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UniProtKB - Q9BPW5 (RSLBB_HUMAN)
Protein
Ras-like protein family member 11B
Gene
RASL11B
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.6.5.2By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 40 – 47 | GTPBy similarity | 8 | |
Nucleotide bindingi | 87 – 94 | GTPBy similarity | 8 | |
Nucleotide bindingi | 152 – 155 | GTPBy similarity | 4 |
GO - Molecular functioni
- G protein activity Source: UniProtKB-EC
- GTP binding Source: UniProtKB-KW
- transforming growth factor beta receptor binding Source: Ensembl
GO - Biological processi
Keywordsi
Molecular function | Hydrolase |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9BPW5 |
SignaLinki | Q9BPW5 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:RASL11BImported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23804, RASL11B |
MIMi | 612404, gene |
neXtProti | NX_Q9BPW5 |
VEuPathDBi | HostDB:ENSG00000128045 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 65997 |
OpenTargetsi | ENSG00000128045 |
PharmGKBi | PA134872992 |
Miscellaneous databases
Pharosi | Q9BPW5, Tbio |
Genetic variation databases
BioMutai | RASL11B |
DMDMi | 74732795 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000308365 | 1 – 248 | Ras-like protein family member 11BAdd BLAST | 248 |
Proteomic databases
MassIVEi | Q9BPW5 |
PaxDbi | Q9BPW5 |
PeptideAtlasi | Q9BPW5 |
PRIDEi | Q9BPW5 |
ProteomicsDBi | 78580 |
PTM databases
iPTMneti | Q9BPW5 |
PhosphoSitePlusi | Q9BPW5 |
Expressioni
Tissue specificityi
Widely expressed with highest levels in placenta and primary macrophages.1 Publication
Developmental stagei
Up-regulated during development of primary monocytes into macrophages.1 Publication
Inductioni
By TGFB1.1 Publication
Gene expression databases
Bgeei | ENSG00000128045, Expressed in female gonad and 164 other tissues |
Genevisiblei | Q9BPW5, HS |
Organism-specific databases
HPAi | ENSG00000128045, Tissue enhanced (lymphoid tissue, ovary) |
Interactioni
Binary interactionsi
Q9BPW5
With | #Exp. | IntAct |
---|---|---|
GEMIN6 [Q8WXD5] | 3 | EBI-745409,EBI-752301 |
MAGI1 - isoform 3 [Q96QZ7-3] | 3 | EBI-745409,EBI-8769674 |
GO - Molecular functioni
- transforming growth factor beta receptor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 122444, 21 interactors |
IntActi | Q9BPW5, 3 interactors |
STRINGi | 9606.ENSP00000248706 |
Miscellaneous databases
RNActi | Q9BPW5, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 29 – 246 | Small GTPase-likeAdd BLAST | 218 | |
Regioni | 205 – 226 | DisorderedSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000158643 |
HOGENOMi | CLU_041217_9_7_1 |
InParanoidi | Q9BPW5 |
OMAi | KEVEPQH |
OrthoDBi | 1384728at2759 |
PhylomeDBi | Q9BPW5 |
TreeFami | TF318030 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9BPW5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLIQNMCTI AEYPAPGNAA ASDCCVGAAG RRLVKIAVVG ASGVGKTALV
60 70 80 90 100
VRFLTKRFIG DYERNAGNLY TRQVQIEGET LALQVQDTPG IQVHENSLSC
110 120 130 140 150
SEQLNRCIRW ADAVVIVFSI TDYKSYELIS QLHQHVQQLH LGTRLPVVVV
160 170 180 190 200
ANKADLLHIK QVDPQLGLQL ASMLGCSFYE VSVSENYNDV YSAFHVLCKE
210 220 230 240
