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UniProtKB - Q9BPW4 (APOL4_HUMAN)

Entry version 126 (17 Jun 2020)
Sequence version 3 (03 Apr 2007)
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Protein

Apolipoprotein L4

Gene

APOL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • lipid binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apolipoprotein L4
Alternative name(s):
Apolipoprotein L-IV
Short name:
ApoL-IV
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APOL4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000100336.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:14867 APOL4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607254 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BPW4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		80832

MalaCards human disease database

More...MalaCardsi		APOL4

Open Targets

More...OpenTargetsi		ENSG00000100336

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24907

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BPW4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		APOL4

Domain mapping of disease mutations (DMDM)

More...DMDMi		143811364

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000204122 – 351Apolipoprotein L4Add BLAST330

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BPW4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BPW4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BPW4

PeptideAtlas

More...PeptideAtlasi		Q9BPW4

PRoteomics IDEntifications database

More...PRIDEi		Q9BPW4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78577 [Q9BPW4-1]
78578 [Q9BPW4-2]
78579 [Q9BPW4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BPW4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BPW4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed; the highest levels are in spinal cord, placenta, adrenal gland; also detected in spleen, bone marrow, uterus, trachea, mammary gland and testis; levels are low in brain, heart and pancreas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100336 Expressed in parotid gland and 165 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BPW4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BPW4 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100336 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123325, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q9BPW4, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000338260

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BPW4 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the apolipoprotein L family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IWES Eukaryota
ENOG410Y0AF LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182782

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_046288_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BPW4

KEGG Orthology (KO)

More...KOi		K14480

Identification of Orthologs from Complete Genome Data

More...OMAi		EGLMEWW

Database of Orthologous Groups

More...OrthoDBi		1060131at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BPW4

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008405 ApoL

The PANTHER Classification System

More...PANTHERi		PTHR14096 PTHR14096, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05461 ApoL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BPW4-1) [UniParc]FASTAAdd to basket
Also known as: B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGAALLKIF VVCIWVQQNH PGWTVAGQFQ EKKRFTEEVI EYFQKKVSPV 
        60         70         80         90        100
HLKILLTSDE AWKRFVRVAE LPREEADALY EALKNLTPYV AIEDKDMQQK 
       110        120        130        140        150
EQQFREWFLK EFPQIRWKIQ ESIERLRVIA NEIEKVHRGC VIANVVSGST 
       160        170        180        190        200
GILSVIGVML APFTAGLSLS ITAAGVGLGI ASATAGIASS IVENTYTRSA 
       210        220        230        240        250
ELTASRLTAT STDQLEALRD ILRDITPNVL SFALDFDEAT KMIANDVHTL 
       260        270        280        290        300
RRSKATVGRP LIAWRYVPIN VVETLRTRGA PTRIVRKVAR NLGKATSGVL 
       310        320        330        340        350
VVLDVVNLVQ DSLDLHKGAK SESAESLRQW AQELEENLNE LTHIHQSLKA 

G
Length:351
Mass (Da):39,164
Last modified:April 3, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE8EC440BA0292412
GO
Isoform 2 (identifier: Q9BPW4-2) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MEGAALLKIFVVCIW → MGSWVQLITSVG

Show »
Length:348
Mass (Da):38,748
Checksum:i9C2F9E9912C6F175
GO
Isoform 3 (identifier: Q9BPW4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MEGAALLKIFVVCIW → MGSWVQLITSVG
     111-111: Missing.

Show »
Length:347
Mass (Da):38,619
Checksum:i7BEB91F9A47A5B39
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AHJ0B1AHJ0_HUMAN
Apolipoprotein L4
APOL4
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H1P9F5H1P9_HUMAN
Apolipoprotein L4
APOL4
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PS31E9PS31_HUMAN
Apolipoprotein L4
APOL4
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9BRG6Q9BRG6_HUMAN
APOL4 protein
APOL4 hCG_41448
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AHJ2B1AHJ2_HUMAN
Apolipoprotein L4
APOL4
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0530089I → V. Corresponds to variant dbSNP:rs132736Ensembl.1
Natural variantiVAR_05300912V → L. Corresponds to variant dbSNP:rs80587Ensembl.1
Natural variantiVAR_053010159M → V. Corresponds to variant dbSNP:rs132700Ensembl.1
Natural variantiVAR_059966223R → H. Corresponds to variant dbSNP:rs2227168Ensembl.1
Natural variantiVAR_059967319A → E. Corresponds to variant dbSNP:rs6000173Ensembl.1
Natural variantiVAR_059968326S → L. Corresponds to variant dbSNP:rs6000172Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0002951 – 15MEGAA…VVCIW → MGSWVQLITSVG in isoform 2 and isoform 3. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_024380111Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY014915 mRNA Translation: AAG50353.1
AY014913 AY014912 Genomic DNA Translation: AAG50350.1
AY014914 mRNA Translation: AAG50352.1
AY014913 AY014912 Genomic DNA Translation: AAG50351.1
AF305226 mRNA Translation: AAK20212.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS74851.1 [Q9BPW4-2]
CCDS74852.1 [Q9BPW4-1]

