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Protein

Polyadenylate-binding protein-interacting protein 2

Gene

PAIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.1 Publication

GO - Molecular functioni

  • mRNA binding Source: Ensembl
  • translation repressor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processTranslation regulation

Protein family/group databases

MoonDBiQ9BPZ3 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein-interacting protein 2
Short name:
PABP-interacting protein 2
Short name:
PAIP-2
Short name:
Poly(A)-binding protein-interacting protein 2
Gene namesi
Name:PAIP2
Synonyms:PAIP2A
ORF Names:HSPC218
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000120727.12
HGNCiHGNC:17970 PAIP2
MIMi605604 gene
neXtProtiNX_Q9BPZ3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi51247
OpenTargetsiENSG00000120727
PharmGKBiPA134897284

Polymorphism and mutation databases

DMDMi46397013

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000581791 – 127Polyadenylate-binding protein-interacting protein 2Add BLAST127

Post-translational modificationi

Ubiquitinated, leading to its degradation by the proteasome.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ9BPZ3
MaxQBiQ9BPZ3
PaxDbiQ9BPZ3
PeptideAtlasiQ9BPZ3
PRIDEiQ9BPZ3
ProteomicsDBi78598

PTM databases

iPTMnetiQ9BPZ3
PhosphoSitePlusiQ9BPZ3

Expressioni

Tissue specificityi

Expressed at highest level in testis, but also abundant in brain, cervix, lung, ovary, placenta, adipose tissue, thymus and thyroid.1 Publication

Gene expression databases

BgeeiENSG00000120727 Expressed in 203 organ(s), highest expression level in cerebellar vermis
CleanExiHS_PAIP2
ExpressionAtlasiQ9BPZ3 baseline and differential
GenevisibleiQ9BPZ3 HS

Organism-specific databases

HPAiCAB037212
HPA035945
HPA056766

Interactioni

Subunit structurei

Interacts with the second and third RRM domains and C-terminus regions of PABPC1 in a 2:1 stoichiometry.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi119404, 15 interactors
ELMiQ9BPZ3
IntActiQ9BPZ3, 8 interactors
MINTiQ9BPZ3
STRINGi9606.ENSP00000265192

Structurei

3D structure databases

ProteinModelPortaliQ9BPZ3
SMRiQ9BPZ3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BPZ3

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 75PABPC1-interacting motif-1 (PAM1)Add BLAST54
Regioni105 – 120PABPC1-interacting motif-2 (PAM2)Add BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 72Glu-richAdd BLAST40

Domaini

Only the PABPC1-interacting motif-1 (PAM1) interferes with the binding of PABPC1 to poly(A) RNA and translation initiation.

Sequence similaritiesi

Belongs to the PAIP2 family.Curated

Phylogenomic databases

eggNOGiENOG410IW9Y Eukaryota
ENOG410Y214 LUCA
GeneTreeiENSGT00390000017284
HOGENOMiHOG000008098
HOVERGENiHBG053493
InParanoidiQ9BPZ3
OMAiWEEEFME
OrthoDBiEOG091G1372
PhylomeDBiQ9BPZ3
TreeFamiTF326855

Family and domain databases

InterProiView protein in InterPro
IPR009818 Ataxin-2_C
PfamiView protein in Pfam
PF07145 PAM2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9BPZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDPSRSSTS PSIINEDVII NGHSHEDDNP FAEYMWMENE EEFNRQIEEE
60 70 80 90 100
LWEEEFIERC FQEMLEEEEE HEWFIPARDL PQTMDQIQDQ FNDLVISDGS
110 120
SLEDLVVKSN LNPNAKEFVP GVKYGNI
Length:127
Mass (Da):14,984
Last modified:June 1, 2001 - v1
Checksum:iCAC27C537E5C6E22
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9Y1D6R9Y1_HUMAN
Polyadenylate-binding protein-inter...
PAIP2
67Annotation score:
D6RA77D6RA77_HUMAN
Polyadenylate-binding protein-inter...
PAIP2
93Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98D → E in CAB66575 (PubMed:11230166).Curated1
Sequence conflicti116K → T in AAF36138 (PubMed:11042152).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317675 mRNA Translation: AAK11562.1
AF151052 mRNA Translation: AAF36138.1
AL136640 mRNA Translation: CAB66575.1
AK314672 mRNA Translation: BAG37228.1
CH471062 Genomic DNA Translation: EAW62107.1
CH471062 Genomic DNA Translation: EAW62108.1
CH471062 Genomic DNA Translation: EAW62111.1
CH471062 Genomic DNA Translation: EAW62112.1
BC001716 mRNA Translation: AAH01716.1
BC048106 mRNA Translation: AAH48106.1
BC062718 mRNA Translation: AAH62718.1
CCDSiCCDS4211.1
RefSeqiNP_001028284.1, NM_001033112.2
NP_057564.3, NM_016480.4
XP_011541730.1, XM_011543428.1
XP_016865011.1, XM_017009522.1
XP_016865012.1, XM_017009523.1
UniGeneiHs.396644

