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Entry version 158 (08 May 2019)
Sequence version 2 (14 Aug 2001)
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Protein

Target of rapamycin complex 2 subunit MAPKAP1

Gene

MAPKAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processStress response

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-6804757 Regulation of TP53 Degradation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9BPZ7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Target of rapamycin complex 2 subunit MAPKAP1
Short name:
TORC2 subunit MAPKAP1
Alternative name(s):
Mitogen-activated protein kinase 2-associated protein 1
Stress-activated map kinase-interacting protein 1
Short name:
SAPK-interacting protein 1
Short name:
mSIN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAPKAP1
Synonyms:MIP1, SIN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18752 MAPKAP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610558 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BPZ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79109

Open Targets

More...
OpenTargetsi
ENSG00000119487

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38674

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAPKAP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
15214282

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002187682 – 522Target of rapamycin complex 2 subunit MAPKAP1Add BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1
Modified residuei186PhosphoserineCombined sources1
Modified residuei510PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BPZ7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BPZ7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BPZ7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BPZ7

PeptideAtlas

More...
PeptideAtlasi
Q9BPZ7

PRoteomics IDEntifications database

More...
PRIDEi
Q9BPZ7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78599
78600 [Q9BPZ7-2]
78601 [Q9BPZ7-3]
78602 [Q9BPZ7-4]
78603 [Q9BPZ7-5]
78604 [Q9BPZ7-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BPZ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BPZ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed, with highest levels in heart and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119487 Expressed in 224 organ(s), highest expression level in urinary bladder

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BPZ7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BPZ7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029091
HPA029092

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

All isoforms except isoform 4 can be incorporated into the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts with ATF2, MAP3K2 and MAPK8. Interacts with GTP-bound HRAS and KRAS. Interacts with IFNAR2 and SGK1. Isoform 2 interacts with NBN. Isoform 1 interacts with CCDC28B.7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PRKDCP785272EBI-749938,EBI-352053

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122551, 104 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9BPZ7

Database of interacting proteins

More...
DIPi
DIP-39480N

Protein interaction database and analysis system

More...
IntActi
Q9BPZ7, 28 interactors

Molecular INTeraction database

More...
MINTi
Q9BPZ7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265960

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1522
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BPZ7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 267Interaction with NBN1 PublicationAdd BLAST266
Regioni2 – 184Interaction with MAP3K21 PublicationAdd BLAST183
Regioni468 – 522Interaction with ATF21 PublicationAdd BLAST55

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SIN1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3739 Eukaryota
ENOG410XR57 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000642

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BPZ7

KEGG Orthology (KO)

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KOi
K20410

Identification of Orthologs from Complete Genome Data

More...
OMAi
NAKFWPQ

Database of Orthologous Groups

More...
OrthoDBi
1492466at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BPZ7

TreeFam database of animal gene trees

More...
TreeFami
TF315174

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031567 CRIM_dom
IPR011993 PH-like_dom_sf
IPR032679 Sin1_N
IPR031313 Sin1_PH_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16978 CRIM, 1 hit
PF05422 SIN1, 1 hit
PF16979 SIN1_PH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BPZ7-1) [UniParc]FASTAAdd to basket
Also known as: beta, gamma

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFLDNPTII LAHIRQSHVT SDDTGMCEMV LIDHDVDLEK IHPPSMPGDS
60 70 80 90 100
GSEIQGSNGE TQGYVYAQSV DITSSWDFGI RRRSNTAQRL ERLRKERQNQ
110 120 130 140 150
IKCKNIQWKE RNSKQSAQEL KSLFEKKSLK EKPPISGKQS ILSVRLEQCP
160 170 180 190 200
LQLNNPFNEY SKFDGKGHVG TTATKKIDVY LPLHSSQDRL LPMTVVTMAS
210 220 230 240 250
ARVQDLIGLI CWQYTSEGRE PKLNDNVSAY CLHIAEDDGE VDTDFPPLDS
260 270 280 290 300
NEPIHKFGFS TLALVEKYSS PGLTSKESLF VRINAAHGFS LIQVDNTKVT
310 320 330 340 350
MKEILLKAVK RRKGSQKVSG PQYRLEKQSE PNVAVDLDST LESQSAWEFC
360 370 380 390 400
LVRENSSRAD GVFEEDSQID IATVQDMLSS HHYKSFKVSM IHRLRFTTDV
410 420 430 440 450
QLGISGDKVE IDPVTNQKAS TKFWIKQKPI SIDSDLLCAC DLAEEKSPSH
460 470 480 490 500
AIFKLTYLSN HDYKHLYFES DAATVNEIVL KVNYILESRA STARADYFAQ
510 520
KQRKLNRRTS FSFQKEKKSG QQ
Length:522
Mass (Da):59,123
Last modified:August 14, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE3B808C6E58F7C48
GO
Isoform 2 (identifier: Q9BPZ7-2) [UniParc]FASTAAdd to basket
Also known as: alpha, beta

