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Protein

Resistin-like beta

Gene

RETNLB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable hormone.

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: UniProtKB

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Resistin-like beta
Alternative name(s):
Colon and small intestine-specific cysteine-rich protein
Colon carcinoma-related gene protein
Cysteine-rich secreted protein A12-alpha-like 1
Cysteine-rich secreted protein FIZZ2
RELMbeta
Gene namesi
Name:RETNLB
Synonyms:CCRG, FIZZ2, HXCP2, RETNL2
ORF Names:UNQ408/PRO770
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163515.6
HGNCiHGNC:20388 RETNLB
MIMi605645 gene
neXtProtiNX_Q9BQ08

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi84666
OpenTargetsiENSG00000163515
PharmGKBiPA134906814

Polymorphism and mutation databases

BioMutaiRETNLB
DMDMi18202730

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003034524 – 111Resistin-like betaAdd BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25InterchainCurated
Disulfide bondi55 ↔ 108By similarity
Disulfide bondi67 ↔ 107By similarity
Disulfide bondi76 ↔ 93By similarity
Disulfide bondi78 ↔ 95By similarity
Disulfide bondi82 ↔ 97By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9BQ08
PeptideAtlasiQ9BQ08
PRIDEiQ9BQ08
ProteomicsDBi78607

Expressioni

Tissue specificityi

Expressed only in the gastrointestinal tract, particularly the colon.

Gene expression databases

BgeeiENSG00000163515 Expressed in 37 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_RETNLB
GenevisibleiQ9BQ08 HS

Organism-specific databases

HPAiHPA049152

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124186, 20 interactors
STRINGi9606.ENSP00000295755

Structurei

3D structure databases

ProteinModelPortaliQ9BQ08
SMRiQ9BQ08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the resistin/FIZZ family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JDSE Eukaryota
ENOG410ZE8R LUCA
GeneTreeiENSGT00390000016177
HOGENOMiHOG000137607
HOVERGENiHBG018297
InParanoidiQ9BQ08
OMAiCHCQCSV
OrthoDBiEOG091G11FA
PhylomeDBiQ9BQ08
TreeFamiTF337024

Family and domain databases

CDDicd16333 RELM, 1 hit
Gene3Di3.30.1660.20, 1 hit
InterProiView protein in InterPro
IPR009714 Resistin
IPR036262 Resistin-like_sf
PANTHERiPTHR21101 PTHR21101, 1 hit
PfamiView protein in Pfam
PF06954 Resistin, 1 hit
SUPFAMiSSF111423 SSF111423, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BQ08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPSSCLLLI LIPLLQLINP GSTQCSLDSV MDKKIKDVLN SLEYSPSPIS
60 70 80 90 100
KKLSCASVKS QGRPSSCPAG MAVTGCACGY GCGSWDVQLE TTCHCQCSVV
110
DWTTARCCHL T
Length:111
Mass (Da):11,730
Last modified:June 1, 2001 - v1
Checksum:iBD64233AF302B4C0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05179120P → L. Corresponds to variant dbSNP:rs11708527Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352731 Genomic DNA Translation: AAK18622.1
AF323084 mRNA Translation: AAG59827.1
AF290873 mRNA Translation: AAK83105.1
AF323921 mRNA Translation: AAL96378.1
AY358655 mRNA Translation: AAQ89018.1
BC069318 mRNA Translation: AAH69318.1
BC113502 mRNA Translation: AAI13503.1
BC113528 mRNA Translation: AAI13529.1
CCDSiCCDS2953.1
RefSeqiNP_115968.1, NM_032579.2
UniGeneiHs.307047

Genome annotation databases

EnsembliENST00000295755; ENSP00000295755; ENSG00000163515
GeneIDi84666
KEGGihsa:84666
UCSCiuc003dxh.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352731 Genomic DNA Translation: AAK18622.1
AF323084 mRNA Translation: AAG59827.1
AF290873 mRNA Translation: AAK83105.1
AF323921 mRNA Translation: AAL96378.1
AY358655 mRNA Translation: AAQ89018.1
BC069318 mRNA Translation: AAH69318.1
BC113502 mRNA Translation: AAI13503.1
BC113528 mRNA Translation: AAI13529.1
CCDSiCCDS2953.1
RefSeqiNP_115968.1, NM_032579.2
UniGeneiHs.307047

3D structure databases

ProteinModelPortaliQ9BQ08
SMRiQ9BQ08
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124186, 20 interactors
STRINGi9606.ENSP00000295755

Polymorphism and mutation databases

BioMutaiRETNLB
DMDMi18202730

Proteomic databases

PaxDbiQ9BQ08
PeptideAtlasiQ9BQ08
PRIDEiQ9BQ08
ProteomicsDBi78607

Protocols and materials databases

DNASUi84666
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295755; ENSP00000295755; ENSG00000163515
GeneIDi84666
KEGGihsa:84666
UCSCiuc003dxh.3 human

Organism-specific databases

CTDi84666
DisGeNETi84666
EuPathDBiHostDB:ENSG00000163515.6
GeneCardsiRETNLB
HGNCiHGNC:20388 RETNLB
HPAiHPA049152
MIMi605645 gene
neXtProtiNX_Q9BQ08
OpenTargetsiENSG00000163515
PharmGKBiPA134906814
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JDSE Eukaryota
ENOG410ZE8R LUCA
GeneTreeiENSGT00390000016177
HOGENOMiHOG000137607
HOVERGENiHBG018297
InParanoidiQ9BQ08
OMAiCHCQCSV
OrthoDBiEOG091G11FA
PhylomeDBiQ9BQ08
TreeFamiTF337024

Miscellaneous databases

ChiTaRSiRETNLB human
GeneWikiiRETNLB
GenomeRNAii84666
PROiPR:Q9BQ08
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163515 Expressed in 37 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_RETNLB
GenevisibleiQ9BQ08 HS

Family and domain databases

CDDicd16333 RELM, 1 hit
Gene3Di3.30.1660.20, 1 hit
InterProiView protein in InterPro
IPR009714 Resistin
IPR036262 Resistin-like_sf
PANTHERiPTHR21101 PTHR21101, 1 hit
PfamiView protein in Pfam
PF06954 Resistin, 1 hit
SUPFAMiSSF111423 SSF111423, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRETNB_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ08
Secondary accession number(s): Q14D27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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