VSHKQQPSST PEKRRTSLIP RPKSPNMQDL KRRFKQALSA KVRTVTSV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | L → H in BAB55008 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 50 | V → L in BAB55008 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY839725 mRNA Translation: AAX46798.1 AK027267 mRNA Translation: BAB55008.1 AK314942 mRNA Translation: BAG37448.1 CH471057 Genomic DNA Translation: EAX05441.1 BC001087 mRNA Translation: AAH01087.1 BC001846 mRNA Translation: AAH01846.1 BC025694 mRNA Translation: AAH25694.1 BK001672 mRNA Translation: DAA02135.1 |
CCDSi | CCDS3490.1 |
RefSeqi | NP_076429.1, NM_023940.2 |
Genome annotation databases
Ensembli | ENST00000248706.5; ENSP00000248706.3; ENSG00000128045.7 |
GeneIDi | 65997 |
KEGGi | hsa:65997 |
MANE-Selecti | ENST00000248706.5; ENSP00000248706.3; NM_023940.3; NP_076429.1 |
UCSCi | uc003gzt.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY839725 mRNA Translation: AAX46798.1 AK027267 mRNA Translation: BAB55008.1 AK314942 mRNA Translation: BAG37448.1 CH471057 Genomic DNA Translation: EAX05441.1 BC001087 mRNA Translation: AAH01087.1 BC001846 mRNA Translation: AAH01846.1 BC025694 mRNA Translation: AAH25694.1 BK001672 mRNA Translation: DAA02135.1 |
CCDSi | CCDS3490.1 |
RefSeqi | NP_076429.1, NM_023940.2 |
3D structure databases
AlphaFoldDBi | Q9BPW5 |
SMRi | Q9BPW5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122444, 21 interactors |
IntActi | Q9BPW5, 3 interactors |
STRINGi | 9606.ENSP00000248706 |
PTM databases
iPTMneti | Q9BPW5 |
PhosphoSitePlusi | Q9BPW5 |
Genetic variation databases
BioMutai | RASL11B |
DMDMi | 74732795 |
Proteomic databases
MassIVEi | Q9BPW5 |
PaxDbi | Q9BPW5 |
PeptideAtlasi | Q9BPW5 |
PRIDEi | Q9BPW5 |
ProteomicsDBi | 78580 |
Protocols and materials databases
Antibodypediai | 23900, 95 antibodies from 24 providers |
DNASUi | 65997 |
Genome annotation databases
Ensembli | ENST00000248706.5; ENSP00000248706.3; ENSG00000128045.7 |
GeneIDi | 65997 |
KEGGi | hsa:65997 |
MANE-Selecti | ENST00000248706.5; ENSP00000248706.3; NM_023940.3; NP_076429.1 |
UCSCi | uc003gzt.4, human |
Organism-specific databases
CTDi | 65997 |
DisGeNETi | 65997 |
GeneCardsi | RASL11B |
HGNCi | HGNC:23804, RASL11B |
HPAi | ENSG00000128045, Tissue enhanced (lymphoid tissue, ovary) |
MIMi | 612404, gene |
neXtProti | NX_Q9BPW5 |
OpenTargetsi | ENSG00000128045 |
PharmGKBi | PA134872992 |
VEuPathDBi | HostDB:ENSG00000128045 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000158643 |
HOGENOMi | CLU_041217_9_7_1 |
InParanoidi | Q9BPW5 |
OMAi | KEVEPQH |
OrthoDBi | 1384728at2759 |
PhylomeDBi | Q9BPW5 |
TreeFami | TF318030 |
Enzyme and pathway databases
PathwayCommonsi | Q9BPW5 |
SignaLinki | Q9BPW5 |
Miscellaneous databases
BioGRID-ORCSi | 65997, 9 hits in 1065 CRISPR screens |
ChiTaRSi | RASL11B, human |
GeneWikii | RASL11B |
GenomeRNAii | 65997 |
Pharosi | Q9BPW5, Tbio |
PROi | PR:Q9BPW5 |
RNActi | Q9BPW5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000128045, Expressed in female gonad and 164 other tissues |
Genevisiblei | Q9BPW5, HS |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RSLBB_HUMAN | |
Accessioni | Q9BPW5Primary (citable) accession number: Q9BPW5 Secondary accession number(s): B2RC51, Q96KC5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families