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Entry version 141 (17 Jun 2020)
Sequence version 2 (13 Apr 2004)
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Protein

Major heat shock 70 kDa protein Bb

Gene

Hsp70Bb

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Most strains have three copies of the gene coding for this protein at chromosome locus 87C1; two tandemly repeated Hsp70 genes (Hsp70Bb and Hsp70Bc) and one in reverse orientation (Hsp70Ba). Some strains, including that sequenced in the Drosophila genome project have three tandemly repeated Hsp70 genes (Hsp70Bb, Hsp70Bbb and Hsp70Bc).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-3371453 Regulation of HSF1-mediated heat shock response
R-DME-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-DME-3371571 HSF1-dependent transactivation
R-DME-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DME-6798695 Neutrophil degranulation
R-DME-72163 mRNA Splicing - Major Pathway
R-DME-8856828 Clathrin-mediated endocytosis
R-DME-888590 GABA synthesis, release, reuptake and degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Major heat shock 70 kDa protein Bb
Short name:
Heat shock protein 70Bb
Alternative name(s):
HSP70-87C1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hsp70Bb
ORF Names:CG31359
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0013278 Hsp70Bb

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000783331 – 641Major heat shock 70 kDa protein BbAdd BLAST641

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9BIS2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Heat shock induces the synthesis of seven proteins at five otherwise inactive sites in the polytene chromosomes of fruit fly larvae. Two separate sites, producing two and three copies, respectively, code for the 70 kDa protein.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0013278 Expressed in larva and 2 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BIS2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BIS2 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
71512, 47 interactors
71513, 47 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BIS2, 18 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BIS2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0101 Eukaryota
COG0443 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154813

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005965_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BIS2

KEGG Orthology (KO)

More...
KOi
K03283

Identification of Orthologs from Complete Genome Data

More...
OMAi
PCQSVNP

Database of Orthologous Groups

More...
OrthoDBi
288077at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BIS2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.10, 1 hit
2.60.34.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043129 ATPase_NBD
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam

