UniProtKB - Q9BPY3 (F118B_HUMAN)
Protein
Protein FAM118B
Gene
FAM118B
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in Cajal bodies formation.1 Publication
Miscellaneous
Overexpression changes the morphology of Cajal bodies, while depletion disrupts the localization of components of Cajal bodies, reduces splicing capacity and inhibits cell proliferation.1 Publication
GO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- Cajal body organization Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q9BPY3 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein FAM118B |
Gene namesi | Name:FAM118B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26110, FAM118B |
MIMi | 616587, gene |
neXtProti | NX_Q9BPY3 |
VEuPathDBi | HostDB:ENSG00000197798.8 |
Subcellular locationi
Nucleus
- Cajal body 1 Publication
Nucleus
- Cajal body Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000197798 |
PharmGKBi | PA145008413 |
Miscellaneous databases
Pharosi | Q9BPY3, Tdark |
Genetic variation databases
BioMutai | FAM118B |
DMDMi | 74732801 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000295103 | 2 – 351 | Protein FAM118BAdd BLAST | 350 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 9 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9BPY3 |
jPOSTi | Q9BPY3 |
MassIVEi | Q9BPY3 |
MaxQBi | Q9BPY3 |
PaxDbi | Q9BPY3 |
PeptideAtlasi | Q9BPY3 |
PRIDEi | Q9BPY3 |
ProteomicsDBi | 78594 |
PTM databases
iPTMneti | Q9BPY3 |
PhosphoSitePlusi | Q9BPY3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000197798, Expressed in quadriceps femoris and 208 other tissues |
ExpressionAtlasi | Q9BPY3, baseline and differential |
Genevisiblei | Q9BPY3, HS |
Organism-specific databases
HPAi | ENSG00000197798, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9BPY3
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 122742, 55 interactors |
IntActi | Q9BPY3, 48 interactors |
MINTi | Q9BPY3 |
STRINGi | 9606.ENSP00000433343 |
Miscellaneous databases
RNActi | Q9BPY3, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the FAM118 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QSNY, Eukaryota |
GeneTreei | ENSGT00390000010215 |
InParanoidi | Q9BPY3 |
OMAi | TNPCGIV |
OrthoDBi | 752035at2759 |
PhylomeDBi | Q9BPY3 |
TreeFami | TF332439 |
Family and domain databases
InterProi | View protein in InterPro IPR038916, FAM118 IPR033352, FAM118B IPR039444, SIR2-like |
PANTHERi | PTHR28623, PTHR28623, 1 hit PTHR28623:SF1, PTHR28623:SF1, 1 hit |
Pfami | View protein in Pfam PF13289, SIR2_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q9BPY3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASTGSQASD IDEIFGFFND GEPPTKKPRK LLPSLKTKKP RELVLVIGTG
60 70 80 90 100
ISAAVAPQVP ALKSWKGLIQ ALLDAAIDFD LLEDEESKKF QKCLHEDKNL
110 120 130 140 150
VHVAHDLIQK LSPRTSNVRS TFFKDCLYEV FDDLESKMED SGKQLLQSVL
160 170 180 190 200
HLMENGALVL TTNFDNLLEL YAADQGKQLE SLDLTDEKKV LEWAQEKRKL
210 220 230 240 250
SVLHIHGVYT NPSGIVLHPA GYQNVLRNTE VMREIQKLYE NKSFLFLGCG
260 270 280 290 300
WTVDDTTFQA LFLEAVKHKS DLEHFMLVRR GDVDEFKKLR ENMLDKGIKV
310 320 330 340 350
ISYGDDYADL PEYFKRLTCE ISTRGTSAGM VREGQLNGSS AAHSEIRGCS
T
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V179 | G3V179_HUMAN | Protein FAM118B | FAM118B FLJ21103, hCG_1811519 | 275 | Annotation score: | ||
