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Entry version 141 (02 Jun 2021)
Sequence version 1 (01 Jun 2001)
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Protein

Homeobox protein cut-like ceh-44

Gene

ceh-44

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable DNA-binding regulatory protein involved in cell-fate specification.

By similarity

Miscellaneous

Asn-1149 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi591 – 681CUT 1PROSITE-ProRule annotationAdd BLAST91
DNA bindingi832 – 919CUT 2PROSITE-ProRule annotationAdd BLAST88
DNA bindingi978 – 1065CUT 3PROSITE-ProRule annotationAdd BLAST88
DNA bindingi1103 – 1162HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein cut-like ceh-44
Short name:
Homeobox protein 44
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ceh-44
ORF Names:Y54F10AM.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
Y54F10AM.4a ; CE27288 ; WBGene00000464 ; ceh-44

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002023911 – 1273Homeobox protein cut-like ceh-44Add BLAST1273

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BL02

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BL02

PeptideAtlas

More...
PeptideAtlasi
Q9BL02

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000464, Expressed in multi-cellular organism and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BL02, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
40620, 3 interactors

STRING: functional protein association networks

More...
STRINGi
6239.Y54F10AM.4a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BL02

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1069 – 1100DisorderedSequence analysisAdd BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili101 – 407Sequence analysisAdd BLAST307
Coiled coili440 – 468Sequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1081 – 1100Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CUT homeobox family.Curated

Keywords - Domaini

Coiled coil, Homeobox, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0963, Eukaryota
KOG2252, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000172657

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003980_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BL02

Database of Orthologous Groups

More...
OrthoDBi
181575at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BL02

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.260.40, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003350, CUT_dom
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR010982, Lambda_DNA-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02376, CUT, 3 hits
PF00046, Homeodomain, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01109, CUT, 3 hits
SM00389, HOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit
SSF47413, SSF47413, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51042, CUT, 3 hits
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: Q9BL02-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIVSRAWES VDWDRIQTRV EAEVTALGQR QDDSEIRKTR LVEESNAYRG
60 70 80 90 100
RTNKDSRKVA IPLIKAFQSE FDGLLARSTA AENALIDICK SIVSLPDPKS
110 120 130 140 150
LLKGAEAWKN DAEKTQKAVE EREELKRQLI KVNNELEDLR GKDVKVRKLK
160 170 180 190 200
DKLAKLESEQ DIFIENAVNE VEKKAEQELN DRLTELIAEK EKMKEQNEIL
210 220 230 240 250
EKNMDSLESK NKDIQRKLEI AKQTVEQKDG LENEQLSIAM KDLADAKHKI
260 270 280 290 300
VFLEERVSQL ENEAEKVNES KKAGNIEDIA ALGSVLVQKD DVIQQLTNDI
310 320 330 340 350
KRHEASHVEE LAKWKLAVSA VEKKNKTLIG ELNELKNQLE SRNDYEAIKN
360 370 380 390 400
ELRLLREIEF GDSAEANAES IERLGETVET LDRLLAEKNR RLQNENASLR
410 420 430 440 450
VANDGFKGDE VMKAIVSGSH SRVVETVGKR VGAEEANSYR QKNTDSELIE
460 470 480 490 500
KIQEAKRNKA VCELKFEDPT INVLTYLKNQ KAKEAGKRDA PTPILAAPVT
510 520 530 540 550
PKHVTKLGTH TITTTALPPR TQTAETTQSI LQRLSNGSNK HLLNEDLKLS
560 570 580 590 600
TVLNLKRFSG NPAKPLEAKT SEEQKAELET IEKMQKRIQV NVQALNGHPL
610 620 630 640 650
NTTEIASHCK RLMIAYNIGQ RLFAKHVMNQ VVKSQGSLSE LLSKPRHWNK
660 670 680 690 700
LTDKGREAFR RIYGWISDDE AINLLCSLSP RRVWPADQNI EHPKAETLLD
710 720 730 740 750
TSDPMEFKEE PVIRYDVTPK VEPVIEKIKS PVESPCSSQA GASSLRASRW
760 770 780 790 800
RHDDISKEKI LSILQTELKK IEEETTESKV VVPVKPTATG GNRRFSSNST
810 820 830 840 850
YESSSLTGKS RPSTVELILK QRISTGLQPL TQAQYDAYTV LDTDFLVKQI
860 870 880 890 900
KEFLTMNSIS QRQFGEYILG LSQGSVSDLL ARPKTWAQLT QKGREPFIRM
910 920 930 940 950
QLFMDDVEAS EENDEKQPKI TICDEDSDLA KTLATLLNAV HREPSEPKTS
960 970 980 990 1000
VKLEPLSEID VIMQVPSASK PSSVVKSIDE SSGEEILDTF EIVYQVKGIL
1010 1020 1030 1040 1050
EENGISPRVF GDEYLHCTSS MCADLMIRTK SFENSKASEK LMYTRMKTFL
1060 1070 1080 1090 1100
SDPIAIPLLV EKEESKETVK AKIESVPAPR EAPRPVKRKH SSDTDDYDLN
1110 1120 1130 1140 1150
TKKPIQRTVI TDYQKDTLRF VFVNEQHPSN ELCEQISLKL DMSLRTVQNW
1160 1170 1180 1190 1200
FHNHRTRSKA REKEGKVYSD ALPNGTAVKS LTWKDDLQKM LDEAPAITSQ
1210 1220 1230 1240 1250
WAPDYQNRAG SVKSSTSADS PTNNNYSSPI FSFDKASTTS TVKKPSSTGK
1260 1270
LDNLVARMIR LAEGREAAAA KAS
Length:1,273
Mass (Da):143,526
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAB4F43B8C12B258D
GO
Isoform b (identifier: Q8IA98-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q8IA98.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:621
Mass (Da):70,952
GO
Isoform c (identifier: Q8IA98-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q8IA98.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:619
Mass (Da):70,663
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO081806 Genomic DNA Translation: CCD73822.1

