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Protein

Major heat shock 70 kDa protein Bc

Gene

Hsp70Bc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

Most strains have three copies of the gene coding for this protein at chromosome locus 87C1; two tandemly repeated Hsp70 genes (Hsp70Bb and Hsp70Bc) and one in reverse orientation (Hsp70Ba). Some strains, including that sequenced in the Drosophila genome project have three tandemly repeated Hsp70 genes (Hsp70Bb, Hsp70Bbb and Hsp70Bc).

GO - Molecular functioni

GO - Biological processi

  • heat shock-mediated polytene chromosome puffing Source: FlyBase
  • response to heat Source: FlyBase
  • response to hypoxia Source: FlyBase
  • response to toxic substance Source: FlyBase
  • response to unfolded protein Source: UniProtKB

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Major heat shock 70 kDa protein Bc
Short name:
Heat shock protein 70Bc
Alternative name(s):
HSP70-87C1
Gene namesi
Name:Hsp70Bc
ORF Names:CG6489
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0013279 Hsp70Bc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000783351 – 641Major heat shock 70 kDa protein BcAdd BLAST641

Proteomic databases

PRIDEiQ9BIR7

Expressioni

Inductioni

Heat shock induces the synthesis of seven proteins at five otherwise inactive sites in the polytene chromosomes of fruit fly larvae. Two separate sites, producing two and three copies, respectively, code for the 70 kDa protein.

Gene expression databases

BgeeiFBgn0013278 Expressed in 3 organ(s), highest expression level in larva
ExpressionAtlasiQ9BIR7 baseline and differential
GenevisibleiQ9BIR7 DM

Interactioni

Protein-protein interaction databases

BioGridi71512, 43 interactors
71513, 43 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9BIR7
SMRiQ9BIR7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
InParanoidiQ9BIR7
KOiK03283
OrthoDBiEOG091G03SF
PhylomeDBiQ9BIR7

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BIR7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAIGIDLGT TYSCVGVYQH GKVEIIANDQ GNRTTPSYVA FTDSERLIGD
60 70 80 90 100
PAKNQVAMNP RNTVFDAKRL IGRKYDDPKI AEDMKHWPFK VVSDGGKPKI
110 120 130 140 150
GVEYKGESKR FAPEEISSMV LTKMKETAEA YLGESITDAV ITVPAYFNDS
160 170 180 190 200
QRQATKDAGH IAGLNVLRII NEPTAAALAY GLDKNLKGER NVLIFDLGGG
210 220 230 240 250
TFDVSILTID EGSLFEVRST AGDTHLGGED FDNRLVTHLA EEFKRKYKKD
260 270 280 290 300
LRSNPRALRR LRTAAERAKR TLSSSTEATI EIDALFEGQD FYTKVSRARF
310 320 330 340 350
EELCADLFRN TLQPVEKALN DAKMDKGQIH DIVLVGGSTR IPKVQSLLQE
360 370 380 390 400
FFHGKNLNLS INPDEAVAYG AAVQAAILSG DQSGKIQDVL LVDVAPLSLG
410 420 430 440 450
IETAGGVMTK LIERNCRIPC KQTKTFSTYS DNQPGVSIQV YEGERAMTKD
460 470 480 490 500
NNALGTFDLS GIPPAPRGVP QIEVTFDLDA NGILNVSAKE MSTGKAKNIT
510 520 530 540 550
IKNDKGRLSQ AEIDRMVNEA EKYADEDEKH RQRITSRNAL ESYVFNVKQS
560 570 580 590 600
VEQAPAGKLD EADKNSVLDK CNETIRWLDS NTTAEKEEFD HKMEELTRHC
610 620 630 640
SPIMTKMHQQ GAGAAGGPGA NCGQQAGGFG GYSGPTVEEV D
Length:641
Mass (Da):70,195
Last modified:April 13, 2004 - v2
Checksum:iF2C9C204F67EBB59
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti45E → A in strain: 3CPA81. 1
Natural varianti74K → R in strain: 3CPA2. 1
Natural varianti93S → I in strain: FrV3-1. 1
Natural varianti135S → G in strain: 3CPA2. 1
Natural varianti187K → N in strain: 3CPA2. 1
Natural varianti210D → Y in strain: AUS. 1
Natural varianti330H → N in strain: 3CPA43 and 3CPA81. 1
Natural varianti342P → S in strain: 3CPA43. 1
Natural varianti458D → Y in strain: 3CPA43 and 3CPA81. 1
Natural varianti475T → I in strain: B28. 1
Natural varianti601S → P in strain: 3CPA126. 1
Natural varianti634G → R in strain: AUS. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295958 Genomic DNA Translation: AAG26912.1
AF295959 Genomic DNA Translation: AAG26913.1
AF295960 Genomic DNA Translation: AAG26914.1
AF295961 Genomic DNA Translation: AAG26915.1
AF295962 Genomic DNA Translation: AAG26916.1
AF350484 Genomic DNA Translation: AAK30241.1
AF350485 Genomic DNA Translation: AAK30242.1
AF350486 Genomic DNA Translation: AAK30243.1
AF350487 Genomic DNA Translation: AAK30244.1
AF350488 Genomic DNA Translation: AAK30245.1
AF350489 Genomic DNA Translation: AAK30246.1
AF350490 Genomic DNA Translation: AAK30247.1
AF350491 Genomic DNA Translation: AAK30248.1
AE014297 Genomic DNA Translation: AAG22149.2
BT011541 mRNA Translation: AAS15677.1
J01104 Genomic DNA Translation: AAD15227.1
PIRiA03307 HHFF72
RefSeqiNP_524927.2, NM_080188.3
NP_650209.1, NM_141952.2
UniGeneiDm.18947
Dm.33336

