UniProtKB - Q9BQ24 (ZFY21_HUMAN)
Zinc finger FYVE domain-containing protein 21
ZFYVE21
Functioni
Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression.
2 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 50 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 53 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 66 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 69 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 74 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 77 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 96 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 99 | Zinc 2PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 44 – 104 | FYVE-typePROSITE-ProRule annotationAdd BLAST | 61 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9BQ24 |
SignaLinki | Q9BQ24 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger FYVE domain-containing protein 21Short name: ZF21 |
Gene namesi | Name:ZFYVE21 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20760, ZFYVE21 |
MIMi | 613504, gene |
neXtProti | NX_Q9BQ24 |
VEuPathDBi | HostDB:ENSG00000100711 |
Subcellular locationi
Endosome
Other locations
Note: Within cytoplasmic vesicles, partially colocalizes with EEA1, an endosomal marker.
Endosome
- endosome Source: UniProtKB-SubCell
Other locations
- focal adhesion Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell junction, Cytoplasmic vesicle, EndosomePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 64 – 65 | HH → NN: Diffuse cytoplasmic localization. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 79038 |
OpenTargetsi | ENSG00000100711 |
PharmGKBi | PA134879875 |
Miscellaneous databases
Pharosi | Q9BQ24, Tbio |
Genetic variation databases
BioMutai | ZFYVE21 |
DMDMi | 66774028 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000098720 | 1 – 234 | Zinc finger FYVE domain-containing protein 21Add BLAST | 234 |
Proteomic databases
EPDi | Q9BQ24 |
jPOSTi | Q9BQ24 |
MassIVEi | Q9BQ24 |
MaxQBi | Q9BQ24 |
PeptideAtlasi | Q9BQ24 |
PRIDEi | Q9BQ24 |
ProteomicsDBi | 78615 [Q9BQ24-1] 78616 [Q9BQ24-2] |
PTM databases
iPTMneti | Q9BQ24 |
PhosphoSitePlusi | Q9BQ24 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100711, Expressed in secondary oocyte and 228 other tissues |
ExpressionAtlasi | Q9BQ24, baseline and differential |
Genevisiblei | Q9BQ24, HS |
Organism-specific databases
HPAi | ENSG00000100711, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with PTK2/FAK1.
2 PublicationsBinary interactionsi
Q9BQ24
Protein-protein interaction databases
BioGRIDi | 122502, 79 interactors |
IntActi | Q9BQ24, 34 interactors |
STRINGi | 9606.ENSP00000216602 |
Miscellaneous databases
RNActi | Q9BQ24, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q9BQ24 |
SMRi | Q9BQ24 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BQ24 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 107 – 234 | PH-likeAdd BLAST | 128 |
Domaini
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 44 – 104 | FYVE-typePROSITE-ProRule annotationAdd BLAST | 61 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QRR6, Eukaryota |
GeneTreei | ENSGT00940000159639 |
HOGENOMi | CLU_103398_0_0_1 |
InParanoidi | Q9BQ24 |
OMAi | KRPAAAW |
OrthoDBi | 1256682at2759 |
PhylomeDBi | Q9BQ24 |
TreeFami | TF329481 |
Family and domain databases
Gene3Di | 2.30.29.160, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR032031, ZFYVE21_C IPR038632, ZFYVE21_C_sf IPR000306, Znf_FYVE IPR017455, Znf_FYVE-rel IPR011011, Znf_FYVE_PHD IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF01363, FYVE, 1 hit PF16696, ZFYVE21_C, 1 hit |
SMARTi | View protein in SMART SM00064, FYVE, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50178, ZF_FYVE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSEVSARRD AKKLVRSPSG LRMVPEHRAF GSPFGLEEPQ WVPDKECRRC
60 70 80 90 100
MQCDAKFDFL TRKHHCRRCG KCFCDRCCSQ KVPLRRMCFV DPVRQCAECA
110 120 130 140 150
LVSLKEAEFY DKQLKVLLSG ATFLVTFGNS EKPETMTCRL SNNQRYLFLD
160 170 180 190 200
GDSHYEIEIV HISTVQILTE GFPPGGGNAR ATGMFLQYTV PGTEGVTQLK
210 220 230
LTVVEDVTVG RRQAVAWLVA MHKAAKLLYE SRDQ
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketR4GN42 | R4GN42_HUMAN | Zinc finger FYVE domain-containing ... | ZFYVE21 | 115 | Annotation score: | ||
