Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Major heat shock 70 kDa protein Bb

Gene

Hsp70Bb

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

Most strains have three copies of the gene coding for this protein at chromosome locus 87C1; two tandemly repeated Hsp70 genes (Hsp70Bb and Hsp70Bc) and one in reverse orientation (Hsp70Ba). Some strains, including that sequenced in the Drosophila genome project have three tandemly repeated Hsp70 genes (Hsp70Bb, Hsp70Bbb and Hsp70Bc).

GO - Molecular functioni

GO - Biological processi

  • heat shock-mediated polytene chromosome puffing Source: FlyBase
  • response to heat Source: FlyBase
  • response to hypoxia Source: FlyBase
  • response to unfolded protein Source: UniProtKB

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Major heat shock 70 kDa protein Bb
Short name:
Heat shock protein 70Bb
Alternative name(s):
HSP70-87C1
Gene namesi
Name:Hsp70Bb
ORF Names:CG31359
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0013278 Hsp70Bb

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000783331 – 641Major heat shock 70 kDa protein BbAdd BLAST641

Proteomic databases

PRIDEiQ9BIS2

Expressioni

Inductioni

Heat shock induces the synthesis of seven proteins at five otherwise inactive sites in the polytene chromosomes of fruit fly larvae. Two separate sites, producing two and three copies, respectively, code for the 70 kDa protein.

Gene expression databases

BgeeiFBgn0013278 Expressed in 3 organ(s), highest expression level in larva
ExpressionAtlasiQ9BIS2 baseline and differential
GenevisibleiQ9BIS2 DM

Interactioni

Protein-protein interaction databases

BioGridi71512, 43 interactors
71513, 43 interactors
IntActiQ9BIS2, 18 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9BIS2
SMRiQ9BIS2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00920000149060
InParanoidiQ9BIS2
KOiK03283
OrthoDBiEOG091G03SF
PhylomeDBiQ9BIS2

