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Protein

17-beta-hydroxysteroid dehydrogenase 14

Gene

HSD17B14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei141SubstrateBy similarity1
Active sitei154Proton acceptorPROSITE-ProRule annotation1
Binding sitei158NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 40NADBy similarityAdd BLAST28

GO - Molecular functioni

  • estradiol 17-beta-dehydrogenase activity Source: HGNC
  • identical protein binding Source: IntAct
  • testosterone 17-beta-dehydrogenase (NADP+) activity Source: HGNC

GO - Biological processi

  • estrogen biosynthetic process Source: Reactome
  • steroid catabolic process Source: HGNC

Keywordsi

Molecular functionOxidoreductase
Biological processLipid metabolism, Steroid metabolism
LigandNAD

Enzyme and pathway databases

BRENDAi1.1.1.62 2681
ReactomeiR-HSA-193144 Estrogen biosynthesis

Chemistry databases

SwissLipidsiSLP:000001216

Names & Taxonomyi

Protein namesi
Recommended name:
17-beta-hydroxysteroid dehydrogenase 14 (EC:1.1.1.-)
Short name:
17-beta-HSD 14
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase DHRS10
Dehydrogenase/reductase SDR family member 10
Retinal short-chain dehydrogenase/reductase retSDR3
Short chain dehydrogenase/reductase family 47C member 1
Gene namesi
Name:HSD17B14
Synonyms:DHRS10, SDR3, SDR47C1
ORF Names:UNQ502/PRO474
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000087076.8
HGNCiHGNC:23238 HSD17B14
MIMi612832 gene
neXtProtiNX_Q9BPX1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000087076
PharmGKBiPA162391674

Chemistry databases

ChEMBLiCHEMBL3712868

Polymorphism and mutation databases

BioMutaiHSD17B14
DMDMi74752228

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546541 – 27017-beta-hydroxysteroid dehydrogenase 14Add BLAST270

Proteomic databases

PaxDbiQ9BPX1
PeptideAtlasiQ9BPX1
PRIDEiQ9BPX1
ProteomicsDBi78585

PTM databases

iPTMnetiQ9BPX1
PhosphoSitePlusiQ9BPX1

Expressioni

Tissue specificityi

Highly expressed in brain, placenta, liver and kidney.2 Publications

Gene expression databases

BgeeiENSG00000087076
CleanExiHS_HSD17B14
ExpressionAtlasiQ9BPX1 baseline and differential
GenevisibleiQ9BPX1 HS

Organism-specific databases

HPAiHPA021467

Interactioni

Subunit structurei

Homotetramer.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi119350, 40 interactors
IntActiQ9BPX1, 28 interactors
MINTiQ9BPX1
STRINGi9606.ENSP00000263278

Structurei

Secondary structure

1270
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni6 – 9Combined sources4
Beta strandi11 – 15Combined sources5
Turni16 – 18Combined sources3
Helixi20 – 31Combined sources12
Beta strandi35 – 41Combined sources7
Helixi43 – 52Combined sources10
Beta strandi56 – 60Combined sources5
Helixi66 – 80Combined sources15
Beta strandi85 – 88Combined sources4
Helixi99 – 101Combined sources3
Helixi104 – 114Combined sources11
Helixi116 – 132Combined sources17
Beta strandi135 – 139Combined sources5
Helixi143 – 146Combined sources4
Helixi152 – 172Combined sources21
Helixi173 – 175Combined sources3
Beta strandi178 – 184Combined sources7
Helixi190 – 197Combined sources8
Beta strandi199 – 201Combined sources3
Helixi202 – 211Combined sources10
Helixi221 – 233Combined sources13
Beta strandi242 – 246Combined sources5
Turni247 – 250Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YDEX-ray2.40A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-270[»]
5EN4X-ray1.52A1-270[»]
5HS6X-ray2.02A1-270[»]
5ICMX-ray1.68A1-270[»]
5ICSX-ray1.52A/C/D/F1-270[»]
5JS6X-ray2.00A1-270[»]
5JSFX-ray1.84A1-270[»]
5L7TX-ray1.98A1-270[»]
5L7WX-ray1.76A1-270[»]
5L7YX-ray1.91A1-270[»]
ProteinModelPortaliQ9BPX1
SMRiQ9BPX1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BPX1

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00920000148965
HOVERGENiHBG105555
InParanoidiQ9BPX1
OMAiICDKDES
OrthoDBiEOG091G0GO6
PhylomeDBiQ9BPX1
TreeFamiTF354307

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BPX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGTRYAGK VVVVTGGGRG IGAGIVRAFV NSGARVVICD KDESGGRALE
60 70 80 90 100
QELPGAVFIL CDVTQEDDVK TLVSETIRRF GRLDCVVNNA GHHPPPQRPE
110 120 130 140 150
ETSAQGFRQL LELNLLGTYT LTKLALPYLR KSQGNVINIS SLVGAIGQAQ
160 170 180 190 200
AVPYVATKGA VTAMTKALAL DESPYGVRVN CISPGNIWTP LWEELAALMP
210 220 230 240 250
DPRATIREGM LAQPLGRMGQ PAEVGAAAVF LASEANFCTG IELLVTGGAE
260 270
LGYGCKASRS TPVDAPDIPS
Length:270
Mass (Da):28,317
Last modified:June 1, 2001 - v1
Checksum:iDAB68FB8CA422ABC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205T → S in AAF06940 (PubMed:10800688).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05230731N → D. Corresponds to variant dbSNP:rs8110220Ensembl.1
Natural variantiVAR_052308130R → W. Corresponds to variant dbSNP:rs35299026Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126781 mRNA Translation: AAF06940.1
AY358430 mRNA Translation: AAQ88796.1
BC006294 mRNA Translation: AAH06294.1
BC006283 mRNA Translation: AAH06283.1
CCDSiCCDS12736.1
RefSeqiNP_057330.2, NM_016246.2
UniGeneiHs.18788

Genome annotation databases

EnsembliENST00000263278; ENSP00000263278; ENSG00000087076
GeneIDi51171
KEGGihsa:51171
UCSCiuc002pkv.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDHB14_HUMAN
AccessioniPrimary (citable) accession number: Q9BPX1
Secondary accession number(s): Q9UKU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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