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Protein

Ras-like protein family member 11B

Gene

RASL11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 47GTPBy similarity8
Nucleotide bindingi87 – 94GTPBy similarity8
Nucleotide bindingi152 – 155GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-like protein family member 11B
Gene namesi
Name:RASL11BImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000128045.6
HGNCiHGNC:23804 RASL11B
MIMi612404 gene
neXtProtiNX_Q9BPW5

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi65997
OpenTargetsiENSG00000128045
PharmGKBiPA134872992

Polymorphism and mutation databases

BioMutaiRASL11B
DMDMi74732795

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003083651 – 248Ras-like protein family member 11BAdd BLAST248

Proteomic databases

EPDiQ9BPW5
PaxDbiQ9BPW5
PeptideAtlasiQ9BPW5
PRIDEiQ9BPW5
ProteomicsDBi78580

PTM databases

iPTMnetiQ9BPW5
PhosphoSitePlusiQ9BPW5

Expressioni

Tissue specificityi

Widely expressed with highest levels in placenta and primary macrophages.1 Publication

Developmental stagei

Up-regulated during development of primary monocytes into macrophages.1 Publication

Inductioni

By TGFB1.1 Publication

Gene expression databases

BgeeiENSG00000128045 Expressed in 150 organ(s), highest expression level in female gonad
CleanExiHS_RASL11B
GenevisibleiQ9BPW5 HS

Organism-specific databases

HPAiHPA057803

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122444, 7 interactors
IntActiQ9BPW5, 3 interactors
STRINGi9606.ENSP00000248706

Structurei

3D structure databases

ProteinModelPortaliQ9BPW5
SMRiQ9BPW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 246Small GTPase-likeAdd BLAST218

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00930000150874
HOGENOMiHOG000233973
HOVERGENiHBG108422
InParanoidiQ9BPW5
KOiK07853
OMAiMLGCTFY
OrthoDBiEOG091G0M6D
PhylomeDBiQ9BPW5
TreeFamiTF318030

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BPW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLIQNMCTI AEYPAPGNAA ASDCCVGAAG RRLVKIAVVG ASGVGKTALV
60 70 80 90 100
VRFLTKRFIG DYERNAGNLY TRQVQIEGET LALQVQDTPG IQVHENSLSC
110 120 130 140 150
SEQLNRCIRW ADAVVIVFSI TDYKSYELIS QLHQHVQQLH LGTRLPVVVV
160 170 180 190 200
ANKADLLHIK QVDPQLGLQL ASMLGCSFYE VSVSENYNDV YSAFHVLCKE
210 220 230 240
VSHKQQPSST PEKRRTSLIP RPKSPNMQDL KRRFKQALSA KVRTVTSV
Length:248
Mass (Da):27,508
Last modified:June 1, 2001 - v1
Checksum:iE45301814B6C2ABC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3L → H in BAB55008 (PubMed:14702039).Curated1
Sequence conflicti50V → L in BAB55008 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY839725 mRNA Translation: AAX46798.1
AK027267 mRNA Translation: BAB55008.1
AK314942 mRNA Translation: BAG37448.1
CH471057 Genomic DNA Translation: EAX05441.1
BC001087 mRNA Translation: AAH01087.1
BC001846 mRNA Translation: AAH01846.1
BC025694 mRNA Translation: AAH25694.1
BK001672 mRNA Translation: DAA02135.1
CCDSiCCDS3490.1
RefSeqiNP_076429.1, NM_023940.2
UniGeneiHs.8035

Genome annotation databases

EnsembliENST00000248706; ENSP00000248706; ENSG00000128045
GeneIDi65997
KEGGihsa:65997
UCSCiuc003gzt.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY839725 mRNA Translation: AAX46798.1
AK027267 mRNA Translation: BAB55008.1
AK314942 mRNA Translation: BAG37448.1
CH471057 Genomic DNA Translation: EAX05441.1
BC001087 mRNA Translation: AAH01087.1
BC001846 mRNA Translation: AAH01846.1
BC025694 mRNA Translation: AAH25694.1
BK001672 mRNA Translation: DAA02135.1
CCDSiCCDS3490.1
RefSeqiNP_076429.1, NM_023940.2
UniGeneiHs.8035

3D structure databases

ProteinModelPortaliQ9BPW5
SMRiQ9BPW5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122444, 7 interactors
IntActiQ9BPW5, 3 interactors
STRINGi9606.ENSP00000248706

PTM databases

iPTMnetiQ9BPW5
PhosphoSitePlusiQ9BPW5

Polymorphism and mutation databases

BioMutaiRASL11B
DMDMi74732795

Proteomic databases

EPDiQ9BPW5
PaxDbiQ9BPW5
PeptideAtlasiQ9BPW5
PRIDEiQ9BPW5
ProteomicsDBi78580

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248706; ENSP00000248706; ENSG00000128045
GeneIDi65997
KEGGihsa:65997
UCSCiuc003gzt.4 human

Organism-specific databases

CTDi65997
DisGeNETi65997
EuPathDBiHostDB:ENSG00000128045.6
GeneCardsiRASL11B
H-InvDBiHIX0004215
HGNCiHGNC:23804 RASL11B
HPAiHPA057803
MIMi612404 gene
neXtProtiNX_Q9BPW5
OpenTargetsiENSG00000128045
PharmGKBiPA134872992
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00930000150874
HOGENOMiHOG000233973
HOVERGENiHBG108422
InParanoidiQ9BPW5
KOiK07853
OMAiMLGCTFY
OrthoDBiEOG091G0M6D
PhylomeDBiQ9BPW5
TreeFamiTF318030

Miscellaneous databases

ChiTaRSiRASL11B human
GeneWikiiRASL11B
GenomeRNAii65997
PROiPR:Q9BPW5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128045 Expressed in 150 organ(s), highest expression level in female gonad
CleanExiHS_RASL11B
GenevisibleiQ9BPW5 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRSLBB_HUMAN
AccessioniPrimary (citable) accession number: Q9BPW5
Secondary accession number(s): B2RC51, Q96KC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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