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Protein

BTB/POZ domain-containing protein KCTD14

Gene

KCTD14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD14
Gene namesi
Name:KCTD14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000151364.16
HGNCiHGNC:23295 KCTD14
neXtProtiNX_Q9BQ13

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151364
PharmGKBiPA134875104

Polymorphism and mutation databases

BioMutaiKCTD14
DMDMi251757290

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912991 – 255BTB/POZ domain-containing protein KCTD14Add BLAST255

Proteomic databases

EPDiQ9BQ13
MaxQBiQ9BQ13
PaxDbiQ9BQ13
PeptideAtlasiQ9BQ13
PRIDEiQ9BQ13
ProteomicsDBi78608

PTM databases

iPTMnetiQ9BQ13
PhosphoSitePlusiQ9BQ13

Expressioni

Gene expression databases

BgeeiENSG00000151364 Expressed in 142 organ(s), highest expression level in parotid gland
CleanExiHS_KCTD14
GenevisibleiQ9BQ13 HS

Organism-specific databases

HPAiHPA041118
HPA042181

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi122436, 5 interactors
IntActiQ9BQ13, 3 interactors
STRINGi9606.ENSP00000316482

Structurei

3D structure databases

ProteinModelPortaliQ9BQ13
SMRiQ9BQ13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 130BTBAdd BLAST98

Phylogenomic databases

eggNOGiKOG2723 Eukaryota
ENOG410Z155 LUCA
GeneTreeiENSGT00920000149007
HOGENOMiHOG000113201
HOVERGENiHBG052220
InParanoidiQ9BQ13
KOiK21917
OMAiDCVKMDI
OrthoDBiEOG091G0X03
PhylomeDBiQ9BQ13
TreeFamiTF315332

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BQ13-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWQGCAVERP VGRMTSQTPL PQSPRPRRPT MSTVVELNVG GEFHTTTLGT
60 70 80 90 100
LRKFPGSKLA EMFSSLAKAS TDAEGRFFID RPSTYFRPIL DYLRTGQVPT
110 120 130 140 150
QHIPEVYREA QFYEIKPLVK LLEDMPQIFG EQVSRKQFLL QVPGYSENLE
160 170 180 190 200
LMVRLARAEA ITARKSSVLV CLVETEEQDA YYSEVLCFLQ DKKMFKSVVK
210 220 230 240 250
FGPWKAVLDN SDLMHCLEMD IKAQGYKVFS KFYLTYPTKR NEFHFNIYSF

TFTWW
Length:255
Mass (Da):29,591
Last modified:July 7, 2009 - v2
Checksum:i8CACBE1B28951536
GO
Isoform 3b (identifier: Q9BQ13-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: Missing.

Note: No experimental confirmation available.
Show »
Length:225
Mass (Da):26,188
Checksum:iBA8435C5D6C2476D
GO
Isoform 2 (identifier: E9PQ53-1) [UniParc]FASTAAdd to basket
Also known as: NDUFC2-KCTD14
The sequence of this isoform can be found in the external entry E9PQ53.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a readthrough transcript which may produce a NDUFC2-KCTD14 fusion protein. No experimental confirmation available.
Length:114
Mass (Da):13,408
GO

Sequence cautioni

The sequence AAH01062 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH01929 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BX359005 differs from that shown. Reason: Frameshift at position 182.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0545621 – 30Missing in isoform 3b. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX359005 mRNA No translation available.
AK313892 mRNA Translation: BAG36615.1
AP003032 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW75043.1
BC001062 mRNA Translation: AAH01062.1 Different initiation.
BC001929 mRNA Translation: AAH01929.1 Different initiation.
CCDSiCCDS60908.1 [Q9BQ13-2]
CCDS8255.2 [Q9BQ13-1]
RefSeqiNP_001269335.1, NM_001282406.1 [Q9BQ13-2]
NP_076419.2, NM_023930.3 [Q9BQ13-1]
UniGeneiHs.709780

Genome annotation databases

EnsembliENST00000353172; ENSP00000316482; ENSG00000151364 [Q9BQ13-1]
ENST00000533144; ENSP00000431155; ENSG00000151364 [Q9BQ13-2]
GeneIDi65987
KEGGihsa:65987
UCSCiuc001oyw.5 human [Q9BQ13-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX359005 mRNA No translation available.
AK313892 mRNA Translation: BAG36615.1
AP003032 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW75043.1
BC001062 mRNA Translation: AAH01062.1 Different initiation.
BC001929 mRNA Translation: AAH01929.1 Different initiation.
CCDSiCCDS60908.1 [Q9BQ13-2]
CCDS8255.2 [Q9BQ13-1]
RefSeqiNP_001269335.1, NM_001282406.1 [Q9BQ13-2]
NP_076419.2, NM_023930.3 [Q9BQ13-1]
UniGeneiHs.709780

3D structure databases

ProteinModelPortaliQ9BQ13
SMRiQ9BQ13
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122436, 5 interactors
IntActiQ9BQ13, 3 interactors
STRINGi9606.ENSP00000316482

PTM databases

iPTMnetiQ9BQ13
PhosphoSitePlusiQ9BQ13

Polymorphism and mutation databases

BioMutaiKCTD14
DMDMi251757290

Proteomic databases

EPDiQ9BQ13
MaxQBiQ9BQ13
PaxDbiQ9BQ13
PeptideAtlasiQ9BQ13
PRIDEiQ9BQ13
ProteomicsDBi78608

Protocols and materials databases

DNASUi65987
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000353172; ENSP00000316482; ENSG00000151364 [Q9BQ13-1]
ENST00000533144; ENSP00000431155; ENSG00000151364 [Q9BQ13-2]
GeneIDi65987
KEGGihsa:65987
UCSCiuc001oyw.5 human [Q9BQ13-1]

Organism-specific databases

CTDi65987
EuPathDBiHostDB:ENSG00000151364.16
GeneCardsiKCTD14
HGNCiHGNC:23295 KCTD14
HPAiHPA041118
HPA042181
neXtProtiNX_Q9BQ13
OpenTargetsiENSG00000151364
PharmGKBiPA134875104
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2723 Eukaryota
ENOG410Z155 LUCA
GeneTreeiENSGT00920000149007
HOGENOMiHOG000113201
HOVERGENiHBG052220
InParanoidiQ9BQ13
KOiK21917
OMAiDCVKMDI
OrthoDBiEOG091G0X03
PhylomeDBiQ9BQ13
TreeFamiTF315332

Miscellaneous databases

ChiTaRSiKCTD14 human
GenomeRNAii65987
PROiPR:Q9BQ13

Gene expression databases

BgeeiENSG00000151364 Expressed in 142 organ(s), highest expression level in parotid gland
CleanExiHS_KCTD14
GenevisibleiQ9BQ13 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCD14_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ13
Secondary accession number(s): B2R9R8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 7, 2009
Last modified: November 7, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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