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UniProtKB - Q9BPY3 (F118B_HUMAN)

Entry version 122 (10 Apr 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Protein FAM118B

Gene

FAM118B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in Cajal bodies formation.1 Publication

Miscellaneous

Overexpression changes the morphology of Cajal bodies, while depletion disrupts the localization of components of Cajal bodies, reduces splicing capacity and inhibits cell proliferation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM118B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM118B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000197798.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:26110 FAM118B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616587 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BPY3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000197798

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA145008413

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FAM118B

Domain mapping of disease mutations (DMDM)

More...DMDMi		74732801

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002951032 – 351Protein FAM118BAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei9PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BPY3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BPY3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BPY3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BPY3

PeptideAtlas

More...PeptideAtlasi		Q9BPY3

PRoteomics IDEntifications database

More...PRIDEi		Q9BPY3

ProteomicsDB human proteome resource

More...ProteomicsDBi		78594

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BPY3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BPY3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197798 Expressed in 193 organ(s), highest expression level in tendon

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BPY3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BPY3 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA041644
HPA042100

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		122742, 51 interactors

Protein interaction database and analysis system

More...IntActi		Q9BPY3, 29 interactors

Molecular INTeraction database

More...MINTi		Q9BPY3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000433343

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q9BPY3

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM118 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IHIR Eukaryota
ENOG410YDRZ LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000010215

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000072713

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG055230

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BPY3

Identification of Orthologs from Complete Genome Data

More...OMAi		CKMEHAG

Database of Orthologous Groups

More...OrthoDBi		924064at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BPY3

TreeFam database of animal gene trees

More...TreeFami		TF332439

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038916 FAM118
IPR033352 FAM118B
IPR039444 SIR2-like

The PANTHER Classification System

More...PANTHERi		PTHR28623 PTHR28623, 1 hit
PTHR28623:SF1 PTHR28623:SF1, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13289 SIR2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9BPY3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTGSQASD IDEIFGFFND GEPPTKKPRK LLPSLKTKKP RELVLVIGTG 
        60         70         80         90        100
ISAAVAPQVP ALKSWKGLIQ ALLDAAIDFD LLEDEESKKF QKCLHEDKNL 
       110        120        130        140        150
VHVAHDLIQK LSPRTSNVRS TFFKDCLYEV FDDLESKMED SGKQLLQSVL 
       160        170        180        190        200
HLMENGALVL TTNFDNLLEL YAADQGKQLE SLDLTDEKKV LEWAQEKRKL 
       210        220        230        240        250
SVLHIHGVYT NPSGIVLHPA GYQNVLRNTE VMREIQKLYE NKSFLFLGCG 
       260        270        280        290        300
WTVDDTTFQA LFLEAVKHKS DLEHFMLVRR GDVDEFKKLR ENMLDKGIKV 
       310        320        330        340        350
ISYGDDYADL PEYFKRLTCE ISTRGTSAGM VREGQLNGSS AAHSEIRGCS 

T
Length:351
Mass (Da):39,499
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD298067C1D17E339
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V179G3V179_HUMAN
Protein FAM118B
FAM118B FLJ21103, hCG_1811519
275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KP39J3KP39_HUMAN
Protein FAM118B
FAM118B
350Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIM5E9PIM5_HUMAN
Protein FAM118B
FAM118B
235Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMJ2E9PMJ2_HUMAN
Protein FAM118B
FAM118B
346Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMW3E9PMW3_HUMAN
Protein FAM118B
FAM118B
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti133D → G in BAB14987 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK024756 mRNA Translation: BAB14987.1
CR457334 mRNA Translation: CAG33615.1
BC001340 mRNA Translation: AAH01340.1
BC001647 mRNA Translation: AAH01647.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8470.1

NCBI Reference Sequences

More...RefSeqi		NP_078832.1, NM_024556.3
XP_011541279.1, XM_011542977.2

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.276315

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000533050; ENSP00000433343; ENSG00000197798

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79607

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79607

UCSC genome browser

More...UCSCi		uc001qdf.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024756 mRNA Translation: BAB14987.1
CR457334 mRNA Translation: CAG33615.1
BC001340 mRNA Translation: AAH01340.1
BC001647 mRNA Translation: AAH01647.1
CCDSiCCDS8470.1
RefSeqiNP_078832.1, NM_024556.3
XP_011541279.1, XM_011542977.2
UniGeneiHs.276315

3D structure databases

ProteinModelPortaliQ9BPY3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122742, 51 interactors
IntActiQ9BPY3, 29 interactors
MINTiQ9BPY3
STRINGi9606.ENSP00000433343

PTM databases

iPTMnetiQ9BPY3
PhosphoSitePlusiQ9BPY3

Polymorphism and mutation databases

BioMutaiFAM118B
DMDMi74732801

Proteomic databases

EPDiQ9BPY3
jPOSTiQ9BPY3
MaxQBiQ9BPY3
PaxDbiQ9BPY3
PeptideAtlasiQ9BPY3
PRIDEiQ9BPY3
ProteomicsDBi78594

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		79607
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000533050; ENSP00000433343; ENSG00000197798
GeneIDi79607
KEGGihsa:79607
UCSCiuc001qdf.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79607
EuPathDBiHostDB:ENSG00000197798.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		FAM118B

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0010251
HGNCiHGNC:26110 FAM118B
HPAiHPA041644
HPA042100
MIMi616587 gene
neXtProtiNX_Q9BPY3
OpenTargetsiENSG00000197798
PharmGKBiPA145008413

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IHIR Eukaryota
ENOG410YDRZ LUCA
GeneTreeiENSGT00390000010215
HOGENOMiHOG000072713
HOVERGENiHBG055230
InParanoidiQ9BPY3
OMAiCKMEHAG
OrthoDBi924064at2759
PhylomeDBiQ9BPY3
TreeFamiTF332439

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FAM118B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79607

Protein Ontology

More...PROi		PR:Q9BPY3

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000197798 Expressed in 193 organ(s), highest expression level in tendon
ExpressionAtlasiQ9BPY3 baseline and differential
GenevisibleiQ9BPY3 HS

Family and domain databases

InterProiView protein in InterPro
IPR038916 FAM118
IPR033352 FAM118B
IPR039444 SIR2-like
PANTHERiPTHR28623 PTHR28623, 1 hit
PTHR28623:SF1 PTHR28623:SF1, 1 hit
PfamiView protein in Pfam
PF13289 SIR2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF118B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BPY3
Secondary accession number(s): Q9H7B0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 1, 2001
Last modified: April 10, 2019
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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