The sequence of this isoform differs from the canonical sequence as follows:
     321-356: Missing.

Show »
Length:486
Mass (Da):54,971
Checksum:iC880D5047EEEC4A0
GO
Isoform 3 (identifier: Q9BPZ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     357-403: Missing.

Show »
Length:475
Mass (Da):53,744
Checksum:iAC1274FBE11ED04E
GO
Isoform 4 (identifier: Q9BPZ7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-192: Missing.

Note: Not involved in a TORC2 complex.
Show »
Length:330
Mass (Da):37,320
Checksum:iE9ABF4B32E394142
GO
Isoform 5 (identifier: Q9BPZ7-5) [UniParc]FASTAAdd to basket
Also known as: alpha

The sequence of this isoform differs from the canonical sequence as follows:
     321-438: Missing.
     442-522: Missing.

Show »
Length:323
Mass (Da):36,237
Checksum:iFECEC53E16862340
GO
Isoform 6 (identifier: Q9BPZ7-6) [UniParc]FASTAAdd to basket
Also known as: gamma

The sequence of this isoform differs from the canonical sequence as follows:
     357-372: SRADGVFEEDSQIDIA → TLAASLHARFVRCKLA
     373-522: Missing.

Show »
Length:372
Mass (Da):41,838
Checksum:i228CE1A0DB9E2CD8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AMB2B1AMB2_HUMAN
Target of rapamycin complex 2 subun...
MAPKAP1
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AMA5B1AMA5_HUMAN
Target of rapamycin complex 2 subun...
MAPKAP1
253Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PGB8E9PGB8_HUMAN
Target of rapamycin complex 2 subun...
MAPKAP1
245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AMA6B1AMA6_HUMAN
Target of rapamycin complex 2 subun...
MAPKAP1
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y866H0Y866_HUMAN
Target of rapamycin complex 2 subun...
MAPKAP1
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AMB1B1AMB1_HUMAN
Target of rapamycin complex 2 subun...
MAPKAP1
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7F8H0Y7F8_HUMAN
Target of rapamycin complex 2 subun...
MAPKAP1
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti76 – 86WDFGIRRRSNT → ADPARSVEAAS in AAA36551 (PubMed:1849280).CuratedAdd BLAST11
Sequence conflicti178D → N in AAT46480 (PubMed:15988011).Curated1
Sequence conflicti178D → N in AAT46478 (PubMed:15988011).Curated1
Sequence conflicti178D → N in AAT46479 (PubMed:15988011).Curated1
Sequence conflicti305L → F in BAF82749 (PubMed:14702039).Curated1
Sequence conflicti478I → T in CAH56311 (PubMed:17974005).Curated1
Sequence conflicti491S → N in AAT46478 (PubMed:15988011).Curated1
Sequence conflicti491S → N in AAT46479 (PubMed:15988011).Curated1
Sequence conflicti502Q → K in AAA36551 (PubMed:1849280).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0332021 – 192Missing in isoform 4. 2 PublicationsAdd BLAST192
Alternative sequenceiVSP_033203321 – 438Missing in isoform 5. 1 PublicationAdd BLAST118
Alternative sequenceiVSP_006098321 – 356Missing in isoform 2. 4 PublicationsAdd BLAST36
Alternative sequenceiVSP_033204357 – 403Missing in isoform 3. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_033205357 – 372SRADG…QIDIA → TLAASLHARFVRCKLA in isoform 6. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_033206373 – 522Missing in isoform 6. 1 PublicationAdd BLAST150
Alternative sequenceiVSP_033207442 – 522Missing in isoform 5. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY524429 mRNA Translation: AAS90839.1
AY524430 mRNA Translation: AAS90840.1
AY524431 mRNA Translation: AAS90841.1
AY524432 mRNA Translation: AAS90842.1
AY633624 mRNA Translation: AAT46478.1
AY633625 mRNA Translation: AAT46479.1
AY633626 mRNA Translation: AAT46480.1
AK290060 mRNA Translation: BAF82749.1
AK295364 mRNA Translation: BAH12045.1
AK316149 mRNA Translation: BAH14520.1
AL833042 mRNA Translation: CAH56311.1
AL162584 Genomic DNA No translation available.
AL359632 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87630.1
CH471090 Genomic DNA Translation: EAW87631.1
CH471090 Genomic DNA Translation: EAW87632.1
BC003044 mRNA Translation: AAH03044.1
BC002326 mRNA Translation: AAH02326.1
M37191 mRNA Translation: AAA36551.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35139.1 [Q9BPZ7-3]
CCDS35140.1 [Q9BPZ7-1]
CCDS35141.1 [Q9BPZ7-4]
CCDS48020.1 [Q9BPZ7-5]
CCDS6864.1 [Q9BPZ7-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
C38637