NCBI Reference Sequences

More...RefSeqi		NP_085146.2, NM_030643.4 [Q9BPW4-2]
NP_663693.1, NM_145660.2 [Q9BPW4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000332987; ENSP00000333229; ENSG00000100336 [Q9BPW4-2]
ENST00000352371; ENSP00000338260; ENSG00000100336 [Q9BPW4-1]
ENST00000616056; ENSP00000483497; ENSG00000100336 [Q9BPW4-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		80832

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:80832

UCSC genome browser

More...UCSCi		uc032qne.2 human [Q9BPW4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014915 mRNA Translation: AAG50353.1
AY014913 AY014912 Genomic DNA Translation: AAG50350.1
AY014914 mRNA Translation: AAG50352.1
AY014913 AY014912 Genomic DNA Translation: AAG50351.1
AF305226 mRNA Translation: AAK20212.1
CCDSiCCDS74851.1 [Q9BPW4-2]
CCDS74852.1 [Q9BPW4-1]
RefSeqiNP_085146.2, NM_030643.4 [Q9BPW4-2]
NP_663693.1, NM_145660.2 [Q9BPW4-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi123325, 1 interactor
IntActiQ9BPW4, 1 interactor
STRINGi9606.ENSP00000338260

PTM databases

iPTMnetiQ9BPW4
PhosphoSitePlusiQ9BPW4

Polymorphism and mutation databases

BioMutaiAPOL4
DMDMi143811364

Proteomic databases

jPOSTiQ9BPW4
MassIVEiQ9BPW4
PaxDbiQ9BPW4
PeptideAtlasiQ9BPW4
PRIDEiQ9BPW4
ProteomicsDBi78577 [Q9BPW4-1]
78578 [Q9BPW4-2]
78579 [Q9BPW4-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25529 200 antibodies

The DNASU plasmid repository

More...DNASUi		80832

Genome annotation databases

EnsembliENST00000332987; ENSP00000333229; ENSG00000100336 [Q9BPW4-2]
ENST00000352371; ENSP00000338260; ENSG00000100336 [Q9BPW4-1]
ENST00000616056; ENSP00000483497; ENSG00000100336 [Q9BPW4-2]
GeneIDi80832
KEGGihsa:80832
UCSCiuc032qne.2 human [Q9BPW4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80832
DisGeNETi80832
EuPathDBiHostDB:ENSG00000100336.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		APOL4
HGNCiHGNC:14867 APOL4
HPAiENSG00000100336 Low tissue specificity
MalaCardsiAPOL4
MIMi607254 gene
neXtProtiNX_Q9BPW4
OpenTargetsiENSG00000100336
PharmGKBiPA24907

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IWES Eukaryota
ENOG410Y0AF LUCA
GeneTreeiENSGT00950000182782
HOGENOMiCLU_046288_1_0_1
InParanoidiQ9BPW4
KOiK14480
OMAiEGLMEWW
OrthoDBi1060131at2759
PhylomeDBiQ9BPW4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		80832 0 hits in 67 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		APOL4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		80832
PharosiQ9BPW4 Tbio

Protein Ontology

More...PROi		PR:Q9BPW4
RNActiQ9BPW4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100336 Expressed in parotid gland and 165 other tissues
ExpressionAtlasiQ9BPW4 baseline and differential
GenevisibleiQ9BPW4 HS

Family and domain databases

InterProiView protein in InterPro
IPR008405 ApoL
PANTHERiPTHR14096 PTHR14096, 1 hit
PfamiView protein in Pfam
PF05461 ApoL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPOL4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BPW4
Secondary accession number(s): Q9BQ37, Q9BXQ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: April 3, 2007
Last modified: June 17, 2020
This is version 126 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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