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Protein

Protein FAM118B

Gene

FAM118B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in Cajal bodies formation.1 Publication

Miscellaneous

Overexpression changes the morphology of Cajal bodies, while depletion disrupts the localization of components of Cajal bodies, reduces splicing capacity and inhibits cell proliferation.1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM118B
Gene namesi
Name:FAM118B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000197798.8
HGNCiHGNC:26110 FAM118B
MIMi616587 gene
neXtProtiNX_Q9BPY3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197798
PharmGKBiPA145008413

Polymorphism and mutation databases

BioMutaiFAM118B
DMDMi74732801

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002951032 – 351Protein FAM118BAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei9PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BPY3
MaxQBiQ9BPY3
PaxDbiQ9BPY3
PeptideAtlasiQ9BPY3
PRIDEiQ9BPY3
ProteomicsDBi78594

PTM databases

iPTMnetiQ9BPY3
PhosphoSitePlusiQ9BPY3

Expressioni

Gene expression databases

BgeeiENSG00000197798 Expressed in 193 organ(s), highest expression level in tendon
CleanExiHS_FAM118B
ExpressionAtlasiQ9BPY3 baseline and differential
GenevisibleiQ9BPY3 HS

Organism-specific databases

HPAiHPA041644
HPA042100

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi122742, 51 interactors
IntActiQ9BPY3, 29 interactors
MINTiQ9BPY3

Structurei

3D structure databases

ProteinModelPortaliQ9BPY3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM118 family.Curated

Phylogenomic databases

eggNOGiENOG410IHIR Eukaryota
ENOG410YDRZ LUCA
GeneTreeiENSGT00390000010215
HOGENOMiHOG000072713
HOVERGENiHBG055230
InParanoidiQ9BPY3
OMAiCKMEHAG
OrthoDBiEOG091G0ABT
PhylomeDBiQ9BPY3
TreeFamiTF332439

Family and domain databases

InterProiView protein in InterPro
IPR038916 FAM118
IPR033352 FAM118B
IPR039444 SIR2-like
PANTHERiPTHR28623 PTHR28623, 1 hit
PTHR28623:SF1 PTHR28623:SF1, 1 hit
PfamiView protein in Pfam
PF13289 SIR2_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9BPY3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTGSQASD IDEIFGFFND GEPPTKKPRK LLPSLKTKKP RELVLVIGTG
60 70 80 90 100
ISAAVAPQVP ALKSWKGLIQ ALLDAAIDFD LLEDEESKKF QKCLHEDKNL
110 120 130 140 150
VHVAHDLIQK LSPRTSNVRS TFFKDCLYEV FDDLESKMED SGKQLLQSVL
160 170 180 190 200
HLMENGALVL TTNFDNLLEL YAADQGKQLE SLDLTDEKKV LEWAQEKRKL
210 220 230 240 250
SVLHIHGVYT NPSGIVLHPA GYQNVLRNTE VMREIQKLYE NKSFLFLGCG
260 270 280 290 300
WTVDDTTFQA LFLEAVKHKS DLEHFMLVRR GDVDEFKKLR ENMLDKGIKV
310 320 330 340 350
ISYGDDYADL PEYFKRLTCE ISTRGTSAGM VREGQLNGSS AAHSEIRGCS

T
Length:351
Mass (Da):39,499
Last modified:June 1, 2001 - v1
Checksum:iD298067C1D17E339
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V179G3V179_HUMAN
Protein FAM118B
FAM118B FLJ21103, hCG_1811519
275Annotation score:
J3KP39J3KP39_HUMAN
Protein FAM118B
FAM118B
350Annotation score:
E9PIM5E9PIM5_HUMAN
Protein FAM118B
FAM118B
235Annotation score:
E9PMJ2E9PMJ2_HUMAN
Protein FAM118B
FAM118B
346Annotation score:
E9PMW3E9PMW3_HUMAN
Protein FAM118B
FAM118B
153Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133D → G in BAB14987 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024756 mRNA Translation: BAB14987.1
CR457334 mRNA Translation: CAG33615.1
BC001340 mRNA Translation: AAH01340.1
BC001647 mRNA Translation: AAH01647.1
CCDSiCCDS8470.1
RefSeqiNP_078832.1, NM_024556.3
XP_011541279.1, XM_011542977.2
UniGeneiHs.276315

Genome annotation databases

EnsembliENST00000533050; ENSP00000433343; ENSG00000197798
GeneIDi79607
KEGGihsa:79607
UCSCiuc001qdf.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024756 mRNA Translation: BAB14987.1
CR457334 mRNA Translation: CAG33615.1
BC001340 mRNA Translation: AAH01340.1
BC001647 mRNA Translation: AAH01647.1
CCDSiCCDS8470.1
RefSeqiNP_078832.1, NM_024556.3
XP_011541279.1, XM_011542977.2
UniGeneiHs.276315

3D structure databases

ProteinModelPortaliQ9BPY3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122742, 51 interactors
IntActiQ9BPY3, 29 interactors
MINTiQ9BPY3

PTM databases

iPTMnetiQ9BPY3
PhosphoSitePlusiQ9BPY3

Polymorphism and mutation databases

BioMutaiFAM118B
DMDMi74732801

Proteomic databases

EPDiQ9BPY3
MaxQBiQ9BPY3
PaxDbiQ9BPY3
PeptideAtlasiQ9BPY3
PRIDEiQ9BPY3
ProteomicsDBi78594

Protocols and materials databases

DNASUi79607
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000533050; ENSP00000433343; ENSG00000197798
GeneIDi79607
KEGGihsa:79607
UCSCiuc001qdf.4 human

Organism-specific databases

CTDi79607
EuPathDBiHostDB:ENSG00000197798.8
GeneCardsiFAM118B
H-InvDBiHIX0010251
HGNCiHGNC:26110 FAM118B
HPAiHPA041644
HPA042100
MIMi616587 gene
neXtProtiNX_Q9BPY3
OpenTargetsiENSG00000197798
PharmGKBiPA145008413
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHIR Eukaryota
ENOG410YDRZ LUCA
GeneTreeiENSGT00390000010215
HOGENOMiHOG000072713
HOVERGENiHBG055230
InParanoidiQ9BPY3
OMAiCKMEHAG
OrthoDBiEOG091G0ABT
PhylomeDBiQ9BPY3
TreeFamiTF332439

Miscellaneous databases

ChiTaRSiFAM118B human
GenomeRNAii79607
PROiPR:Q9BPY3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197798 Expressed in 193 organ(s), highest expression level in tendon
CleanExiHS_FAM118B
ExpressionAtlasiQ9BPY3 baseline and differential
GenevisibleiQ9BPY3 HS

Family and domain databases

InterProiView protein in InterPro
IPR038916 FAM118
IPR033352 FAM118B
IPR039444 SIR2-like
PANTHERiPTHR28623 PTHR28623, 1 hit
PTHR28623:SF1 PTHR28623:SF1, 1 hit
PfamiView protein in Pfam
PF13289 SIR2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF118B_HUMAN
AccessioniPrimary (citable) accession number: Q9BPY3
Secondary accession number(s): Q9H7B0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 1, 2001
Last modified: October 10, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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