NCBI Reference Sequences

More...
RefSeqi
NP_001006618.1, NM_001006617.1 [Q9BPZ7-1]
NP_001006619.1, NM_001006618.1 [Q9BPZ7-5]
NP_001006620.1, NM_001006619.1 [Q9BPZ7-3]
NP_001006621.1, NM_001006620.1 [Q9BPZ7-4]
NP_001006622.1, NM_001006621.1 [Q9BPZ7-4]
NP_077022.1, NM_024117.3 [Q9BPZ7-2]
XP_011517312.1, XM_011519010.2 [Q9BPZ7-4]
XP_016870615.1, XM_017015126.1 [Q9BPZ7-1]
XP_016870616.1, XM_017015127.1 [Q9BPZ7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265960; ENSP00000265960; ENSG00000119487 [Q9BPZ7-1]
ENST00000350766; ENSP00000265961; ENSG00000119487 [Q9BPZ7-2]
ENST00000373498; ENSP00000362597; ENSG00000119487 [Q9BPZ7-1]
ENST00000373503; ENSP00000362602; ENSG00000119487 [Q9BPZ7-4]
ENST00000373511; ENSP00000362610; ENSG00000119487 [Q9BPZ7-3]
ENST00000394060; ENSP00000377624; ENSG00000119487 [Q9BPZ7-5]
ENST00000394063; ENSP00000377627; ENSG00000119487 [Q9BPZ7-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79109

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79109

UCSC genome browser

More...
UCSCi
uc004bpv.3 human [Q9BPZ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY524429 mRNA Translation: AAS90839.1
AY524430 mRNA Translation: AAS90840.1
AY524431 mRNA Translation: AAS90841.1
AY524432 mRNA Translation: AAS90842.1
AY633624 mRNA Translation: AAT46478.1
AY633625 mRNA Translation: AAT46479.1
AY633626 mRNA Translation: AAT46480.1
AK290060 mRNA Translation: BAF82749.1
AK295364 mRNA Translation: BAH12045.1
AK316149 mRNA Translation: BAH14520.1
AL833042 mRNA Translation: CAH56311.1
AL162584 Genomic DNA No translation available.
AL359632 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87630.1
CH471090 Genomic DNA Translation: EAW87631.1
CH471090 Genomic DNA Translation: EAW87632.1
BC003044 mRNA Translation: AAH03044.1
BC002326 mRNA Translation: AAH02326.1
M37191 mRNA Translation: AAA36551.1
CCDSiCCDS35139.1 [Q9BPZ7-3]
CCDS35140.1 [Q9BPZ7-1]
CCDS35141.1 [Q9BPZ7-4]
CCDS48020.1 [Q9BPZ7-5]
CCDS6864.1 [Q9BPZ7-2]
PIRiC38637
RefSeqiNP_001006618.1, NM_001006617.1 [Q9BPZ7-1]
NP_001006619.1, NM_001006618.1 [Q9BPZ7-5]
NP_001006620.1, NM_001006619.1 [Q9BPZ7-3]
NP_001006621.1, NM_001006620.1 [Q9BPZ7-4]
NP_001006622.1, NM_001006621.1 [Q9BPZ7-4]
NP_077022.1, NM_024117.3 [Q9BPZ7-2]
XP_011517312.1, XM_011519010.2 [Q9BPZ7-4]
XP_016870615.1, XM_017015126.1 [Q9BPZ7-1]
XP_016870616.1, XM_017015127.1 [Q9BPZ7-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VOQX-ray2.00A/B372-493[»]
5ZCSelectron microscopy4.90G/H141-522[»]
SMRiQ9BPZ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122551, 104 interactors
CORUMiQ9BPZ7
DIPiDIP-39480N
IntActiQ9BPZ7, 28 interactors
MINTiQ9BPZ7
STRINGi9606.ENSP00000265960