The PANTHER Classification System

More...
PANTHERi
PTHR19375 PTHR19375, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00012 HSP70, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
SSF53067 SSF53067, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9BIS2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAIGIDLGT TYSCVGVYQH GKVEIIANDQ GNRTTPSYVA FTDSERLIGD
60 70 80 90 100
PAKNQVAMNP RNTVFDAKRL IGRKYDDPKI AEDMKHWPFK VVSDGGKPKI
110 120 130 140 150
GVEYKGESKR FAPEEISSMV LTKMKETAEA YLGESITDAV ITVPAYFNDS
160 170 180 190 200
QRQATKDAGH IAGLNVLRII NEPTAAALAY GLDKNLKGER NVLIFDLGGG
210 220 230 240 250
TFDVSILTID EGSLFEVRST AGDTHLGGED FDNRLVTHLA EEFKRKYKKD
260 270 280 290 300
LRSNPRALRR LRTAAERAKR TLSSSTEATI EIDALFEGQD FYTKVSRARF
310 320 330 340 350
EELCADLFRN TLQPVEKALN DAKMDKGQIH DIVLVGGSTR IPKVQSLLQE
360 370 380 390 400
FFHGKNLNLS INPDEAVAYG AAVQAAILSG DQSGKIQDVL LVDVAPLSLG
410 420 430 440 450
IETAGGVMTK LIERNCRIPC KQTKTFSTYS DNQPGVSIQV YEGERAMTKD
460 470 480 490 500
NNALGTFDLS GIPPAPRGVP QIEVTFDLDA NGILNVSAKE MSTGKAKNIT
510 520 530 540 550
IKNDKGRLSQ AEIDRMVNEA EKYADEDEKH RQRITSRNAL ESYVFNVKQS
560 570 580 590 600
VEQAPAGKLD EADKNSVLDK CNETIRWLDS NTTAEKEEFD HKMEELTRHC
610 620 630 640
SPIMTKMHQQ GAGAAGGPGA NCGQQAGGFG GYSGPTVEEV D
Length:641
Mass (Da):70,195
Last modified:April 13, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2C9C204F67EBB59
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti26 – 28IAN → NAY in AAD15226 (PubMed:6777045).Curated3
Sequence conflicti48 – 50IGD → NGE in AAD15226 (PubMed:6777045).Curated3
Sequence conflicti306D → N in AAD15226 (PubMed:6777045).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti43D → E in strain: 3CPA86. 1
Natural varianti60P → S in strain: FrV3-1. 1
Natural varianti67A → P in Z(S)29. 1
Natural varianti71I → T in Z(S)2. 1
Natural varianti187K → N in strain: IS2, IS3, IS4, IS5, IS25 and QD18. 1
Natural varianti195F → L in strain: ZZ30. 1
Natural varianti241E → D in strain: Z(H)1. 1
Natural varianti350E → D in strain: Z(H)1. 1
Natural varianti430S → A in strain: Z(H)1. 1
Natural varianti437S → P in strain: IS4 and IS5. 1
Natural varianti516M → I in strain: B28. 1
Natural varianti524A → V in strain: B28. 1
Natural varianti544V → I in strain: Z(S)24 and Z(S)49. 1
Natural varianti606K → T in strain: 3CPA126. 1
Natural varianti607M → V in strain: Z(S)30A. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J01104 Genomic DNA Translation: AAD15226.1
AF295951 Genomic DNA Translation: AAG26905.1
AF295952 Genomic DNA Translation: AAG26906.1
AF295953 Genomic DNA Translation: AAG26907.1
AF295954 Genomic DNA Translation: AAG26908.1
AF295955 Genomic DNA Translation: AAG26909.1
AF295956 Genomic DNA Translation: AAG26910.1
AF295957 Genomic DNA Translation: AAG26911.1
AF350476 Genomic DNA Translation: AAK30233.1
AF350477 Genomic DNA Translation: AAK30234.1
AF350478 Genomic DNA Translation: AAK30235.1
AF350479 Genomic DNA Translation: AAK30236.1
AF350480 Genomic DNA Translation: AAK30237.1
AF350481 Genomic DNA Translation: AAK30238.1
AF350482 Genomic DNA Translation: AAK30239.1
AF350483 Genomic DNA Translation: AAK30240.1
AE014297 Genomic DNA Translation: AAN13546.1
BT011058 mRNA Translation: AAR31129.1
BT011379 mRNA Translation: AAR96171.1
BT031349 mRNA Translation: ABY76186.1
AY846848 Genomic DNA Translation: AAW34339.1
AY846849 Genomic DNA Translation: AAW34340.1
AY846850 Genomic DNA Translation: AAW34341.1
AY846851 Genomic DNA Translation: AAW34342.1
AY846852 Genomic DNA Translation: AAW34343.1
AY846853 Genomic DNA Translation: AAW34344.1
AY846854 Genomic DNA Translation: AAW34345.1
AY846855 Genomic DNA Translation: AAW34346.1
AY846856 Genomic DNA Translation: AAW34347.1
AY846857 Genomic DNA Translation: AAW34348.1
AY846858 Genomic DNA Translation: AAW34349.1
AY846859 Genomic DNA Translation: AAW34350.1
AY846860 Genomic DNA Translation: AAW34351.1
AY846861 Genomic DNA Translation: AAW34352.1
AY846862 Genomic DNA Translation: AAW34353.1
AY846863 Genomic DNA Translation: AAW34354.1
AY846864 Genomic DNA Translation: AAW34355.1
AY846865 Genomic DNA Translation: AAW34356.1
AY370940 Genomic DNA Translation: AAQ75092.1

NCBI Reference Sequences

More...
RefSeqi
NP_524927.2, NM_080188.3
NP_650209.1, NM_141952.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0082637; FBpp0082106; FBgn0013278
FBtr0082638; FBpp0082107; FBgn0013279

