UniProtKB - Q9BPW4 (APOL4_HUMAN)
Protein
Apolipoprotein L4
Gene
APOL4
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity).By similarity
GO - Molecular functioni
- lipid binding Source: GO_Central
GO - Biological processi
- lipid metabolic process Source: UniProtKB
- lipid transport Source: UniProtKB-KW
- lipoprotein metabolic process Source: InterPro
Keywordsi
Biological process | Lipid transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9BPW4 |
Names & Taxonomyi
Protein namesi | Recommended name: Apolipoprotein L4Alternative name(s): Apolipoprotein L-IV Short name: ApoL-IV |
Gene namesi | Name:APOL4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14867, APOL4 |
MIMi | 607254, gene |
neXtProti | NX_Q9BPW4 |
VEuPathDBi | HostDB:ENSG00000100336.17 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular space Source: BHF-UCL
Other locations
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 80832 |
MalaCardsi | APOL4 |
OpenTargetsi | ENSG00000100336 |
PharmGKBi | PA24907 |
Miscellaneous databases
Pharosi | Q9BPW4, Tbio |
Genetic variation databases
BioMutai | APOL4 |
DMDMi | 143811364 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000002041 | 22 – 351 | Apolipoprotein L4Add BLAST | 330 |
Proteomic databases
MassIVEi | Q9BPW4 |
PaxDbi | Q9BPW4 |
PeptideAtlasi | Q9BPW4 |
PRIDEi | Q9BPW4 |
ProteomicsDBi | 78577 [Q9BPW4-1] 78578 [Q9BPW4-2] 78579 [Q9BPW4-3] |
PTM databases
iPTMneti | Q9BPW4 |
PhosphoSitePlusi | Q9BPW4 |
Expressioni
Tissue specificityi
Widely expressed; the highest levels are in spinal cord, placenta, adrenal gland; also detected in spleen, bone marrow, uterus, trachea, mammary gland and testis; levels are low in brain, heart and pancreas.
Gene expression databases
Bgeei | ENSG00000100336, Expressed in parotid gland and 181 other tissues |
ExpressionAtlasi | Q9BPW4, baseline and differential |
Genevisiblei | Q9BPW4, HS |
Organism-specific databases
HPAi | ENSG00000100336, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 123325, 2 interactors |
IntActi | Q9BPW4, 1 interactor |
STRINGi | 9606.ENSP00000338260 |
Miscellaneous databases
RNActi | Q9BPW4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the apolipoprotein L family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RZGU, Eukaryota |
GeneTreei | ENSGT01010000222409 |
HOGENOMi | CLU_046288_1_0_1 |
InParanoidi | Q9BPW4 |
OMAi | EGLMEWW |
OrthoDBi | 1060131at2759 |
PhylomeDBi | Q9BPW4 |
Family and domain databases
InterProi | View protein in InterPro IPR008405, ApoL |
PANTHERi | PTHR14096, PTHR14096, 1 hit |
Pfami | View protein in Pfam PF05461, ApoL, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BPW4-1) [UniParc]FASTAAdd to basket
Also known as: B
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEGAALLKIF VVCIWVQQNH PGWTVAGQFQ EKKRFTEEVI EYFQKKVSPV
60 70 80 90 100
HLKILLTSDE AWKRFVRVAE LPREEADALY EALKNLTPYV AIEDKDMQQK
110 120 130 140 150
EQQFREWFLK EFPQIRWKIQ ESIERLRVIA NEIEKVHRGC VIANVVSGST
160 170 180 190 200
GILSVIGVML APFTAGLSLS ITAAGVGLGI ASATAGIASS IVENTYTRSA
210 220 230 240 250
ELTASRLTAT STDQLEALRD ILRDITPNVL SFALDFDEAT KMIANDVHTL
260 270 280 290 300
RRSKATVGRP LIAWRYVPIN VVETLRTRGA PTRIVRKVAR NLGKATSGVL
310 320 330 340 350
VVLDVVNLVQ DSLDLHKGAK SESAESLRQW AQELEENLNE LTHIHQSLKA
G
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H1P9 | F5H1P9_HUMAN | Apolipoprotein L4 | APOL4 | 72 | Annotation score: | ||
B1AHJ0 | B1AHJ0_HUMAN | Apolipoprotein L4 | APOL4 | 64 | Annotation score: | ||
E9PS31 | E9PS31_HUMAN | Apolipoprotein L4 | APOL4 | 70 | Annotation score: | ||
Q9BRG6 | Q9BRG6_HUMAN | APOL4 protein | APOL4 hCG_41448 | 107 | Annotation score: | ||
B1AHJ2 | B1AHJ2_HUMAN | Apolipoprotein L4 | APOL4 | 25 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053008 | 9 | I → V. Corresponds to variant dbSNP:rs132736Ensembl. | 1 | |
Natural variantiVAR_053009 | 12 | V → L. Corresponds to variant dbSNP:rs80587Ensembl. | 1 | |
Natural variantiVAR_053010 | 159 | M → V. Corresponds to variant dbSNP:rs132700Ensembl. | 1 | |
