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Protein

RNA-binding protein 4B

Gene

RBM4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri160 – 177CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, RNA-binding
Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 4B
Alternative name(s):
RNA-binding motif protein 30
RNA-binding motif protein 4B
RNA-binding protein 30
Gene namesi
Name:RBM4B
Synonyms:RBM30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000173914.11
HGNCiHGNC:28842 RBM4B
neXtProtiNX_Q9BQ04

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173914
PharmGKBiPA134977404

Polymorphism and mutation databases

DMDMi62511129

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817871 – 359RNA-binding protein 4BAdd BLAST359

Proteomic databases

EPDiQ9BQ04
MaxQBiQ9BQ04
PaxDbiQ9BQ04
PeptideAtlasiQ9BQ04
PRIDEiQ9BQ04
ProteomicsDBi78606

2D gel databases

SWISS-2DPAGEiQ9BQ04

PTM databases

iPTMnetiQ9BQ04
PhosphoSitePlusiQ9BQ04

Expressioni

Tissue specificityi

Expressed in liver and kidney (at protein level). Ubiquitously expressed.2 Publications

Gene expression databases

BgeeiENSG00000173914 Expressed in 193 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_RBM4B
ExpressionAtlasiQ9BQ04 baseline and differential
GenevisibleiQ9BQ04 HS

Organism-specific databases

HPAiHPA042174
HPA047849

Interactioni

Subunit structurei

Interacts with TNPO3, which may mediate nuclear import of the protein.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi123760, 72 interactors
IntActiQ9BQ04, 17 interactors
MINTiQ9BQ04
STRINGi9606.ENSP00000310471

Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BQ04
SMRiQ9BQ04
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BQ04

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 72RRM 1PROSITE-ProRule annotationAdd BLAST71
Domaini78 – 148RRM 2PROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni196 – 359Interaction with TNPO3By similarityAdd BLAST164

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi231 – 240Poly-Ala10
Compositional biasi286 – 293Poly-Ala8

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri160 – 177CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0109 Eukaryota
ENOG41105PP LUCA
GeneTreeiENSGT00390000020883
HOGENOMiHOG000026790
HOVERGENiHBG062217
InParanoidiQ9BQ04
KOiK13187
OMAiVYYNDAY
OrthoDBiEOG091G08PZ
PhylomeDBiQ9BQ04
TreeFamiTF320661

Family and domain databases

CDDicd12606 RRM1_RBM4, 1 hit
cd12607 RRM2_RBM4, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034897 RBM4_RRM1
IPR034898 RBM4_RRM2
IPR000504 RRM_dom
IPR001878 Znf_CCHC
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SM00343 ZnF_C2HC, 1 hit
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
PS50158 ZF_CCHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9BQ04-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKLFIGNLP REATEQEIRS LFEQYGKVLE CDIIKNYGFV HIEDKTAAED
60 70 80 90 100
AIRNLHHYKL HGVNINVEAS KNKSKASTKL HVGNISPTCT NQELRAKFEE
110 120 130 140 150
YGPVIECDIV KDYAFVHMER AEDAVEAIRG LDNTEFQGKR MHVQLSTSRL
160 170 180 190 200
RTAPGMGDQS GCYRCGKEGH WSKECPVDRT GRVADFTEQY NEQYGAVRTP
210 220 230 240 250
YTMGYGESMY YNDAYGALDY YKRYRVRSYE AVAAAAAASA YNYAEQTMSH
260 270 280 290 300
LPQVQSTTVT SHLNSTSVDP YDRHLLPNSG AAATSAAMAA AAATTSSYYG
310 320 330 340 350
RDRSPLRRAA AMLPTVGEGY GYGPESELSQ ASAATRNSLY DMARYEREQY

