UniProtKB - Q9BPV8 (P2Y13_HUMAN)
Protein
P2Y purinoceptor 13
Gene
P2RY13
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.1 Publication
Miscellaneous
Stimulation by ADP in stably transfected CHO cells resulted in inhibition of adenylyl cyclase and the phosphorylation of the MAP kinases MAPK3 and MAPK1 in a pertussis toxin-sensitive way. Inhibition of adenylyl cyclase and phosphorylation of the MAP kinases are transduction mechanisms that involve G(i) proteins.
GO - Molecular functioni
- G protein-coupled purinergic nucleotide receptor activity Source: GO_Central
GO - Biological processi
- cellular response to organic cyclic compound Source: Ensembl
- G protein-coupled receptor signaling pathway Source: GO_Central
- negative regulation of adenylate cyclase activity Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q9BPV8 |
Reactomei | R-HSA-417957, P2Y receptors R-HSA-418594, G alpha (i) signalling events |
SIGNORi | Q9BPV8 |
Names & Taxonomyi
Protein namesi | Recommended name: P2Y purinoceptor 13Short name: P2Y13 Alternative name(s): G-protein coupled receptor 86 G-protein coupled receptor 94 |
Gene namesi | Name:P2RY13 Synonyms:GPR86, GPR94 ORF Names:FKSG77 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4537, P2RY13 |
MIMi | 606380, gene |
neXtProti | NX_Q9BPV8 |
VEuPathDBi | HostDB:ENSG00000181631.6 |
Subcellular locationi
Plasma membrane
Endoplasmic reticulum
- endoplasmic reticulum Source: Ensembl
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 49 | ExtracellularSequence analysisAdd BLAST | 49 | |
Transmembranei | 50 – 70 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 71 – 77 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 78 – 98 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 99 – 117 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 118 – 138 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 139 – 161 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 162 – 182 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 183 – 211 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 212 – 232 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 233 – 252 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 253 – 273 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 274 – 300 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 301 – 321 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 322 – 333 | CytoplasmicSequence analysisAdd BLAST | 12 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 53829 |
OpenTargetsi | ENSG00000181631 |
Miscellaneous databases
Pharosi | Q9BPV8, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3321651 |
DrugBanki | DB01069, Promethazine |
DrugCentrali | Q9BPV8 |
GuidetoPHARMACOLOGYi | 329 |
Genetic variation databases
BioMutai | P2RY13 |
DMDMi | 322510112 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070040 | 1 – 354 | P2Y purinoceptor 13Add BLAST | 354 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 23 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 31 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 116 ↔ 194 | PROSITE-ProRule annotation | ||
Glycosylationi | 285 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q9BPV8 |
PaxDbi | Q9BPV8 |
PeptideAtlasi | Q9BPV8 |
PRIDEi | Q9BPV8 |
ProteomicsDBi | 78575 [Q9BPV8-1] 78576 [Q9BPV8-2] |
PTM databases
GlyGeni | Q9BPV8, 3 sites |
iPTMneti | Q9BPV8 |
PhosphoSitePlusi | Q9BPV8 |
Expressioni
Tissue specificityi
Strong expression in spleen and adult brain. Lower expression in placenta, lung, liver, spinal cord, thymus, small intestine, uterus, stomach, testis, fetal brain, and adrenal gland. Not detected in pancreas, heart, kidney, skeletal muscle, ovary or fetal aorta. Clearly detected in lymph node and bone marrow, weakly detected in peripheral blood mononuclear cells (PBMC) and in peripheral blood leukocytes (PBL), but not detected in polymorphonuclear cells (PMN). In the brain, detected in all brain regions examined.
Gene expression databases
Bgeei | ENSG00000181631, Expressed in blood and 159 other tissues |
Genevisiblei | Q9BPV8, HS |
Organism-specific databases
HPAi | ENSG00000181631, Group enriched (blood, lymphoid tissue) |
Interactioni
Binary interactionsi
Q9BPV8
With | #Exp. | IntAct |
---|---|---|
GJA8 [P48165] | 3 | EBI-17459480,EBI-17458373 |
Protein-protein interaction databases
BioGRIDi | 119802, 1 interactor |
IntActi | Q9BPV8, 1 interactor |
STRINGi | 9606.ENSP00000320376 |
Chemistry databases
BindingDBi | Q9BPV8 |
Miscellaneous databases
RNActi | Q9BPV8, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QUS2, Eukaryota |
GeneTreei | ENSGT01010000222511 |
HOGENOMi | CLU_009579_8_2_1 |
InParanoidi | Q9BPV8 |
OMAi | KIIRPFG |
OrthoDBi | 971778at2759 |
PhylomeDBi | Q9BPV8 |
TreeFami | TF330969 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR008109, P2Y13_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01735, P2Y13PRNCPTR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9BPV8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTAAIRRQRE LSILPKVTLE AMNTTVMQGF NRSERCPRDT RIVQLVFPAL
