UniProtKB - Q9BPY3 (F118B_HUMAN)

BLAST

>sp|Q9BPY3|F118B_HUMAN Protein FAM118B OS=Homo sapiens OX=9606 GN=FAM118B PE=1 SV=1
MASTGSQASDIDEIFGFFNDGEPPTKKPRKLLPSLKTKKPRELVLVIGTGISAAVAPQVP
ALKSWKGLIQALLDAAIDFDLLEDEESKKFQKCLHEDKNLVHVAHDLIQKLSPRTSNVRS
TFFKDCLYEVFDDLESKMEDSGKQLLQSVLHLMENGALVLTTNFDNLLELYAADQGKQLE
SLDLTDEKKVLEWAQEKRKLSVLHIHGVYTNPSGIVLHPAGYQNVLRNTEVMREIQKLYE
NKSFLFLGCGWTVDDTTFQALFLEAVKHKSDLEHFMLVRRGDVDEFKKLRENMLDKGIKV
ISYGDDYADLPEYFKRLTCEISTRGTSAGMVREGQLNGSSAAHSEIRGCST

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History
Entry version 119 (10 Oct 2018)
Sequence version 1 (01 Jun 2001)
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Protein

Protein FAM118B

Gene

FAM118B

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May play a role in Cajal bodies formation.1 Publication

Miscellaneous

Overexpression changes the morphology of Cajal bodies, while depletion disrupts the localization of components of Cajal bodies, reduces splicing capacity and inhibits cell proliferation.1 Publication

GO - Biological processⁱ

Cajal body organization Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein FAM118B
Gene namesⁱ	Name:FAM118B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197798.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26110 FAM118B
MIMⁱ	616587 gene
neXtProtⁱ	NX_Q9BPY3

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000197798
PharmGKBⁱ	PA145008413

Polymorphism and mutation databases

BioMutaⁱ	FAM118B
DMDMⁱ	74732801

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000295103	2 – 351	Protein FAM118BAdd BLAST		350

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1
Modified residueⁱ	9	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9BPY3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BPY3
PaxDbⁱ	Q9BPY3
PeptideAtlas More...PeptideAtlasⁱ	Q9BPY3
PRIDEⁱ	Q9BPY3
ProteomicsDBⁱ	78594

PTM databases

iPTMnetⁱ	Q9BPY3
PhosphoSitePlusⁱ	Q9BPY3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000197798 Expressed in 193 organ(s), highest expression level in tendon
CleanExⁱ	HS_FAM118B
ExpressionAtlasⁱ	Q9BPY3 baseline and differential
Genevisibleⁱ	Q9BPY3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041644 HPA042100

HPAⁱ

HPA041644
HPA042100

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
	G2XKQ0	5	EBI-726822,EBI-10175576
BAG5	Q9UL15	3	EBI-726822,EBI-356517
FAM118A	Q9NWS6	7	EBI-726822,EBI-8638992
SDCBP	O00560	3	EBI-726822,EBI-727004
SUMO1	P63165	3	EBI-726822,EBI-80140

Protein-protein interaction databases

BioGridⁱ	122742, 51 interactors
IntActⁱ	Q9BPY3, 29 interactors
Molecular INTeraction database More...MINTⁱ	Q9BPY3

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BPY3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the FAM118 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IHIR Eukaryota ENOG410YDRZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010215
HOGENOMⁱ	HOG000072713
HOVERGENⁱ	HBG055230
InParanoidⁱ	Q9BPY3
OMAⁱ	CKMEHAG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ABT
PhylomeDBⁱ	Q9BPY3
TreeFamⁱ	TF332439

Family and domain databases

InterProⁱ	View protein in InterPro IPR038916 FAM118 IPR033352 FAM118B IPR039444 SIR2-like
PANTHERⁱ	PTHR28623 PTHR28623, 1 hit PTHR28623:SF1 PTHR28623:SF1, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13289 SIR2_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

Q9BPY3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASTGSQASD IDEIFGFFND GEPPTKKPRK LLPSLKTKKP RELVLVIGTG 
        60         70         80         90        100
ISAAVAPQVP ALKSWKGLIQ ALLDAAIDFD LLEDEESKKF QKCLHEDKNL 
       110        120        130        140        150
VHVAHDLIQK LSPRTSNVRS TFFKDCLYEV FDDLESKMED SGKQLLQSVL 
       160        170        180        190        200
HLMENGALVL TTNFDNLLEL YAADQGKQLE SLDLTDEKKV LEWAQEKRKL 
       210        220        230        240        250
SVLHIHGVYT NPSGIVLHPA GYQNVLRNTE VMREIQKLYE NKSFLFLGCG 
       260        270        280        290        300
WTVDDTTFQA LFLEAVKHKS DLEHFMLVRR GDVDEFKKLR ENMLDKGIKV 
       310        320        330        340        350
ISYGDDYADL PEYFKRLTCE ISTRGTSAGM VREGQLNGSS AAHSEIRGCS 