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q9BIS2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAIGIDLGT TYSCVGVYQH GKVEIIANDQ GNRTTPSYVA FTDSERLIGD
60 70 80 90 100
PAKNQVAMNP RNTVFDAKRL IGRKYDDPKI AEDMKHWPFK VVSDGGKPKI
110 120 130 140 150
GVEYKGESKR FAPEEISSMV LTKMKETAEA YLGESITDAV ITVPAYFNDS
160 170 180 190 200
QRQATKDAGH IAGLNVLRII NEPTAAALAY GLDKNLKGER NVLIFDLGGG
210 220 230 240 250
TFDVSILTID EGSLFEVRST AGDTHLGGED FDNRLVTHLA EEFKRKYKKD
260 270 280 290 300
LRSNPRALRR LRTAAERAKR TLSSSTEATI EIDALFEGQD FYTKVSRARF
310 320 330 340 350
EELCADLFRN TLQPVEKALN DAKMDKGQIH DIVLVGGSTR IPKVQSLLQE
360 370 380 390 400
FFHGKNLNLS INPDEAVAYG AAVQAAILSG DQSGKIQDVL LVDVAPLSLG
410 420 430 440 450
IETAGGVMTK LIERNCRIPC KQTKTFSTYS DNQPGVSIQV YEGERAMTKD
460 470 480 490 500
NNALGTFDLS GIPPAPRGVP QIEVTFDLDA NGILNVSAKE MSTGKAKNIT
510 520 530 540 550
IKNDKGRLSQ AEIDRMVNEA EKYADEDEKH RQRITSRNAL ESYVFNVKQS
560 570 580 590 600
VEQAPAGKLD EADKNSVLDK CNETIRWLDS NTTAEKEEFD HKMEELTRHC
610 620 630 640
SPIMTKMHQQ GAGAAGGPGA NCGQQAGGFG GYSGPTVEEV D
Length:641
Mass (Da):70,195
Last modified:April 13, 2004 - v2
Checksum:iF2C9C204F67EBB59
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8INI8HSP72_DROME
Major heat shock 70 kDa protein Ba
Hsp70Ba CG31449
641Annotation score:
Q9BIR7HSP75_DROME
Major heat shock 70 kDa protein Bc
Hsp70Bc CG6489
641Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26 – 28IAN → NAY in AAD15226 (PubMed:6777045).Curated3
Sequence conflicti48 – 50IGD → NGE in AAD15226 (PubMed:6777045).Curated3
Sequence conflicti306D → N in AAD15226 (PubMed:6777045).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti43D → E in strain: 3CPA86. 1
Natural varianti60P → S in strain: FrV3-1. 1
Natural varianti67A → P in Z(S)29. 1
Natural varianti71I → T in Z(S)2. 1
Natural varianti187K → N in strain: IS2, IS3, IS4, IS5, IS25 and QD18. 1
Natural varianti195F → L in strain: ZZ30. 1
Natural varianti241E → D in strain: Z(H)1. 1
Natural varianti350E → D in strain: Z(H)1. 1
Natural varianti430S → A in strain: Z(H)1. 1
Natural varianti437S → P in strain: IS4 and IS5. 1
Natural varianti516M → I in strain: B28. 1
Natural varianti524A → V in strain: B28. 1
Natural varianti544V → I in strain: Z(S)24 and Z(S)49. 1
Natural varianti606K → T in strain: 3CPA126. 1
Natural varianti607M → V in strain: Z(S)30A. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01104 Genomic DNA Translation: AAD15226.1
AF295951 Genomic DNA Translation: AAG26905.1
AF295952 Genomic DNA Translation: AAG26906.1
AF295953 Genomic DNA Translation: AAG26907.1
AF295954 Genomic DNA Translation: AAG26908.1
AF295955 Genomic DNA Translation: AAG26909.1
AF295956 Genomic DNA Translation: AAG26910.1
AF295957 Genomic DNA Translation: AAG26911.1
AF350476 Genomic DNA Translation: AAK30233.1
AF350477 Genomic DNA Translation: AAK30234.1
AF350478 Genomic DNA Translation: AAK30235.1
AF350479 Genomic DNA Translation: AAK30236.1
AF350480 Genomic DNA Translation: AAK30237.1
AF350481 Genomic DNA Translation: AAK30238.1
AF350482 Genomic DNA Translation: AAK30239.1
AF350483 Genomic DNA Translation: AAK30240.1
AE014297 Genomic DNA Translation: AAN13546.1
BT011058 mRNA Translation: AAR31129.1
BT011379 mRNA Translation: AAR96171.1
BT031349 mRNA Translation: ABY76186.1
AY846848 Genomic DNA Translation: AAW34339.1
AY846849 Genomic DNA Translation: AAW34340.1
AY846850 Genomic DNA Translation: AAW34341.1
AY846851 Genomic DNA Translation: AAW34342.1
AY846852 Genomic DNA Translation: AAW34343.1
AY846853 Genomic DNA Translation: AAW34344.1
AY846854 Genomic DNA Translation: AAW34345.1
AY846855 Genomic DNA Translation: AAW34346.1
AY846856 Genomic DNA Translation: AAW34347.1
AY846857 Genomic DNA Translation: AAW34348.1
AY846858 Genomic DNA Translation: AAW34349.1
AY846859 Genomic DNA Translation: AAW34350.1
AY846860 Genomic DNA Translation: AAW34351.1
AY846861 Genomic DNA Translation: AAW34352.1
AY846862 Genomic DNA Translation: AAW34353.1
AY846863 Genomic DNA Translation: AAW34354.1
AY846864 Genomic DNA Translation: AAW34355.1
AY846865 Genomic DNA Translation: AAW34356.1
AY370940 Genomic DNA Translation: AAQ75092.1
RefSeqiNP_524927.2, NM_080188.3
NP_650209.1, NM_141952.2
UniGeneiDm.18947
Dm.33336

Genome annotation databases

EnsemblMetazoaiFBtr0082637; FBpp0082106; FBgn0013278
FBtr0082638; FBpp0082107; FBgn0013279
GeneIDi48582
48583
KEGGidme:Dmel_CG31359
dme:Dmel_CG6489

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHSP73_DROME
AccessioniPrimary (citable) accession number: Q9BIS2
Secondary accession number(s): B0BNN7
, P02824, Q53XF0, Q5I7H2, Q5I7H4, Q5I7H6, Q5I7H8, Q5I7I3, Q5I7I6, Q5I7I8, Q9BIS1, Q9I7J6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 13, 2004
Last modified: September 12, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again