RASL11B

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	40 – 47	GTPBy similarity	8
Nucleotide bindingⁱ	87 – 94	GTPBy similarity	8
Nucleotide bindingⁱ	152 – 155	GTPBy similarity	4

GO - Molecular functionⁱ

GTPase activity Source: InterPro
GTP binding Source: UniProtKB-KW
transforming growth factor beta receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
signal transduction Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	GTP-binding, Nucleotide-binding

Ligand

GTP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-like protein family member 11B
Gene namesⁱ	Name:RASL11BImported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000128045.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23804 RASL11B
MIMⁱ	612404 gene
neXtProtⁱ	NX_Q9BPW5

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	65997
Open Targets More...OpenTargetsⁱ	ENSG00000128045
PharmGKBⁱ	PA134872992

Polymorphism and mutation databases

BioMutaⁱ	RASL11B
DMDMⁱ	74732795

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000308365	1 – 248	Ras-like protein family member 11BAdd BLAST		248

Proteomic databases

EPDⁱ	Q9BPW5
PaxDbⁱ	Q9BPW5
PeptideAtlas More...PeptideAtlasⁱ	Q9BPW5
PRIDEⁱ	Q9BPW5
ProteomicsDBⁱ	78580

PTM databases

iPTMnetⁱ	Q9BPW5
PhosphoSitePlusⁱ	Q9BPW5

Expressionⁱ

Tissue specificityⁱ

Widely expressed with highest levels in placenta and primary macrophages.1 Publication

Developmental stageⁱ

Up-regulated during development of primary monocytes into macrophages.1 Publication

Inductionⁱ

By TGFB1.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000128045 Expressed in 150 organ(s), highest expression level in female gonad
CleanExⁱ	HS_RASL11B
Genevisibleⁱ	Q9BPW5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA057803

HPAⁱ

HPA057803

Interactionⁱ

GO - Molecular functionⁱ

transforming growth factor beta receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	122444, 7 interactors
IntActⁱ	Q9BPW5, 3 interactors
STRINGⁱ	9606.ENSP00000248706

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BPW5
SMRⁱ	Q9BPW5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	29 – 246	Small GTPase-likeAdd BLAST		218

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Ras family.Sequence analysis

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150874
HOGENOMⁱ	HOG000233973
HOVERGENⁱ	HBG108422
InParanoidⁱ	Q9BPW5
KEGG Orthology (KO) More...KOⁱ	K07853
OMAⁱ	MLGCTFY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0M6D
PhylomeDBⁱ	Q9BPW5
TreeFamⁱ	TF318030

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9BPW5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRLIQNMCTI AEYPAPGNAA ASDCCVGAAG RRLVKIAVVG ASGVGKTALV 
        60         70         80         90        100
VRFLTKRFIG DYERNAGNLY TRQVQIEGET LALQVQDTPG IQVHENSLSC 
       110        120        130        140        150
SEQLNRCIRW ADAVVIVFSI TDYKSYELIS QLHQHVQQLH LGTRLPVVVV 
       160        170        180        190        200
ANKADLLHIK QVDPQLGLQL ASMLGCSFYE VSVSENYNDV YSAFHVLCKE 
       210        220        230        240 
VSHKQQPSST PEKRRTSLIP RPKSPNMQDL KRRFKQALSA KVRTVTSV

Length:248

Mass (Da):27,508

Last modified:June 1, 2001 - v1

Checksum:ⁱE45301814B6C2ABC

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	3	L → H in BAB55008 (PubMed:14702039).Curated		1
Sequence conflictⁱ	50	V → L in BAB55008 (PubMed:14702039).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY839725 mRNA Translation: AAX46798.1 AK027267 mRNA Translation: BAB55008.1 AK314942 mRNA Translation: BAG37448.1 CH471057 Genomic DNA Translation: EAX05441.1 BC001087 mRNA Translation: AAH01087.1 BC001846 mRNA Translation: AAH01846.1 BC025694 mRNA Translation: AAH25694.1 BK001672 mRNA Translation: DAA02135.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3490.1
NCBI Reference Sequences More...RefSeqⁱ	NP_076429.1, NM_023940.2
UniGeneⁱ	Hs.8035