60 70 80 90 100
YTVVFLTGIL LNTLALWVFV HIPSSSTFII YLKNTLVADL IMTLMLPFKI
110 120 130 140 150
LSDSHLAPWQ LRAFVCRFSS VIFYETMYVG IVLLGLIAFD RFLKIIRPLR
160 170 180 190 200
NIFLKKPVFA KTVSIFIWFF LFFISLPNTI LSNKEATPSS VKKCASLKGP
210 220 230 240 250
LGLKWHQMVN NICQFIFWTV FILMLVFYVV IAKKVYDSYR KSKSKDRKNN
260 270 280 290 300
KKLEGKVFVV VAVFFVCFAP FHFARVPYTH SQTNNKTDCR LQNQLFIAKE
310 320 330 340 350
TTLFLAATNI CMDPLIYIFL CKKFTEKLPC MQGRKTTASS QENHSSQTDN
ITLG
Sequence cautioni
The sequence AAH29363 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH41116 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG36024 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028299 | 179 | T → M8 PublicationsCorresponds to variant dbSNP:rs1466684Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036226 | 1 – 21 | Missing in isoform 2. 3 PublicationsAdd BLAST | 21 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF411113 Genomic DNA Translation: AAL26484.1 AF406692 mRNA Translation: AAL01038.1 AF295368 mRNA Translation: AAK01864.1 AF345565 mRNA Translation: AAK29068.1 AB083597 Genomic DNA Translation: BAB89310.1 AK313208 mRNA Translation: BAG36024.1 Different initiation. AC024886 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78805.1 BC029363 mRNA Translation: AAH29363.1 Sequence problems. BC041116 mRNA Translation: AAH41116.2 Different initiation. BC066887 mRNA Translation: AAH66887.1 AF178982 mRNA Translation: AAK18752.1 |
CCDSi | CCDS3158.2 [Q9BPV8-1] |
RefSeqi | NP_795713.2, NM_176894.2 [Q9BPV8-1] |
Genome annotation databases
Ensembli | ENST00000325602; ENSP00000320376; ENSG00000181631 [Q9BPV8-1] |
GeneIDi | 53829 |
KEGGi | hsa:53829 |
UCSCi | uc003eyv.3, human [Q9BPV8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF411113 Genomic DNA Translation: AAL26484.1 AF406692 mRNA Translation: AAL01038.1 AF295368 mRNA Translation: AAK01864.1 AF345565 mRNA Translation: AAK29068.1 AB083597 Genomic DNA Translation: BAB89310.1 AK313208 mRNA Translation: BAG36024.1 Different initiation. AC024886 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78805.1 BC029363 mRNA Translation: AAH29363.1 Sequence problems. BC041116 mRNA Translation: AAH41116.2 Different initiation. BC066887 mRNA Translation: AAH66887.1 AF178982 mRNA Translation: AAK18752.1 |
CCDSi | CCDS3158.2 [Q9BPV8-1] |
RefSeqi | NP_795713.2, NM_176894.2 [Q9BPV8-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2B6U | model | - | A | 22-354 | [»] | |
SMRi | Q9BPV8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119802, 1 interactor |
IntActi | Q9BPV8, 1 interactor |
STRINGi | 9606.ENSP00000320376 |
Chemistry databases
BindingDBi | Q9BPV8 |
ChEMBLi | CHEMBL3321651 |
DrugBanki | DB01069, Promethazine |
DrugCentrali | Q9BPV8 |
GuidetoPHARMACOLOGYi | 329 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9BPV8, 3 sites |
iPTMneti | Q9BPV8 |
PhosphoSitePlusi | Q9BPV8 |
Genetic variation databases
BioMutai | P2RY13 |
DMDMi | 322510112 |
Proteomic databases
MassIVEi | Q9BPV8 |
PaxDbi | Q9BPV8 |
PeptideAtlasi | Q9BPV8 |
PRIDEi | Q9BPV8 |
ProteomicsDBi | 78575 [Q9BPV8-1] 78576 [Q9BPV8-2] |
Protocols and materials databases
Antibodypediai | 33610, 355 antibodies |
DNASUi | 53829 |
Genome annotation databases
Ensembli | ENST00000325602; ENSP00000320376; ENSG00000181631 [Q9BPV8-1] |
GeneIDi | 53829 |
KEGGi | hsa:53829 |
UCSCi | uc003eyv.3, human [Q9BPV8-1] |
Organism-specific databases
CTDi | 53829 |
DisGeNETi | 53829 |
GeneCardsi | P2RY13 |
HGNCi | HGNC:4537, P2RY13 |
HPAi | ENSG00000181631, Group enriched (blood, lymphoid tissue) |
MIMi | 606380, gene |
neXtProti | NX_Q9BPV8 |
OpenTargetsi | ENSG00000181631 |
VEuPathDBi | HostDB:ENSG00000181631.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUS2, Eukaryota |
GeneTreei | ENSGT01010000222511 |
HOGENOMi | CLU_009579_8_2_1 |
InParanoidi | Q9BPV8 |
OMAi | KIIRPFG |
OrthoDBi | 971778at2759 |
PhylomeDBi | Q9BPV8 |
TreeFami | TF330969 |
Enzyme and pathway databases
PathwayCommonsi | Q9BPV8 |
Reactomei | R-HSA-417957, P2Y receptors R-HSA-418594, G alpha (i) signalling events |
SIGNORi | Q9BPV8 |
Miscellaneous databases
BioGRID-ORCSi | 53829, 6 hits in 875 CRISPR screens |
GeneWikii | P2RY13 |
GenomeRNAii | 53829 |
Pharosi | Q9BPV8, Tchem |
PROi | PR:Q9BPV8 |
RNActi | Q9BPV8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000181631, Expressed in blood and 159 other tissues |
Genevisiblei | Q9BPV8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR008109, P2Y13_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01735, P2Y13PRNCPTR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | P2Y13_HUMAN | |
Accessioni | Q9BPV8Primary (citable) accession number: Q9BPV8 Secondary accession number(s): B2R827 Q9BY61 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | February 8, 2011 | |
Last modified: | February 10, 2021 | |
This is version 169 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants