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Protein

Conotoxin TxMEKL-021

Gene
N/A
Organism
Conus textile (Cloth-of-gold cone)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionNeurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin TxMEKL-021
Alternative name(s):
Conotoxin TxMEKL-022
OrganismiConus textile (Cloth-of-gold cone)
Taxonomic identifieri6494 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusCylinder

Organism-specific databases

ConoServeri705 TxMEKL-022/TxMEKL-021 precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000040478620 – 47Sequence analysisAdd BLAST28
PeptideiPRO_000040478748 – 79Conotoxin TxMEKL-021Sequence analysisAdd BLAST32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 65By similarity
Disulfide bondi58 ↔ 69By similarity
Disulfide bondi64 ↔ 75By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiQ9BHB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
The cysteine framework is VI/VII (C-C-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin O2 superfamily.Curated

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiView protein in InterPro
IPR004214 Conotoxin
PfamiView protein in Pfam
PF02950 Conotoxin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BHB7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKLTILLLV AVVLMSTQAL PQGGGEKRPR ENIRFLSKRK SNAERWREGS
60 70
CTSWLATCTD ASQCCTGVCY KRAYCALWE
Length:79
Mass (Da):8,915
Last modified:June 1, 2001 - v1
Checksum:i1A281EA818DE1A8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF215018 mRNA Translation: AAG60446.1
AF215027 mRNA Translation: AAG60455.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF215018 mRNA Translation: AAG60446.1
AF215027 mRNA Translation: AAG60455.1

3D structure databases

SMRiQ9BHB7
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri705 TxMEKL-022/TxMEKL-021 precursor

Family and domain databases

InterProiView protein in InterPro
IPR004214 Conotoxin
PfamiView protein in Pfam
PF02950 Conotoxin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO261_CONTE
AccessioniPrimary (citable) accession number: Q9BHB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: June 1, 2001
Last modified: October 10, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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