Genome annotation databases

EnsemblMetazoaiFBtr0082637; FBpp0082106; FBgn0013278
FBtr0082638; FBpp0082107; FBgn0013279
GeneIDi48582
48583
KEGGidme:Dmel_CG31359
dme:Dmel_CG6489

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295958 Genomic DNA Translation: AAG26912.1
AF295959 Genomic DNA Translation: AAG26913.1
AF295960 Genomic DNA Translation: AAG26914.1
AF295961 Genomic DNA Translation: AAG26915.1
AF295962 Genomic DNA Translation: AAG26916.1
AF350484 Genomic DNA Translation: AAK30241.1
AF350485 Genomic DNA Translation: AAK30242.1
AF350486 Genomic DNA Translation: AAK30243.1
AF350487 Genomic DNA Translation: AAK30244.1
AF350488 Genomic DNA Translation: AAK30245.1
AF350489 Genomic DNA Translation: AAK30246.1
AF350490 Genomic DNA Translation: AAK30247.1
AF350491 Genomic DNA Translation: AAK30248.1
AE014297 Genomic DNA Translation: AAG22149.2
BT011541 mRNA Translation: AAS15677.1
J01104 Genomic DNA Translation: AAD15227.1
PIRiA03307 HHFF72
RefSeqiNP_524927.2, NM_080188.3
NP_650209.1, NM_141952.2
UniGeneiDm.18947
Dm.33336

3D structure databases

ProteinModelPortaliQ9BIR7
SMRiQ9BIR7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi71512, 43 interactors
71513, 43 interactors

Proteomic databases

PRIDEiQ9BIR7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082637; FBpp0082106; FBgn0013278
FBtr0082638; FBpp0082107; FBgn0013279
GeneIDi48582
48583
KEGGidme:Dmel_CG31359
dme:Dmel_CG6489

Organism-specific databases

CTDi48582
48583
FlyBaseiFBgn0013279 Hsp70Bc

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
InParanoidiQ9BIR7
KOiK03283
OrthoDBiEOG091G03SF
PhylomeDBiQ9BIR7

Miscellaneous databases

PROiPR:Q9BIR7

Gene expression databases

BgeeiFBgn0013278 Expressed in 3 organ(s), highest expression level in larva
ExpressionAtlasiQ9BIR7 baseline and differential
GenevisibleiQ9BIR7 DM

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSP75_DROME
AccessioniPrimary (citable) accession number: Q9BIR7
Secondary accession number(s): P02824
, Q53XF0, Q9BIR8, Q9BIR9, Q9BIS0, Q9I7J6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 13, 2004
Last modified: September 12, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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Main funding by: National Institutes of Health

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