G3V5D6 | G3V5D6_HUMAN | Zinc finger FYVE domain-containing ... | ZFYVE21 | 62 | Annotation score: | ||
G3V2M2 | G3V2M2_HUMAN | Zinc finger FYVE domain-containing ... | ZFYVE21 | 93 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013794 | 175 | G → GEKDIHAYTSLRGSQPASE in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY395756 mRNA Translation: AAR14313.1 BX248261 mRNA Translation: CAD62589.1 Different initiation. AK057816 mRNA Translation: BAB71589.1 AK290519 mRNA Translation: BAF83208.1 CH471061 Genomic DNA Translation: EAW81844.1 BC001130 mRNA Translation: AAH01130.1 BC005999 mRNA Translation: AAH05999.1 |
CCDSi | CCDS55948.1 [Q9BQ24-2] CCDS9985.1 [Q9BQ24-1] |
RefSeqi | NP_001185882.1, NM_001198953.1 [Q9BQ24-2] NP_076976.1, NM_024071.3 [Q9BQ24-1] |
Genome annotation databases
Ensembli | ENST00000216602; ENSP00000216602; ENSG00000100711 [Q9BQ24-2] ENST00000311141; ENSP00000310543; ENSG00000100711 |
GeneIDi | 79038 |
KEGGi | hsa:79038 |
MANE-Selecti | ENST00000311141.7; ENSP00000310543.2; NM_024071.4; NP_076976.1 |
UCSCi | uc001yoc.4, human [Q9BQ24-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY395756 mRNA Translation: AAR14313.1 BX248261 mRNA Translation: CAD62589.1 Different initiation. AK057816 mRNA Translation: BAB71589.1 AK290519 mRNA Translation: BAF83208.1 CH471061 Genomic DNA Translation: EAW81844.1 BC001130 mRNA Translation: AAH01130.1 BC005999 mRNA Translation: AAH05999.1 |
CCDSi | CCDS55948.1 [Q9BQ24-2] CCDS9985.1 [Q9BQ24-1] |
RefSeqi | NP_001185882.1, NM_001198953.1 [Q9BQ24-2] NP_076976.1, NM_024071.3 [Q9BQ24-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2RRF | NMR | - | A | 107-234 | [»] | |
BMRBi | Q9BQ24 | |||||
SMRi | Q9BQ24 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122502, 79 interactors |
IntActi | Q9BQ24, 34 interactors |
STRINGi | 9606.ENSP00000216602 |
PTM databases
iPTMneti | Q9BQ24 |
PhosphoSitePlusi | Q9BQ24 |
Genetic variation databases
BioMutai | ZFYVE21 |
DMDMi | 66774028 |
Proteomic databases
EPDi | Q9BQ24 |
jPOSTi | Q9BQ24 |
MassIVEi | Q9BQ24 |
MaxQBi | Q9BQ24 |
PeptideAtlasi | Q9BQ24 |
PRIDEi | Q9BQ24 |
ProteomicsDBi | 78615 [Q9BQ24-1] 78616 [Q9BQ24-2] |
Protocols and materials databases
Antibodypediai | 28114, 103 antibodies from 23 providers |
DNASUi | 79038 |
Genome annotation databases
Ensembli | ENST00000216602; ENSP00000216602; ENSG00000100711 [Q9BQ24-2] ENST00000311141; ENSP00000310543; ENSG00000100711 |
GeneIDi | 79038 |
KEGGi | hsa:79038 |
MANE-Selecti | ENST00000311141.7; ENSP00000310543.2; NM_024071.4; NP_076976.1 |
UCSCi | uc001yoc.4, human [Q9BQ24-1] |
Organism-specific databases
CTDi | 79038 |
DisGeNETi | 79038 |
GeneCardsi | ZFYVE21 |
HGNCi | HGNC:20760, ZFYVE21 |
HPAi | ENSG00000100711, Low tissue specificity |
MIMi | 613504, gene |
neXtProti | NX_Q9BQ24 |
OpenTargetsi | ENSG00000100711 |
PharmGKBi | PA134879875 |
VEuPathDBi | HostDB:ENSG00000100711 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRR6, Eukaryota |
GeneTreei | ENSGT00940000159639 |
HOGENOMi | CLU_103398_0_0_1 |
InParanoidi | Q9BQ24 |
OMAi | KRPAAAW |
OrthoDBi | 1256682at2759 |
PhylomeDBi | Q9BQ24 |
TreeFami | TF329481 |
Enzyme and pathway databases
PathwayCommonsi | Q9BQ24 |
SignaLinki | Q9BQ24 |
Miscellaneous databases
BioGRID-ORCSi | 79038, 10 hits in 1052 CRISPR screens |
ChiTaRSi | ZFYVE21, human |
EvolutionaryTracei | Q9BQ24 |
GenomeRNAii | 79038 |
Pharosi | Q9BQ24, Tbio |
PROi | PR:Q9BQ24 |
RNActi | Q9BQ24, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100711, Expressed in secondary oocyte and 228 other tissues |
ExpressionAtlasi | Q9BQ24, baseline and differential |
Genevisiblei | Q9BQ24, HS |
Family and domain databases
Gene3Di | 2.30.29.160, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR032031, ZFYVE21_C IPR038632, ZFYVE21_C_sf IPR000306, Znf_FYVE IPR017455, Znf_FYVE-rel IPR011011, Znf_FYVE_PHD IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF01363, FYVE, 1 hit PF16696, ZFYVE21_C, 1 hit |
SMARTi | View protein in SMART SM00064, FYVE, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50178, ZF_FYVE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ZFY21_HUMAN | |
Accessioni | Q9BQ24Primary (citable) accession number: Q9BQ24 Secondary accession number(s): A8K3A4, Q86T05, Q96LT1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2005 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references