Genome annotation databases

Ensemblⁱ	ENST00000248706; ENSP00000248706; ENSG00000128045
GeneIDⁱ	65997
KEGGⁱ	hsa:65997
UCSC genome browser More...UCSCⁱ	uc003gzt.4 human

Protein	Similar proteins		Species	Score	Length	Source
Q9BPW5	Uncharacterized protein		PANPA		248	UniRef100_Q9BPW5
RAS like family 11 member B		GORGO		248

Protein	Similar proteins		Species	Score	Length	Source
Q9BPW5	Ras-like protein family member 11B		MOUSE		247	UniRef90_Q922H7
Ras-like protein family member 11B		BOVIN		248
Ras-like protein family member 11B		RAT		247
Ras-like protein family member 11B		PTEAL		251
Uncharacterized protein		OTOGA		250
+84

Protein	Similar proteins		Species	Score	Length	Source
Q9BPW5	Ras-like protein family member 11B		MOUSE		247	UniRef50_Q922H7
Ras-like protein family member 11B		BOVIN		248
Ras-like protein family member 11B		RAT		247
Ras-like protein family member 11B		XENLA		248
Ras-like protein family member 11B		XENTR		247
+235

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY839725 mRNA Translation: AAX46798.1 AK027267 mRNA Translation: BAB55008.1 AK314942 mRNA Translation: BAG37448.1 CH471057 Genomic DNA Translation: EAX05441.1 BC001087 mRNA Translation: AAH01087.1 BC001846 mRNA Translation: AAH01846.1 BC025694 mRNA Translation: AAH25694.1 BK001672 mRNA Translation: DAA02135.1
CCDSⁱ	CCDS3490.1
RefSeqⁱ	NP_076429.1, NM_023940.2
UniGeneⁱ	Hs.8035

3D structure databases

ProteinModelPortalⁱ	Q9BPW5
SMRⁱ	Q9BPW5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122444, 7 interactors
IntActⁱ	Q9BPW5, 3 interactors
STRINGⁱ	9606.ENSP00000248706

PTM databases

iPTMnetⁱ	Q9BPW5
PhosphoSitePlusⁱ	Q9BPW5

Polymorphism and mutation databases

BioMutaⁱ	RASL11B
DMDMⁱ	74732795

Proteomic databases

EPDⁱ	Q9BPW5
PaxDbⁱ	Q9BPW5
PeptideAtlasⁱ	Q9BPW5
PRIDEⁱ	Q9BPW5
ProteomicsDBⁱ	78580

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000248706; ENSP00000248706; ENSG00000128045
GeneIDⁱ	65997
KEGGⁱ	hsa:65997
UCSCⁱ	uc003gzt.4 human

Organism-specific databases

CTDⁱ	65997
DisGeNETⁱ	65997
EuPathDBⁱ	HostDB:ENSG00000128045.6
GeneCardsⁱ	RASL11B
H-InvDBⁱ	HIX0004215
HGNCⁱ	HGNC:23804 RASL11B
HPAⁱ	HPA057803
MIMⁱ	612404 gene
neXtProtⁱ	NX_Q9BPW5
OpenTargetsⁱ	ENSG00000128045
PharmGKBⁱ	PA134872992
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
GeneTreeⁱ	ENSGT00930000150874
HOGENOMⁱ	HOG000233973
HOVERGENⁱ	HBG108422
InParanoidⁱ	Q9BPW5
KOⁱ	K07853
OMAⁱ	MLGCTFY
OrthoDBⁱ	EOG091G0M6D
PhylomeDBⁱ	Q9BPW5
TreeFamⁱ	TF318030

Miscellaneous databases

ChiTaRSⁱ	RASL11B human
GeneWikiⁱ	RASL11B
GenomeRNAiⁱ	65997
Protein Ontology More...PROⁱ	PR:Q9BPW5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000128045 Expressed in 150 organ(s), highest expression level in female gonad
CleanExⁱ	HS_RASL11B
Genevisibleⁱ	Q9BPW5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RSLBB_HUMAN
Accessionⁱ	Q9BPW5Primary (citable) accession number: Q9BPW5 Secondary accession number(s): B2RC51, Q96KC5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - Q9BPW5 (RSLBB_HUMAN)

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Ras-like protein family member 11B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