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
48582
48583

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG31359
dme:Dmel_CG6489

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01104 Genomic DNA Translation: AAD15226.1
AF295951 Genomic DNA Translation: AAG26905.1
AF295952 Genomic DNA Translation: AAG26906.1
AF295953 Genomic DNA Translation: AAG26907.1
AF295954 Genomic DNA Translation: AAG26908.1
AF295955 Genomic DNA Translation: AAG26909.1
AF295956 Genomic DNA Translation: AAG26910.1
AF295957 Genomic DNA Translation: AAG26911.1
AF350476 Genomic DNA Translation: AAK30233.1
AF350477 Genomic DNA Translation: AAK30234.1
AF350478 Genomic DNA Translation: AAK30235.1
AF350479 Genomic DNA Translation: AAK30236.1
AF350480 Genomic DNA Translation: AAK30237.1
AF350481 Genomic DNA Translation: AAK30238.1
AF350482 Genomic DNA Translation: AAK30239.1
AF350483 Genomic DNA Translation: AAK30240.1
AE014297 Genomic DNA Translation: AAN13546.1
BT011058 mRNA Translation: AAR31129.1
BT011379 mRNA Translation: AAR96171.1
BT031349 mRNA Translation: ABY76186.1
AY846848 Genomic DNA Translation: AAW34339.1
AY846849 Genomic DNA Translation: AAW34340.1
AY846850 Genomic DNA Translation: AAW34341.1
AY846851 Genomic DNA Translation: AAW34342.1
AY846852 Genomic DNA Translation: AAW34343.1
AY846853 Genomic DNA Translation: AAW34344.1
AY846854 Genomic DNA Translation: AAW34345.1
AY846855 Genomic DNA Translation: AAW34346.1
AY846856 Genomic DNA Translation: AAW34347.1
AY846857 Genomic DNA Translation: AAW34348.1
AY846858 Genomic DNA Translation: AAW34349.1
AY846859 Genomic DNA Translation: AAW34350.1
AY846860 Genomic DNA Translation: AAW34351.1
AY846861 Genomic DNA Translation: AAW34352.1
AY846862 Genomic DNA Translation: AAW34353.1
AY846863 Genomic DNA Translation: AAW34354.1
AY846864 Genomic DNA Translation: AAW34355.1
AY846865 Genomic DNA Translation: AAW34356.1
AY370940 Genomic DNA Translation: AAQ75092.1
RefSeqiNP_524927.2, NM_080188.3
NP_650209.1, NM_141952.2

3D structure databases

SMRiQ9BIS2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi71512, 47 interactors
71513, 47 interactors
IntActiQ9BIS2, 18 interactors

Proteomic databases

PRIDEiQ9BIS2

Genome annotation databases

EnsemblMetazoaiFBtr0082637; FBpp0082106; FBgn0013278
FBtr0082638; FBpp0082107; FBgn0013279
GeneIDi48582
48583
KEGGidme:Dmel_CG31359
dme:Dmel_CG6489

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
48582
48583
FlyBaseiFBgn0013278 Hsp70Bb

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00940000154813
HOGENOMiCLU_005965_3_0_1
InParanoidiQ9BIS2
KOiK03283
OMAiPCQSVNP
OrthoDBi288077at2759
PhylomeDBiQ9BIS2

Enzyme and pathway databases

ReactomeiR-DME-3371453 Regulation of HSF1-mediated heat shock response
R-DME-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-DME-3371571 HSF1-dependent transactivation
R-DME-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DME-6798695 Neutrophil degranulation
R-DME-72163 mRNA Splicing - Major Pathway
R-DME-8856828 Clathrin-mediated endocytosis
R-DME-888590 GABA synthesis, release, reuptake and degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
48582 0 hits in 5 CRISPR screens
48583 0 hits in 5 CRISPR screens

Protein Ontology

More...
PROi
PR:Q9BIS2

Gene expression databases

BgeeiFBgn0013278 Expressed in larva and 2 other tissues
ExpressionAtlasiQ9BIS2 baseline and differential
GenevisibleiQ9BIS2 DM

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR043129 ATPase_NBD
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
SSF53067 SSF53067, 2 hits
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHSP73_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BIS2
Secondary accession number(s): B0BNN7
, P02824, Q53XF0, Q5I7H2, Q5I7H4, Q5I7H6, Q5I7H8, Q5I7I3, Q5I7I6, Q5I7I8, Q9BIS1, Q9I7J6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 13, 2004
Last modified: June 17, 2020
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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