NCBI Reference Sequences

More...
RefSeqi
NP_497576.1, NM_065175.5 [Q9BL02-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y54F10AM.4a.1; Y54F10AM.4a.1; WBGene00000464 [Q9BL02-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175372

UCSC genome browser

More...
UCSCi
Y54F10AM.4c, c. elegans [Q9BL02-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081806 Genomic DNA Translation: CCD73822.1
RefSeqiNP_497576.1, NM_065175.5 [Q9BL02-1]

3D structure databases

SMRiQ9BL02
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi40620, 3 interactors
STRINGi6239.Y54F10AM.4a

Proteomic databases

EPDiQ9BL02
PaxDbiQ9BL02
PeptideAtlasiQ9BL02

Genome annotation databases

EnsemblMetazoaiY54F10AM.4a.1; Y54F10AM.4a.1; WBGene00000464 [Q9BL02-1]
GeneIDi175372
UCSCiY54F10AM.4c, c. elegans [Q9BL02-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175372
WormBaseiY54F10AM.4a ; CE27288 ; WBGene00000464 ; ceh-44

Phylogenomic databases

eggNOGiKOG0963, Eukaryota
KOG2252, Eukaryota
GeneTreeiENSGT00940000172657
HOGENOMiCLU_003980_0_0_1
InParanoidiQ9BL02
OrthoDBi181575at2759
PhylomeDBiQ9BL02

Gene expression databases

BgeeiWBGene00000464, Expressed in multi-cellular organism and 5 other tissues
ExpressionAtlasiQ9BL02, baseline and differential

Family and domain databases

CDDicd00086, homeodomain, 1 hit
Gene3Di1.10.260.40, 3 hits
InterProiView protein in InterPro
IPR003350, CUT_dom
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR010982, Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF02376, CUT, 3 hits
PF00046, Homeodomain, 1 hit
SMARTiView protein in SMART
SM01109, CUT, 3 hits
SM00389, HOX, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
SSF47413, SSF47413, 3 hits
PROSITEiView protein in PROSITE
PS51042, CUT, 3 hits
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCUT_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BL02
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2001
Last modified: June 2, 2021
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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