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Protein

Conotoxin TsMMSK-011

Gene
N/A
Organism
Conus tessulatus (Tessellate cone)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionNeurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin TsMMSK-011
Alternative name(s):
Conotoxin TsMMSK-012
OrganismiConus tessulatus (Tessellate cone)
Taxonomic identifieri101317 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusTesselliconus

Organism-specific databases

ConoServeri627 Ts3.4 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000040491423 – 50By similarityAdd BLAST28
PeptideiPRO_000040491553 – 67Conotoxin TsMMSK-011Add BLAST15

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 65By similarity
Disulfide bondi54 ↔ 61By similarity
Disulfide bondi58 ↔ 64By similarity
Modified residuei634-hydroxyprolineBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The cysteine framework is III (CC-C-C-CC). Classified in the M-2 branch, since 2 residues stand between the fourth and the fifth cysteine residues.

Sequence similaritiesi

Belongs to the conotoxin M superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR004214 Conotoxin
PfamiView protein in Pfam
PF02950 Conotoxin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BPI4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSKLGVLLT ICLLLFPLTV LPMDGDQPAD LPALRTQDIA TDQSPWFDPV
60
KRCCSRYCWK CIPCCPY
Length:67
Mass (Da):7,593
Last modified:June 1, 2001 - v1
Checksum:i1A65FBD58E8DD811
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214940 mRNA Translation: AAG60368.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214940 mRNA Translation: AAG60368.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri627 Ts3.4 precursor

Family and domain databases

InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR004214 Conotoxin
PfamiView protein in Pfam
PF02950 Conotoxin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiM23C_CONTS
AccessioniPrimary (citable) accession number: Q9BPI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: June 1, 2001
Last modified: October 10, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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