Natural variantiVAR_059966 | 223 | R → H. Corresponds to variant dbSNP:rs2227168Ensembl. | 1 | |
Natural variantiVAR_059967 | 319 | A → E. Corresponds to variant dbSNP:rs6000173Ensembl. | 1 | |
Natural variantiVAR_059968 | 326 | S → L. Corresponds to variant dbSNP:rs6000172Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000295 | 1 – 15 | MEGAA…VVCIW → MGSWVQLITSVG in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 15 | |
Alternative sequenceiVSP_024380 | 111 | Missing in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY014915 mRNA Translation: AAG50353.1 AY014913 , AY014909, AY014911, AY014912 Genomic DNA Translation: AAG50350.1 AY014914 mRNA Translation: AAG50352.1 AY014913 , AY014910, AY014911, AY014912 Genomic DNA Translation: AAG50351.1 AF305226 mRNA Translation: AAK20212.1 |
CCDSi | CCDS74851.1 [Q9BPW4-2] CCDS74852.1 [Q9BPW4-1] |
RefSeqi | NP_085146.2, NM_030643.4 [Q9BPW4-2] NP_663693.1, NM_145660.2 [Q9BPW4-1] |
Genome annotation databases
Ensembli | ENST00000332987; ENSP00000333229; ENSG00000100336 [Q9BPW4-2] ENST00000352371; ENSP00000338260; ENSG00000100336 [Q9BPW4-1] ENST00000616056; ENSP00000483497; ENSG00000100336 [Q9BPW4-2] |
GeneIDi | 80832 |
KEGGi | hsa:80832 |
UCSCi | uc032qne.2, human [Q9BPW4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY014915 mRNA Translation: AAG50353.1 AY014913 , AY014909, AY014911, AY014912 Genomic DNA Translation: AAG50350.1 AY014914 mRNA Translation: AAG50352.1 AY014913 , AY014910, AY014911, AY014912 Genomic DNA Translation: AAG50351.1 AF305226 mRNA Translation: AAK20212.1 |
CCDSi | CCDS74851.1 [Q9BPW4-2] CCDS74852.1 [Q9BPW4-1] |
RefSeqi | NP_085146.2, NM_030643.4 [Q9BPW4-2] NP_663693.1, NM_145660.2 [Q9BPW4-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123325, 2 interactors |
IntActi | Q9BPW4, 1 interactor |
STRINGi | 9606.ENSP00000338260 |
PTM databases
iPTMneti | Q9BPW4 |
PhosphoSitePlusi | Q9BPW4 |
Genetic variation databases
BioMutai | APOL4 |
DMDMi | 143811364 |
Proteomic databases
MassIVEi | Q9BPW4 |
PaxDbi | Q9BPW4 |
PeptideAtlasi | Q9BPW4 |
PRIDEi | Q9BPW4 |
ProteomicsDBi | 78577 [Q9BPW4-1] 78578 [Q9BPW4-2] 78579 [Q9BPW4-3] |
Protocols and materials databases
Antibodypediai | 25529, 201 antibodies |
DNASUi | 80832 |
Genome annotation databases
Ensembli | ENST00000332987; ENSP00000333229; ENSG00000100336 [Q9BPW4-2] ENST00000352371; ENSP00000338260; ENSG00000100336 [Q9BPW4-1] ENST00000616056; ENSP00000483497; ENSG00000100336 [Q9BPW4-2] |
GeneIDi | 80832 |
KEGGi | hsa:80832 |
UCSCi | uc032qne.2, human [Q9BPW4-1] |
Organism-specific databases
CTDi | 80832 |
DisGeNETi | 80832 |
GeneCardsi | APOL4 |
HGNCi | HGNC:14867, APOL4 |
HPAi | ENSG00000100336, Low tissue specificity |
MalaCardsi | APOL4 |
MIMi | 607254, gene |
neXtProti | NX_Q9BPW4 |
OpenTargetsi | ENSG00000100336 |
PharmGKBi | PA24907 |
VEuPathDBi | HostDB:ENSG00000100336.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RZGU, Eukaryota |
GeneTreei | ENSGT01010000222409 |
HOGENOMi | CLU_046288_1_0_1 |
InParanoidi | Q9BPW4 |
OMAi | EGLMEWW |
OrthoDBi | 1060131at2759 |
PhylomeDBi | Q9BPW4 |
Enzyme and pathway databases
PathwayCommonsi | Q9BPW4 |
Miscellaneous databases
BioGRID-ORCSi | 80832, 3 hits in 143 CRISPR screens |
ChiTaRSi | APOL4, human |
GenomeRNAii | 80832 |
Pharosi | Q9BPW4, Tbio |
PROi | PR:Q9BPW4 |
RNActi | Q9BPW4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100336, Expressed in parotid gland and 181 other tissues |
ExpressionAtlasi | Q9BPW4, baseline and differential |
Genevisiblei | Q9BPW4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008405, ApoL |
PANTHERi | PTHR14096, PTHR14096, 1 hit |
Pfami | View protein in Pfam PF05461, ApoL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | APOL4_HUMAN | |
Accessioni | Q9BPW4Primary (citable) accession number: Q9BPW4 Secondary accession number(s): Q9BQ37, Q9BXQ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 29, 2001 |
Last sequence update: | April 3, 2007 | |
Last modified: | February 10, 2021 | |
This is version 130 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families