PTM databases

iPTMnetiQ9BPZ7
PhosphoSitePlusiQ9BPZ7

Polymorphism and mutation databases

BioMutaiMAPKAP1
DMDMi15214282

Proteomic databases

EPDiQ9BPZ7
jPOSTiQ9BPZ7
MaxQBiQ9BPZ7
PaxDbiQ9BPZ7
PeptideAtlasiQ9BPZ7
PRIDEiQ9BPZ7
ProteomicsDBi78599
78600 [Q9BPZ7-2]
78601 [Q9BPZ7-3]
78602 [Q9BPZ7-4]
78603 [Q9BPZ7-5]
78604 [Q9BPZ7-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79109
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265960; ENSP00000265960; ENSG00000119487 [Q9BPZ7-1]
ENST00000350766; ENSP00000265961; ENSG00000119487 [Q9BPZ7-2]
ENST00000373498; ENSP00000362597; ENSG00000119487 [Q9BPZ7-1]
ENST00000373503; ENSP00000362602; ENSG00000119487 [Q9BPZ7-4]
ENST00000373511; ENSP00000362610; ENSG00000119487 [Q9BPZ7-3]
ENST00000394060; ENSP00000377624; ENSG00000119487 [Q9BPZ7-5]
ENST00000394063; ENSP00000377627; ENSG00000119487 [Q9BPZ7-4]
GeneIDi79109
KEGGihsa:79109
UCSCiuc004bpv.3 human [Q9BPZ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79109
DisGeNETi79109

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MAPKAP1
HGNCiHGNC:18752 MAPKAP1
HPAiHPA029091
HPA029092
MIMi610558 gene
neXtProtiNX_Q9BPZ7
OpenTargetsiENSG00000119487
PharmGKBiPA38674

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3739 Eukaryota
ENOG410XR57 LUCA
GeneTreeiENSGT00390000000642
InParanoidiQ9BPZ7
KOiK20410
OMAiNAKFWPQ
OrthoDBi1492466at2759
PhylomeDBiQ9BPZ7
TreeFamiTF315174

Enzyme and pathway databases

ReactomeiR-HSA-1257604 PIP3 activates AKT signaling
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-6804757 Regulation of TP53 Degradation
SIGNORiQ9BPZ7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MAPKAP1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MAPKAP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79109

Protein Ontology

More...
PROi
PR:Q9BPZ7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000119487 Expressed in 224 organ(s), highest expression level in urinary bladder
ExpressionAtlasiQ9BPZ7 baseline and differential
GenevisibleiQ9BPZ7 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR031567 CRIM_dom
IPR011993 PH-like_dom_sf
IPR032679 Sin1_N
IPR031313 Sin1_PH_dom
PfamiView protein in Pfam
PF16978 CRIM, 1 hit
PF05422 SIN1, 1 hit
PF16979 SIN1_PH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BPZ7
Secondary accession number(s): A8K1Z5
, B1AMA4, B7Z309, Q00426, Q5JSV5, Q5JSV6, Q5JSV9, Q658R0, Q699U1, Q699U2, Q699U3, Q699U4, Q6GVJ0, Q6GVJ1, Q6GVJ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: May 8, 2019
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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