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Protein

17-beta-hydroxysteroid dehydrogenase 14

Gene

HSD17B14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei141SubstrateBy similarity1
Active sitei154Proton acceptorPROSITE-ProRule annotation1
Binding sitei158NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 40NADBy similarityAdd BLAST28

GO - Molecular functioni

  • estradiol 17-beta-dehydrogenase activity Source: HGNC
  • identical protein binding Source: IntAct
  • testosterone 17-beta-dehydrogenase (NADP+) activity Source: HGNC

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLipid metabolism, Steroid metabolism
LigandNAD

Enzyme and pathway databases

BRENDAi1.1.1.62 2681
ReactomeiR-HSA-193144 Estrogen biosynthesis

Chemistry databases

SwissLipidsiSLP:000001216

Names & Taxonomyi

Protein namesi
Recommended name:
17-beta-hydroxysteroid dehydrogenase 14 (EC:1.1.1.-)
Short name:
17-beta-HSD 14
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase DHRS10
Dehydrogenase/reductase SDR family member 10
Retinal short-chain dehydrogenase/reductase retSDR3
Short chain dehydrogenase/reductase family 47C member 1
Gene namesi
Name:HSD17B14
Synonyms:DHRS10, SDR3, SDR47C1
ORF Names:UNQ502/PRO474
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000087076.8
HGNCiHGNC:23238 HSD17B14
MIMi612832 gene
neXtProtiNX_Q9BPX1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000087076
PharmGKBiPA162391674

Chemistry databases

ChEMBLiCHEMBL3712868

Polymorphism and mutation databases

BioMutaiHSD17B14
DMDMi74752228

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546541 – 27017-beta-hydroxysteroid dehydrogenase 14Add BLAST270

Proteomic databases

EPDiQ9BPX1
PaxDbiQ9BPX1
PeptideAtlasiQ9BPX1
PRIDEiQ9BPX1
ProteomicsDBi78585

PTM databases

iPTMnetiQ9BPX1
PhosphoSitePlusiQ9BPX1

Expressioni

Tissue specificityi

Highly expressed in brain, placenta, liver and kidney.2 Publications

Gene expression databases

BgeeiENSG00000087076 Expressed in 186 organ(s), highest expression level in right lobe of liver
CleanExiHS_HSD17B14
ExpressionAtlasiQ9BPX1 baseline and differential
GenevisibleiQ9BPX1 HS

Organism-specific databases

HPAiHPA021467

Interactioni

Subunit structurei

Homotetramer.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119350, 41 interactors
IntActiQ9BPX1, 27 interactors
MINTiQ9BPX1
STRINGi9606.ENSP00000263278

Structurei

Secondary structure

1270
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BPX1
SMRiQ9BPX1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BPX1

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00920000148965
HOVERGENiHBG105555
InParanoidiQ9BPX1
OMAiMFWLCKA
OrthoDBiEOG091G0GO6
PhylomeDBiQ9BPX1
TreeFamiTF354307

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9BPX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATGTRYAGK VVVVTGGGRG IGAGIVRAFV NSGARVVICD KDESGGRALE
60 70 80 90 100
QELPGAVFIL CDVTQEDDVK TLVSETIRRF GRLDCVVNNA GHHPPPQRPE
110 120 130 140 150
ETSAQGFRQL LELNLLGTYT LTKLALPYLR KSQGNVINIS SLVGAIGQAQ
160 170 180 190 200
AVPYVATKGA VTAMTKALAL DESPYGVRVN CISPGNIWTP LWEELAALMP
210 220 230 240 250
DPRATIREGM LAQPLGRMGQ PAEVGAAAVF LASEANFCTG IELLVTGGAE
260 270
LGYGCKASRS TPVDAPDIPS
Length:270
Mass (Da):28,317
Last modified:June 1, 2001 - v1
Checksum:iDAB68FB8CA422ABC
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R2R3M0R2R3_HUMAN
17-beta-hydroxysteroid dehydrogenas...
HSD17B14
246Annotation score:
M0QY35M0QY35_HUMAN
17-beta-hydroxysteroid dehydrogenas...
HSD17B14
176Annotation score:
M0R147M0R147_HUMAN
17-beta-hydroxysteroid dehydrogenas...
HSD17B14
106Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205T → S in AAF06940 (PubMed:10800688).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05230731N → D. Corresponds to variant dbSNP:rs8110220Ensembl.1
Natural variantiVAR_052308130R → W. Corresponds to variant dbSNP:rs35299026Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126781 mRNA Translation: AAF06940.1
AY358430 mRNA Translation: AAQ88796.1
BC006294 mRNA Translation: AAH06294.1
BC006283 mRNA Translation: AAH06283.1
CCDSiCCDS12736.1
RefSeqiNP_057330.2, NM_016246.2
UniGeneiHs.18788