Genome annotation databases

EnsembliENST00000265192; ENSP00000265192; ENSG00000120727
ENST00000394795; ENSP00000378275; ENSG00000120727
ENST00000510080; ENSP00000422508; ENSG00000120727
GeneIDi51247
KEGGihsa:51247
UCSCiuc003led.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317675 mRNA Translation: AAK11562.1
AF151052 mRNA Translation: AAF36138.1
AL136640 mRNA Translation: CAB66575.1
AK314672 mRNA Translation: BAG37228.1
CH471062 Genomic DNA Translation: EAW62107.1
CH471062 Genomic DNA Translation: EAW62108.1
CH471062 Genomic DNA Translation: EAW62111.1
CH471062 Genomic DNA Translation: EAW62112.1
BC001716 mRNA Translation: AAH01716.1
BC048106 mRNA Translation: AAH48106.1
BC062718 mRNA Translation: AAH62718.1
CCDSiCCDS4211.1
RefSeqiNP_001028284.1, NM_001033112.2
NP_057564.3, NM_016480.4
XP_011541730.1, XM_011543428.1
XP_016865011.1, XM_017009522.1
XP_016865012.1, XM_017009523.1
UniGeneiHs.396644

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JGNNMR-B106-127[»]
3KUSX-ray1.40C/D109-123[»]
3KUTX-ray1.50C/D109-125[»]
ProteinModelPortaliQ9BPZ3
SMRiQ9BPZ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119404, 15 interactors
ELMiQ9BPZ3
IntActiQ9BPZ3, 8 interactors
MINTiQ9BPZ3
STRINGi9606.ENSP00000265192

Protein family/group databases

MoonDBiQ9BPZ3 Predicted

PTM databases

iPTMnetiQ9BPZ3
PhosphoSitePlusiQ9BPZ3

Polymorphism and mutation databases

DMDMi46397013

Proteomic databases

EPDiQ9BPZ3
MaxQBiQ9BPZ3
PaxDbiQ9BPZ3
PeptideAtlasiQ9BPZ3
PRIDEiQ9BPZ3
ProteomicsDBi78598

Protocols and materials databases

DNASUi51247
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265192; ENSP00000265192; ENSG00000120727
ENST00000394795; ENSP00000378275; ENSG00000120727
ENST00000510080; ENSP00000422508; ENSG00000120727
GeneIDi51247
KEGGihsa:51247
UCSCiuc003led.5 human

Organism-specific databases

CTDi51247
DisGeNETi51247
EuPathDBiHostDB:ENSG00000120727.12
GeneCardsiPAIP2
HGNCiHGNC:17970 PAIP2
HPAiCAB037212
HPA035945
HPA056766
MIMi605604 gene
neXtProtiNX_Q9BPZ3
OpenTargetsiENSG00000120727
PharmGKBiPA134897284
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW9Y Eukaryota
ENOG410Y214 LUCA
GeneTreeiENSGT00390000017284
HOGENOMiHOG000008098
HOVERGENiHBG053493
InParanoidiQ9BPZ3
OMAiWEEEFME
OrthoDBiEOG091G1372
PhylomeDBiQ9BPZ3
TreeFamiTF326855

Miscellaneous databases

ChiTaRSiPAIP2 human
EvolutionaryTraceiQ9BPZ3
GeneWikiiPAIP2
GenomeRNAii51247
PROiPR:Q9BPZ3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120727 Expressed in 203 organ(s), highest expression level in cerebellar vermis
CleanExiHS_PAIP2
ExpressionAtlasiQ9BPZ3 baseline and differential
GenevisibleiQ9BPZ3 HS

Family and domain databases

InterProiView protein in InterPro
IPR009818 Ataxin-2_C
PfamiView protein in Pfam
PF07145 PAM2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAIP2_HUMAN
AccessioniPrimary (citable) accession number: Q9BPZ3
Secondary accession number(s): B2RBI1
, D3DQC6, Q49A06, Q9H0Y5, Q9P0Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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