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Entry version 141 (08 May 2019)
Sequence version 1 (01 Jun 2001)
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Protein
Submitted name:

Calmodulin-domain protein kinase 1

Gene

CDPK1

Organism
Toxoplasma gondii
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei80ATP analogCombined sources1
Binding sitei112ATP analogCombined sources1
Binding sitei195ATP analogCombined sources1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi368Calcium 1Combined sources1
Metal bindingi370Calcium 1Combined sources1
Metal bindingi372Calcium 1Combined sources1
Metal bindingi374Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi379Calcium 1Combined sources1
Metal bindingi415Calcium 2Combined sources1
Metal bindingi415Calcium 3Combined sources1
Metal bindingi415Calcium 4Combined sources1
Metal bindingi417Calcium 2Combined sources1
Metal bindingi417Calcium 3Combined sources1
Metal bindingi419Calcium 2Combined sources1
Metal bindingi419Calcium 3Combined sources1
Metal bindingi419Calcium 4Combined sources1
Metal bindingi421Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi421Calcium 3; via carbonyl oxygenCombined sources1
Metal bindingi421Calcium 4; via carbonyl oxygenCombined sources1
Metal bindingi423Calcium 2Combined sources1
Metal bindingi423Calcium 4Combined sources1
Metal bindingi426Calcium 3Combined sources1
Metal bindingi426Calcium 4Combined sources1
Metal bindingi451Calcium 5Combined sources1
Metal bindingi451Calcium 6Combined sources1
Metal bindingi453Calcium 5Combined sources1
Metal bindingi453Calcium 6Combined sources1
Metal bindingi455Calcium 5Combined sources1
Metal bindingi455Calcium 6Combined sources1
Metal bindingi457Calcium 5; via carbonyl oxygenCombined sources1
Metal bindingi457Calcium 6; via carbonyl oxygenCombined sources1
Metal bindingi462Calcium 5Combined sources1
Metal bindingi462Calcium 6Combined sources1
Metal bindingi485Calcium 7Combined sources1
Metal bindingi487Calcium 7Combined sources1
Metal bindingi489Calcium 7Combined sources1
Metal bindingi491Calcium 7; via carbonyl oxygenCombined sources1
Metal bindingi496Calcium 7Combined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi59 – 63ATP analogCombined sources5
Nucleotide bindingi129 – 131ATP analogCombined sources3
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi368 – 379PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi415 – 426PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi451 – 462PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi485 – 496PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseImported, Transferase
LigandCalciumPROSITE-ProRule annotationCombined sources, Metal-bindingCombined sources, Nucleotide-bindingCombined sources

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Calmodulin-domain protein kinase 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDPK1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiToxoplasma gondiiImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5811 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1781862

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi247 ↔ 505Combined sources
Disulfide bondi247InterchainCombined sources

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HX4X-ray1.95A1-507[»]
3I79X-ray2.04A30-507[»]
3I7BX-ray1.99A30-507[»]
3I7CX-ray1.98A30-507[»]
3KU2X-ray2.30A1-507[»]
3MA6X-ray2.50A/B36-315[»]
3N51X-ray2.10A30-507[»]
3NYVX-ray1.88A30-507[»]
3SX9X-ray2.65A30-507[»]
3SXFX-ray2.04A30-507[»]
3T3UX-ray2.10A30-507[»]
3T3VX-ray2.04A30-507[»]
3UPXX-ray2.27A30-507[»]
3UPZX-ray2.20A30-507[»]
3V51X-ray1.95A30-507[»]
3V5PX-ray2.10A30-507[»]
3V5TX-ray2.13A30-507[»]
4IEBX-ray2.05A1-507[»]
4IFGX-ray2.11A1-507[»]
4IH8X-ray2.88A1-507[»]
4IHPX-ray2.27A1-507[»]
4JBVX-ray1.95A27-507[»]
4M84X-ray2.00A30-507[»]
4ONAX-ray2.40A30-507[»]
4TZRX-ray2.00A30-507[»]
4WG3X-ray2.20A30-507[»]
4WG4X-ray2.30A30-507[»]
4WG5X-ray2.30A30-507[»]
4YGAX-ray2.94A/C/E/G1-507[»]
4YJNX-ray2.60A30-507[»]
5DVRX-ray2.40A1-507[»]
5JMSX-ray2.30A1-507[»]
5JN2X-ray2.20A1-507[»]
5T6AX-ray2.05A1-507[»]
5T6IX-ray2.05A1-507[»]
5T6KX-ray2.40A1-507[»]
5W80X-ray2.00A30-507[»]
5W8RX-ray2.20A30-507[»]
5W91X-ray2.40A30-507[»]
5W9EX-ray2.44A30-507[»]
5W9RX-ray2.70A30-507[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BJF5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9BJF5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 308Protein kinaseInterPro annotationAdd BLAST258
Domaini355 – 390EF-handInterPro annotationAdd BLAST36
Domaini402 – 437EF-handInterPro annotationAdd BLAST36
Domaini438 – 467EF-handInterPro annotationAdd BLAST30
Domaini472 – 507EF-handInterPro annotationAdd BLAST36