T

Length:351

Mass (Da):39,499

Last modified:June 1, 2001 - v1

Checksum:ⁱD298067C1D17E339

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3V179	G3V179_HUMAN	Protein FAM118B Protein FAM118B	FAM118B FLJ21103, hCG_1811519	275	Annotation score:
J3KP39	J3KP39_HUMAN	Protein FAM118B Protein FAM118B	FAM118B	350	Annotation score:
E9PIM5	E9PIM5_HUMAN	Protein FAM118B Protein FAM118B	FAM118B	235	Annotation score:
E9PMJ2	E9PMJ2_HUMAN	Protein FAM118B Protein FAM118B	FAM118B	346	Annotation score:
E9PMW3	E9PMW3_HUMAN	Protein FAM118B Protein FAM118B	FAM118B	153	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	133	D → G in BAB14987 (PubMed:14702039).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK024756 mRNA Translation: BAB14987.1 CR457334 mRNA Translation: CAG33615.1 BC001340 mRNA Translation: AAH01340.1 BC001647 mRNA Translation: AAH01647.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8470.1
NCBI Reference Sequences More...RefSeqⁱ	NP_078832.1, NM_024556.3 XP_011541279.1, XM_011542977.2
UniGeneⁱ	Hs.276315

Genome annotation databases

Ensemblⁱ	ENST00000533050; ENSP00000433343; ENSG00000197798
GeneIDⁱ	79607
KEGGⁱ	hsa:79607
UCSC genome browser More...UCSCⁱ	uc001qdf.4 human

Protein	Similar proteins		Species	Score	Length	Source
Q9BPY3	Uncharacterized protein		HUMAN		351	UniRef100_Q9BPY3
FAM118B isoform 1		PANTR		351
Uncharacterized protein		PANPA		351
FAM118B isoform 9 (Fragment)		PONAB		153
Protein FAM118B (Fragment)		HUMAN		153
+1

Protein	Similar proteins		Species	Score	Length	Source
Q9BPY3	Protein FAM118B		BOVIN		351	UniRef90_Q9BPY3
Protein FAM118B		MOUSE		351
Protein FAM118B		MACFA		350
Protein FAM118B		RAT		350
Uncharacterized protein		HUMAN		351
+169

Protein	Similar proteins		Species	Score	Length	Source
Q9BPY3	Protein FAM118B		MOUSE		351	UniRef50_Q9BPY3
Protein FAM118B		BOVIN		351
Protein FAM118B		RAT		350
Protein FAM118B		MACFA		350
Uncharacterized protein		HUMAN		351
+477

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK024756 mRNA Translation: BAB14987.1 CR457334 mRNA Translation: CAG33615.1 BC001340 mRNA Translation: AAH01340.1 BC001647 mRNA Translation: AAH01647.1
CCDSⁱ	CCDS8470.1
RefSeqⁱ	NP_078832.1, NM_024556.3 XP_011541279.1, XM_011542977.2
UniGeneⁱ	Hs.276315

3D structure databases

ProteinModelPortalⁱ	Q9BPY3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122742, 51 interactors
IntActⁱ	Q9BPY3, 29 interactors
MINTⁱ	Q9BPY3

PTM databases

iPTMnetⁱ	Q9BPY3
PhosphoSitePlusⁱ	Q9BPY3

Polymorphism and mutation databases

BioMutaⁱ	FAM118B
DMDMⁱ	74732801

Proteomic databases

EPDⁱ	Q9BPY3
MaxQBⁱ	Q9BPY3
PaxDbⁱ	Q9BPY3
PeptideAtlasⁱ	Q9BPY3
PRIDEⁱ	Q9BPY3
ProteomicsDBⁱ	78594

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	79607
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000533050; ENSP00000433343; ENSG00000197798
GeneIDⁱ	79607
KEGGⁱ	hsa:79607
UCSCⁱ	uc001qdf.4 human

Organism-specific databases

CTDⁱ	79607
EuPathDBⁱ	HostDB:ENSG00000197798.8
GeneCardsⁱ	FAM118B
H-InvDBⁱ	HIX0010251
HGNCⁱ	HGNC:26110 FAM118B
HPAⁱ	HPA041644 HPA042100
MIMⁱ	616587 gene
neXtProtⁱ	NX_Q9BPY3
OpenTargetsⁱ	ENSG00000197798
PharmGKBⁱ	PA145008413
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHIR Eukaryota ENOG410YDRZ LUCA
GeneTreeⁱ	ENSGT00390000010215
HOGENOMⁱ	HOG000072713
HOVERGENⁱ	HBG055230
InParanoidⁱ	Q9BPY3
OMAⁱ	CKMEHAG
OrthoDBⁱ	EOG091G0ABT
PhylomeDBⁱ	Q9BPY3
TreeFamⁱ	TF332439

Miscellaneous databases

ChiTaRSⁱ	FAM118B human
GenomeRNAiⁱ	79607
Protein Ontology More...PROⁱ	PR:Q9BPY3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000197798 Expressed in 193 organ(s), highest expression level in tendon
CleanExⁱ	HS_FAM118B
ExpressionAtlasⁱ	Q9BPY3 baseline and differential
Genevisibleⁱ	Q9BPY3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR038916 FAM118 IPR033352 FAM118B IPR039444 SIR2-like
PANTHERⁱ	PTHR28623 PTHR28623, 1 hit PTHR28623:SF1 PTHR28623:SF1, 1 hit
Pfamⁱ	View protein in Pfam PF13289 SIR2_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F118B_HUMAN
Accessionⁱ	Q9BPY3Primary (citable) accession number: Q9BPY3 Secondary accession number(s): Q9H7B0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
	Last sequence update:	June 1, 2001
	Last modified:	October 10, 2018
	This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BPY3 (F118B_HUMAN)

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Protein FAM118B

FAM118B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