Genome annotation databases

EnsembliENST00000263278; ENSP00000263278; ENSG00000087076
GeneIDi51171
KEGGihsa:51171
UCSCiuc002pkv.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126781 mRNA Translation: AAF06940.1
AY358430 mRNA Translation: AAQ88796.1
BC006294 mRNA Translation: AAH06294.1
BC006283 mRNA Translation: AAH06283.1
CCDSiCCDS12736.1
RefSeqiNP_057330.2, NM_016246.2
UniGeneiHs.18788

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YDEX-ray2.40A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-270[»]
5EN4X-ray1.52A1-270[»]
5HS6X-ray2.02A1-270[»]
5ICMX-ray1.68A1-270[»]
5ICSX-ray1.52A/C/D/F1-270[»]
5JS6X-ray2.00A1-270[»]
5JSFX-ray1.84A1-270[»]
5L7TX-ray1.98A1-270[»]
5L7WX-ray1.76A1-270[»]
5L7YX-ray1.91A1-270[»]
5O42X-ray1.76A1-270[»]
5O43X-ray1.50A1-270[»]
5O6OX-ray1.45A1-270[»]
5O6XX-ray1.35A1-270[»]
5O6ZX-ray1.57A1-270[»]
5O72X-ray1.91A1-270[»]
5O7CX-ray1.60A1-270[»]
ProteinModelPortaliQ9BPX1
SMRiQ9BPX1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119350, 41 interactors
IntActiQ9BPX1, 27 interactors
MINTiQ9BPX1
STRINGi9606.ENSP00000263278

Chemistry databases

ChEMBLiCHEMBL3712868
SwissLipidsiSLP:000001216

PTM databases

iPTMnetiQ9BPX1
PhosphoSitePlusiQ9BPX1

Polymorphism and mutation databases

BioMutaiHSD17B14
DMDMi74752228

Proteomic databases

EPDiQ9BPX1
PaxDbiQ9BPX1
PeptideAtlasiQ9BPX1
PRIDEiQ9BPX1
ProteomicsDBi78585

Protocols and materials databases

DNASUi51171
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263278; ENSP00000263278; ENSG00000087076
GeneIDi51171
KEGGihsa:51171
UCSCiuc002pkv.2 human

Organism-specific databases

CTDi51171
EuPathDBiHostDB:ENSG00000087076.8
GeneCardsiHSD17B14
HGNCiHGNC:23238 HSD17B14
HPAiHPA021467
MIMi612832 gene
neXtProtiNX_Q9BPX1
OpenTargetsiENSG00000087076
PharmGKBiPA162391674
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0725 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00920000148965
HOVERGENiHBG105555
InParanoidiQ9BPX1
OMAiMFWLCKA
OrthoDBiEOG091G0GO6
PhylomeDBiQ9BPX1
TreeFamiTF354307

Enzyme and pathway databases

BRENDAi1.1.1.62 2681
ReactomeiR-HSA-193144 Estrogen biosynthesis

Miscellaneous databases

EvolutionaryTraceiQ9BPX1
GenomeRNAii51171
PROiPR:Q9BPX1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000087076 Expressed in 186 organ(s), highest expression level in right lobe of liver
CleanExiHS_HSD17B14
ExpressionAtlasiQ9BPX1 baseline and differential
GenevisibleiQ9BPX1 HS

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDHB14_HUMAN
AccessioniPrimary (citable) accession number: Q9BPX1
Secondary accession number(s): Q9UKU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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