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0032 Eukaryota
ENOG41124N9 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BJF5

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051 EFh, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13499 EF-hand_7, 2 hits
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054 EFh, 4 hits
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9BJF5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQQESTLGG AAGEPRSRGH AAGTSGGPGD HLHATPGMFV QHSTAIFSDR
60 70 80 90 100
YKGQRVLGKG SFGEVILCKD KITGQECAVK VISKRQVKQK TDKESLLREV
110 120 130 140 150
QLLKQLDHPN IMKLYEFFED KGYFYLVGEV YTGGELFDEI ISRKRFSEVD
160 170 180 190 200
AARIIRQVLS GITYMHKNKI VHRDLKPENL LLESKSKDAN IRIIDFGLST
210 220 230 240 250
HFEASKKMKD KIGTAYYIAP EVLHGTYDEK CDVWSTGVIL YILLSGCPPF
260 270 280 290 300
NGANEYDILK KVEKGKYTFE LPQWKKVSES AKDLIRKMLT YVPSMRISAR
310 320 330 340 350
DALDHEWIQT YTKEQISVDV PSLDNAILNI RQFQGTQKLA QAALLYMGSK
360 370 380 390 400
LTSQDETKEL TAIFHKMDKN GDGQLDRAEL IEGYKELMRM KGQDASMLDA
410 420 430 440 450
SAVEHEVDQV LDAVDFDKNG YIEYSEFVTV AMDRKTLLSR ERLERAFRMF
460 470 480 490 500
DSDNSGKISS TELATIFGVS DVDSETWKSV LSEVDKNNDG EVDFDEFQQM

LLKLCGN
Length:507
Mass (Da):57,253
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87008C2075A9CBA2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF333958 mRNA Translation: AAG53993.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333958 mRNA Translation: AAG53993.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HX4X-ray1.95A1-507[»]
3I79X-ray2.04A30-507[»]
3I7BX-ray1.99A30-507[»]
3I7CX-ray1.98A30-507[»]
3KU2X-ray2.30A1-507[»]
3MA6X-ray2.50A/B36-315[»]
3N51X-ray2.10A30-507[»]
3NYVX-ray1.88A30-507[»]
3SX9X-ray2.65A30-507[»]
3SXFX-ray2.04A30-507[»]
3T3UX-ray2.10A30-507[»]
3T3VX-ray2.04A30-507[»]
3UPXX-ray2.27A30-507[»]
3UPZX-ray2.20A30-507[»]
3V51X-ray1.95A30-507[»]
3V5PX-ray2.10A30-507[»]
3V5TX-ray2.13A30-507[»]
4IEBX-ray2.05A1-507[»]
4IFGX-ray2.11A1-507[»]
4IH8X-ray2.88A1-507[»]
4IHPX-ray2.27A1-507[»]
4JBVX-ray1.95A27-507[»]
4M84X-ray2.00A30-507[»]
4ONAX-ray2.40A30-507[»]
4TZRX-ray2.00A30-507[»]
4WG3X-ray2.20A30-507[»]
4WG4X-ray2.30A30-507[»]
4WG5X-ray2.30A30-507[»]
4YGAX-ray2.94A/C/E/G1-507[»]
4YJNX-ray2.60A30-507[»]
5DVRX-ray2.40A1-507[»]
5JMSX-ray2.30A1-507[»]
5JN2X-ray2.20A1-507[»]
5T6AX-ray2.05A1-507[»]
5T6IX-ray2.05A1-507[»]
5T6KX-ray2.40A1-507[»]
5W80X-ray2.00A30-507[»]
5W8RX-ray2.20A30-507[»]
5W91X-ray2.40A30-507[»]
5W9EX-ray2.44A30-507[»]
5W9RX-ray2.70A30-507[»]
SMRiQ9BJF5
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL1781862

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG41124N9 LUCA
InParanoidiQ9BJF5

Miscellaneous databases

EvolutionaryTraceiQ9BJF5

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9BJF5_TOXGO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BJF5
Secondary accession number(s): B9Q301, B9QPZ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 8, 2019
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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