-dep_Kv9 IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF00520, Ion_trans, 1 hit |
PRINTSi | PR01494, KV9CHANNEL PR01491, KVCHANNEL |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9BQ31-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVFGEFFHRP GQDEELVNLN VGGFKQSVDQ STLLRFPHTR LGKLLTCHSE
60 70 80 90 100
EAILELCDDY SVADKEYYFD RNPSLFRYVL NFYYTGKLHV MEELCVFSFC
110 120 130 140 150
QEIEYWGINE LFIDSCCSNR YQERKEENHE KDWDQKSHDV STDSSFEESS
160 170 180 190 200
LFEKELEKFD TLRFGQLRKK IWIRMENPAY CLSAKLIAIS SLSVVLASIV
210 220 230 240 250
AMCVHSMSEF QNEDGEVDDP VLEGVEIACI AWFTGELAVR LAAAPCQKKF
260 270 280 290 300
WKNPLNIIDF VSIIPFYATL AVDTKEEESE DIENMGKVVQ ILRLMRIFRI
310 320 330 340 350
LKLARHSVGL RSLGATLRHS YHEVGLLLLF LSVGISIFSV LIYSVEKDDH
360 370 380 390 400
TSSLTSIPIC WWWATISMTT VGYGDTHPVT LAGKLIASTC IICGILVVAL
410 420 430 440 450
PITIIFNKFS KYYQKQKDID VDQCSEDAPE KCHELPYFNI RDIYAQRMHT
460 470 480 490
FITSLSSVGI VVSDPDSTDA SSIEDNEDIC NTTSLENCTA K
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9J187 | C9J187_HUMAN | Potassium voltage-gated channel sub... | KCNS3 | 74 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 27 | S → Y in AAH15947 (PubMed:15815621).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036986 | 225 | V → L1 PublicationCorresponds to variant dbSNP:rs17856097Ensembl. | 1 | |
Natural variantiVAR_014200 | 450 | T → A3 PublicationsCorresponds to variant dbSNP:rs4832524Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF043472 mRNA Translation: AAC13164.1 AK314451 mRNA Translation: BAG37059.1 AC093731 Genomic DNA Translation: AAX88969.1 CH471053 Genomic DNA Translation: EAX00861.1 CH471053 Genomic DNA Translation: EAX00862.1 BC004148 mRNA Translation: AAH04148.1 BC004987 mRNA Translation: AAH04987.1 BC015947 mRNA Translation: AAH15947.1 |
CCDSi | CCDS1692.1 |
RefSeqi | NP_001269357.1, NM_001282428.1 NP_002243.3, NM_002252.4 XP_011531127.1, XM_011532825.1 XP_016859548.1, XM_017004059.1 |
Genome annotation databases
Ensembli | ENST00000304101; ENSP00000305824; ENSG00000170745 ENST00000403915; ENSP00000385968; ENSG00000170745 |
GeneIDi | 3790 |
KEGGi | hsa:3790 |
UCSCi | uc002rcv.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF043472 mRNA Translation: AAC13164.1 AK314451 mRNA Translation: BAG37059.1 AC093731 Genomic DNA Translation: AAX88969.1 CH471053 Genomic DNA Translation: EAX00861.1 CH471053 Genomic DNA Translation: EAX00862.1 BC004148 mRNA Translation: AAH04148.1 BC004987 mRNA Translation: AAH04987.1 BC015947 mRNA Translation: AAH15947.1 |
CCDSi | CCDS1692.1 |
RefSeqi | NP_001269357.1, NM_001282428.1 NP_002243.3, NM_002252.4 XP_011531127.1, XM_011532825.1 XP_016859548.1, XM_017004059.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 109991, 36 interactors |
IntActi | Q9BQ31, 33 interactors |
STRINGi | 9606.ENSP00000385968 |
Chemistry databases
ChEMBLi | CHEMBL2362996 |
DrugBanki | DB00228, Enflurane DB01110, Miconazole DB01069, Promethazine |
DrugCentrali | Q9BQ31 |
Protein family/group databases
TCDBi | 1.A.1.2.15, the voltage-gated ion channel (vic) superfamily |
Genetic variation databases
BioMutai | KCNS3 |
DMDMi | 311033434 |
Proteomic databases
MassIVEi | Q9BQ31 |
PaxDbi | Q9BQ31 |
PeptideAtlasi | Q9BQ31 |
PRIDEi | Q9BQ31 |
ProteomicsDBi | 78618 |
Protocols and materials databases
Antibodypediai | 3102, 118 antibodies |
DNASUi | 3790 |
Genome annotation databases
Ensembli | ENST00000304101; ENSP00000305824; ENSG00000170745 ENST00000403915; ENSP00000385968; ENSG00000170745 |
GeneIDi | 3790 |
KEGGi | hsa:3790 |
UCSCi | uc002rcv.4, human |
Organism-specific databases
CTDi | 3790 |
DisGeNETi | 3790 |
GeneCardsi | KCNS3 |
HGNCi | HGNC:6302, KCNS3 |
HPAi | ENSG00000170745, Tissue enhanced (skeletal) |
MIMi | 603888, gene |
neXtProti | NX_Q9BQ31 |
OpenTargetsi | ENSG00000170745 |
PharmGKBi | PA30080 |
VEuPathDBi | HostDB:ENSG00000170745.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3713, Eukaryota |
GeneTreei | ENSGT00940000155979 |
HOGENOMi | CLU_011722_4_1_1 |
InParanoidi | Q9BQ31 |
OMAi | YIWLRLE |
OrthoDBi | 818306at2759 |
PhylomeDBi | Q9BQ31 |
TreeFami | TF313103 |
Enzyme and pathway databases
PathwayCommonsi | Q9BQ31 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
Miscellaneous databases
BioGRID-ORCSi | 3790, 6 hits in 986 CRISPR screens |
ChiTaRSi | KCNS3, human |
GeneWikii | KCNS3 |
GenomeRNAii | 3790 |
Pharosi | Q9BQ31, Tclin |
PROi | PR:Q9BQ31 |
RNActi | Q9BQ31, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170745, Expressed in skeletal muscle tissue and 207 other tissues |
ExpressionAtlasi | Q9BQ31, baseline and differential |
Genevisiblei | Q9BQ31, HS |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003971, K_chnl_volt-dep_Kv9 IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF00520, Ion_trans, 1 hit |
PRINTSi | PR01494, KV9CHANNEL PR01491, KVCHANNEL |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCNS3_HUMAN | |
Accessioni | Q9BQ31Primary (citable) accession number: Q9BQ31 Secondary accession number(s): D6W520 Q96B56 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2002 |
Last sequence update: | November 2, 2010 | |
Last modified: | April 7, 2021 | |
This is version 164 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families