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UniProtKB - Q9BGW0 (THTPA_MACFA)
Protein
Thiamine-triphosphatase
Gene
THTPA
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Functioni
Hydrolase highly specific for thiamine triphosphate (ThTP).
By similarityCatalytic activityi
- EC:3.6.1.28
Cofactori
Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 7 | MagnesiumBy similarity | 1 | |
Metal bindingi | 9 | MagnesiumBy similarity | 1 | |
Binding sitei | 11 | SubstrateBy similarity | 1 | |
Binding sitei | 55 | SubstrateBy similarity | 1 | |
Binding sitei | 57 | SubstrateBy similarity | 1 | |
Binding sitei | 65 | SubstrateBy similarity | 1 | |
Binding sitei | 125 | SubstrateBy similarity | 1 | |
Metal bindingi | 145 | MagnesiumBy similarity | 1 | |
Metal bindingi | 157 | MagnesiumBy similarity | 1 | |
Binding sitei | 157 | SubstrateBy similarity | 1 | |
Metal bindingi | 159 | MagnesiumBy similarity | 1 | |
Binding sitei | 193 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- magnesium ion binding Source: UniProtKB
- thiamin-triphosphatase activity Source: UniProtKB
GO - Biological processi
- thiamine diphosphate metabolic process Source: UniProtKB
- thiamine metabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Ligand | Magnesium, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:THTPA ORF Names:QflA-12514 |
Organismi | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
Taxonomic identifieri | 9541 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000221491 | 2 – 230 | Thiamine-triphosphataseAdd BLAST | 229 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 |
Keywords - PTMi
AcetylationInteractioni
Subunit structurei
Monomer.
By similarityProtein-protein interaction databases
STRINGi | 9541.XP_005560942.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 201 | CYTHPROSITE-ProRule annotationAdd BLAST | 197 |
Sequence similaritiesi
Belongs to the ThTPase family.Curated
Phylogenomic databases
eggNOGi | ENOG502S5G9, Eukaryota |
Family and domain databases
CDDi | cd07758, ThTPase, 1 hit |
InterProi | View protein in InterPro IPR033469, CYTH-like_dom_sf IPR023577, CYTH_domain IPR039582, THTPA IPR012177, ThTPase_euk |
PANTHERi | PTHR14586, PTHR14586, 1 hit |
Pfami | View protein in Pfam PF01928, CYTH, 1 hit |
PIRSFi | PIRSF036561, ThTPase, 1 hit |
SMARTi | View protein in SMART SM01118, CYTH, 1 hit |
SUPFAMi | SSF55154, SSF55154, 1 hit |
PROSITEi | View protein in PROSITE PS51707, CYTH, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9BGW0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQGLIEVER KFLPGPGTEE RLQELGGTLE HRVTFRDTYY DTPELSLMQA
60 70 80 90 100
DHWLRRREDS GWELKCPGAA GVLGHHTEYK ELTAEPTIVA QLCKVLGADG
110 120 130 140 150
LGAGDVAAVL DPLGLQEVAS FVTKRSAWKL VLLGTDEEEP QLKVDLGTAD
160 170 180 190 200
FGYAVGEVEA LVHEEAEVPA ALEKIHRLSS MLGVPAQETA PAKLIVYLQR
210 220 230
FRPQNYQRLL EVNSSKQRPQ ATEDPDNCLG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB055296 mRNA Translation: BAB21921.1 |
RefSeqi | NP_001270466.1, NM_001283537.1 |
Genome annotation databases
GeneIDi | 102122817 |
KEGGi | mcf:102122817 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB055296 mRNA Translation: BAB21921.1 |
RefSeqi | NP_001270466.1, NM_001283537.1 |
3D structure databases
AlphaFoldDBi | Q9BGW0 |
SMRi | Q9BGW0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9541.XP_005560942.1 |
Genome annotation databases
GeneIDi | 102122817 |
KEGGi | mcf:102122817 |
Organism-specific databases
CTDi | 79178 |
Phylogenomic databases
eggNOGi | ENOG502S5G9, Eukaryota |
Family and domain databases
CDDi | cd07758, ThTPase, 1 hit |
InterProi | View protein in InterPro IPR033469, CYTH-like_dom_sf IPR023577, CYTH_domain IPR039582, THTPA IPR012177, ThTPase_euk |
PANTHERi | PTHR14586, PTHR14586, 1 hit |
Pfami | View protein in Pfam PF01928, CYTH, 1 hit |
PIRSFi | PIRSF036561, ThTPase, 1 hit |
SMARTi | View protein in SMART SM01118, CYTH, 1 hit |
SUPFAMi | SSF55154, SSF55154, 1 hit |
PROSITEi | View protein in PROSITE PS51707, CYTH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | THTPA_MACFA | |
Accessioni | Q9BGW0Primary (citable) accession number: Q9BGW0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2003 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 88 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families