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Protein

CD166 antigen

Gene

ALCAM

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM (By similarity). Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Cell adhesion, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
CD166 antigen
Alternative name(s):
Activated leukocyte cell adhesion molecule
CD_antigen: CD166
Gene namesi
Name:ALCAM
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 527ExtracellularSequence analysisAdd BLAST500
Transmembranei528 – 549HelicalSequence analysisAdd BLAST22
Topological domaini550 – 583CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001465828 – 583CD166 antigenAdd BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 113PROSITE-ProRule annotation
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi157 ↔ 220PROSITE-ProRule annotation
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi270 ↔ 313PROSITE-ProRule annotation
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi354 ↔ 392PROSITE-ProRule annotation
Glycosylationi361N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi435 ↔ 485PROSITE-ProRule annotation
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi480N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi499N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BH13
PeptideAtlasiQ9BH13
PRIDEiQ9BH13

Expressioni

Tissue specificityi

Constitutively expressed in the autonomic nervous system. Sympathetic and parasympathetic nerve fibers but not myelinated nerve fibers in the spinal nerve.1 Publication

Interactioni

Subunit structurei

Homodimer. Interacts (via extracellular domain) with CD6 (via extracellular domain). Homodimerization and interaction with CD6 involve the same region and cannot occur simultaneously. The affinity for CD6 is much higher than the affinity for self-association. Interacts (via glycosylated extracellular domain) with LGALS1 and LGALS3. Interaction with LGALS1 or LGALS3 inhibits interaction with CD6.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000097

Structurei

3D structure databases

ProteinModelPortaliQ9BH13
SMRiQ9BH13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 120Ig-like V-type 1Add BLAST93
Domaini125 – 234Ig-like V-type 2Add BLAST110
Domaini245 – 328Ig-like C2-type 1Add BLAST84
Domaini333 – 409Ig-like C2-type 2Add BLAST77
Domaini416 – 501Ig-like C2-type 3Add BLAST86

Domaini

The CD6 binding site is located in the N-terminal Ig-like domain.By similarity

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFQ2 Eukaryota
ENOG410ZWU9 LUCA
HOGENOMiHOG000070101
HOVERGENiHBG050847
InParanoidiQ9BH13
KOiK06547

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9BH13-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASKAAPSCR LVFCLLISAT VLRPGLGWYT VNSAYGDTII MPCRVDVPQN
60 70 80 90 100
LMFGKWKYEK PDGSPVFIAF RSSTKKSVQY DDVPEYKDRL NLSENYTLSI
110 120 130 140 150
SNAKISDEKR FVCMLVTEDD VFEAPTVVKV FKQPSKPEIV SKAPFLETDK
160 170 180 190 200
LKKLGECISK DSYPDGNITW YRNGKVLQAL EGAVVIIFRK QMDSVTQLYT
210 220 230 240 250
MTSSLEYKTT KADIQMPFTC SVTYYGPSGQ KTVYSEQAVF DIYYPTEQVT
260 270 280 290 300
IQVLPSKNAI KEGDNITLKC LGNGNPPPEE FLFYLPGQPE GIRSSNTYTL
310 320 330 340 350
TDVKRNATGD YKCSLVDKKS MIASAAITVH YLDLSLNPSG EVTKQIGDAL
360 370 380 390 400
PVSCTISASR NATVVWMKDN VKLRSSPSFS SLHYQDAGNY VCETALQEVE
410 420 430 440 450
GLKKRESLTL IVEGKPQIKM TKKTDPSGLS KTIICHVEGF PKPAIQWTIT
460 470 480 490 500
GSGSVINQTE ESPYINGRYY SKIIISPEEN VTLTCTAENQ LERTVNSLNV
510 520 530 540 550
SAISIPEHDE ADEISDENKE KVNDQAKLIV GIVVGLLLAA LVAGVVYWLY
560 570 580
MKKSKTASKH VNKDLGNMEE NKKLEENNHK TEA
Length:583
Mass (Da):64,766
Last modified:June 1, 2001 - v1
Checksum:i56B69D0C135B5BA5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1MHN8F1MHN8_BOVIN
CD166 antigen
ALCAM
583Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039957 mRNA Translation: BAB32790.1
RefSeqiNP_776663.1, NM_174238.1
UniGeneiBt.107510

Genome annotation databases

GeneIDi281614
KEGGibta:281614

Similar proteinsi

Entry informationi

Entry nameiCD166_BOVIN
AccessioniPrimary (citable) accession number: Q9BH13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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