VDRARYSAF
Length:359
Mass (Da):40,150
Last modified:June 1, 2001 - v1
Checksum:iC336DF80460BD474
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLB0E9PLB0_HUMAN
RNA-binding protein 4B
RBM4B
143Annotation score:
U3KQD5U3KQD5_HUMAN
RNA-binding protein 4B
RBM4B
151Annotation score:
E9PM61E9PM61_HUMAN
RNA-binding protein 4B
RBM4B
147Annotation score:
H0YDG8H0YDG8_HUMAN
RNA-binding protein 4B
RBM4B
20Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06476693E → V1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095158 mRNA Translation: BAG52995.1
CH471076 Genomic DNA Translation: EAW74558.1
BC003503 mRNA Translation: AAH03503.1
BC004951 mRNA Translation: AAH04951.1
CCDSiCCDS8149.1
RefSeqiNP_001273064.1, NM_001286135.1
NP_113680.1, NM_031492.3
XP_011543599.1, XM_011545297.2
XP_016873891.1, XM_017018402.1
UniGeneiHs.618713

Genome annotation databases

EnsembliENST00000310046; ENSP00000310471; ENSG00000173914
ENST00000525754; ENSP00000433071; ENSG00000173914
GeneIDi83759
KEGGihsa:83759
UCSCiuc001oja.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095158 mRNA Translation: BAG52995.1
CH471076 Genomic DNA Translation: EAW74558.1
BC003503 mRNA Translation: AAH03503.1
BC004951 mRNA Translation: AAH04951.1
CCDSiCCDS8149.1
RefSeqiNP_001273064.1, NM_001286135.1
NP_113680.1, NM_031492.3
XP_011543599.1, XM_011545297.2
XP_016873891.1, XM_017018402.1
UniGeneiHs.618713

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DGTNMR-A75-153[»]
ProteinModelPortaliQ9BQ04
SMRiQ9BQ04
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123760, 72 interactors
IntActiQ9BQ04, 17 interactors
MINTiQ9BQ04
STRINGi9606.ENSP00000310471

PTM databases

iPTMnetiQ9BQ04
PhosphoSitePlusiQ9BQ04

Polymorphism and mutation databases

DMDMi62511129

2D gel databases

SWISS-2DPAGEiQ9BQ04

Proteomic databases

EPDiQ9BQ04
MaxQBiQ9BQ04
PaxDbiQ9BQ04
PeptideAtlasiQ9BQ04
PRIDEiQ9BQ04
ProteomicsDBi78606

Protocols and materials databases

DNASUi83759
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310046; ENSP00000310471; ENSG00000173914
ENST00000525754; ENSP00000433071; ENSG00000173914
GeneIDi83759
KEGGihsa:83759
UCSCiuc001oja.5 human

Organism-specific databases

CTDi83759
EuPathDBiHostDB:ENSG00000173914.11
GeneCardsiRBM4B
HGNCiHGNC:28842 RBM4B
HPAiHPA042174
HPA047849
neXtProtiNX_Q9BQ04
OpenTargetsiENSG00000173914
PharmGKBiPA134977404
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0109 Eukaryota
ENOG41105PP LUCA
GeneTreeiENSGT00390000020883
HOGENOMiHOG000026790
HOVERGENiHBG062217
InParanoidiQ9BQ04
KOiK13187
OMAiVYYNDAY
OrthoDBiEOG091G08PZ
PhylomeDBiQ9BQ04
TreeFamiTF320661

Miscellaneous databases

ChiTaRSiRBM4B human
EvolutionaryTraceiQ9BQ04
GenomeRNAii83759
PROiPR:Q9BQ04

Gene expression databases

BgeeiENSG00000173914 Expressed in 193 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_RBM4B
ExpressionAtlasiQ9BQ04 baseline and differential
GenevisibleiQ9BQ04 HS

Family and domain databases

CDDicd12606 RRM1_RBM4, 1 hit
cd12607 RRM2_RBM4, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034897 RBM4_RRM1
IPR034898 RBM4_RRM2
IPR000504 RRM_dom
IPR001878 Znf_CCHC
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SM00343 ZnF_C2HC, 1 hit
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
PS50158 ZF_CCHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRBM4B_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ04
Secondary accession number(s): B3KT83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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