J3KP39 | J3KP39_HUMAN | Protein FAM118B | FAM118B | 350 | Annotation score: | ||
E9PIM5 | E9PIM5_HUMAN | Protein FAM118B | FAM118B | 235 | Annotation score: | ||
E9PMJ2 | E9PMJ2_HUMAN | Protein FAM118B | FAM118B | 346 | Annotation score: | ||
E9PMW3 | E9PMW3_HUMAN | Protein FAM118B | FAM118B | 153 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 133 | D → G in BAB14987 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK024756 mRNA Translation: BAB14987.1 CR457334 mRNA Translation: CAG33615.1 BC001340 mRNA Translation: AAH01340.1 BC001647 mRNA Translation: AAH01647.1 |
CCDSi | CCDS8470.1 |
RefSeqi | NP_078832.1, NM_024556.3 XP_011541279.1, XM_011542977.2 |
Genome annotation databases
Ensembli | ENST00000533050; ENSP00000433343; ENSG00000197798 |
GeneIDi | 79607 |
KEGGi | hsa:79607 |
UCSCi | uc001qdf.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK024756 mRNA Translation: BAB14987.1 CR457334 mRNA Translation: CAG33615.1 BC001340 mRNA Translation: AAH01340.1 BC001647 mRNA Translation: AAH01647.1 |
CCDSi | CCDS8470.1 |
RefSeqi | NP_078832.1, NM_024556.3 XP_011541279.1, XM_011542977.2 |
3D structure databases
SMRi | Q9BPY3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122742, 55 interactors |
IntActi | Q9BPY3, 48 interactors |
MINTi | Q9BPY3 |
STRINGi | 9606.ENSP00000433343 |
PTM databases
iPTMneti | Q9BPY3 |
PhosphoSitePlusi | Q9BPY3 |
Genetic variation databases
BioMutai | FAM118B |
DMDMi | 74732801 |
Proteomic databases
EPDi | Q9BPY3 |
jPOSTi | Q9BPY3 |
MassIVEi | Q9BPY3 |
MaxQBi | Q9BPY3 |
PaxDbi | Q9BPY3 |
PeptideAtlasi | Q9BPY3 |
PRIDEi | Q9BPY3 |
ProteomicsDBi | 78594 |
Protocols and materials databases
Antibodypediai | 46048, 153 antibodies |
DNASUi | 79607 |
Genome annotation databases
Ensembli | ENST00000533050; ENSP00000433343; ENSG00000197798 |
GeneIDi | 79607 |
KEGGi | hsa:79607 |
UCSCi | uc001qdf.4, human |
Organism-specific databases
CTDi | 79607 |
GeneCardsi | FAM118B |
HGNCi | HGNC:26110, FAM118B |
HPAi | ENSG00000197798, Low tissue specificity |
MIMi | 616587, gene |
neXtProti | NX_Q9BPY3 |
OpenTargetsi | ENSG00000197798 |
PharmGKBi | PA145008413 |
VEuPathDBi | HostDB:ENSG00000197798.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSNY, Eukaryota |
GeneTreei | ENSGT00390000010215 |
InParanoidi | Q9BPY3 |
OMAi | TNPCGIV |
OrthoDBi | 752035at2759 |
PhylomeDBi | Q9BPY3 |
TreeFami | TF332439 |
Enzyme and pathway databases
PathwayCommonsi | Q9BPY3 |
Miscellaneous databases
BioGRID-ORCSi | 79607, 4 hits in 997 CRISPR screens |
ChiTaRSi | FAM118B, human |
GenomeRNAii | 79607 |
Pharosi | Q9BPY3, Tdark |
PROi | PR:Q9BPY3 |
RNActi | Q9BPY3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197798, Expressed in quadriceps femoris and 208 other tissues |
ExpressionAtlasi | Q9BPY3, baseline and differential |
Genevisiblei | Q9BPY3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR038916, FAM118 IPR033352, FAM118B IPR039444, SIR2-like |
PANTHERi | PTHR28623, PTHR28623, 1 hit PTHR28623:SF1, PTHR28623:SF1, 1 hit |
Pfami | View protein in Pfam PF13289, SIR2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F118B_HUMAN | |
Accessioni | Q9BPY3Primary (citable) accession number: Q9BPY3 Secondary accession number(s): Q9H7B0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 10, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families